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Comprehensive analysis of advanced glycation end-products in commonly consumed foods:presenting a database for dietary AGEs and associated exposure assessment

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Food Science and Human Wellness 2024年第4期13卷 1917-1928页

作者： Qiaozhi zhang Huatao Li Ruixing Zheng Lili Cao shufen zhang Shuifeng zhang Huadong Sheng Yuhao Jiang Yanbo Wang Linglin Fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Ningbo Academy of Product and Food Quality Inspection(Ningbo Fibre Inspection Institute) Ningbo 315048China National Pre-packaged Food Quality Supervision and Inspection Center(Zhejiang) Zhejiang Fangyuan Test Group Co.Ltd.Hangzhou 310018China

Advanced glycation end-products(AGEs)are a group of heterogeneous compounds formed in heatprocessed foods and are proven to be detrimental to human ***,there is no comprehensive database for AGEs in foods that covers the entire range of food categories,which limits the accurate risk assessment of dietary AGEs in human *** this study,we first established an isotope dilution UHPLCQq Q-MS/MS-based method for simultaneous quantification of 10 major AGEs in *** contents of these AGEs were detected in 334 foods covering all main groups consumed in Western and Chinese populations.Nε-Carboxymethyllysine,methylglyoxal-derived hydroimidazolone isomers,and glyoxal-derived hydroimidazolone-1 are predominant AGEs found in most *** amounts of AGEs were high in processed nuts,bakery products,and certain types of cereals and meats(>150 mg/kg),while low in dairy products,vegetables,fruits,and beverages(<40 mg/kg).Assessment of estimated daily intake implied that the contribution of food groups to daily AGE intake varied a lot under different eating patterns,and selection of high-AGE foods leads to up to a 2.7-fold higher intake of AGEs through daily *** presented AGE database allows accurate assessment of dietary exposure to these glycotoxins to explore their physiological impacts on human health.

关键词： Advanced glycation end-products Maillard reaction Processed foods Dietary database Exposure assessment

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基于苯硼酸衍生物的糖类传感器

化学进展 2024年第1期36卷 106-119页

作者：施坦寇东辉薛亚南张淑芬马威大连理工大学精细化工国家重点实验室智能材料化工前沿科学中心大连116024

苯硼酸作为全人工合成的新型糖类识别分子在糖类检测领域受到了广泛的关注,其具有稳定性好、识别能力强等特点,并且易于与多种检测方法耦合。本文首先介绍了苯硼酸与糖类的结合机理,然后总结了对苯硼酸进行结构修饰的策略,主要论述了在... 详细信息

苯硼酸作为全人工合成的新型糖类识别分子在糖类检测领域受到了广泛的关注,其具有稳定性好、识别能力强等特点,并且易于与多种检测方法耦合。本文首先介绍了苯硼酸与糖类的结合机理,然后总结了对苯硼酸进行结构修饰的策略,主要论述了在硼酸基团的邻、间、对位引入吸电子基团或供电子基团的方法,以及在降低pKa和提高糖类检测选择性方面取得的进展;同时也总结了近年来基于这些新型苯硼酸衍生物的糖类传感器,包括电化学传感器、荧光传感器、凝胶传感器和光子晶体传感器,主要分析物为结构类似的葡萄糖、果糖等单糖,并分别论述了检测原理。最后对基于苯硼酸衍生物的糖类传感器进行比较,分析各自的优缺点,并分别从诊疗一体化和复杂化学环境糖类识别检测两个方向对未来苯硼酸衍生物的糖类检测应用进行展望。

关键词：苯硼酸糖电化学荧光凝胶光子晶体

Innovation and application of dyes with high fixation

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Chinese Journal of Chemical Engineering 2022年第11期51卷 146-152页

作者： shufen zhang Wei Ma Bingtao Tang Bin Shan State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian 116024China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266033China

Reactive dyes are the main species for cotton dyeing due to their wide range of hue, satisfactory color fastness and facile application method. Aiming at increasing fixation on cotton fibers, benzimidazolone yellow reactive dyes, sulfonamide red reactive dyes and anthraquinone azo blue reactive dyes are designed. The preparation, characterization and application properties of these dyes with high fixation are introduced in detail. In order to achieve dye fixation to near 100%, macromolecular crosslinking reactive dyes are designed, their dyeing and fixing mechanism are discussed. These novel reactive dyes show promising application prospect in dyeing and printing of cotton fibers.

关键词： Reactive dyes Macromolecular crosslinking dyes Cotton fibers Fixation Dyeing properties

Polysulfide nanoparticles-reduced graphene oxide composite aerogel for efficient solar-driven water purification

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Green Energy & Environment 2023年第1期8卷 267-274页

作者： Fantao Meng Yuang zhang shufen zhang Benzhi Ju Bingtao Tang State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116023China

Along with the environmental pollution, the scarcity of clean water seriously threatens the sustainable development of human ***, the rapid development of solar evaporators has injected new vitality into the field of water purification. However, the industry faces a considerable challenge of achieving comprehensive purification of ions, especially the efficient removal of mercury ions. In this work, we introduce an ideal mercury-removal platform based on facilely and cost-effectively synthesized polysulfide nanoparticles(PSNs). Further development of PSN-functionalized reduced graphene oxide(PSN-rGO) aerogel evaporator results in achieving a high evaporation rate of 1.55 kg m^(-2)h^(-1)with energy efficiency of 90.8% under 1 sun. With the merits of interconnected porous structure and adsorption ability, the photothermal aerogel presents overall purification of heavy metal ions from wastewater. During solar desalination, salt ions can be rejected with long-term stability. Compared with traditional water purification technologies, this highly efficient solar evaporator provides a new practical method to utilize clean energy for clean water production.

关键词： Composite aerogel Solar vapor generation Photothermal conversion Water purification

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温针灸治疗类风湿关节炎的选穴规律分析

中国中医药现代远程教育 2024年第4期22卷 92-95页

作者：张淑芬郭添枫广东药科大学中医学院广东云浮527300 广东药科大学第二附属医院/云浮中医院针灸科广东云浮527300

目的研究温针灸治疗类风湿关节炎(RA)中的穴位选取规律。方法通过对现有关于温针灸治疗类风湿关节炎的期刊文献进行整理归纳,对主、配穴进行统计分析。结果在经络选取上以阳经为主,如主穴选取的经络频次排在前4的分别为足太阳膀胱经[... 详细信息

目的研究温针灸治疗类风湿关节炎(RA)中的穴位选取规律。方法通过对现有关于温针灸治疗类风湿关节炎的期刊文献进行整理归纳,对主、配穴进行统计分析。结果在经络选取上以阳经为主,如主穴选取的经络频次排在前4的分别为足太阳膀胱经[19.68%(61/310)]、任脉[14.52%(45/310)]、足阳明胃经[13.55%(42/310)]和足太阴脾经[13.23%(41/310)];而配穴选取的经络频次排前4的分别是手阳明大肠经[16.73%(85/508)]、经外奇穴[12.80%(65/508)]、足少阳胆经[12.01%(61/508)]和手少阳三焦经[12.01%(61/508)]。在穴位的选取上,主穴以足三里出现的频次最高[78.26%(36/46)],其次是关元[56.52%(26/46)]和肾俞[43.48%(20/46)];配穴则以解溪出现的频次最高[56.52%(26/46)],其次则是阳池[50.00%(23/46)]和八邪[50.00%(23/46)]。结论利用温针灸治疗类风湿关节炎时选穴规律遵循标本同治和固护脾胃的法则。

关键词：痹证类风湿关节炎温针灸选穴规律

文旅融合视域下长岛渔号保护传承面临的困境及协同发展路径研究

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山东农业工程学院学报 2024年第3期41卷 95-101页

作者：孙磊杨沼佩张淑芬齐鲁师范学院山东济南250200

长岛渔号是长岛渔民在风帆时代进行渔猎生产时喊的劳动号子,距今有近400年历史,是国家级非物质文化遗产。文旅融合视域下,依托长岛得天独厚的自然条件和文化底蕴,对“长岛渔号”这一文化符号进行产业化开发和商业运作,不仅有利于推进对... 详细信息

长岛渔号是长岛渔民在风帆时代进行渔猎生产时喊的劳动号子,距今有近400年历史,是国家级非物质文化遗产。文旅融合视域下,依托长岛得天独厚的自然条件和文化底蕴,对“长岛渔号”这一文化符号进行产业化开发和商业运作,不仅有利于推进对其的非遗保护和传承发展,也对推进海岛旅游文化产业的繁荣发展具有重要意义。本文拟使用SWOT分析法探索长岛渔号在推进长岛文旅融合规划中的适应度,运用协同发展理论深入探索长岛渔号创新发展路径等。

关键词：国家非遗长岛渔号文旅融合协同发展

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光子晶体结构色材料的研究及应用进展

染料与染色 2024年第2期61卷 1-10页

作者：孟凡浩马威张淑芬大连理工大学化工学院精细化工国家重点实验室教育部智能材料化工前沿科学中心大连116024

通过在光子晶体中引入刺激响应性材料,或构建多孔结构,可以制备具有响应变色特性的结构色。本文从光子晶体结构色特点出发,介绍了近年来的光子晶体在着色、防伪、相对湿度监测、温度传感、VOCs检测、pH、应力监测等领域的应用研究,并对... 详细信息

通过在光子晶体中引入刺激响应性材料,或构建多孔结构,可以制备具有响应变色特性的结构色。本文从光子晶体结构色特点出发,介绍了近年来的光子晶体在着色、防伪、相对湿度监测、温度传感、VOCs检测、pH、应力监测等领域的应用研究,并对光子晶体结构色材料在不同领域中的应用前景进行展望。

关键词：光子晶体结构色响应变色检测

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基于联邦集成算法对不同脱敏数据的研究

应用科学学报 2024年第1期42卷 94-102页

作者：罗长银陈学斌张淑芬尹志强石义李风军宁夏大学数学统计学院宁夏银川750021 华北理工大学理学院河北唐山063210 华北理工大学河北省数据科学与应用重点实验室河北唐山063210

针对联邦学习中存在梯度更新导致本地数据可能泄露的问题,提出基于本地脱敏数据上的联邦集成算法。该算法用变异率与适应度阈值的不同取值对原始数据进行脱敏,且使用不同类型的模型在经不同程度脱敏的数据上进行本地模型训练,以确定适... 详细信息

针对联邦学习中存在梯度更新导致本地数据可能泄露的问题,提出基于本地脱敏数据上的联邦集成算法。该算法用变异率与适应度阈值的不同取值对原始数据进行脱敏,且使用不同类型的模型在经不同程度脱敏的数据上进行本地模型训练,以确定适合的联邦集成算法参数。实验结果表明,与联邦平均算法和传统集中式训练相比,stacking联邦集成算法与voting联邦集成算法的准确率要优于基线准确率。在实际应用中,可根据不同的需求设置不同的脱敏参数来保护数据,以此提升数据的安全性。

关键词：联邦学习梯度更新联邦集成算法集成算法

Cell membrane coated-nanoparticles for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3233-3254页

作者： Yingping Zeng Sufen Li shufen zhang Li Wang Hong Yuan Fuqiang Hu College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China

Cancer immunotherapy can effectively inhibit cancer progression by activating the autoimmune system, with low toxicity and high effectiveness. Some of cancer immunotherapy had positive effects on clinical cancer treatment. However, cancer immunotherapy is still restricted by cancer heterogeneity, immune cell disability, tumor immunosuppressive microenvironment and systemic immune toxicity. Cell membrane-coated nanoparticles(CMCNs) inherit abundant source cell-relevant functions, including “self” markers, cross-talking with the immune system, biological targeting, and homing to specific regions. These enable them to possess preferred characteristics, including better biological compatibility, weak immunogenicity, immune escaping, a prolonged circulation, and tumor ***, they are applied to precisely deliver drugs and promote the effect of cancer *** the review, we summarize the latest researches of biomimetic CMCNs for cancer immunotherapy,outline the existing specific cancer immune therapies, explore the unique functions and molecular mechanisms of various cell membrane-coated nanoparticles, and analyze the challenges which CMCNs face in clinical translation.

关键词： Biomimetic Cell membrane-coated nanoparticles Drug delivery “Self”markers Tumor targeting Cancer immunotherapy Cancer vaccines Immune checkpoint blockade inhibitors