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经济地理 2017年第9期37卷 102-110页

作者：郭淑芬李晓琪阎晓山西财经大学资源型经济转型协同创新中心中国山西太原030006

借融入环渤海地区合作发展的机会窗口,山西承接京津冀产业转移是其推进全省产业转型的重要路径。区际产业转移和承接是两地间产业相互吸引的结果,只有两者相互耦合才是有效的产业转移与承接。文章在利用产业集聚指数、全局空间自相关指... 详细信息

借融入环渤海地区合作发展的机会窗口,山西承接京津冀产业转移是其推进全省产业转型的重要路径。区际产业转移和承接是两地间产业相互吸引的结果,只有两者相互耦合才是有效的产业转移与承接。文章在利用产业集聚指数、全局空间自相关指数测度京津冀地区具有转移趋势的第二产业范围基础上,结合山西产业承接能力和产业承接需求,着重通过构建产业引力模型测算山西对京津冀转移工业细分门类的吸引力情况,确定山西最可能承接的京津冀转移产业。结果表明:(1)京津冀地区有转移趋势的产业集中在河北和天津两地,以资源密集型产业和资本密集型产业为主。转移产业包括煤炭开采和洗选业,黑色金属矿采选业,纺织业,石油加工、炼焦和核燃料加工业,黑色金属冶炼和压延加工业,金属制品业,汽车制造业,计算机、通信和其他电子设备制造业,电力、热力生产和供应业,水的生产和供应业等。(2)通过承接需求筛选,目前山西有承接需求的产业包括:黑色金属冶炼压延加工业,电力、热力生产和供应业,石油加工、炼焦和核燃料加工业,金属制造业,计算机、通信和其他电子设备制造业等。

关键词：环渤海地区京津冀产业承接产业集聚指数引力模型山西

Synthesis and Characterization of ZTA-TiC Composite Fabricated by Spark Plasma Sintering

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IMP & HIRFL Annual Report 2018年第1期 96-97页

作者： Zhu Yabin liu Chao Tai Pengfei Chai Jianlong Guo Yawei li shufen Wang Zhiguang 不详

ZTA-TiC composite,which possesses attractive mechanical properties,good electrical and thermal conductivities,has attracted significant attention because of its potential applications in many aspects,such as bearing components,cutting tool inserts,valve seats,pump components,oxygen sensors,dies and prosthetic components *** commercialα-Al_(2)O_(3)(99.99%)with average particle size of 30 nm YSZ(3 mol%Y2O3 stabilized ZrO_(2) 99.99%)and TiC(99%)both with average particle size of 50 nm were used as starting ***α-Al_(2)O_(3),ZrO_(2) and TiC was mixed in different ratios and mechanically milled in a planetary ball *** as the milling media was added into the powder mixture and was wet-mixed by ZrO_(2) grinding ball milling in a zirconia jar for 20 *** being mixed,dried and sieved,the powders were loaded into the cylinder dies and sintered by the spark plasma sintering(SPS)apparatus in vacuum(<10 Pa)at temperature of 1400℃,with a pressing pressure of 40 *** holding time was 10 *** examination,the surfaces of the samples were ground to remove the graphite layer.

关键词： powders dried remove

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乳腺癌术后辅助化疗的进展

中国肿瘤临床 2007年第13期34卷 772-775页

作者：佟仲生李淑芬天津医科大学附属肿瘤医院肿瘤内二科乳腺癌防治教育部重点实验室天津市300060

辅助化疗是乳腺癌综合治疗中的重要组成部分,也是预防远处转移的主要手段。本文对近年来乳腺癌术后辅助化疗进展的相关文献进行了回顾,在内科治疗方面,规范化、个体化是乳腺癌辅助治疗的方向。

关键词：乳腺癌综合治疗辅助化疗

Schizophrenia-associated rs4702 G allele-specific downregulation of FURIN expression by miR-338-3p reduces BDNF production

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Schizophrenia-associated rs4702 G allele-specific downregula...

The Relationships between Executive Function and Problem Behavior of Preschool Children:Contextual Specificity and Gender Differences

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Wenquan liang Yu Hou Wenquan liang Jian Zhang Qiyang li Haiyan Ou Zhongju Wang shufen li Cunyou Zhao Department of Medical Genetics School of Basic Medical SciencesSouthern Medical University Guangdong Technology and Engineering Research Center for Molecular Diagnostics of Human Genetic Diseases Guangdong Province Key Laboratory of Psychiatric Disorders

Genome-wide association studies（GWAS） have revealed numerous schizophrenia（SCZ）-associated single-nucleotide polymorphisms（SNPs）;however, functional characterizations of the risk variants remain to be established. Using data from 108 SCZ GWAS loci, we performed systematic miRNA binding site screening of 128 SCZ-associated SNPs and found that 2 out of 3 SNPs located in the 3’UTR were predicted to alter 3 miRNAs’ binding sites in 2 target genes. Of the identified SNPs, the most genomewide significant SNP rs4702（A/G） in the FURIN 3’UTR, previously identified as an SCZ-associated cisexpression quantitative trait loci（downregulated by the risk G allele）, is located in the binding site of miR-338-3 p in the presence of the risk G allele. Allele-specific downregulation of FURIN by miR-338-3 p was validated with a luciferase reporter assay. Furthermore, we demonstrated that miR-338-3 p-mediated FURIN inhibition reduced brain-derived neurotrophic factor（BDNF） maturation and secretion in human embryonic kidney 293 T cells. Our data reveal that schizophrenia-associated rs4702 G allele-specific downregulation of FURIN by mi R-338-3 p reduces mature BDNF production. These data help elucidate the mechanism of genetic predisposition toward schizophrenia or other neurodevelopmental diseases.

关键词： miRNA FURIN genome-wide association study schizophrenia single-nucleotide polymorphism BDNF

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Frontiers of Education in China 2024年第2期19卷 119-137页

作者： BAI Rong YAN Rong WANG Qian li Ye XING shufen Beijing Key Laboratory of Learning and Cognition School of PsychologyCapital Normal UniversityBeijing 100048China Institute of Leadership and Education Advanced Development Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

This study utilized a longitudinal design to examine the relationships between the specific components of executive function(EF)and the internalizing and externalizing behavior across different genders and contexts in Chinese cultural ***,cognitive flexibility,and working memory of EF based on 101 preschool children’s(48 boys and 53 girls)(M_(T1)=4.25,SD=0.76)performances were measured when completing tasks in NIH *** months later,boys’and girls’internalizing and externalizing behavior in home-and school-settings was assessed through mother’s feedback on the Strengths and Difficulties Questionnaire and teachers’reports of the Child Behavior Rating *** results show that boys’inhibition,cognitive flexibility,and working memory negatively predict their externalizing behavior in the home context,while their cognitive flexibility negatively predicts externalizing behavior in the school ***,boys’inhibition positively predicts their internalizing behavior only in the school *** girls,their cognitive flexibility positively predicts externalizing behavior only in the school *** significant relationship is found among the girls between EF and problem behavior in the home *** findings suggest that gender differences and a shift in contexts could alternate the relationship between EF and children’s problem *** study sheds light on targeted preventions and interventions based on contexts and gender.

关键词： executive function(EF) problem behavior contextual specificity gender differences preschool children

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挥发油的超临界流体萃取与分离进展

化工进展 2007年第1期26卷 42-46页

作者：侯彩霞李淑芬天津大学化工学院绿色合成与转化教育部重点实验室天津300072

挥发油是天然产物中一类重要的活性成分。挥发油的选择性萃取与分离具有非常重要的意义。综述了天然产物中挥发油的超临界流体萃取与分离,介绍了单一超临界流体萃取工艺优化,加入夹带剂,超临界流体萃取与精馏、吸附、分子蒸馏、双逆向... 详细信息

挥发油是天然产物中一类重要的活性成分。挥发油的选择性萃取与分离具有非常重要的意义。综述了天然产物中挥发油的超临界流体萃取与分离,介绍了单一超临界流体萃取工艺优化,加入夹带剂,超临界流体萃取与精馏、吸附、分子蒸馏、双逆向蒸发等技术联用,及其在挥发油成分选择性萃取与分离中的应用。

关键词：选择性提取超临界流体挥发油分离

两步扩散模型对超临界CO2萃取丁香油的数值模拟

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化工学报 2011年第7期62卷 1933-1937页

作者：刘乃汇李淑芬关文强天津大学化工学院教育部绿色合成与转化重点实验室天津300072 南开大学化学学院天津300071 国家农产品保鲜工程技术研究中心天津300384

基于扩散模型方程和集总参数模型方程,首次建立了具有3个可调参数的两步扩散模型方程。该模型同时考虑固体颗粒内扩散阻力与内壁的阻力,能较好地描述超临界流体萃取过程。用两步扩散模型方程模拟了超临界CO2萃取丁香油的动态过程,在实... 详细信息

基于扩散模型方程和集总参数模型方程,首次建立了具有3个可调参数的两步扩散模型方程。该模型同时考虑固体颗粒内扩散阻力与内壁的阻力,能较好地描述超临界流体萃取过程。用两步扩散模型方程模拟了超临界CO2萃取丁香油的动态过程,在实验温度与压力范围内模型计算值与实验数据的平均相对误差AARD在2.33%~19.48%之间,所有实验点的AARD为8.09%。而用扩散模型方程和集总参数模型方程模拟,所有实验点的AARD分别为17.51%和8.13%,表明两步扩散模型对于超临界CO2萃取丁香油的传质过程的模拟效果优于扩散模型方程和集总参数模型方程。

关键词：超临界CO2萃取丁香油数值模拟

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酵母细胞微囊化水杨酸甲酯

化工学报 2006年第4期57卷 908-911页

作者：王金宇李淑芬田松江天津大学化工学院绿色合成与转化教育部重点实验室天津300072

以灭活的干酵母细胞为囊壁材料制备水杨酸甲酯微囊.研究了包埋温度、心材比、包埋时间等因素对微囊制备效果的影响.实验结果表明,在包埋温度70℃、心材比2ml·g-1、包埋时间6h条件下,水杨酸甲酯包埋率可以达到48.58%.这种新型的药物微... 详细信息

以灭活的干酵母细胞为囊壁材料制备水杨酸甲酯微囊.研究了包埋温度、心材比、包埋时间等因素对微囊制备效果的影响.实验结果表明,在包埋温度70℃、心材比2ml·g-1、包埋时间6h条件下,水杨酸甲酯包埋率可以达到48.58%.这种新型的药物微囊化方法,具有制备过程简单、包埋率高、不引入有机溶剂的特点.

关键词：微囊化干酵母水杨酸甲酯包埋率

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复合推进剂无烟化的实验研究

推进技术 1989年第1期10卷 47-53页

作者：李疏芬夏幼南中国科学技术大学

本文从实验上研究了一系列复合推进剂在燃烧室内点火所产生的燃气对激光、红外、可见光及微波等信号产生的衰减;对实验结果进行了理论分析和解释,找出了复合推进剂中AP粒度、含量、级配比、Al粉粒度、含量及燃烧室压力等诸因素对衰减大... 详细信息

本文从实验上研究了一系列复合推进剂在燃烧室内点火所产生的燃气对激光、红外、可见光及微波等信号产生的衰减;对实验结果进行了理论分析和解释,找出了复合推进剂中AP粒度、含量、级配比、Al粉粒度、含量及燃烧室压力等诸因素对衰减大小的影响规律;同时也给出了对信号衰减较小的AP粒度级配范围,为复合推进剂无烟化的研究提供了参考依据.

关键词：复合推进剂无烟推进剂信号衰落