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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li Fang-Yi Huo Qian-Fang Meng Ganglin Tong Xuan Wu Lin-Lin Bu Lang Rao shubin wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent sensors.However,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been reported.In this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and amidogen.The synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOD)as low as 15.4 nmol/L,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily life.In cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization analysis.The work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Chemoselective electrochemical seleno-cyclization of dienes to medium-sized benzo[b]azocines

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Chinese Chemical Letters 2024年第2期35卷 431-435页

作者： Zhichuan wang Xin wang Quanxin Li Shaofei Ni Dongyang Zhao shubin Yang Ge Qiu Kai Sun College of Chemistry and Chemical Engineering Yantai UniversityYantai 264005China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063China Aix Marseille Univ. CNRSCentrale MarseilleiSm2MarseilleFrance

The preparation of medium-sized benzo[b]azocines has always been challenging because of inherently unfavorable enthalpy and entropy factors.This report presents a novel approach for accessing 8-membered seleno-benzo[b]azocines via electrochemically-driven seleno-cyclization.This method enables room-temperature preparation of various structurally diverse medium-sized seleno-benzo[b]azocines.The facile deselenation of the seleno-cyclization products to generate functionalized dienes is an additional benefit of this indispensable reaction.Mechanistic insights are presented based on radical inhibition experiments and cyclic voltammetry measurements,which elucidate the radical pathway.Finally,density functional theory calculations further rationalize the rate-determining step and the unique chemoselectivity observed in this transformation.

关键词： Medium-sized n-heterocycles Electrocatalysis Radical Mechanistic insights Selenylation

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A Railway Fastener Inspection Method Based on Abnormal Sample Generation

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 565-592页

作者： shubin Zheng Yue wang Liming Li Xieqi Chen Lele Peng Zhanhao Shang Higher Vocational and Technical College Shanghai University of Engineering ScienceShanghai200437China School of Urban Railway Transportation Shanghai University of Engineering ScienceShanghai201620China Shanghai Engineering Research Centre of Vibration and Noise Control Technologies for Rail Transit Shanghai University of Engineering ScienceShanghai201620China

Regular fastener detection is necessary to ensure the safety of railways.However,the number of abnormal fasteners is significantly lower than the number of normal fasteners in real railways.Existing supervised inspectionmethods have insufficient detection ability in cases of imbalanced samples.To solve this problem,we propose an approach based on deep convolutional neural networks(DCNNs),which consists of three stages:fastener localization,abnormal fastener sample generation based on saliency detection,and fastener state inspection.First,a lightweight YOLOv5s is designed to achieve fast and precise localization of fastener regions.Then,the foreground clip region of a fastener image is extracted by the designed fastener saliency detection network(F-SDNet),combined with data augmentation to generate a large number of abnormal fastener samples and balance the number of abnormal and normal samples.Finally,a fastener inspection model called Fastener ResNet-8 is constructed by being trained with the augmented fastener dataset.Results show the effectiveness of our proposed method in solving the problem of sample imbalance in fastener detection.Qualitative and quantitative comparisons show that the proposed F-SDNet outperforms other state-of-the-art methods in clip region extraction,reaching MAE and max F-measure of 0.0215 and 0.9635,respectively.In addition,the FPS of the fastener state inspection model reached 86.2,and the average accuracy reached 98.7%on 614 augmented fastener test sets and 99.9%on 7505 real fastener datasets.

关键词： Railway fastener sample generation inspection model deep learning

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Dislocation glide and mechanical twinning in a ductile VNbTi medium entropy alloy

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Journal of Materials Science & Technology 2022年第15期110卷 210-215页

作者： Mingxu Wu shubin wang Fei Xiao Guoliang Zhu Chao Yang Da Shu Baode Sun Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming and State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

An equiatomic VNbTi medium-entropy alloy with outstanding tensile properties and unique deformation behavior is reported.The screw dislocation glide,deformation twinning,and dislocation accumulation induced kink bands are identified as three deformation mechanisms that contribute to a large elongation above 20%.The{112}twins are activated at the beginning of the yield stage accompanied by sudden stress-drop and pronounced acoustic emission.Dislocations dominate subsequent tensile deformation,and the prevalent multiplanar dislocation slip promotes the formation of complex dislocation configurations(e.g.,debris,dipoles,and loops)and dense dislocation networks.The twin bands and kink bands can further impede the dislocation motion meanwhile effectively alleviate stress concentration.The synergistic activation of these deformation mechanisms provides new opportunities to design ductile refractory medium-and high-entropy alloys.

关键词： Medium-entropy alloy Mechanical twinning Screw dislocation Multiplanar slip Tensile deformation

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A wide load-range OTA using a digitally assisted compensating technique

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Science China(Information Sciences) 2024年第7期67卷 343-344页

作者： Haolin HAN shubin LIU Yi SHEN Hongzhi LIANG Yue CAO Longjie ZHONG Zhangming ZHU School of Microelectronics Xidian University

To keep pace with rapid advancements in high-quality liquid crystal displays (LCDs), there has been a growing focus on the development of low-power, high-speed output drivers in recent years. An LCD column driver typically compromises registers, data latches [1], digital-to-analog converters [2],and output buffers.

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Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao Yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao Liping Ma Liping Qi Xiaoyan Yan Haibo wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei wang Yutian Ding Qiang Guo Wanjun Dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu shubin Qiao Department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking University Clinical Research Institute Peking University First HospitalBeijing 100191China Department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China Department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China Department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China Department of Cardiology Puyang People’s HospitalPuyangHenan 457099China Department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China Department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China Department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China Department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China Department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China Department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China Department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China Department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China Department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)patients.This study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-PA)in Chinese patients with STEMI.Methods:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tPA or an intravenous bolus of 8 mg rt-PA followed by an infusion of 42 mg in 90 min.The primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2 or 3.The secondary endpoint was clinically justified recanalization.Other endpoints included 30-day major adverse cardiovascular and cerebrovascular events(MACCEs)and safety endpoints.Results:From July 2016 to September 2019,767 eligible patients were randomly assigned to receive rhTNK-tPA(n=384)or rt-PA(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified recanalization.Both used a–15%difference as the non-inferiority efficacy margin.In comparison to rt-PA,both the proportion of patients with TIMI grade 2 or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tPA group were non-inferior.The occurrence of 30-day MACCEs(10.2%[39/384]vs.11.0%[42/383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between groups.No safety outcomes significantly differed between groups.Conclusion:rhTNK-tPA was non-inferior to rt-PA in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute STEMI.Trial registration:www.ClinicalTrials.gov(No.NCT028355

关键词： Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction

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Three-Soliton Interactions and the Implementation of Their All-Optical Switching Function

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Chinese Physics Letters 2024年第4期41卷 51-58页

作者：伊厚会张鑫石领先姚延立王树斌马国利 School of Intelligent Manufacturing Weifang University of Science and TechnologyWeifang 262700China Institute of Aeronautical Engineering Shandong University of AeronauticsBinzhou 256603China Flight College Shandong University of AeronauticsBinzhou 256603China Tianjin Sino-German University of Applied Sciences Tianjin 300350China

As a key component in all-optical networks,all-optical switches play a role in constructing all-optical switching.Due to the absence of photoelectric conversion,all-optical networks can overcome the constraints of electronic bottlenecks,thereby improving communication speed and expanding their communication bandwidth.We study all-optical switches based on the interactions among three optical solitons.By analytically solving the coupled nonlinear Schr¨odinger equation,we obtain the three-soliton solution to the equation.We discuss the nonlinear dynamic characteristics of various optical solitons under different initial conditions.Meanwhile,we analyze the influence of relevant physical parameters on the realization of all-optical switching function during the process of three-soliton interactions.The relevant conclusions will be beneficial for expanding network bandwidth and reducing power consumption to meet the growing demand for bandwidth and traffic.

关键词： soliton expanding networks

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无温度传感器下地铁车辆制动电阻温度在线监测方法

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城市轨道交通研究 2024年第7期27卷 231-236页

作者：王树宾中车长春轨道客车股份有限公司长春130062

[目的]为实现无温度传感器下地铁车辆制动电阻的实时温度监测,提出一种无需额外安装传感器的新型制动电阻温度估算方法。[方法]对制动电阻结构和散热过程进行分析,建立由制动电阻单元及其冷却域构成的控制体温度模型,基于能量守恒定律... 详细信息

[目的]为实现无温度传感器下地铁车辆制动电阻的实时温度监测,提出一种无需额外安装传感器的新型制动电阻温度估算方法。[方法]对制动电阻结构和散热过程进行分析,建立由制动电阻单元及其冷却域构成的控制体温度模型,基于能量守恒定律与牛顿冷却定律构建制动电阻单元温度及控制体内冷却空气平均温度方程组,根据制动电阻阻值与温度的关系不断更新制动电阻发热功率并迭代计算,得到制动电阻的实时温度。通过有限元热仿真得到稳态和瞬态下的制动电阻温度分布,对新型制动电阻温度估算方法进行验证。[结果及结论]基于直流牵引网电压与斩波电路占空比计算制动电阻发热功率,无需额外安装传感器,可实现对硬件的纯软件替代。该方法与制动电阻温度估算算法相结合,提高了制动电阻温度估算的可靠性。新型制动电阻温度估算方法得到的制动电阻温度与基于Fluent软件的热仿真结果基本一致,其相对误差在可接受范围内,证明了该估算方法的有效性。制动电阻温度实时估算方法可实现制动电阻温度在线监测,并根据实时监测的制动电阻温度值调节地铁车辆电制动力指令值,提高牵引传动系统的可靠性及安全性。

关键词：地铁车辆制动电阻温度在线监测散热分析发热功率计算有限元热仿真

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以全过程人民民主推进中国式现代化

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马克思主义研究 2024年第2期 57-70页

作者：董树彬吉林大学马克思主义学院(吉林长春130012)

中国共产党在领导人民探索中国式现代化进程中孕育产生了全过程人民民主,发展全过程人民民主是中国式现代化的本质要求和核心要义.在全面建设社会主义现代化国家的新征程中,要以全过程人民民主破解大规模国家治理难题,满足人民对美好生... 详细信息

中国共产党在领导人民探索中国式现代化进程中孕育产生了全过程人民民主,发展全过程人民民主是中国式现代化的本质要求和核心要义.在全面建设社会主义现代化国家的新征程中,要以全过程人民民主破解大规模国家治理难题,满足人民对美好生活的向往,实现物的现代化与人的现代化的有机统一,实现人与自然之间天人合一的现代和解,为构建人类命运共同体贡献中国智慧,从而全面推进中国式现代化.通过党的集中统一领导,发挥全过程人民民主的良政善治优势,确保中国式现代化始终沿着社会主义方向前进,保证全体人民共享现代化发展的成果,为推进中国式现代化凝心聚力、团结奋斗.

关键词：全过程人民民主中国式现代化以人民为中心

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全过程人民民主：中国式现代化的显著标志与本质要求

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山东大学学报(哲学社会科学版) 2024年第2期 1-11页

作者：董树彬吉林大学马克思主义学院

民主是衡量现代化水平的重要指标，现代化是推进民主发展的必要保障。全过程人民民主作为中国民主发展的时代升华，以最广泛、最真实、最管用为其特色和优势。它基于中国国情和历史文化，吸收借鉴世界民主发展的有益经验，开创了人类政... 详细信息

民主是衡量现代化水平的重要指标，现代化是推进民主发展的必要保障。全过程人民民主作为中国民主发展的时代升华，以最广泛、最真实、最管用为其特色和优势。它基于中国国情和历史文化，吸收借鉴世界民主发展的有益经验，开创了人类政治文明新形态。全过程人民民主是中国式现代化的重要构成部分，充分契合中国式现代化的中国特色，并在促进中国式现代化良政善治和弘扬全人类民主共同价值的过程中，展现出了民主的治理效能，成为中国式现代化超越西方现代化的显著标志。发展全过程人民民主是中国式现代化的本质要求。这就需要以人民逻辑统领全过程人民民主的发展，以人民代表大会和人民政协为组织载体推进全过程人民民主的实践运行。同时，中国式现代化进程中的全过程人民民主，在民主话语建构、民主形象塑造以及推动政治文明交流互鉴等方面，将为后发型现代化国家进行现代化建设和推进民主发展提供全新选择。

关键词：全过程人民民主中国式现代化国家治理政治文明

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