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Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China Life Sciences 2024年第8期 1666-1675页

作者： Zhennan Lin Jianxin Li Fangchao Liu Jie Cao shufeng chen Jichun chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular Diseases Medical School Southern University of Science and Technology

Individuals with a high degree of salt sensitivity(SS) have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains unclear.This study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the Meta Salt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt intervention.Plasma untargeted metabolomics,lipidomics,and BP measurements were scheduled at each stage.Participants were grouped into extreme SS,moderate SS,and salt-resistant(SR) individuals according to their BP responses to salt.Linear mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial stiffness.Mendelian randomization(MR) analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and CVDs.Among the 713 metabolites,467 were significantly changed after the high-salt intervention.Among them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS groups.Of the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to SS.These 41 metabolites explained 23% of the variance in SS.Moreover,SS and its metabolomics signature were positively correlated with arterial stiffness.MR analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the cause.Our study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster CVDs.This study provides insight into understanding the biology and targets of SS and its role in CVDs.

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Cerium oxide inclusion nucleation mechanism based on classical nucleation theory and two-step nucleation

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Journal of Rare Earths 2024年第4期42卷 793-802页

作者： Yutang Li Jun Wang Linzhu Wang Chaoyi chen shufeng Yang Junqi Li Xiang Li School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Department of Materials&Metallurgy Engineering Guizhou Institute of TechnologyGuiyang550003China

It is challenging to assess the mechanism responsible for the nucleation of inclusions in metals at high temperatures.The present work therefore systematically investigates the nucleation of cerium oxide inclusions according to classical nucleation theory and a two-step nucleation mechanism.The nucleation rates and nucleation radii of these inclusions are obtained,and the results demonstrate a considerable difference between theoretical and experimental values.On the basis of a two-step nucleation mechanism,(CeO_(2))_(n) and(Ce_(2)O_(3))_(n)(n=1-6)clusters were constructed and the thermodynamic properties of both these clusters and of cerium oxide nanoparticles were analyzed.In addition,the entropies and heat capacity changes of cerium oxides were determined using first principles calculations and are found to be consistent with literature data.The present data indicate that the cerium oxide inclusion nucleation pathway can be summarized as[Ce]+[O]→(CeO_(2))n/(Ce_(2)O_(3))_(n)→(Ce_(2)O_(3))_(n)→(Ce_(2)O_(3))_(2)→core(Ce_(2)O_(3)crystal)-shell((Ce_(2)O_(3))_(2) cluster)nanoparticles→(Ce_(2)O_(3))bulk.

关键词： Cerium oxide inclusion Classical nucleation theory Two-step nucleation mechanism First principles Rare earths

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Balancing electron transfer and intermediate adsorption ability of metallic Ni-Fe-RE-P bifunctional catalysts via 4f-2p-3d electron interaction for enhanced water splitting

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Journal of Energy Chemistry 2024年第7期94卷 458-465页

作者： Hong-Rui Zhao cheng-Zong Yuan chenliang Zhou Wenkai Zhao Lunliang Zhang Cong-Hui Li Lei Xin Fuling Wu shufeng Ye Xiaomeng Zhang Yunfa chen School of Rare Earths University of Science and Technology of ChinaHefei 230026AnhuiChina Jiangxi Province Research Institute of Rare Earths Ganjiang Innovation AcademyChinese Academy of SciencesGanzhou 341119JiangxiChina State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Balancing electron transfer and intermediate adsorption ability of bifunctional catalysts via tailoring elec-tronic structures is crucial for green hydrogen production,while it still remains challenging due to lack-ing efficient strategies.Herein,one efficient and universal strategy is developed to greatly regulate electronic structures of the metallic Ni-Fe-P catalysts via in-situ introducing the rare earth(RE)atoms(Ni-Fe-RE-P,RE=La,Ce,Pr,and Nd).Accordingly,the as-prepared optimal Ni-Fe-Ce-P/CC self-supported bifunctional electrodes exhibited superior electrocatalytic activity and excellent stability with the low overpotentials of 247 and 331 mV at 100 mA cm^(-2) for HER and OER,respectively.In the assem-bled electrolyzer,the Ni-Fe-Ce-P/cC as bifunctional electrodes displayed low operation potential of 1.49 V to achieve a current density of 10 mA cm^(-2),and the catalytic performance can be maintained for 10o h.Experimental results combined with density functional theory(DFT)calculation reveal that Ce doping leads to electron decentralization and crystal structure distortion,which can tailor the band structures and d-band center of Ni-Fe-P,further increasing conductivity and optimizing intermediate adsorption energy.Our work not only proposes a valuable strategy to regulate the electron transfer and intermediate adsorption of electrocatalysts via RE atoms doping,but also provides a deep under-standing of regulation mechanism of metallic electrocatalysts for enhanced water splitting.

关键词： RE atoms Electron transfer Adsorption energy Oxygen evolution Hydrogen evolution

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A Facile Construction of Bisheterocyclic Methane Scaffolds through Palladium-Catalyzed Domino Cyclization

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Chinese Journal of Chemistry 2021年第10期39卷 2699-2704页

作者： Hongbo Qi Kaiming Han shufeng chen Inner Mongolia Key Laboratory of Fine Organic Synthesis Department of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhotInner Mongolia010021 China

Main observation and conclusion A convenient palladium-catalyzed domino cyclization reaction for the construction of bis(benzofuranyl)methane scaffolds bearing an all-carbon quaternary center has been described.In the cascade process,one C(sp2)—O bond,two C(sp2)—C(sp3)bonds as well as two benzofuran rings are formed in a single synthetic sequence.The approach shows wide scope of substrates and good functional-group tolerance.Moreover,this methodology is successfully extended to the synthesis of benzofuranyl methyl chromane derivatives.

关键词： Bisheterocyclic methane Heterocycles Palladium Catalysis Domino cyclization

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正态型寿命分布设备的可用性分析

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兵工学报 2024年第3期45卷 986-996页

作者：陈旭张书锋李岳陈循汪亚顺国防科技大学智能科学学院湖南长沙410073 国防科技大学装备综合保障技术重点实验室湖南长沙410073

设备可用性的解析计算方法具有过程直接、结果准确的优点,但其建模过程复杂,目前研究相对较少,而多采用随机过程或仿真的方法进行分析。针对寿命服从正态分布的设备,考虑预防性维修与视情维修情形,推导出设备使用可用度与瞬时可用度的... 详细信息

设备可用性的解析计算方法具有过程直接、结果准确的优点,但其建模过程复杂,目前研究相对较少,而多采用随机过程或仿真的方法进行分析。针对寿命服从正态分布的设备,考虑预防性维修与视情维修情形,推导出设备使用可用度与瞬时可用度的解析求解方法,模拟设备的工作与维修过程,构建了设备使用可用度与瞬可时用度的仿真分析方法。采用不同寿命分布参数的设备进行算例验证,结果表明两种方法具有较好的一致性,可为正态型寿命分布设备的预防性维修与视情维修方案评价与优化提供技术途径。

关键词：设备使用可用度瞬时可用度预防性维修视情维修

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Fruit and vegetable consumption,cardiovascular disease,and all-cause mortality in China

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Science China(Life Sciences) 2022年第1期65卷 119-128页

作者： Jun Wang Fangchao Liu Jianxin Li Keyong Huang Xueli Yang Jichun chen Xiaoqing Liu Jie Cao shufeng chen Chong Shen Ling Yu Fanghong Lu Xianping Wu Liancheng Zhao Ying Li Dongsheng Hu Jianfeng Huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Tianjin Key Laboratory of Environment Nutrition and Public Health/Department of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjin 300070China Division of Epidemiology Guangdong Provincial People’s Hospital and Cardiovascular InstituteGuangzhou 510080China Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjing 211166China Department of Cardiology Fujian Provincial HospitalFuzhou 350014China Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinan 250062China Sichuan Center for Disease Control and Prevention Chengdu 610041China Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Epidemiology and Health Statistics School of Public HealthShenzhen University Health Science CentreShenzhen 518060China School of Medicine Southern University of Science and TechnologyShenzhen 518055China

Evidence about the response patterns of fruit and vegetable consumption with the risk of cardiovascular disease(CVD)and allcause mortality was inconsistent.These associations were examined using a large-scale,population-based Chinese cohort comprising 100,728 participants.A food-frequency questionnaire was used to assess fruit and vegetable consumption.Outcomes were ascertained by interviewing individuals or their proxies and checking hospital records or death certificates.Cox proportional hazards regression was used to calculate hazard ratios(HRs)with 95% confidence intervals(CIs).At the 736,668 person-years of follow-up,3,677 CVD cases and 5,466 deaths were identified.The multivariable-adjusted HRs for CVD across increasing quartiles of total fruit and vegetable consumption were 1(reference),0.94(95%CI=0.85-1.04),0.89(95%CI=0.80-0.98),and 0.85(95%CI=0.77-0.95).Moreover,participants in the highest quartile displayed a 13% lower risk of all-cause mortality(HR=0.87;95%CI=0.80-0.95).A nonlinear dose-response relation was found for CVD,without additional benefits beyond a consumption of600 g d-1,whereas the all-cause mortality risk decreased along with higher consumption,with a linear trend.These associations remained significant for fruit consumption but not for vegetable consumption.Our findings indicated that greater fruit and vegetable consumption was significantly associated with a lower risk of CVD and all-cause mortality.Increasing fruit and vegetable consumption,especially fruit,in the general population would prevent CVD and premature mortality.

关键词： fruit vegetable cardiovascular disease mortality

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数控车床主轴热误差SHO–LSTM预测建模

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工程科学与技术 2024年第2期56卷 277-288页

作者：陈庚郭世杰丁强强苏哲唐术锋内蒙古工业大学机械工程学院内蒙古呼和浩特010051 内蒙古自治区特殊服役机器人重点实验室内蒙古呼和浩特010051

在高精度加工过程中,数控机床主轴误差对加工精度的影响较为严重。数控机床热误差占总误差比例高达40%~70%,是主要的误差源之一。为了提高热误差预测的精度,本文提出一种使用海马优化算法(SHO)优化时序预测网络(LSTM)的精密车床主轴热... 详细信息

在高精度加工过程中,数控机床主轴误差对加工精度的影响较为严重。数控机床热误差占总误差比例高达40%~70%,是主要的误差源之一。为了提高热误差预测的精度,本文提出一种使用海马优化算法(SHO)优化时序预测网络(LSTM)的精密车床主轴热误差预测建模方法。首先,利用羚羊优化算法(GOA)对模糊C均值聚类(FCM)的模糊矩阵常数、最大迭代次数、迭代终止条件进行优化并结合皮尔逊(Person)、斯皮尔曼(Spearman)和肯德尔(Kendall)相关分析方法优化温度测点,使用手肘法确定最优分组规模,根据DB(Davies–Bouldin)、BWP(Bregman Within–class Projection)和Silhouette(Silhouette coefficient)聚类评估指标评估温度测点聚类效果。其次,以车床主轴五点法获取的热误差数据和优化后的温度数据作为输入,使用海马优化算法(SHO)对时序预测网络(LSTM)的隐含层节点、全连接层节点、学习率、L2正则化常数进行优化,并使用S折交叉试验方法确定最优分组规模,建立主轴热误差SHO–LSTM预测模型。再次,在不同转速下对构建的热误差模型对基于平均绝对误差(MAE)、均方根误差(RMSE)和平均绝对百分比误差(MAPE)的预测效果进行评估。最后,在CKA6163A型车床上进行实例验证,使用五点法进行测量辨识,同时测量主轴附近的温度。结果表明:本文所提出的温度测点优化算法相比未优化的模糊C均值聚类(FCM)的DB指标降低了89.00%,BWP和Silhouette分别提高了59.00%和8.17%,优化后的聚类算法可有效降低温度测点间的共线性,提高预测模型的预测效率。本文所提出的海马优化算法(SHO)优化时序预测网络(LSTM)与未优化的时序预测网络(LSTM)相比,均方根误差降低了42%,表明海马优化算法(SHO)可以提高时序预测网络(LSTM)的准确性;与天鹰(AO)优化卷积神经网络(CNN)、反向传播神经网络(BP)相比,本文所提出的预测网络的均方根误差分别降低了3%、57%,SHO–LSTM主轴热误差预测模型的鲁棒性和准确性更高。

关键词：数控机床主轴热误差 GOA-FCM算法热误差预测 SHO-LSTM网络

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Construction of Alkenyl-Functionalized Spirocarbocyclic Scaffolds from Alkyne-Containing Phenol-Based Biaryls via Sequential lodine-Induced Cyclization/Dearomatization and Pd-Catalyzed Coupling of N-Tosylhydrazones

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Chinese Journal of Chemistry 2020年第11期38卷 1257-1262页

作者： Anjia Liu Kaiming Han Xin-Xing Wu shufeng chen Jianbo Wang Inner Mongolia Key Laboratory of Fine Organic Synthesis College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhotInner Mongolia 010021China Beijing National Laboratory of Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

of main obse rvation and conclusion An efficient strategy for the formation of alkenyl-functionalized spirocarbocyclic scaffolds from alkyne-containing phenol-based biaryls via sequential iodine-induced cyclization/dearomatization and Pd-catalyzed coupling of N-tosylhydrazones is developed.The approach provides various spirocarbocyclic compounds in moderate to excellent yields with good functional tolerance.The results also demonstrate the feasibility for the direct cross-couplings of N-tosyl hydrazones with sterically congested tetrasubstituted alkenyl halides.

关键词： coupling substituted Phenol

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Fruit and vegetable intake and the risk of arterial hypertension in China:A prospective cohort study

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Chronic Diseases and Translational Medicine 2023年第4期9卷 309-319页

作者： Zhi He Yanhui Jia Jianxin Li IJie Cao Fangchao Liu Hongfan Li Jichun chen Dongsheng Hu Chong Shen Yingxin Zhao Xiaoqing Liu Ling Yu Jianfeng Huang Xiangfeng Lu Dongfeng Gu shufeng chen Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBeijingChina Department of Epidemiology and Health Statistics Cllege of Public HealthZhengzhou UniversityZhengzhouHenanChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen UniversityShenzhenGuangdongChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical University(Shandong Academy of Medicine Sciences)JinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouGuangdongChina Department of Cardiology Fujian Provincial HospitalFuzhouFujianChina

Background:Population-based epidemiological evidence regarding the association between fruit and vegetable intake and the incidence of hypertension is inconsistent.This prospective cohort study aimed to investigate the association between fruit and vegetable intake and the risk of new-onset hypertension.Methods:Based on the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR),58,981 Chinese adults without hypertension at baseline were included.Information on fruit and vegetable intake was collected using a food-frequency questionnaire.Cox proportional hazards models were performed to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)of incident hypertension.Results:During 640,795 person-years of follow-up,21,008 new cases of hypertension were recorded.Compared with participants in the lowest quintile(Q1)of total fruit and vegetable(TFV)intake,the HRs(95%CIs)of incident hypertension were 0.90(0.86-0.95),0.85(0.81-0.90),0.82(0.78-0.86),and 0.83(0.78-0.88)for the Q2 to Q5 group(ptrend<0.001),respectively.In further analyses categorizing participants according to the recommended intake level(500 g/day),we found that increasing the intake of TFV,even though it was still insufficient for the recommendation,also had a protective effect against the incident hypertension.When considering the intake of fruit or vegetable separately,we found similar trends as the TFV intake.Conclusion:These results suggest that a higher intake of fruit and vegetable is beneficial for preventing hypertension in Chinese adults.

关键词： fruit and vegetable hypertension prospective study

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无人机系统MTBF和使用可用度的建模与仿真

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系统工程与电子技术 2024年第7期46卷 2401-2412页

作者：陈旭李岳张书锋国防科技大学智能科学学院湖南长沙410073 国防科技大学装备综合保障技术重点实验室湖南长沙410073

针对无人机系统组成结构复杂、影响其可靠性可用性的维修保障因素较多的问题,基于设备寿命分布假设,构建了考虑预防性维修和起飞前故障检查的系统平均故障间隔时间(mean time between failures,MTBF)和使用可用度解析模型。并模拟无人... 详细信息

针对无人机系统组成结构复杂、影响其可靠性可用性的维修保障因素较多的问题,基于设备寿命分布假设,构建了考虑预防性维修和起飞前故障检查的系统平均故障间隔时间(mean time between failures,MTBF)和使用可用度解析模型。并模拟无人机的维修过程,采用蒙特卡罗仿真的方法进行MTBF和使用可用度的仿真分析。解析与仿真两种方法的结果具有较好的一致性,可为无人机确定保障方案提供技术途径。

关键词：平均故障间隔时间使用可用度预防性维修起飞前检查

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