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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui Liu Meng Zhang Ting Li shuangsuo dang Yaping Li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

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Effects of Saikosaponin-D on syndecan-2,matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma

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Journal of Traditional Chinese Medicine 2012年第3期32卷 415-422页

作者： Xiaoli Jia shuangsuo dang Yanan Cheng Xin Zhang Mei Li Yaping Li Siyuan Li Department of Infectious Diseases theSecond Hospital of Xi'an Jiaotong University Xi'an Shaanxi710004 China Key Laboratory of Environment and Genes Relat-ed to Diseases (Xi'an Jiaotong University) Ministry of Educa-tion Xi'an Shaanxi 710061 China

OBJECTIVE:To investigate effects of Saikosaponin D(SSd) on syndecan-2,matrix metalloproteinases(MMPs) and tissue inhibitor of metalloproteinases-2(TIMP-2) in livers of rat with hepatocellular carcinoma(HCC).METHODS:Male SD rats were divided into control(n=10),model(n=20) and SSd(n=20) groups,and model and SSd groups given intragastric 0.2%(w/v) N-diethylnitrosamine to induce *** group received 0.03%(w/v) SSd in *** samples were analysed immunohistochemically for syndecan-2,MMP-2,MMP-13 and TIMP-2 at 16 ***:The model group had more malignant nodules than the SSd group;all model-group HCC cells were grade III;SSd-group HCC cells were grades *** showed normal hepatic cell phenotypes and no syndecan-2 + ***-2 + staining was greater in the model group(35.2%,P≤0.001) than in controls or the SSd group(16.5%,P ≤ 0.001).The model group had more intense MMP-2 + staining than controls(0.37 vs 0.27,P≤0.01) or the SSd group(0.31 vs 0.37,P≤0.05);and higher MMP-13 + staining(72.55%) than in controls(12.55%,P≤0.001) and SSd group(20.18%,P≤0.01).The model group also had more TIMP-2 + staining(57.2%) than controls(20.9%,P≤0.001) and SSd group(22.7%,P≤0.001).Controls and SSd group showed no difference in TIMP-2 + ***:SSd inhibited HCC development,and downregulated expression of syndecan-2,MMP-2,MMP-13 and TIMP-2 in rat HCC liver tissue.

关键词： Carcinoma,Hepatocellular Saikosaponin Syndecan-2 Matrix metalloproteinases Tissue inhibitor of metalloproteinase inhibitor-2

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Liver Stiffness Measurement Can Reflect the Active Liver Necroinflammation in Population with Chronic Liver Disease:A Real-world Evidence Study

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Journal of Clinical and Translational Hepatology 2019年第4期7卷 313-321页

作者： Leijie Wang Mingyu Zhu Lihua Cao Mingjie Yao Yiwei Lu Xiajie Wen Ying Zhang Jing Ning Huiling Long Yueyong Zhu Guoxin Hu shuangsuo dang Qingchun Fu Liang Chen Xinxin Zhang Jingmin Zhao Zhiliang Gao Yuemin Nan Fengmin Lu Department of Microbiology&Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Department of Infectious Diseases Rui Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Liver Disease Center Qinhuangdao Third HospitalQinhuangdaoHebeiChina Department of Anatomy and Embryology School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Eshelman School of Pharmacy University of North CarolinaChapel HillNCUSA Department of Traditional and Western Medical Hepatology The Third Hospital of Hebei Medical UniversityShijiazhuangHebeiChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdongChina Liver Research Center First Affiliated Hospital of Fujian Medical UniversityFuzhouFujianChina Department of Infectious Diseases Peking University Shenzhen HospitalShenzhenGuangdongChina Department of Infectious Diseases Second Affiliated Hospital of Medical College of Xi'an Jiaotong UniversityXi'anShaanxiChina Shanghai Liver Diseases Research Center 85th HospitalNanjing Military CommandShanghaiChina Department of Liver Disease Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Pathology and Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Intervention and Cell Therapy Center Peking University Shenzhen HospitalShenzhenGuangdongChina

Background and Aims: Non-invasive evaluation of liver nec-roinflammation in patients with chronic liver disease is an un-met need in clinical *** diagnostic accuracy of transient elastography-based liver stiffness measurement(LSM)for liver fibrosis could be affected by liver necroinflam-mation,the latter of which could intensify stiffness of the *** results have prompted us to explore the diagnosis potential of LSM for liver ***: Three cross-sectional cohorts of liver biopsy-proven chronic liver dis-ease patients were enrolled,including 1417 chronic hepatitis B(CHB)patients from 10 different medical centers,106 non-al-coholic steatohepatitis patients,and 143 patients with auto-immune-related liver *** longitudinal cohort of 14 entecavir treatment patients was also *** re-ceiver operating characteristic(ROC)curve was employed to explore the diagnostic value of ***: In CHB patients,LSM value ascended with the increased severity of liver nec-roinflammation in patients with the same fibrosis *** positive correlation between LSM and liver necroinflammation was also found in non-alcoholic steatohepatitis and autoim-mune-related liver diseases ***,the ROC curve exhibited that LSM could identify moderate and se-vere inflammation in CHB patients(area under the ROC curve as 0.779 and 0.838)and in non-alcoholic steatohepatitis pa-tients(area under the ROC curve as 0.826 and 0.871),*** moderate diagnostic value was also found in autoimmune-related liver diseases *** addition,in the longitudinal entecavir treated CHB cohort,a decline of LSM values was observed in parallel with the control of inflam-matory activity in ***: Our study implicates a diagnostic potential of LSM to evaluate the severity of liver necroinflammation in chronic liver disease patients.

关键词： Liver stiffness measurement Liver necroinflammatory grade Alanine aminotransferase Chronic liver disease

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The CENP-u gene is expressed in human hepatocellular carcinoma and is important in the proliferation and apoptosis of the human hepatocellular carcinoma cell line SMMC7721

The CENP-u gene is expressed in human hepatocellular carcino...

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中华医学会第十三次全国感染病学术会议

作者： Yuan Wang Xin Zhang Xiaoli Jia Song Zhai Mei Li shuangsuo dang Department of Infectious Diseases the Second Affiliated Hospital of College of MedicineXi’an Jiaotong University

Background CENP-U(also known as CENP-50/PBIP1/MLFIIP)is a constitutive centromere component essential for proper chromosome *** research groups proved CENP-U protein is a constitutive kinetochore *** cell cycle progression,CENP-U function may be regulated by post-translational *** recent studies,CENP-U played a major important role of glioblastoma and erythroleukemias.

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A targeted multiple antigenic peptides vaccine augments the immune response to self TGF-β1 and suppresses ongoing hepatic fibrosis

A targeted multiple antigenic peptides vaccine augments the ...

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中华医学会第十三次全国感染病学术会议

作者： shuangsuo dang Yaping Li Xiaoli Jia Yuan Wang Wenjun Wang Mei Li Department of Infectious Diseases the Second Affiliated Hospital of College of MedicineXi’an Jiaotong University

Aims Transforming growth factor-β1(TGF-β1)is one of the most key cytokines regulating hepatic *** excess TGF-β1 is one of the most hot spots in the research of preventing and intervening hepatic *** TGF-β1 protein can not induce high specific antibody titers in vivo because of immunological tolerance induced by autologous protein,unless the dominant epitopes of TGF-β1 are *** overcome the

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Effect of caffeic acid phenethyl ester on proliferation and activation of hepatic stellate cells in vitro

Effect of caffeic acid phenethyl ester on proliferation and ...

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中华医学会第十三次全国感染病学术会议

作者： shuangsuo dang Ning Yang Wenjun Wang Juanjuan Shi Yuan Wang Xiaoli Jia Department of Infectious Diseases the Second Affiliated Hospital of College of MedicineXi’an Jiaotong University

Aim To observe the influence of caffeic acid phenethyl ester(CAPE)on ultrastructure,proliferation,autophagy and apoptosis of hepatic steUate ceils(HSC)in vitro,and to study the effect of CAPE on the expression ofα-SMA and TGF-β1 in *** MTr assay was used to detect the influence of CAPE on the proliferation of HSC,transmission electron microscope(TEM)was applied to observe the ultrastructural change of HSC after treatment by *** cytometry(FCM)was employed to investigate the effect of CAPEon the ratio

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Meta-analysis:prevention of interferon-associated depression in chronic hepatitis C with antidepressants

Meta-analysis:prevention of interferon-associated depression...

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中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Wenjun Wang shuangsuo dang Yaping Li Mingzhu Sun Xiaoli Jia Rui Wang Jingkun Liu Department of Infectious Diseases Second Affiliated Hospital of Medical SchoolXi'an Jiaotong University Department of Epidemiology and Biostatistics Xi'an Jiaotong University College of Medicine

Background Depression,a common side effect of interferon therapy in patients with chronic hepatitis C, is closely associated with antiviral dosage reduction,discontinuation and failure of *** randomized controlled trials have been conducted to prevent interferon-associated depression with antidepressants;however, their Conclusions are *** To perform a meta-analysis to assess the prophylactic effect of antidepressants on interferon-associated depression in patients with chronic hepatitis *** We searched

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恩替卡韦相关的中毒性表皮坏死松解症1例报告并文献复习

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临床肝胆病杂志 2022年第6期38卷 1364-1366页

作者：鲁瑞耿晓珍党双锁王文俊西安交通大学第二附属医院感染科西安710004

恩替卡韦是目前治疗HBV感染的一线用药,不良反应少见且多属轻微[1]。中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)是一种罕见的严重皮肤反应,绝大多数由药物引起[2]。本文报道1例恩替卡韦相关的TEN,此前类似病例国内外仅报道1... 详细信息

恩替卡韦是目前治疗HBV感染的一线用药,不良反应少见且多属轻微[1]。中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)是一种罕见的严重皮肤反应,绝大多数由药物引起[2]。本文报道1例恩替卡韦相关的TEN,此前类似病例国内外仅报道1例[3]。同时,本文对恩替卡韦相关的皮肤不良反应作一文献复习.

关键词：恩替卡韦表皮坏死松解症,中毒性乙型肝炎病毒

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抗-HBs／抗-HBc阳性非霍奇金淋巴瘤化疗后HBV再激活1例

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中华肝脏病杂志 2017年第6期25卷 469-470页

作者：王文俊党双锁刘捷王佰言西安交通大学第二附属医院感染科 710004 西安交通大学第二附属医院血液科 710004

乙型肝炎再活动（HBVr）是化学药物治疗（化疗）和免疫抑制剂治疗的潜在严重并发症。HBVr的发生最常见于慢性乙型肝炎病毒（HBV）感染者，

关键词：肝炎病毒乙型非霍奇金淋巴瘤再激活

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原位PCR法检测结节性红斑皮损组织中TBDNA、HSVⅡDNA、CMVDNA

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中华微生物学和免疫学杂志 1999年第5期19卷 436-439页

作者：崔荣张忠祥党双锁高丽琴陈金穆西安市第一医院皮肤科 710002 西安医科大学分子生物学研究室西京医院皮肤病理

目的　探讨结节性红斑（ＥＮ）的发病与结核杆菌（ＴＢ）、Ⅱ型单纯疱疹病毒（ＨＳＶⅡ）、人巨细胞病毒（ＨＣＭＶ）等病原微生物的关系。方法　用原位聚合酶链反应法（ＩＳＰＣＲ）及聚合酶链反应（ＰＣＲ）... 详细信息

目的　探讨结节性红斑（ＥＮ）的发病与结核杆菌（ＴＢ）、Ⅱ型单纯疱疹病毒（ＨＳＶⅡ）、人巨细胞病毒（ＨＣＭＶ）等病原微生物的关系。方法　用原位聚合酶链反应法（ＩＳＰＣＲ）及聚合酶链反应（ＰＣＲ）法对３５例常规福尔马林石蜡包埋及冰冻ＥＮ皮损组织切片中的ＴＢＤＮＡ、ＨＳＶⅡ ＤＮＡ及ＨＣＭＶＤＮＡ进行扩增，ＳＰ免疫组化染色，ＡＥＣ显色。结果　每一例ＥＮ标本均有病原微生物检出，检出率分别为６３．６％（２１／３３）、５７．１％（２０／３５）及６５．７％（２３／３５），其中检出两种或两种以上者为６０．６％（２０／３３）；１４例正常组织中病原微生物的检出率为０，８．３％（２／１４），０。ＩＳＰＣＲ的研究发现：ＤＮＡ阳性信号分布于皮损部位，以小血管为著。细胞内的分布各有特点：ＴＢＤＮＡ主要在细胞间，细胞膜及核膜，核内少见；ＨＳＶⅡ ＤＮＡ与ＨＣＭＶＤＮＡ的分布，主要在细胞核内。结论　ＥＮ的发病可能与ＴＢ、ＨＳＶⅡ、ＨＣＭＶ等均有关，需进一步探讨。ＩＳＰＣＲ法是一种可定位且敏感、特异的检测方法，?

关键词：结节性红斑结核杆菌巨细胞病毒聚合酶链反应

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