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Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis

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Cancer Communications 2019年第1期39卷 482-498页

作者： Fei Shao Xueying Yang Wei Wang Juhong Wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue shugeng gao Yibo gao Zhimin Lu Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17 PanjiayuannanliChaoyang DistrictBeijing 100021P.R.China Qingdao Cancer Institute Cancer Institute of The Affiliated Hospital of Qingdao UniversityQingdao 266003ShandongP.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029ZhejiangP.R.China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Background:Cancer cells reprogram metabolism for *** kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial ***,the clini-cal significance of PGK1 expression and function in cancer progression is ***,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism ***:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas *** specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer ***:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,*** breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor *** correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal ***1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach ***:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of ***1 and PDHK1 phosphorylation may be potential prognostic biomarkers.

关键词： PGK1 Cancer metabolism Epigenetics Phosphorylation Methylation The Cancer Genome Atlas Pan-cancer analysis Prognosis Overall survival

Primary intrathoracic liposarcoma:a clinical analysis of 31 cases

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Cancer Communications 2019年第1期39卷 148-150页

作者： Zhixue Fu Kun Yang Xu Yang Shulan Chen Wenqing Wang Dongfu Chen Jun Zhao Zhishan Li Qinfu Feng Zongmei Zhou Luhua Wang shugeng gao Jun Liang Department of Radiation Oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Thoracic Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Records National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Dear Editor,Liposarcoma is a common soft tissue malignancy in *** most commonly occurs in the deep soft tis-sue of the extremities and *** intrathoracic liposarcoma is rare,represents 2.7%of all liposarcomas[1].According to the distinct tumor loca-tions,it can be divided into mediastinal,pleural,and pulmonary *** literature has reviewed the clinicopathological or molecular cytogenetic char-acteristics of mediastinal and thoracic liposarcomas[2,3].However,intrathoracic liposarcoma is poorly docu-mented because of its *** surgical resection is thought to be the best treatment for primary intratho-racic liposarcoma,but the impact of radiotherapy and systemic therapy remains ***,we ana-lyzed the clinicopathological data of 31 patients with primary intrathoracic liposarcoma who were treated in the Cancer Hospital of Chinese Academy of Medical Sci-ences between October 1970 and July 2015 to explore their clinicopathologic features and treatment outcomes(Additional file 1:Table S1).

关键词： sarcoma thoracic Cancer

Long-term outcomes of lobectomy *** for stage I lung invasive mucinous adenocarcinoma

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Chinese Medical Journal 2024年第15期137卷 1879-1881页

作者： Lide Wang Guochao Zhang Chao Zheng Long Zhang Jia Jia Liyan Xue shugeng gao Yushun gao Fengwei Tan Qi Xue Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

To the Editor:Lung invasive mucinous adenocarcinoma(LIMA)is regarded as a subtype of invasive lung adenocarcinoma(LUAD).No significant differences exist in the overall survival(OS)or recurrence-free survival(RFS)between lobectomy and sublobectomy in clinical stage IA non small cell lung cancer(NSCLC)≤2 cm.[1]Besides,the studies on surgical methods in early LIMA are *** this study,we reviewed the clinicopathological features of LIMA and compared its prognosis under different surgical methods.

关键词： adenocarcinoma lung invasive

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加速康复外科在肺癌围术期管理中的应用

山东大学学报（医学版） 2022年第11期60卷 1-10页

作者：高树庚国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院胸外科北京100021

加速康复外科(ERAS)是一种综合的围手术期管理理念,涉及多个学科领域,通过对围手术期各阶段进行优化,实现患者术后快速康复的目的。随着现代科学技术的大力发展,使ERAS理念得以在胸外科领域推广,形成了具有胸外科专科特色的ERAS管理模... 详细信息

加速康复外科(ERAS)是一种综合的围手术期管理理念,涉及多个学科领域,通过对围手术期各阶段进行优化,实现患者术后快速康复的目的。随着现代科学技术的大力发展,使ERAS理念得以在胸外科领域推广,形成了具有胸外科专科特色的ERAS管理模式。综合近年来胸外科肺癌领域ERAS理念的临床应用经验和研究进展,从术前准备、术中管理、术后康复等方面,对目前肺癌围术期管理经验进行总结述评,以期为临床医师将ERAS理念应用在肺癌诊疗时的决策提供参考。

关键词：加速康复外科肺癌胸外科围手术期管理多学科

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An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma

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Signal Transduction and Targeted Therapy 2020年第1期5卷 886-895页

作者： Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang shugeng gao Qi Xue Yi Zhang Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology Anyang Cancer HospitalThe Fourth Affiliated Hospital of Henan University of Science and TechnologyAnyang 455000 HenanChina Department of Radiotherapy The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008 HenanChina Department of General Surgery The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008 HenanChina Department of Otology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052 HenanChina

No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter *** the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs(

关键词： esophageal patients immunity

Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4174-4189页

作者： Yanhua Tian Qingqing Li Zhenlin Yang Shu Zhang Jiachen Xu Zhijie Wang Hua Bai Jianchun Duan Bo Zheng Wen Li Yueli Cui Xin Wang Rui Wan Kailun Fei Jia Zhong shugeng gao Jie He Carl MGay Jianjun Zhang Jie Wang Fuchou Tang State Key Laboratory of Molecular Oncology Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijingChina Beijing Advanced Innovation Center for Genomics&Ministry of Education Key Laboratory of Cell Proliferation and Differentiation BeijingChina Department of Throacic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina Department of Thoracic/Head&Neck Medical Oncology UT MD Anderson Cancer CenterHoustonTX77030USA Peking-Tsinghua Center for Life Sciences Peking UniversityBeijingChina

Small-cell lung cancer(SCLC)is the most aggressive and lethal subtype of lung cancer,for which,better understandings of its biology are urgently ***-cell sequencing technologies provide an opportunity to profile individual cells within the tumor microenvironment(TME)and investigate their roles in tumorigenic ***,we performed high-precision single-cell transcriptomic analysis of~5000 individual cells from primary tumors(PTs)and matched normal adjacent tissues(NATs)from 11 SCLC patients,including one patient with both PT and relapsed tumor(RT).The comparison revealed an immunosuppressive landscape of human *** cells in SCLC tumors exhibited diverse states mainly related to the cell cycle,immune,and hypoxic *** data also revealed the intratumor heterogeneity(ITH)of key transcription factors(TFs)in SCLC and related gene expression patterns and *** non-neuroendocrine(non-NE)tumors were correlated with increased inflammatory gene signatures and immune cell infiltrates in SCLC,which contributed to better responses to immune checkpoint *** findings indicate a significant heterogeneity of human SCLC,and intensive crosstalk between cancer cells and the TME at single-cell resolution,and thus,set the stage for a better understanding of the biology of SCLC as well as for developing new therapeutics for SCLC.

关键词： cancer lung matched

我国食管癌外科治疗目前存在的热点争议与未来研究方向

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中华胃肠外科杂志 2015年第9期18卷 851-854页

作者：赫捷高树庚薛奇中国医学科学院北京协和医学院肿瘤医院胸外科 100021

食管癌是我国高发恶性肿瘤之一，手术治疗在食管癌诊治中仍具有重要地位。但目前还存在较多具有争议的热点问题需要研究解决。这些问题包括食管癌手术入路选择，淋巴结清扫范围与方式的确定，微创手术治疗流程优化和与常规开胸手术的优... 详细信息

食管癌是我国高发恶性肿瘤之一，手术治疗在食管癌诊治中仍具有重要地位。但目前还存在较多具有争议的热点问题需要研究解决。这些问题包括食管癌手术入路选择，淋巴结清扫范围与方式的确定，微创手术治疗流程优化和与常规开胸手术的优劣比较等。将通过网络平台组织全国优秀食管癌治疗中心开展多中心、前瞻性随机分组对照研究来寻求解决这些问题的循证医学证据以便未来修改食管癌诊治指南。

关键词：食管肿瘤手术治疗临床研究

肺纤毛黏液结节性乳头状肿瘤的临床特征和外科治疗

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中华肿瘤杂志 2020年第6期42卷 491-494页

作者：张默言宋朋赵亮高树庚国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院胸外科100021

目的探讨肺纤毛黏液结节性乳头状肿瘤(CMPT)的临床特点和治疗方法。方法回顾性分析2017年1月至2019年4月在中国医学科学院肿瘤医院胸外科接受外科治疗的15例肺CMPT患者的临床、影像学和病理学资料。结果肺CMPT常见于中老年患者,12例CMP... 详细信息

目的探讨肺纤毛黏液结节性乳头状肿瘤(CMPT)的临床特点和治疗方法。方法回顾性分析2017年1月至2019年4月在中国医学科学院肿瘤医院胸外科接受外科治疗的15例肺CMPT患者的临床、影像学和病理学资料。结果肺CMPT常见于中老年患者,12例CMPT患者的肿瘤直径<1 cm,3例CMPT患者的肿瘤直径为1~2 cm。影像学表现以实性结节最为多见(9例),表现为磨玻璃影4例,2例患者的影像学表现不明显。15例患者均采用外科手术治疗,2例患者为开胸手术,13例患者为胸腔镜手术。15例患者中,肺叶切除8例,解剖性部分肺叶切除3例,肺叶楔形切除4例。8例患者的术中冰冻结果为腺癌,其中3例为黏液腺癌,5例诊断为CMPT,2例诊断为炎性结节。2例患者术后出现心律失常,1例患者出现了肺部感染。所有患者在随访期间均无CMPT肿瘤复发。结论肺CMPT往往无明显的临床症状,可与原发性肺癌同时发生,或由查体时影像学筛查发现。其主要治疗手段为手术切除,影像学以实性结节或磨玻璃结节为主要表现,冰冻病理结果易与腺癌或黏液腺癌混淆。

关键词：肺肿瘤纤毛黏液结节性乳头状肿瘤临床特征外科治疗

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精准医学时代的肺癌外科治疗走向

中国肺癌杂志 2016年第6期19卷 318-320页

作者：谭锋维李宁高树庚赫捷中国医学科学院肿瘤医院胸外科北京100021

精准医学是根据每个人从宏观到微观层面的个体差异,制定最为合适的个性化治疗方案。基因组、蛋白组、代谢组等海量生物学数据及大数据分析方法是精准医学模式的精髓。精准医学为人类攻克肿瘤带来了希望。肺癌是对人类危害最大的肿瘤。... 详细信息

精准医学是根据每个人从宏观到微观层面的个体差异,制定最为合适的个性化治疗方案。基因组、蛋白组、代谢组等海量生物学数据及大数据分析方法是精准医学模式的精髓。精准医学为人类攻克肿瘤带来了希望。肺癌是对人类危害最大的肿瘤。本文就肺癌的外科治疗在精准医学时代发展的方向进行了综述。

关键词：精准医学肺肿瘤基因组蛋白组