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Evaluation of Groundwater Quality and Its Suitability for Domestic and Irrigation Use in Parts of the Chandauli-Varanasi Region, Uttar Pradesh, India

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Journal of Water Resource and Protection 2015年第7期7卷 572-587页

作者： shubhra singh N. Janardhana Raju Ch. Ramakrishna School of Environmental Sciences Jawaharlal Nehru University New Delhi India Department of Environmental Studies GITAM University Visakhapatnam India

The present study focused on the hydrochemistry of groundwater in parts of Chandauli-Varanasi region to assess the quality of groundwater for determining its suitability for drinking and agricultural purposes. Urbanization and agriculture activities have a lot of impacts on the groundwater quality of the study area. A total of 70 ground water samples were collected randomly from different sources viz. hand pump, dug wells and bore wells, and analyzed for major cations and anions. The domination of cations and anions was in the order of Na > Ca > Mg > K and HCO3 > Cl > SO4 > NO3 > F. The Piper classification for hydrogeochemical facies indicates that alkaline earth exceeds alkalis and weak acids exceed strong acid. Water quality index rating was calculated to quantify overall water quality for human consumption. Out of 70 groundwater samples, 7% and 10% samples exhibit water unsuitable for drinking purposes in pre- and post-monsoon, respectively, due to effective leaching of ions, direct discharge of domestic effluents and agricultural activities. Residual sodium carbonate values revealed that 6% sample is not suitable for irrigation purposes in both the seasons due to low permeability of the soil. The calculated values of PI indicate that the water for irrigation uses is excellent to good quality in both seasons. As per Wilcox’s diagram and US salinity laboratory classification, most of the groundwater samples are suitable for irrigation except one sample which is unsuitable for irrigation purposes. The overall quality of groundwater in post-monsoon season in all chemical constituents is on the higher side due to dissolution of surface pollutants during the infiltration and percolation of rainwater at few places due to agricultural and domestic activities.

关键词： Groundwater Quality Hydrogeochemical Facies Drinking Water Irrigation Water

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RARRES2's impact on lipid metabolism in triplenegative breast cancer:a pathway to brain metastasis

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Military Medical Research 2024年第2期11卷 311-312页

作者： Quazi T.H.shubhra Institute of Chemistry University of Silesia in Katowice41‑500 ChorzowPoland Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China

Breast cancer brain metastasis(BCBrM)is a crucial and hard area of research which guarantees an urgent need to understand the underlying molecular mechanisms.A recent study by Li et al.[1]published in Military Medical Research investigated the role of retinoic acid receptor responder 2(RARRES2)in regulating lipid metabolism in BCBrM,highlighting the clinical relevance of alterations in lipid metabolites,such as phosphatidylcholine(PC)and triacylglycerols(TAGs),by RARRES2 through the modulation of phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling *** commentary aims to elaborate on the key findings and their relevance to the field.

关键词： Retinoic acid receptor responder 2(RARRES2) Lipid metabolism Cancer PTEN-mTOR-SREBP1 signaling Metabolic reprogramming Brain metastasis

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Pre-activated macrophage membrane-encased aggregationinduced emission featuring nanoparticles:a novel possibility for tuberculosis treatment

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2848-2850页

作者： Qiang Cai Yihao Tian Quazi T.H.shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanChina Department of Human Anatomy and Histology and Embryology School of Basic Medical SciencesWuhan UniversityWuhanChina Institute of Chemistry University of Silesia in KatowiceSzkolna 9KatowicePoland

In a recent study published in Nature Nanotechnology,Li et *** the synthesis of a novel photosensitizer with unique aggregation-induced emission(AIE)characteristics.1 They microencapsulated this photosensitizer inside engineered nanoparticles(NPs)coated with pre-activated macrophage cell membranes(CMs),an innovative approach marking a significant leap in nanomedicine by offering a pathway to potent tuberculosis(TB)treatments that bypass antibiotic resistance with unparalleled precision.

关键词： tuberculosis macrophage aggregation

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mRNA vaccines:a new era in vaccine development

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Oncology Research 2024年第10期32卷 1543-1564页

作者： shubhra CHANDRA JENNIFER C.WILSON DAVID GOOD MING Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of COVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated encouraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufacturing complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufacturing processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： Cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

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Metagenomic Surveys of Gut Microbiota

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Genomics, Proteomics & Bioinformatics 2015年第3期13卷 148-158页

作者： Rahul shubhra Mandal Sudipto Saha Santasabuj Das Biomedical Informatics Centre National Institute of Cholera and Enteric Diseases Bioinformatics Centre Bose Institute Division of Clinical Medicine National Institute of Cholera and Enteric Diseases

Gut microbiota of higher vertebrates is host-specific. The number and diversity of the organisms residing within the gut ecosystem are defined by physiological and environmental factors, such as host genotype, habitat, and diet. Recently, culture-independent sequencing techniques have added a new dimension to the study of gut microbiota and the challenge to analyze the large volume of sequencing data is increasingly addressed by the development of novel computational tools and methods. Interestingly, gut microbiota maintains a constant relative abundance at operational tax- onomic unit （OTU） levels and altered bacterial abundance has been associated with complex diseases such as symptomatic atherosclerosis, type 2 diabetes, obesity, and colorectal cancer. Therefore, the study of gut microbial population has emerged as an important field of research in order to ulti- mately achieve better health. In addition, there is a spontaneous, non-linear, and dynamic interac- tion among different bacterial species residing in the gut. Thus, predicting the influence of perturbed microbe-microbe interaction network on health can aid in developing novel therapeutics. Here, we summarize the population abundance of gut microbiota and its variation in different clinical states, computational tools available to analyze the pyrosequencing data, and gut microbe-microbe inter- action networks.

关键词： Disease Sequencing 16S rRNA Operational taxonomic unit Microbial interactionnetwork

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Non-coding RNAs and stem cells:the dream team for neural regeneration in Parkinson’s disease?

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Neural Regeneration Research 2021年第10期16卷 2017-2018页

作者： shubhra Acharya Andrew I.Lumley Yvan Devaux Cardiovascular Research Unit Department of Population HealthLuxembourg Institute of HealthL-1445 StrassenLuxembourg Faculty of Science Technology and MedicineUniversity of LuxembourgL-4365 Esch-sur-AlzetteLuxembourg

Parkinson’s disease(PD)is a widely spread neurodegenerative movement disorder,affecting approximately 10 million people *** is primarily caused by the loss of dopaminergic neurons in the substantia nigra,which causes decreased secretion of dopamine leading to tremors,bradykinesia and rigid muscle *** development of PD is complex and needs to be better *** treatment strategies primarily involve targeting disease symptoms,however,since there is a continuous loss of dopaminergic neurons in the brain,PD appears to be ***,treatment strategies often carry severe side effects related to dopamine production,where too little or too much can cause debilitating issues such as *** pool of neural stem/progenitor cells(NSCs)located in sub-ventricular zone and hippocampal dentate gyrus,proliferate and are responsible to give rise to neurons and glia in response to any cellular *** this activation of NSCs is highly regulated,it is insufficient to overcome the loss of dopaminergic neurons in *** this line,non-coding RNAs(ncRNAs)are involved in the underlying mechanisms of PD and are known to have important functional roles in neural regeneration(Acharya et al.,2020).Thus,the study of ncRNAs in NSC activation and adult neurogenesis post PD development is an extremely attractive area of research with significant clinical application potential.

关键词： neural primarily overcome

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Iron oxide nanoparticles in magnetic drug targeting and ferroptosis-based cancer therapy

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Medical Review 2023年第5期3卷 444-447页

作者： Quazi T.H.shubhra Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Institute of Chemistry University of Silesia in Katowice41-500 ChorzówPoland

Iron oxide(IO)nanoparticles(NPs)have gained significant attention in the field of biomedicine,particularly in drug targeting and cancer *** potential in magnetic drug targeting(MDT)and ferroptosis-based cancer therapy is highly *** NPs serve as an effective drug delivery system(DDS),utilizing external magnetic fields(EMFs)to target cancer cells while minimizing damage to healthy ***,IO NPs can generate reactive oxygen species(ROS)and induce ferroptosis,resulting in cytotoxic effects on cancer *** article explores how IO NPs can potentially revolutionize cancer research,focusing on their applications in MDT and ferroptosis-based therapy.

关键词： magnetic nanoparticles ferroptosis drug targeting cancer

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Alcoholic Liver Disease and COVID-19 Pneumonia:A Case Series

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 463-466页

作者： Devika Kapuria shubhra Upadhyay Rahul Shekhar Euriko Torrazza-Perez Department of Gastroenterology University of New Mexico Health Science CenterAlbuquerqueNMUSA Department of Internal Medicine University of New Mexico Health Science CenterAlbuquerqueNMUSA

The novel coronavirus 2019(COVID-19)was reported by the World Health Organization in December 2019,and since then it has progressed into a worldwide pandemic,causing significant morbidity and *** symptoms of COVID-19 and elevated liver chemistries are seen in up to 50%of infected *** reports have suggested a high mortality rate for COVID-19 in patients with pre-existing liver disease,having an associated mortality of 39.8%.Alcoholic liver disease is a significant cause of morbidity and mortality in New Mexico(USA),and we report here the clinical course and characteristics of three cases of patients with alcoholic cir-rhosis who were admitted to our hospital with COVID-19.

关键词： COVID-19 Alcoholic liver disease ARDS Acute kidney injury

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Functional Role of miRNAs: Key Players in Soybean Improvement

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Phyton-International Journal of Experimental Botany 2021年第5期90卷 1339-1362页

作者： Kapil Gupta Sujit Kumar Mishra shubhra Gupta Saurabh Pandey Jogeswar Panigrahi Shabir Hussain Wani CSIR-Central Institute of Medicinal and Aromatic Plants Lucknow226015India Department of Zoology School of Applied SciencesCenturion University of Technology and ManagementBhubaneswar751009India Department of Biotechnology Central University of RajasthanAjmer305817India Plant Molecular Biology International Center for Genetic Engineering&BiotechnologyNew Delhi110067India Department of Biosciences and Bioinformatics Khallikote UniversityBerhampur761008India Mountain Research Center for Field Crops KhudwaniSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirAnantnag192101India

Soybean(Glycine max(L.)Merr)is an agro-economic crop growing across the world to cater nutrition for both human and animal feed due to the high oil and protein content in its edible *** genes and QTLs associated with important agronomic traits in this crop have already been identified and validated for soybean cyst nematode(SCN),Phytophthora root and stem rot,Pythium root rot and aphid resistance,seed quality,nutrient values,and also employed for genetic improvement in *** the last decade,micro RNAs(miRNAs)have been considered the effector molecules,so the detection and characterization of novel miRNAs in soybean have been taken up by several *** advancement in the strategy of sequencing and tools of bioinformatics during last decade has contributed to the discovery of many soybean miRNAs,thus miRNA can be used as a tool in molecular breeding studies,and this has opened new vistas for miRNA mediated genetic improvement of soybean to augment crop productivity as well as nutritional *** review addresses the current state of understanding of miRNAmediated stress responses,nutrient acquisition,plant development and crop production processes in soybean.

关键词： Soybean miRNA quality improvement plant development genetic engineering molecular breeding

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Secondary X-Ray Environment in the Lower Atmosphere of the Earth during Monsoon Season over Udaipur City （India） in July-September 2006

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Chinese Physics Letters 2009年第8期26卷 381-384页

作者： S. N. A. Jaaffrey shubhra Tiwari Laboratory of Astronomy and Astrophysics Department of Physics University College of Science M. L. Sukhadia University UDAIPUR (Raj.)-313001 India

We present a study on the secondary x-rays of energy band 2-100 keV emitted by the intruded principal pollutant components （gases and minerals） brought up in the lower atmosphere by dust storms, monsoon drift and the gravitational pull on meteoritic showers. On the ground we employed a 1.5 × 1 inch^2 NaI crystal in a scintillation detector, suitable for the energy range 2-100 keV of secondary x-rays, providing better energy resolution than a larger sized crystal. In order to eliminate the radioactive background of the Earth, the detector was well shielded on all sides with the help of the lead （Pb） container, except with *** open window at the top to permit only vertically incident secondary radiation. The results from the data analysis obtained during the monsoon over Udaipur city （India） during the period from July to September （2006） have revealed a linear correlation between dust storm cure monsoon clouds and observed luminosities of secondary x-ray radiation from intruded pollutants. We found intense flux of secondary x-rays from the intruded pollutants when heavy dust and monsoon clouds were brought up by dust storms and monsoon drift in the lower atmosphere over Udaipur city as compared to normal days. Thus, secondary x-rays in the environment provide a tool for investigation of local intrusive pollutant components in the lower atmosphere.

关键词： sea surface nonliear interaction numerical method

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