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Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui Liu Meng Zhang Ting Li shuangsuo Dang Yaping Li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

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变电站直流系统运行状态与维护措施分析

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电力设备管理 2024年第7期 51-53页

作者：张双锁山西敬天合创云能源有限公司

变电站直流系统运行维护技术要求高,传统维护方式存在准确性差、效率低等弊端,亟须改进运维方式。基于此,本文在了解变电站直流系统组成及工作原理的基础上,剖析直流系统运行现状,提出日常维护、专项维护、在线监测多种维护方法,阐述直... 详细信息

变电站直流系统运行维护技术要求高,传统维护方式存在准确性差、效率低等弊端,亟须改进运维方式。基于此,本文在了解变电站直流系统组成及工作原理的基础上,剖析直流系统运行现状,提出日常维护、专项维护、在线监测多种维护方法,阐述直流系统故障处理流程,同时结合某变电站直流系统故障实例,提出故障处理方法,评价故障处理效果。为提高直流系统运维水平,提出工作建议,采取科学可行的方法做好变电站直流系统维护工作,保证直流系统安全运行。

关键词：直流系统运行状态维护措施故障处理蓄电池

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Mindin蛋白在经聚乙二醇干扰素α-2b治疗的慢性乙型肝炎中的动态变化及意义

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临床肝胆病杂志 2024年第1期40卷 52-57页

作者：王怡恺吴凤萍刘晨瑞郝苗吕莎莎张苗苗党双锁张欣西安交通大学第二附属医院感染科西安710004

目的分析聚乙二醇干扰素α-2b(PEG-IFNα-2b)治疗慢性乙型肝炎(CHB)过程中Mindin蛋白的变化以及作用。方法选取2018年1月—2019年12月于西安交通大学第二附属医院行PEG-IFNα-2b治疗的CHB患者29例,按照临床结局分为治愈组(n=17)与未... 详细信息

目的分析聚乙二醇干扰素α-2b(PEG-IFNα-2b)治疗慢性乙型肝炎(CHB)过程中Mindin蛋白的变化以及作用。方法选取2018年1月—2019年12月于西安交通大学第二附属医院行PEG-IFNα-2b治疗的CHB患者29例,按照临床结局分为治愈组(n=17)与未治愈组(n=12)。分别采集治愈组和未治愈组基线、12周和24周的外周血样本,测量血常规、肝功能、乙型肝炎标志物定量和Mindin蛋白含量。分析比较各时间点HBsAg、ALT、AST及Minidn蛋白水平的组间差异。符合正态分布的计量资料两组间比较采用成组t检验;非正态分布的计量资料两组间比较采用Mann-Whitney U检验。采用Spearman相关性分析法对Mindin蛋白与HBsAg、ALT、AST的相关性进行分析。多元线性回归分析探讨HBsAg、ALT水平对Mindin蛋白的影响。结果基线资料分析发现,未治愈组和治愈组HBsAg、抗-HBe、Alb和白/球比值(A/G)水平两组间比较差异均有统计学意义(P值均<0.05)。治愈组Mindin蛋白水平呈现持续上升的趋势,24周时Mindin蛋白水平显著高于基线(P<0.05)。24周时治愈组Mindin蛋白水平显著高于未治愈组(P=0.019)。治愈组HBsAg水平均显著低于未治愈组,且组内各时间点与基线比较差异均具有统计学意义(P值均<0.05)。此外,治愈组ALT和AST的变化均呈现先升高后降低的趋势,12周的表达水平均显著高于基线(P值均<0.05)。未治愈组24周ALT和AST水平均显著高治愈组(P值均<0.05)。未治愈组12周时Mindin蛋白水平与ALT呈现出较强的直线相关性(r=0.760 8,P<0.05),进一步的多元线性回归分析同样证明两者间存在线性关系(偏回归系数为1.571,P=0.019)。结论 PEG-IFNα-2b抗病毒治疗24周时的Mindin蛋白水平在治愈组和未治愈组间存在明显差异。提示通过检测Mindin蛋白的动态变化可以更好地预测慢性乙型肝炎的治疗结局,为临床提供参考。

关键词：乙型肝炎慢性 Mindin蛋白干扰素α

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Effects of Saikosaponin-D on syndecan-2,matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma

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Journal of Traditional Chinese Medicine 2012年第3期32卷 415-422页

作者： Xiaoli Jia shuangsuo Dang Yanan Cheng Xin Zhang Mei Li Yaping Li Siyuan Li Department of Infectious Diseases theSecond Hospital of Xi'an Jiaotong University Xi'an Shaanxi710004 China Key Laboratory of Environment and Genes Relat-ed to Diseases (Xi'an Jiaotong University) Ministry of Educa-tion Xi'an Shaanxi 710061 China

OBJECTIVE:To investigate effects of Saikosaponin D(SSd) on syndecan-2,matrix metalloproteinases(MMPs) and tissue inhibitor of metalloproteinases-2(TIMP-2) in livers of rat with hepatocellular carcinoma(HCC).METHODS:Male SD rats were divided into control(n=10),model(n=20) and SSd(n=20) groups,and model and SSd groups given intragastric 0.2%(w/v) N-diethylnitrosamine to induce *** group received 0.03%(w/v) SSd in *** samples were analysed immunohistochemically for syndecan-2,MMP-2,MMP-13 and TIMP-2 at 16 ***:The model group had more malignant nodules than the SSd group;all model-group HCC cells were grade III;SSd-group HCC cells were grades *** showed normal hepatic cell phenotypes and no syndecan-2 + ***-2 + staining was greater in the model group(35.2%,P≤0.001) than in controls or the SSd group(16.5%,P ≤ 0.001).The model group had more intense MMP-2 + staining than controls(0.37 vs 0.27,P≤0.01) or the SSd group(0.31 vs 0.37,P≤0.05);and higher MMP-13 + staining(72.55%) than in controls(12.55%,P≤0.001) and SSd group(20.18%,P≤0.01).The model group also had more TIMP-2 + staining(57.2%) than controls(20.9%,P≤0.001) and SSd group(22.7%,P≤0.001).Controls and SSd group showed no difference in TIMP-2 + ***:SSd inhibited HCC development,and downregulated expression of syndecan-2,MMP-2,MMP-13 and TIMP-2 in rat HCC liver tissue.

关键词： Carcinoma,Hepatocellular Saikosaponin Syndecan-2 Matrix metalloproteinases Tissue inhibitor of metalloproteinase inhibitor-2

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Expert Consensus on the Prevention and Treatment of Chronic Hepatitis B in Children

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Infectious Diseases & Immunity 2024年第3期4卷 106-120页

作者： Chinese Society of Infectious Diseases Chinese Medical Association Chinese Society of Hepatology Chinese Medical Association Group of Infectious Diseases Chinese Pediatric Society Chinese Medical Association National Clinical Research Center for Infectious Diseases(Beijing) Fu-Sheng Wang Shishu Zhu Min Zhang Jianshe Wang Shuangjie Li Junliang Fu Yuanyuan Li Yuming Guo Jing Li Hongmei Xu Wenxian Ouyang Yuemin Nan Sainan Shu shuangsuo Dang Xiaoyuan Xu Taisheng Li Jinlin Hou 不详 The Fifth Medical Center of PLA General Hospital Beijing 100039China Fudan University Children’s Hospital Hunan Children’s Hospital Children’s Hospital of Chongqing Medical University Third Hospital Hebei Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology The Second Affiliated Hospital of Xi’an Jiaotong University Peking University First Hospital Peking Union Medical College Hospital Chinese Academy of Medical Sciences&Peking Union Medical College Nanfang Hospital Southern Medical University

The aim of this consensus is to standardize the prevention, diagnosis, and treatment of chronic hepatitis B in children and to achieve the goal of “eliminating viral hepatitis as a major public health threat by 2030” issued by the World Health Organization. Formulated by organized experts of the Chinese Society of Infectious Diseases and Chinese Society of Hepatology, Chinese Medical Association;Group of Infectious Diseases, Chinese Pediatric Society, Chinese Medical Association;and the National Clinical Research Center for Infectious Diseases (Beijing), the consensus provides the latest evidence and recommendations for the prevention, diagnosis, and treatment of chronic hepatitis B in children.

关键词： Chronic hepatitis B Children Treatment Prevention Consensus

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A CLASS OF r-POINT (r+1)ST-ORDER A-STABLE ONE-BLOCK METHODS WITH DAMPING AT THE INFINITE POINT

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Numerical Mathematics A Journal of Chinese Universities(English Series) 2002年第2期11卷 161-178页

作者： Zhao shuangsuo(赵双锁) Zhang Guofeng(张国风) Dept. of Inform. and Comput. Sci. The Second Northwest University for Nationalities Yinchunan 750021 PRC Dept. of Math. Lanzhou University Lanzhou 73000 PRC

This paper presents a class of r-point (r+1)st-order A-stable one-block methods with damping at the infinite point (DIAOB r,r+1 ). Under the conditions of the same order, A-stability, operation count (at each iterative step) and storage space are the same as the methods in , the methods in the paper improve the stability in a neighborhood at the infinite point. And, by using the OOPI method , it possesses much faster rate of convergence for solving systems of nonlinear equations produced by the DIAOB r,r+1 .

关键词： one-block method, stiff problem, A-stability, damping at infinite point.

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解强刚性块线代数方程组的两类L-收敛迭代法

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计算数学 2006年第4期28卷 409-418页

作者：赵双锁西北第二民族学院信息与计算科学系银川750021

对解强刚性块线代数方程组X=(A(?)J)X+φ,本文提出了L-收敛的最佳单参数迭代法(L-OOPI)和L-收敛的多参数迭代直接法(L-MPID),并给出了数值例子．数例表明,对于强刚性块线代数方程组,该二迭代法是有效的．

关键词：强刚性块线代数方程组迭代法迭代直接法最佳迭代参数 L-收敛

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函数方程求根的一种新型大范围收敛迭代法

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高等学校计算数学学报 2006年第3期28卷 193-201页

作者：赵双锁西北第二民族学院信息与计算科学系银川 750021

1引言实际解函数方程f（x）=0(z∈[α,β],f（α）f（β）＜0,f（x;）=0)时,人们常常希望选用那些仅计算函数值,具有大范围收敛性且效率较高的方法,特别对那些表示式复杂的函数以及病态函数．例如,那种仅在的某个充分小邻域内连续,而在... 详细信息

1引言实际解函数方程f（x）=0(z∈[α,β],f（α）f（β）＜0,f（x;）=0)时,人们常常希望选用那些仅计算函数值,具有大范围收敛性且效率较高的方法,特别对那些表示式复杂的函数以及病态函数．例如,那种仅在的某个充分小邻域内连续,而在该邻域之外光滑性很差的函数；那种在初始含根区间（α,β）上起伏多变的函数；那种|f（α）|和|f（β）|差别甚大,而x;又十分靠近绝对值较大者一端的函数等等,这种欲望就更加强烈．

关键词： functional equation global convergence ill-conditioned function universal suitability efficiency

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The CENP-u gene is expressed in human hepatocellular carcinoma and is important in the proliferation and apoptosis of the human hepatocellular carcinoma cell line SMMC7721

The CENP-u gene is expressed in human hepatocellular carcino...

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中华医学会第十三次全国感染病学术会议

作者： Yuan Wang Xin Zhang Xiaoli Jia Song Zhai Mei Li shuangsuo Dang Department of Infectious Diseases the Second Affiliated Hospital of College of MedicineXi’an Jiaotong University

Background CENP-U(also known as CENP-50/PBIP1/MLFIIP)is a constitutive centromere component essential for proper chromosome *** research groups proved CENP-U protein is a constitutive kinetochore *** cell cycle progression,CENP-U function may be regulated by post-translational *** recent studies,CENP-U played a major important role of glioblastoma and erythroleukemias.

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A targeted multiple antigenic peptides vaccine augments the immune response to self TGF-β1 and suppresses ongoing hepatic fibrosis

A targeted multiple antigenic peptides vaccine augments the ...

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中华医学会第十三次全国感染病学术会议

作者： shuangsuo Dang Yaping Li Xiaoli Jia Yuan Wang Wenjun Wang Mei Li Department of Infectious Diseases the Second Affiliated Hospital of College of MedicineXi’an Jiaotong University

Aims Transforming growth factor-β1(TGF-β1)is one of the most key cytokines regulating hepatic *** excess TGF-β1 is one of the most hot spots in the research of preventing and intervening hepatic *** TGF-β1 protein can not induce high specific antibody titers in vivo because of immunological tolerance induced by autologous protein,unless the dominant epitopes of TGF-β1 are *** overcome the

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