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Non-coding RNAs and stem cells:the dream team for neural regeneration in Parkinson’s disease?

Neural Regeneration Research 2021年第10期16卷 2017-2018页

作者： shubhra acharya Andrew I.Lumley Yvan Devaux Cardiovascular Research Unit Department of Population HealthLuxembourg Institute of HealthL-1445 StrassenLuxembourg Faculty of Science Technology and MedicineUniversity of LuxembourgL-4365 Esch-sur-AlzetteLuxembourg

Parkinson’s disease(PD)is a widely spread neurodegenerative movement disorder,affecting approximately 10 million people *** is primarily caused by the loss of dopaminergic neurons in the substantia nigra,which causes decreased secretion of dopamine leading to tremors,bradykinesia and rigid muscle *** development of PD is complex and needs to be better *** treatment strategies primarily involve targeting disease symptoms,however,since there is a continuous loss of dopaminergic neurons in the brain,PD appears to be ***,treatment strategies often carry severe side effects related to dopamine production,where too little or too much can cause debilitating issues such as *** pool of neural stem/progenitor cells(NSCs)located in sub-ventricular zone and hippocampal dentate gyrus,proliferate and are responsible to give rise to neurons and glia in response to any cellular *** this activation of NSCs is highly regulated,it is insufficient to overcome the loss of dopaminergic neurons in *** this line,non-coding RNAs(ncRNAs)are involved in the underlying mechanisms of PD and are known to have important functional roles in neural regeneration(acharya et al.,2020).Thus,the study of ncRNAs in NSC activation and adult neurogenesis post PD development is an extremely attractive area of research with significant clinical application potential.

关键词： neural primarily overcome

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