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A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications

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Chinese Chemical Letters 2020年第11期31卷 2955-2959页

作者： Kaijie Wang Dazhou xi Chuantao Liu Yahui Chen Hao gu Long Jiang xiaoqiang Chen Fang Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringJiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech UniversityNanjing 211816China

A ratiometric probe(HBT-HBZ)bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid(HClO)with high selectivity and sensitivity is reported in this *** fluorescence intensity ratios(I470nm/I572nm)of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in *** detection limit of 24 nmol/L suggests that the sensor is very sensitive to *** to the series of performed experiments,HBT-HBZ has practical applications,such as the detection of HClO residues in tap water,which has been rarely *** addition,confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells.A ratiometric probe(HBT-HBZ)for sensing HClO with high selectivity and sensitivity is reported in this *** probe exhibited high selectivity for HClO among other ROS,RNS and *** addition,HBTHBZ has some practical applications such as the analysis of the HClO content in tap ***,confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells.

关键词： HClO Benzothiazole Fluorescence probe Tap water Bioimaging

Tensor Effect on Bubble Nuclei

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Chinese Physics Letters 2011年第10期28卷 62-65页

作者： WANG Yan-Zhao gu Jian-Zhong ZHANG xi-Zhen DONG Jian-Min China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413 Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of LanzhouLanzhou 730000 School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000

In the framework of the Hartree–Fock–Bogoliubov(HFB)approach with Skyrme interactions SLy5+T,SLy5+Tw and several sets of TIJ parametrizations,*** Skyrme interaction parametrizations including the tensor terms,the proton density distribution in ^(34)Si and ^(46)Ar nuclei is calculated with and without the tensor *** is shown that the bubble effect in ^(34)Si does not depend a great deal on the Skyrme parametrization and the proton density distribution in ^(34)Si is hardly influenced by the tensor *** to ^(46)Ar,the SLy5+Tw parametrization favors the formation of the bubble structure due to the inversion between the 2s_(1/2) and 1d_(3/2) orbits(2s_(1/2)–1d_(3/2) inversion).The inversion mechanism induced by the SLy5+Tw interaction is analyzed based on the proton single−particle spectra obtained from the SLy5 and SLy5+Tw interactions as well as the wave functions of the 2s_(1/2) and 1d_(3/2) states.

关键词： force tensor bubble

On the anomalous low-resistance state and exceptional Hall component in hard-magnetic Weyl nanoflakes

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 107-113页

作者： QingQi Zeng GangXu gu Gang Shi JianLei Shen Bei Ding Shu Zhang XueKui xi Claudia Felser YongQing Li EnKe Liu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics and Astronomy University of CaliforniaLos Angeles 90095USA Max Planck Institute for Chemical Physics of Solids Dresden D-01187Germany Songshan Lake Materials Laboratory Dongguan 523808China

Magnetic topological materials, which combine magnetism and topology, are expected to host emerging topological states and exotic quantum phenomena. In this study, with the aid of greatly enhanced coercive fields in high-quality nanoflakes of the magnetic Weyl semimetal Co_(3)Sn_(2)S_(2), we investigate anomalous electronic transport properties that are difficult to reveal in bulk Co_(3)Sn_(2)S_(2) or other magnetic materials. When the magnetization is antiparallel to the applied magnetic field, the low longitudinal resistance state occurs, which is in sharp contrast to the high resistance state for the parallel case. Meanwhile, an exceptional Hall component that can be up to three times larger than conventional anomalous Hall resistivity is also observed for transverse transport. These anomalous transport behaviors can be further understood by considering nonlinear magnetic textures and the chiral magnetic field associated with Weyl fermions, extending the longitudinal and transverse transport physics and providing novel degrees of freedom in the spintronic applications of emerging topological magnets.

关键词： hard-magnetic material magnetic Weyl semimetal magnetoresistance Hall effect

A primary study on biological behavior of aluminum using^26Al-AMS

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Nuclear Science and Techniques 2016年第3期27卷 25-30页

作者： Song-Mei Qin xiang-Gao Wang xiao-xi Lan Yun-Ting gu Ke-Jun Dong Ming He Shan Jiang guangxi University of Chinese Medicine Nanning 530001China GXU-NAOC Center for Astrophysics and Space Sciences Department of PhysicsGuangxi UniversityNanning 530004China guangxi Key Laboratory for the Relativistic Astrophysics Nanning 530004China China Institute of Atomic Energy Beijing 102413China

Aluminum is concerned as a possible cause of many *** investigate the long-term A1 biokinetics and bioavailability in various kinds of Al-contained medicine and food,an accelerator mass spectrometry(AMS)based on the HI-13 tandem has been established for biological analysis with ^(26)A1(T_(1/2) = 716,000 years) as the *** this paper,the animal tracing,sample preparation procedure and ^(26)A1-AMS measurement are *** sample preparation procedure has been simplified.A high sensitivity of 5×10^(-15) for ^(26)A1/^(27)A1 has been *** phases were found before and after a break time(t_b)for the ^(26)A1 retained in blood and brain,with t_b≈8 and12 h after the ^(26)Al tracer injection,respectively.

关键词： AMS 生物学特性铝制备过程生物利用度生物动力学加速器质谱生物分析

Investigation of Impact Toughness of Electromagnetic Centrifugal Cast High Speed Steel

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Journal of Iron and Steel Research International 2012年第S1期19卷 335-340页

作者： WANG Ming-jia gu Tao WANG Zi-xi State Key Laboratory of Metastable Materials Science and Technology Yanshan University

The effect of external magnetic field on the solidification structure and impact toughness of high-speed steel(HSS)produced by electromagnetic centrifugal casting(EMCC)have been *** was found that the solidification structure could be improved effectively by electromagnetic stirring,which was characterized by elimination of the inclined columnar dendrites and refinement of the grain *** results may be related to the changes of the fluid layers of liquid-solid phase ***,the impact toughness of the test steel increased with the exciting current increasing from 12 to 18 A,but decreased when the current was above 18 *** analysis showed that impact fracture surface was dimple fracture due to effect of the refined equiaxed grains when the current was 18 A,which was considered an important reason for the improvement of impact toughness.

关键词： electromagnetic centrifugal casting high speed steel Impact toughness grain refinement

Modified robust optimal adaptive control for flight environment simulation system with heat transfer uncertainty

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Chinese Journal of Aeronautics 2021年第2期34卷 420-431页

作者： Meiyin ZHU xi WANG xitong PEI Song ZHANG Zhihong DAN Nannan gu Shubo YANG Keqiang MIAO Huairong CHEN Jiashuai LIU School of Energy and Power Engineering Beihang UniversityBeijing 100083China Collaborative Innovation Center for Advanced Aero Engine Bejing 100083China Science and Technology on Altitude Simulation Laboratory AECC(Aero Engine Corporation of China)Sichuan Gas Turbine EstablishmentMianyang 621000China

To solve the rapid transient control problem of Flight Environment Simulation System(FESS) of Altitude Ground Test Facilities(AGTF) with large heat transfer uncertainty and disturbance, a new adaptive control structure of modified robust optimal adaptive control is *** mathematic modeling of FESS is given and the influence of heat transfer is analyzed through energy view. To consider the influence of heat transfer in controller design, we introduce a matched uncertainty that represents heat transfer influence in the linearized system of FESS. Based on this linear system, we deduce the design of modified robust optimal adaptive control law in a general way. Meanwhile, the robust stability of the modified robust optimal adaptive control law is proved through using Lyapunov stability theory. Then, a typical aero-engine test condition with Mach Dash and Zoom-Climb is used to verify the effectiveness of the devised adaptive controller. The simulation results show that the designed controller has servo tracking and disturbance rejection performance under heat transfer uncertainty and disturbance;the relative steady-state and dynamic errors of pressure and temperature are both smaller than 1% and 0.2% respectively. Furthermore,the influence of the modification parameter c is analyzed through simulation. Finally, comparing with the standard ideal model reference adaptive controller, the modified robust optimal adaptive controller obviously provides better control performance than the ideal model reference adaptive controller does.

关键词： Altitude ground test facilities Flight environment simulation system Heat transfer Model reference adaptive control Optimal control modification Uncertainty

Tetracysteine as a Reporter for Gene Therapy

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Biomedical and Environmental Sciences 2009年第6期22卷 496-501页

作者： CHEN-YU XU YING gu WANG-HENG HOU YU-QIONG QUE shuang-guAN GAO TONG CHENG NING-SHAO xi National Institute of Diagnostics and Vaccine Development for Infectious Diseases School of Life Sciences Xiamen University Xiamen 361005 Fujian China Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 Fujian China

Objective To study the feasibility of using tetracysteine （TC） reporter in gene therapy. Methods Effects of TC reporter and conventional reporter genes encoding green fluorescence protein （GFP） and luciferase （Luc） on expression and function of the therapeutic gene MGMT^P140K were compared. Cytotoxicity and drug resistance were studied by Western blot. TC reporter used in therapy was analyzed by flow cytometry （FCM）. Results The TC reporter had no toxicity to cells and neither affected the expression or activity of therapeutic gene as compared to GFP and Luc. TC could be used in blood sample detection. Conclusion TC is a new kind of reporter gene for lentiviral vector in future gene therapy.

关键词： Tetracysteine Lentiviral vector Reporter Gene therapy

Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation

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Neural Regeneration Research 2022年第10期17卷 2185-2193页

作者： xiao-Lei Chu xi-Zi Song Qi Li Yu-Ru Li Feng He xiao-Song gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Department of Rehabilitation Tianjin HospitalTianjinChina College of Exercise&Health Sciences Tianjin University of SportTianjinChina College of Precision Instruments&Optoelectronics Engineering Tianjin UniversityTianjinChina

Previous studies on the mechanisms of peripheral nerve injury(PNI)have mainly focused on the pathophysiological changes within a single injury ***,recent studies have indicated that within the central nervous system,PNI can lead to changes in both injury sites and target organs at the cellular and molecular ***,the basic mechanisms of PNI have not been comprehensively *** electrical stimulation was found to promote axonal regeneration and functional rehabilitation after PNI,as well as to alleviate neuropathic pain,the specific mechanisms of successful PNI treatment are *** summarize and discuss the basic mechanisms of PNI and of treatment via electrical *** PNI,activity in the central nervous system(spinal cord)is altered,which can limit regeneration of the damaged *** example,cell apoptosis and synaptic stripping in the anterior horn of the spinal cord can reduce the speed of nerve *** pathological changes in the posterior horn of the spinal cord can modulate sensory abnormalities after *** can be observed in cases of ectopic discharge of the dorsal root ganglion leading to increased pain signal *** injured site of the peripheral nerve is also an important factor affecting post-PNI *** PNI,the proximal end of the injured site sends out axial buds to innervate both the skin and muscle at the injury site.A slow speed of axon regeneration leads to low nerve ***,it can take a long time for the proximal nerve to reinnervate the skin and muscle at the injured *** the perspective of target organs,long-term denervation can cause atrophy of the corresponding skeletal muscle,which leads to abnormal sensory perception and hyperalgesia,and finally,the loss of target organ *** mechanisms underlying the use of electrical stimulation to treat PNI include the inhibition of synaptic stripping,addressing the excessive excitability of the dorsal r

关键词： axonal transport brain-derived neurotrophic factor dorsal horn stimulation dorsal root ganglion stimulation electrical stimulation nerve regeneration neuropathic pain peripheral nerve injury spinal cord dorsal stimulation

Physiological property and yield of the sweet sorghum mutants induced by heavy ion irradiation

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Nuclear Science and Techniques 2016年第4期27卷 83-88页

作者： Wen-Ting gu Wen-Jian Li Rui-Yuan Liu Wen-Jie Jin Tao-Li-Wei Yang xi-Cun Dong Institute of Modern Physics Chinese Academy of Sciences

Soil salinity can limit plant growth and productivity. The cultivation of tolerant varieties is convenient and cost-effective for making good use of the saline *** sweet sorghum plant has a high tolerance for saline alkaline soils. The KF1210-3 and KF1210-4 early-maturity mutants of sweet sorghum were obtained via carbon ion irradiation. The study assesses the productivity of three sweet sorghum cultivars(KF1210-3, KF1210-4, and KFJTCK) which were grown in intermediate(4.6 d S m^(-1)) and high(11.9 d S m^(-1)) soil salinity. The sweet sorghum grown in the soil salinity of 4.6 d S m^(-1)produced 50.00–57.30 %greater fresh weight than that in the soil salinity of11.9 d S m^(-1), while the difference was not as obvious among the dry biomass of the three sweet sorghum cultivars. Moreover, the Brix degree of the sweet sorghum grown in the soil salinity of 11.9 d S m^(-1)was greater than that grown in the soil salinity of 4.6 d S m^(-1). The heavy ion irradiation experiment is of great significance in screening plant mutants, improving environmental conditions, and assessing the productivity. This process, in turn, aids in the understanding of the effects of the biochemical and physiological mechanisms of salt stress.

关键词：早熟突变体甜高粱重离子生理特性辐照诱导土壤含盐量产量土壤盐分