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Optimization of the Production Organization Pattern in Tangshan Iron and Steel Co., Ltd.

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Journal of Iron and Steel Research International 2014年第S1期21卷 17-22页

作者： Zong-xi GU An-jun XU Jin-bao CHANG shuang-wu li You-bing XIANG State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgy and Ecology Engineering University of Science and Technology Beijing Tangshan Iron and Steel Company of Hebei Iron and Steel Group

High-efficiency production organization should be simple and "laminar". A one to one "laminar flow" operation mechanism is supposed to be accepted as a prerequisite to build high-efficiency clean steel "production platform". Concerning the fact that establishing a one to one "laminar flow" production pattern is impossible at Tangshan Iron and Steel Co., Ltd., "quasi-laminar flow" production pattern was evaluated. Result shows that rolling bar products of various specifications have great impact on the liquid steel supply model between BOF and CC. Considering the process matching issue of steelmaking-continuous casting-rolling process in bar production line, a "quasi-laminar flow" production pattern between BOF and CC was proposed according to different rolling specification in bar mills. Through analysis and research on current production pattern, combined with principles and strategy for BOF workshop control, and taking the plant layout into account, "quasi-laminar flow" production pattern was finally established. Moreover, Gantt chart of "quasi-laminar flow" production pattern was drawn. It is shown that the relative "order degree" of the "quasi-laminar flow" production pattern rises, which is conductive to production scheduling and ladle operation turnaround in comparison with "turbulence" production pattern. While a careful evaluation should be conducted due to the fluctuant temperature drop caused by the inevitable inserted heats and decreased operation rate of inserted BOF before adapting the production pattern.

关键词： steelmaking-casting process matching between converters and continuous casters 'quasi-laminar flow' production pattern Gantt chart

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环状RNA在肿瘤疾病中的研究进展

中国肿瘤临床 2018年第5期45卷 251-255页

作者：吴宛玲李爽复旦大学附属华山医院血液科上海市200433

环状RNA是一种新型RNA,在生物体中具有microRNA"海绵"、RNA结合蛋白及核转录调节等功能。在肿瘤疾病中,环状RNA主要以miRNA"海绵"的形式发挥调控作用,促进或抑制肿瘤的发生和发展。此外,环状RNA还可以作为肿瘤早期诊断、预后评估的生物... 详细信息

环状RNA是一种新型RNA,在生物体中具有microRNA"海绵"、RNA结合蛋白及核转录调节等功能。在肿瘤疾病中,环状RNA主要以miRNA"海绵"的形式发挥调控作用,促进或抑制肿瘤的发生和发展。此外,环状RNA还可以作为肿瘤早期诊断、预后评估的生物标记物,也可作为抗肿瘤治疗的靶标,具有潜在的临床诊断治疗价值。本文就环状RNA在肿瘤疾病中的作用机制及临床应用进行综述。

关键词：环状RNA 肿瘤 miRNA“海绵” 生物标记物

外源甜菜碱投加增强高盐废水厌氧氨氧化脱氮性能

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环境科学 2018年第4期39卷 1688-1696页

作者：于德爽吴国栋李津周同王骁静青岛大学环境科学与工程学院青岛266071

废水因含盐量高而导致其生物处理效率降低,对于如何提高高盐环境下的生物处理效率已成为目前的研究热点.采用厌氧氨氧化工艺处理高盐废水,以不同甜菜碱浓度对厌氧氨氧化脱氮效能为研究对象,探讨了甜菜碱对厌氧氨氧化脱氮效能的影响.结... 详细信息

废水因含盐量高而导致其生物处理效率降低,对于如何提高高盐环境下的生物处理效率已成为目前的研究热点.采用厌氧氨氧化工艺处理高盐废水,以不同甜菜碱浓度对厌氧氨氧化脱氮效能为研究对象,探讨了甜菜碱对厌氧氨氧化脱氮效能的影响.结果表明:(1)投加甜菜碱对系统脱氮效能有明显的改善作用,甜菜碱浓度为0.1~0.4 mmol·L^(-1)时,添加甜菜碱缓解了盐胁迫对厌氧氨氧化菌生长的抑制,也促进了反硝化菌的生长;甜菜碱浓度为0.4~0.5 mmol·L^(-1)时,推测反硝化菌为优势菌群,但对总氮去除表现为促进作用.甜菜碱浓度大于0.5 mmol·L^(-1)后,添加甜菜碱已无法缓解盐胁迫对反应器脱氮效能的抑制,最终在甜菜碱浓度0.8 mmol·L^(-1)时对反应器产生完全抑制.(2)甜菜碱的添加浓度为0.3 mmol·L^(-1)时,反应去除效能达到最佳,NH_4^+-N和NO_2^--N分别提升了16%和32%,NRR提升了26.8%.(3)在最后的恢复试验中,随着甜菜碱浓度的降低反应器脱氮效能得到快速恢复,NH_4^+-N恢复到50.6%,NO_2^--N平均去除率为63.7%,NRR恢复到0.65 kg·(m^3·d)^(-1),这说明甜菜碱对反应器的影响是可逆的.

关键词：高盐废水厌氧氨氧化甜菜碱盐胁迫脱氮

Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu Xuan wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： Yun li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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利用反例在微积分教学中发展学生的思维

长沙通信职业技术学院学报 2005年第2期4卷 111-114页

作者：吴双利湖南对外经济贸易职业学院湖南长沙410011

文章从数学发展史和辩证逻辑思维的角度说明了反例在微积分教学中的重要作用——反例教学,一方面有利于学生对数学定理中条件的理解,体会数学的严谨性;另一方面有助于学生辩证逻辑思维能力的发展。

关键词：微积分教学学生逻辑思维能力数学发展史反例教学数学定理严谨性辩证

旭龙水电站导流洞施工期安全监测与围岩稳定分析

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价值工程 2024年第25期43卷 61-64页

作者：吴双利国家能源集团金沙江旭龙水电有限公司成都610041

介绍了旭龙水电站导流洞工程地质概况、安全监测设计和监测施工,通过对围岩变形、渗压渗流、应力应变和温度等监测数据的采集分析,对导流洞洞身的稳定性、安全度做出评价,系统掌握导流洞施工开挖过程围岩的变形与应力应变规律。施工期... 详细信息

介绍了旭龙水电站导流洞工程地质概况、安全监测设计和监测施工,通过对围岩变形、渗压渗流、应力应变和温度等监测数据的采集分析,对导流洞洞身的稳定性、安全度做出评价,系统掌握导流洞施工开挖过程围岩的变形与应力应变规律。施工期安全监测在施工过程中起到了反馈设计与指导施工的良好作用。

关键词：旭龙水电站导流洞安全监测变形分析

同方期刊数据库博看期刊评论

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基于改进人工蜂群算法的无人机的航迹规划

电光与控制 2017年第1期24卷 19-23页

作者：于霜丁力吴洪涛南京航空航天大学南京210016 苏州工业职业技术学院江苏苏州215104

针对无人机飞行任务规划系统中的航迹规划问题,提出了一种改进的人工蜂群算法,将其应用于无人机的航迹规划。该算法将航迹规划问题转换成函数优化问题,以蜂群为搜索单位,通过群体之间的信息交流与优胜劣汰机制,使蜂群向更优方向进化。... 详细信息

针对无人机飞行任务规划系统中的航迹规划问题,提出了一种改进的人工蜂群算法,将其应用于无人机的航迹规划。该算法将航迹规划问题转换成函数优化问题,以蜂群为搜索单位,通过群体之间的信息交流与优胜劣汰机制,使蜂群向更优方向进化。在雇佣蜂搜索阶段采用自适应搜索策略来加快算法收敛速度;在跟随蜂搜索阶段引入一种新的概率选择方式来保证种群的多样性;在侦察蜂搜索阶段利用混沌搜索算子提高算法的全局搜索能力。通过标准函数测试与航迹规划仿真对改进后的算法进行验证,结果表明,改进后的算法提高了全局收敛能力,在收敛速度和精度上优于传统的人工蜂群算法,可有效解决无人机的航迹规划问题。

关键词：无人机航迹规划人工蜂群算法改进算子自适应搜索

Breeding for Parents of Hybrid Rice with Maize pepc Gene

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Agricultural Sciences in China 2002年第10期1卷 1067-1073页

作者： WANG De-zheng, JIAO De-mao, wu shuang, li Xia, li li, CHI Wei, WANG Shou-hai, li Cheng-quan, LUO Yan-chang and WANG Xiu-feng(Rice Research Institute , Anhui Academy of Agricultural Sciences , Hefei 230031 , P. R . China Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences , Nanjing 210014 , P. R . China) Rice Research Institute Anhui Academy of Agricultural Sciences Hefei 230031 P.R. China

The results of the investigation on transgenic rice with maize C4-specific phosphoenolpyruvate carboxylase (pepc) gene showed that the transgenic rice plants with the maize pepc gene expressed at high level and the maize PEPC expression was inherited in the progenies in a Mendelian manner. The transgenic plants had PEPC activity of more than 10-fold higher than untransformed plants. As compared with untransformed plants, the panicle per plant, spikelet per panicle, 1000-grain weight and grain-weight per plant for transgenic plants increased by 14.9 % , 5.7%, 1.3 % and 13.9 %, respectively. By crossing the maize pepc gene was incorporated into the parents of hybrid rice, which were the photo-sensitive genie male sterile (PGMS) lines of two-line hybrid rice such as Peiai64s, 7001s, 2302s, 2304s and 2306s-1, and the BT type of cytoplas-mic male sterile (CMS) line of three-line hybrid rice such as shuangjiu A, and restorer lines 5129, Wanjing97 in the spring of 1998. The following progresses were made: (1) The inheritance of the high-level expression of the maize PEPC was stable in different genetic background of rice; (2) PEPC activity of  hybrid was the mean of the two parents. Its saturated photosynthetic rate (Pn) rose to 50 % higher than that of the receptor parent. These results demonstrated that it is possible to increase the vigor of the rice plant by transgenic approach with maize pepc gene; (3) The activity of PEPC in leaf could be considered as the major physiological index because the correlation coefficient between PEPC activity and Pn was 0.6470* * ; (4) We have developed three rice lines with maize pepc gene; (5) The selection method of high photosynthetic efficiency rice has been established, which includes soaking seeds into solution of hygromycin phosphotransferase to germinate, tracing the pepc gene by PCR analysis, evaluating the performance of the rice plants in the field and examining PEPC activities and Pn of rice plants with maize pepc gene.

关键词： Transgenic rice Maize pepc gene Breeding High photosynthetic efficiency Hybrid rice