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Gold nanoparticles cause size-dependent inhibition of embryonic development during murine pregnancy

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Nano Research 2018年第6期11卷 3419-3433页

作者： Xiaowei Ma Xiaolong Yang Yufei Wang Juan Liu shubin jin Shuyi Li Xing-Jie Liang Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of China No. 11 First North Road Zhongguancun Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China College of Biotechnology Tianjin University of Science & Technology Tianjin 300457 China Tissue Engineering Lab Beijing Institute of Transfusion Medicine Beijing 100850 China Beijing Municipallnstitute of Labour Protection No. 55 Taoranting Road Xicheng District Beijing 100054 China

Gold nanoparticles （Au NPs） have been widely utilized in biomedical appli- cations owing to their attractive features and biocompatibility, which greatly increase the risk of humans＂ being exposed to Au NPs, including pregnant women. In contrast to mature cells, embryos are more susceptible to outside disruptive stimuli. Nonetheless, a possible inhibitory effect of nanomaterials on embryonic development is usually ignored as long as the NPs do not have significant cytotoxic effects. According to our results, a minimal ＂nontoxic＂ concentration of Au NPs during early pregnancy can have lethal inhibitory effects on embryos in vivo and in vitro. We conducted important experiments on the influence of Au NPs on embryonic development and found that Au NPs can disturb embryonic development in a size- and concentration-dependent manner. Au NPs of 15 nm in diameter downregulated the expression pattern of distinct germ layer markers both at mRNA and protein levels; this action prevented differentiation of all three embryonic germ layers. Consequentl~ fetal resorption was observed. Our work reveals the impact of Au NPs on embryonic development and will provide an important guidance and serve as a reference for biomedical applications of Au NPs with minimal side effects.

关键词： gold nanoparticles embryonic development fetal resorption differentiation

Preparation and characterization of doxorubicin functionalized tiopronin-capped gold nanorods for cancer therapy

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Chinese Science Bulletin 2013年第33期58卷 4072-4076页

作者： HUO ShuaiDong jin shubin ZHENG KaiYuan HE ShengTai WANG DongLiang LIANG XingJie CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology School of Materials Science and Engineering Tianjin Polytechnic University

Gold nanomaterials are immerging candidates in medical diagnosis and *** them,gold nanorods(Au NRs)are widely used for cancer *** as a novel thiol drug was used to stabilize Au NRs in this ***(DOX),a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis,was linked to Au NRs through electrostatic reaction with tiopronin,to obtain Au-TIOP-DOX *** NRs are also regarded as hyperthermia agents for photothermal cancer *** delivery system(Au-TIOP-DOX NRs)was designed for passively targeting tumor cells in cancer *** importantly,the carboxyl groups of tiopronin can be modified with some biological molecules(DNA/RNA,peptides,or drugs)to make Au NRs as a novel drug-delivery system for cancer treatment.

关键词：癌症治疗硫普罗宁纳米棒黄金阿霉素功能化自然保护区化疗药物

Near-infrared fluorescent aptamer-templated silver nanoclusters facilely synthesized for cellular imaging applications

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Chinese Science Bulletin 2014年第16期59卷 1868-1872页

作者： Shengliang Li Weipeng Cao shubin jin Chunqiu Zhang Juan Liu Guozhang Zou Feng Li Xing-Jie Liang Department of Neurobiology and Anatomy Zhongshan School of MedicineSun Yat-sen University Laboratory of Nanomedicine and Nanosafety Division of Nanomedicine and NanobiologyNational Center for Nanoscience and Technology of China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Chinese Academy of Sciences

Fluorescent metal nanoclusters(NCs)have received extensive attention for their potential uses in ***,we develop a facile strategy to synthesize near-infrared fluorescent silver nanoclusters(Ag NCs)stabilized by MUC1 *** MUC1-Ag NCs are characterized by UV–Vis absorption spectroscopy,fluorescence spectroscopy,transmission electron microscopy,and fluorescence *** results indicated that the MUC1-Ag NCs possess bright near-infrared luminescence,high stability,and excellent *** cellular imaging of MUC1-Ag NCs by confocal laser microscopy demonstrated them to be promising candidates as novel fluorescent probes for biomedical application.

关键词：生物医学应用近红外发光荧光光谱纳米团簇合成适体激光共聚焦显微镜透射电子显微镜

城乡统筹视角下完善西部农村最低生活保障制度的对策分析

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财经科学 2008年第5期 118-124页

作者：金淑彬成都信息工程学院经济贸易系

明显差异的城乡社会保障制度阻碍了城乡统筹发展。西部农村最低生活保障制度的建立,对于解决农村贫困农民的生存问题起到了功不可没的作用。但与此同时,我们还应注意到其存在的一些问题,我们只有不断去发现这些问题并努力寻求解决办法,... 详细信息

明显差异的城乡社会保障制度阻碍了城乡统筹发展。西部农村最低生活保障制度的建立,对于解决农村贫困农民的生存问题起到了功不可没的作用。但与此同时,我们还应注意到其存在的一些问题,我们只有不断去发现这些问题并努力寻求解决办法,才能让已经建立起来的西部农村最低生活保障制度可持续协调发展。

关键词：城乡统筹西部农村最低生活保障对策

当前国情形势下中国农业保险更应加强政府职责

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世界农业 2010年第1期 23-26页

作者：金淑彬成都信息工程学院

农业保险是适应世界贸易组织规则的绿箱政策,也是实现农业保护的一种重要方式,它是一种准公共产品,有较大的正外部效应。本文通过对中国当前国情分析及农业保险实施状况的历史回顾,说明中国农业保险的快速和持续发展需要来自政府的大力... 详细信息

农业保险是适应世界贸易组织规则的绿箱政策,也是实现农业保护的一种重要方式,它是一种准公共产品,有较大的正外部效应。本文通过对中国当前国情分析及农业保险实施状况的历史回顾,说明中国农业保险的快速和持续发展需要来自政府的大力支持,并在此基础上提出了有关中国农业保险的政策建议。

关键词：农业保险政府职责中国国情世界贸易组织农业保护绿箱政策公共产品

Effects of the physicochemical properties of gold nanostructures on cellular internalization

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Regenerative Biomaterials 2015年第4期2卷 273-280页

作者： Ningqiang Gong Shizhu Chen shubin jin jinchao Zhang Paul C.Wang Xing-Jie Liang CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190China Key Laboratory of Chemical Biology of Hebei Province Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationCollege of Chemistry and Environmental ScienceHebei UniversityBaoding 071002P.R.China Laboratory of Molecular Imaging Department of RadiologyHoward UniversityWashingtonDC 20060USA

Unique physicochemical properties of Au nanomaterials make them potential star materials in biomedicalapplications. However, we still know a little about the basic problem of what really mattersin fabrication of Au nanomaterials which can get into biological systems, especially cells, with highefficiency. An understanding of how the physicochemical properties of Au nanomaterials affecttheir cell internalization is of significant interest. Studies devoted to clarify the functions of variousproperties of Au nanostructures such as size, shape and kinds of surface characteristics in cell internalizationare under way. These fundamental investigations will give us a foundation for constructingAu nanomaterial-based biomedical devices in the future. In this review, we present the current advancesand rationales in study of the relationship between the physicochemical properties of Aunanomaterials and cell uptake. We also provide a perspective on the Au nanomaterial-cell interactionresearch.

关键词： gold nanostructures cellular internalization size,shape surface chemistry

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某大峡谷玻璃桥桥址边坡稳定性分析

铁道科学与工程学报 2016年第11期13卷 2197-2203页

作者：金书滨胡涛乔世范贵州省公路工程集团有限公司贵州贵阳550008 中南大学土木工程学院湖南长沙410075

为确保某大峡谷玻璃桥及配套工程建设的安全,基于有限元方法对大峡谷两侧陡立岸坡及拉锚处进行稳定性分析,并对最初设计时的桥址位置是否适宜建设该工程进行评价。采用三维有限元软件,结合现场岩土工程条件,对玻璃桥桥址边坡在天然状态... 详细信息

为确保某大峡谷玻璃桥及配套工程建设的安全,基于有限元方法对大峡谷两侧陡立岸坡及拉锚处进行稳定性分析,并对最初设计时的桥址位置是否适宜建设该工程进行评价。采用三维有限元软件,结合现场岩土工程条件,对玻璃桥桥址边坡在天然状态下和桥梁荷载条件下的位移、应力状态进行数值模拟,获得坡体在玻璃桥荷载作用下塑性区的分布规律。研究结果表明:所计算桥址的位置在外力作用下处于欠稳定—不稳定状态,建议改变桥址设计位置或对不良地质作用发育区域的岩体进行加固治理,为某大峡谷玻璃桥的进一步设计提供参考。

关键词：边坡稳定性分析三维有限元位移状态应力状态数值模拟

ZJ17卷接机组烟丝在线回收装置的研制与应用

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烟草科技 2014年第6期47卷 26-28页

作者：刘禹江金姝彬张朝晖梁丰河北中烟工业有限责任公司张家口卷烟厂

为解决ZJ17卷接机组在吸丝成型过程中因烟丝吸入集中除尘系统而造成的烟丝浪费问题,借鉴打叶复烤生产线切向落料器的工作原理,研制了除尘烟丝在线回收装置。该装置采用两级气流分离方式对物料进行分离:第一级采用旋风分离方式分离除尘... 详细信息

为解决ZJ17卷接机组在吸丝成型过程中因烟丝吸入集中除尘系统而造成的烟丝浪费问题,借鉴打叶复烤生产线切向落料器的工作原理,研制了除尘烟丝在线回收装置。该装置采用两级气流分离方式对物料进行分离:第一级采用旋风分离方式分离除尘气流中的悬浮物,第二级提取物料的有用成分,实现烟丝与烟尘的分离,分离出的烟丝在线回收到卷烟机供料系统中。应用结果表明:ZJ17卷接机组采用回收装置后,所检测的3个品牌卷烟的烟支质量、吸阻、端部落丝量指标均符合工艺要求,平均回收烟丝9.34 kg/班,烟丝回收率达到81.4%,有效降低了烟丝损耗,提高了烟丝利用率。

关键词： ZJ17卷接机组供料系统烟丝回收气流分离切向落料器

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斜坡路堤沉降计算方法

价值工程 2011年第27期30卷 65-67页

作者：金书滨贵州省公路工程集团有限公司贵阳550008

随着我国高等级公路建设不断向山区延伸,斜坡上填筑公路路堤时有发生。本文主要根据斜坡地基上路堤的具体特点,应用土力学中的应力分布原理,详细分析了该工况条件下路堤内部各关键点位的受力计算方法,进而提出了斜坡地基上路堤的沉降计... 详细信息

随着我国高等级公路建设不断向山区延伸,斜坡上填筑公路路堤时有发生。本文主要根据斜坡地基上路堤的具体特点,应用土力学中的应力分布原理,详细分析了该工况条件下路堤内部各关键点位的受力计算方法,进而提出了斜坡地基上路堤的沉降计算方法,对类似工程的建设具有十分重要的参考价值和理论实际意义。

关键词：斜坡地基路堤沉降计算