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分级诊疗制度下洛阳市医疗服务空间可达性及影响因素研究

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河南大学学报（自然科学版） 2024年第2期54卷 142-156,167页

作者：杨珍王伟陈准陈太政何双言关亚宾河南大学地理与环境学院河南开封475004 河南大学文化旅游学院河南开封475004 河南大学哲学与公共管理学院河南开封475004

在分级诊疗的视角下,基于最优供需分配模型、空间自相关和地理探测器等方法,分成首诊、转诊两阶段研究洛阳市域在步行和驾车两种交通出行方式下的就医可达性及其影响因素.结果表明:(1)洛阳市基层医院就医可达性呈多中心-碎片化连片区分... 详细信息

在分级诊疗的视角下,基于最优供需分配模型、空间自相关和地理探测器等方法,分成首诊、转诊两阶段研究洛阳市域在步行和驾车两种交通出行方式下的就医可达性及其影响因素.结果表明:(1)洛阳市基层医院就医可达性呈多中心-碎片化连片区分布,各居民点医疗服务可达性以居民点附近的基层医院为中心向周围递减;上层医疗设施可达性呈现由核心地区医院群向城市外围地区辐射能力衰减的特征,分级诊疗制度下的就医可达性显著高于未实行分级诊疗制度的就医可达性.(2)在首诊阶段市区有超过50%的居民能步行15 min到达医疗设施点,而县域居民在30 min内能到达医疗设施点的人数仅占10%.(3)在转诊阶段,步行出行方式就医可达性较低,市区和县域人数占比大约在20%,驾车出行方式是居民进行转诊时较优的交通方式,上层医疗资源的集中分布造成一定程度的资源浪费.(4)洛阳市乡镇尺度下基层医疗设施可达性的空间格局受医疗点密度和坡度两个因素的显著影响,而人均GDP对基层医疗设施空间可达性作用较小.

关键词：最优供需分配分级诊疗制度可达性地理探测器洛阳市

A 3D-PSF Space Size Selection Method Based on Inflection Point

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Chinese Journal of Electronics 2017年第1期26卷 160-165页

作者： YANG Fengjuan CheN Hua CAI Yi LIANG Riliu he shuangyan School of Computer and Electronics Information Guangxi University

In the three-dimensional microscopic biological image restoration processing of digital confocal microscopy, the selection of three-Dimensional Point spread function(3D-PSF) space size determines the restoration effect and restoration time. Based on 3D-PSF double funnelshaped structure and analyzing the relationship of 3DPSF space size to the image restoration effect and restoration time, it proposed the comprehensive image restoration evaluation criteria based on restoration efficiency,and also proposed the 3D-PSF selection method based on restoration efficiency curve inflection point. Three groups of 3D-PSF with different layer distances were used for image restoration experiments, the relationship between the3D-PSF space sizes of different diameter and the image restoration effect and restoration time was built, and the restoration efficiency curve was obtained. Based on the curve inflection point, the selection of optional minimum space 3D-PSF and 3D-PSF was determined. Experimental results showed the method has good feasibility.

关键词： Microscopic image Three-Dimensional Point spread function(3D-PSF) Selection method Restoration efficiency Inflection point

黑潮延伸区系泊浮标海表pH的年际和季节变化

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海洋科学进展 2024年第3期42卷 466-477页

作者：武雨茜刘聪贺双颜陈栋姜庆岩李培良浙江大学海洋学院浙江舟山316021 浙江大学海南研究院海南三亚572025

西北太平洋海表pH具有显著的长期酸化趋势和季节性变化。近十年来,位于黑潮延伸区的KEO浮标(144°36′E, 32°24′N)提供了丰富的观测数据。基于2008至2019年浮标海表实测盐度、温度、气压和CO_(2)分压数据,利用CO2SYS程序重建了近原位... 详细信息

西北太平洋海表pH具有显著的长期酸化趋势和季节性变化。近十年来,位于黑潮延伸区的KEO浮标(144°36′E, 32°24′N)提供了丰富的观测数据。基于2008至2019年浮标海表实测盐度、温度、气压和CO_(2)分压数据,利用CO2SYS程序重建了近原位海表pH时间序列,并对其年际趋势和季节变化进行了分析讨论。结果表明,KEO站点2008年至2019年海表pH下降速率为(2.18±0.52)×10^(-3)/a,与日本周边海域pH下降速率趋势一致。气候态月平均pH在夏季最小,其季节变化与位于西北太平洋同一纬度的其他两个JMA(Japan Meteorological Agency)站点((137°E, 32°N)和(165°E, 32°N))相似。KEO站点的海表pH季节变化较邻近的近岸CL站点((140°22′E, 35°10′N),位于千叶县)更为显著。KEO站点海表pH最大下降速率发生在夏季(3.22±0.64)×10^(-3)/a,与秋季(2.55±0.44)×10^(-3)/a相当,其次发生在春季(1.89±0.42)×10^(-3)/a,最后在冬季(1.66±0.37)×10^(-3)/a,约为最大值的1/2。本研究所用时间序列较短(小于等于12年)且存在数据缺口,使得趋势计算具有较高不确定性,建议采用更长的时间序列进一步研究海洋酸化的年际和季节趋势差异。本研究有助于加深对黑潮延伸区海洋酸化的认识。

关键词：海洋酸化季节变化年际变化 KEO 海表pH重建

吉林省气象干旱指标适用性及干旱时空演变特征研究

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水利水电技术（中英文） 2024年第6期55卷 120-133页

作者：付平凡杨晓静苏志诚李云霄贺双燕中国水利水电科学研究院北京100038 水利部防洪抗旱减灾工程技术研究中心北京100038 中国地质大学(北京) 北京100083

【目的】吉林省是我国主要的粮食主产区,明确该地区干旱时空特征对于保障粮食生产安全具有重要意义,而适宜的气象干旱指标是准确识别旱情发展的前提。【方法】研究基于吉林省55个气象站点1960—2020年逐月降水和气温数据,计算标准化降... 详细信息

【目的】吉林省是我国主要的粮食主产区,明确该地区干旱时空特征对于保障粮食生产安全具有重要意义,而适宜的气象干旱指标是准确识别旱情发展的前提。【方法】研究基于吉林省55个气象站点1960—2020年逐月降水和气温数据,计算标准化降水指数(SPI)、降水距平百分率(PA)、标准化蒸散指数(SPEI)和相对湿润度指数(MI)3和12个月结果。构建指标适用性识别方法,实现4种气象干旱指数季节尺度监测结果与旱灾记录定量化精准识别分析,并基于最适宜指数分析研究全省年代际、年际和季节的干旱演变特征。【结果】研究结果表明:(1)4种指数监测准确率由高到低分别为SPI(71.15%)、PA(66.67%)、SPEI(66.03%)和MI(55.77%)。(2)年代际尺度,1980 s前吉林省易旱地区主要集中在东部地区吉林市和延边州,干旱频率均高于40%;1980 s后,高值区域转移到吉林省西部白城和松原市,干旱频率均高于20%。(3)年尺度、春、秋和冬季均呈显著湿润化趋势,干旱强度倾向率分别为-1.761%/10 a、-0.124%/10 a、-0.068%/10 a和-0.054%/10 a。【结论】SPI指数是4种指标中最适用于吉林省的指数,全省易旱地区从东南地区转移到西北地区,且中西部地区是干旱高发区。研究结果可为全省旱情监测、农业生产及旱灾防御指挥决策等工作提供参考借鉴。

关键词：气象干旱干旱指标指标适用性干旱监测吉林省气候变化

Performance evaluation of operational atmospheric correction algorithms over the East China Seas

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Chinese Journal of Oceanology and Limnology 2017年第1期35卷 1-22页

作者： he shuangyan[l,2,3] he Mingxia FISCheR Jurgen Ocean Remote Sensing Institute Ocean University of China Qingdao 266003 China Institute for Space Sciences Freie Universitdt Berlin Berlin D-12165 Germany Ocean College Zhejiang University Hangzhou 310058 China

To acquire high-quality operational data products for Chinese in-orbit and scheduled ocean color sensors, the performances of two operational atmospheric correction(AC) algorithms(ESA MEGS 7.4.1 and NASA Sea DAS 6.1) were evaluated over the East China Seas(ECS) using MERIS data. The spectral remote sensing reflectance R_(rs)(λ), aerosol optical thickness(AOT), and ?ngstr?m exponent(α) retrieved using the two algorithms were validated using in situ measurements obtained between May 2002 and October 2009. Match-ups of R_(rs), AOT, and α between the in situ and MERIS data were obtained through strict exclusion criteria. Statistical analysis of R_(rs)(λ) showed a mean percentage difference(MPD) of 9%–13% in the 490–560 nm spectral range, and significant overestimation was observed at 413 nm(MPD>72%). The AOTs were overestimated(MPD>32%), and although the ESA algorithm outperformed the NASA algorithm in the blue-green bands, the situation was reversed in the red-near-infrared bands. The value of α was obviously underestimated by the ESA algorithm(MPD=41%) but not by the NASA algorithm(MPD=35%). To clarify why the NASA algorithm performed better in the retrieval of α, scatter plots of the α single scattering albedo(SSA) density were prepared. These α-SSA density scatter plots showed that the applicability of the aerosol models used by the NASA algorithm over the ECS is better than that used by the ESA algorithm, although neither aerosol model is suitable for the ECS region. The results of this study provide a reference to both data users and data agencies regarding the use of operational data products and the investigation into the improvement of current AC schemes over the ECS.

关键词： validation remote sensing reflectance aerosol optical thickness ocean color atmospheric correction remote sensing

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东方田鼠自发性年龄相关性白内障的鉴定

中南大学学报（医学版） 2024年第4期49卷 553-561页

作者：何天琼周俊康文依信刘倩支文玲杨文豪贺双艳欧阳伶宣夏晓波周智君中南大学湘雅医学院实验动物学部长沙410013 湖南省人类疾病动物模型重点实验室(中南大学) 长沙410013 爱尔眼科动物实验中心长沙410015 中南大学湘雅医院眼科中心长沙410008 湖南省眼科学重点实验室(中南大学) 长沙410008 国家老年疾病临床研究中心(湘雅医院) 长沙410008

目的:年龄相关性白内障是成人白内障中最常见的类型,也是主要的致盲眼科疾病。目前关于年龄相关性白内障动物模型的建立报道较少。本课题组在东方田鼠实验动物化培育过程中首次发现12~15月龄东方田鼠能自然发生白内障。本研究通过对东... 详细信息

目的:年龄相关性白内障是成人白内障中最常见的类型,也是主要的致盲眼科疾病。目前关于年龄相关性白内障动物模型的建立报道较少。本课题组在东方田鼠实验动物化培育过程中首次发现12~15月龄东方田鼠能自然发生白内障。本研究通过对东方田鼠自发性白内障进行鉴定分析,探讨其发展成为年龄相关性白内障动物模型的可能性。方法:分别选用12月龄健康东方田鼠为对照组和12月龄白内障东方田鼠为实验组。通过裂隙灯生物显微镜观察晶状体透明度;苏木精-伊红染色观察东方田鼠的晶状体病理变化;生物化学方法测定2组东方田鼠的血常规、血糖水平及血清中超氧化物歧化酶(superoxide dismutase,SOD)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSHPx)活性。最后通过实时反转录聚合酶链反应(real-time reverse transcription PCR,real-time RT-PCR)检测2组东方田鼠晶状体中白内障发病相关基因的转录水平。结果:与对照组比较,实验组东方田鼠的晶状体呈现不同程度的浑浊,晶状体结构被严重破坏,晶状体上皮细胞出现明显肿胀、大量空泡、变性/坏死、钙化、增生和纤维液化等病理变化,纤维结构紊乱,分布不规则,变性的晶状体纤维中有马氏小体聚集。与对照组比较,实验组东方田鼠的血糖水平差异无统计学意义(P>0.05),白细胞数量(P<0.05)、淋巴细胞数量(P<0.01)、淋巴细胞比率(P<0.05)均显著降低,而中性粒细胞百分比(P<0.05)和单核细胞比率(P<0.01)均显著增加,血清中SOD和GSH-Px活性均降低(均P<0.05);实验组东方田鼠晶状体中白内障发病相关基因CRYAA、CRYBA1、CRYBB3、Bsfp1、GJA3、CRYBA2、MIP、HspB1、DNase2B和GJA8的mRNA水平均显著降低(均P<0.05)。结论:白内障东方田鼠与健康东方田鼠相比,晶状体病理变化、过氧化物酶水平和白内障相关基因表达均有显著差异。东方田鼠自发性白内障具有年龄相关性,白内障东方田鼠有望发展成为年龄相关性白内障研究的理想动物模型。

关键词：东方田鼠年龄相关性白内障晶状体组织病理学氧化损伤基因表达

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2022年江西省干旱时空演变特征研究

中国水利水电科学研究院学报（中英文） 2024年第1期22卷 49-62页

作者：贺双燕杨晓静刘俊钊李云霄李占玲刘业伟中国水利水电科学研究院北京100038 中国地质大学(北京)水资源与环境学院北京100083 水利部防洪抗旱减灾工程技术研究中心北京100038 重庆市水利电力建筑勘测设计研究院有限公司重庆400020 江西省水利科学院江西南昌330029

2022年江西省遭遇了罕见的特大干旱,对社会经济、生产生活带来一定影响,基于标准化降水指数(Standardized Precipitation Index,SPI)和土壤相对湿度指数(Relative soil moisture,Rsm)对2022年江西省干旱时空演变特征进行分析研究。将气... 详细信息

2022年江西省遭遇了罕见的特大干旱,对社会经济、生产生活带来一定影响,基于标准化降水指数(Standardized Precipitation Index,SPI)和土壤相对湿度指数(Relative soil moisture,Rsm)对2022年江西省干旱时空演变特征进行分析研究。将气象干旱发展划分为4个阶段并识别其时空变化特征,利用相关性分析农业干旱与气象干旱之间的时间响应,揭示不同土壤深度的干旱变化过程。研究结果表明:(1)2022年江西省干旱主要发生在7—12月,气象干旱发展过程可划分为干旱露头期、暴发期、持续期、缓解期;(2)2022年江西省农业干旱发生时间比气象干旱晚1个月,降水对研究区Rsm的影响要明显大于气温且20cm的Rsm与SPI-1指标相关性最大;(3)水利工程在抗旱期间发挥了重要作用,江西省粮食生产“十年丰”实现大旱之年无大灾。

关键词：江西省 2022年干旱标准化降水指数土壤相对湿度发展过程滞后时间

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Trends of carbon and nutrient accumulation through time in the Andong salt marsh,Hangzhou Bay,China

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Journal of Oceanology and Limnology 2023年第6期41卷 2134-2145页

作者： Pei Sun LOH Aimin JIN Zhanghua LOU Xuegang CheN shuangyan he Chen-Tung Arthur CheN Stephanie PARKER Jianxiong HU Hongwei YUAN Longxiu CheNG Department of Marine Sciences Ocean CollegeZhejiang UniversityZhoushan 316021China Department of Oceanography National Sun Yat-sen UniversityKaohsiung 804China

Salt marshes are important carbon and nutrient sinks that are threatened by climate changes and human *** this study,the accumulation rates of sedimentary total organic carbon(TOC),total nitrogen(TN),and total phosphorus(TP)from two cores in the Andong salt marsh,Hangzhou Bay,were investigated to determine whether TOC,TN,and TP show increasing or decreasing trends toward the *** TOC accumulation rates at the relatively lower marsh were lower during 1990-1996(1.63-2.37 g/(cm^(2)·a))than 1997-2014(1.15-4.30 g/(cm^(2)·a)).The TN accumulation rates increased from 1990(0.14 g/(cm^(2)·a))toward 2012(0.40 g/(cm^(2)·a)),then decreased toward 2014(0.16 g/(cm^(2)·a)).The TP accumulation rates were lower during 1990-1999(0.10-0.21 mg/(cm^(2)·a)),and decreased from 2000(0.32 mg/(cm^(2)·a))toward 2014(0.15 mg/(cm^(2)·a)).The TOC accumulation rates along the relatively upper marsh during 1982-1992(1.18-3.25 g/(cm^(2)·a))were lower than during 1998-2010(2.30-4.20 g/(cm^(2)·a)),and then decreased toward 2015(2.15 g/(cm^(2)·a)).TN increased from 1982(0.18 g/(cm^(2)·a))to 2005(0.41 g/(cm^(2)·a)),then decreased toward 2015(0.22 g/(cm^(2)·a)).TP accumulation rates fluctuated within a narrow range during 1982-1997(0.21-0.41 mg/(cm^(2)·a)),increased from 1998(0.50 mg/(cm^(2)·a))to 2004(0.87 mg/(cm^(2)·a)),then decreased to 2015(0.38 mg/(cm^(2)·a)).Thus,increases in accumulation rates of TOC,TN,and TP from the 1980s to 1990s indicates that the marsh likely served as carbon and nutrient sinks,then the rates decreased during 2000-2015 due probably to the reduced sediment inputs from rivers and intensified sea level rise.

关键词： wetland climate change anthropogenic activity marsh degradation

The Ca^(2+)/CaN/ACC and cAMP/PKA/HK signal pathways are required for PBAN-mediated sex pheromone biosynthesis in Conogethes punctiferalis

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Journal of Integrative Agriculture 2024年第8期23卷 2735-2751页

作者： Yao Zhang Zelong She Ruolan he shuangyan Yao Xiang Li Xiaoguang Liu Xinming Yin Jizhen Wei Mengfang Du Shiheng An State Key Laboratory of Wheat and Maize Crop Science/henan International Laboratory for Green Pest Control/College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China

Conogethes punctiferalis is a crop and fruit pest that has caused serious economic losses to agricultural *** pest relies heavily on its sex pheromone to ensure sexual encounters and subsequent mating ***,the molecular mechanism underlying sex pheromone biosynthesis in this species remains *** present study investigated the detailed mechanism underlying PBAN-regulated sex pheromone biosynthesis in *** by transcriptome sequencing of the *** pheromone glands(PGs)and subsequent functional identification of the target *** results showed that female mating started from the first scotophase,and peaked at the second to fifth scotophases in accordance with the release of sex *** regulated sex pheromone biosynthesis by employing Ca^(2+)and cAMP as secondary messengers,as demonstrated by RNA interference(RNAi),pharmacological inhibitors,and behavioral *** investigation revealed that calcineurin(CaN)and acetyl-CoA carboxylase(ACC)were activated by PBAN/Ca^(2+)signaling,and the RNAimediated knockdown of CaN and ACC transcripts significantly reduced sex pheromone production,ultimately leading to a significantly reduced ability of females to attract ***,hexokinase(HK)was found to regulate sex pheromone biosynthesis in response to the PBAN/cAMP/PKA signaling pathway,as demonstrated by RNAi,enzyme activity,and pharmacological inhibitor ***,Far2 and Desaturase1 were found to participate in PBAN-regulated sex pheromone ***,our findings revealed that PBAN regulates sex pheromone biosynthesis through the PBANR/Ca^(2+)/CaN/ACC and PBANR/cAMP/PKA/HK pathways in ***,which enriches our comprehension of the details of sex pheromone biosynthesis in moths.

关键词： Conogethes punctiferalis sex pheromone cAMP/PKA calcineurin acetyl-CoA carboxylase hexokinase