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Role of H2 receptor blocker famotidine over the clinical recovery of COVID-19 patients: A randomized controlled trial

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World Journal of Clinical Cases 2022年第23期10卷 8170-8185页

作者： Abu Taiub Mohammed Mohiuddin Chowdhury Aktar Kamal Md Kafil Uddin Abbas Md Rezaul Karim Md Ahsan Ali shubhashis talukder H M Hamidullah Mehedi Hamid Hassan Abul Hossain Shahin Yarui Li Shuixiang He Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Ministry of Health and Family Welfare(OSDDGHS) Dhaka 1212Bangladesh Critical Care Unit M Abdur Rahim Medical College HospitalDinajpur 5200Bangladesh Critical Care Unit Cox's Bazar 250 Bed District Sadar HospitalCox's Bazar 4700Bangladesh Department of Neurology University Hospital LimerickLimerick V94 T9PXIreland Department of Histology Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Intensive Care Unit 250 Bed Chattogram General HospitalChittagong 4000Bangladesh Department of Medicine 250 Bed Chattogram General HospitalChittagong 4000Bangladesh Department of Emergency Chattogram Medical College HospitalChittagong 4000Bangladesh Department of Cardiology 250 Bed Chattogram General HospitalChittagong 4000Bangladesh

BACKGROUND Coronavirus disease 2019(COVID-19)is a global pandemic putting the population at a high risk of infection-related health hazards,mortality and a potential failure of proper medical ***,it is necessary to evaluate the potential use of the existing drugs that could be used as options for the medical management of COVID-19 *** To evaluate the role of the H_(2) receptor blocker“famotidine”in COVID-19 *** This study was done on seriously ill COVID-19 patients admitted to the intensive care unit(ICU)from different institutes in *** were divided into famotidine treatment group“A”(famotidine 40 mg to 60 mg oral formulation every 8 h with other treatment as given),and control group“B”(treatment as given).National early warning score(NEWS)-2,and sequential organ failure assessment day-1 score was calculated to evaluate the *** were evaluated by the time required for clinical improvement,characterized as duration required from enrollment to the achievement of NEWS-2 of≤2 maintained for 24 h;time to symptomatic recovery,defined as the duration in days(from randomization)required for the recovery of the COVID-19 symptoms;mortality rate;duration of ICU and hospital stay;total period of hospitalization;the rate of supplementary oxygen requirement;the computed tomography(CT)chest recovery(%),the time required for the viral clearance and“NEWS-2”on *** A total of 208 patients were enrolled in this study with 104 patients in each *** famotidine treatment group had comparatively better recovery of 75%and a low mortality of 25%than the control with a recovery of 70%and a mortality of 30%.Duration of clinical improvement(group A 9.53 d,group B 14.21 d);hospitalization period among the recovered patients(group A 13.04 d,group B 16.31 d),pulmonary improvement in chest CT(group A 21.7%,group B 13.2%),and the time for viral clearance(group A 20.7 d,group B 23.8 d)were found to be statistically si

关键词： COVID-19 SARS-CoV-2 Famotidine COVID-19 acute respiratory distress syndrome COVID-19 treatment Bangladesh

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