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Does antecolic reconstruction for duodenojejunostomy improve delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy? A systematic review and meta-analysis

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World Journal of Gastroenterology 2012年第43期18卷 6315-6323页

作者： An-Ping Su shuang-shuang Cao Yi zhang Zhao-Da zhang Wei-Ming Hu Bo-Le Tian Department of Hepatobiliopancreatic Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To evaluate whether antecolic reconstruction for duodenojejunostomy (DJ) can decrease delayed gastric emptying (DGE) rate after pylorus-preserving pancreaticoduodenectomy (PPPD) through literature review and meta-analysis. METHODS:Articles published between January 1991 and April 2012 comparing antecolic and retrocolic reconstruction for DJ after PPPD were retrieved from the databases of MEDLINE (PubMed), EMBASE, OVID and Cochrane Library Central. The primary outcome of interest was DGE. Either fixed effects model or random effects model was used to assess the pooled effect based on the heterogeneity. RESULTS:Five articles were identified for inclusion:two randomized controlled trials and three non-randomized controlled trials. The meta-analysis revealed that antecolic reconstruction for DJ after PPPD was associated with a statistically significant decrease in the incidence of DGE [odds ratio (OR), 0.06; 95% CI, 0.02-0.17; P < 0.00 001] and intra-operative blood loss [mean difference (MD), -317.68; 95% CI, -416.67 to -218.70; P < 0.00 001]. There was no significant difference between the groups of antecolic and retrocolic reconstruction in operative time (MD, 25.23; 95% CI, -14.37 to 64.83; P = 0.21), postoperative mortality, overall morbidity (OR, 0.54; 95% CI, 0.20-1.46; P = 0.22) and length of postoperative hospital stay (MD, -9.08; 95% CI, -21.28 to 3.11; P = 0.14). CONCLUSION:Antecolic reconstruction for DJ can decrease the DGE rate after PPPD.

关键词： Pylorus-preserving pancreaticoduodenectomy Delayed gastric emptying Antecolic reconstruction Retrocolic reconstruction Duodenojejunostomy

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The Lumen-Facing Domain Is Important for the Biological Function and Organelle-to-Organelle Movement of bZIP28 during ER Stress in Arabidopsis

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Molecular Plant 2013年第5期6卷 1605-1615页

作者： Le Sun Sun-Jie Lu shuang-shuang zhang Shun-Fan Zhou Ling Sun Jian-Xiang Liu State Key Laboratory of Genetic Engineering Institute of Plant Biology School of Life Sciences Fudan University Shanghai 200433 China

The membrane-associated transcription factor, bZlP28, is relocated from the endoplasmic reticulum （ER） to the Golgi and proteolytically released from the membrane mediated by two proteases, SlP and S2P, in response to ER stress in Arabidopsis. The activated N-terminal domain recruits nuclear factor Y （NF-Y） subunits in the nucleus to regulate ER stress downstream genes. Little is known about the functions of the bZIP28 C-terminal lumen-facing domain. Here, we provide novel insights into how the ER lumen-facing domain affects the biological function and organelle-to-organelle movement of bZIP28 in the ER stress response. First, we demonstrated the functional redundancy of bZlP28 and bZIP60 by generation and analysis of the bZIP28 and bZIP60 double mutant zip28zip60. Subsequent genetic complementation experiments in zip28zip60 background with deletions on bZlP28 lumen-facing domain highlighted the importance of lumen-facing domain for its in vivo function of bZIP28 in the ER stress response. The protein subcellular localization and Western blotting results further revealed that the bZIP28 lumen-facing domain contains ER retention signal which is important for the proteolytic activation of bZIP28. Thus, the bZIP28 lumen-facing C-terminus plays important roles in the ER-to-Golgi movement of bZlP28, which may contribute to the sensing of the ER stress.

关键词： bZIP28 bZIP60 ER stress response ER-to-Golgi translocation unfolded protein response.

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Cellulose synthesis genes CESA6 and CSI1 are important for salt stress tolerance in Arabidopsis

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Journal of Integrative Plant Biology 2016年第7期58卷 623-626页

作者： shuang-shuang zhang Le Sun Xinran Dong Sun-Jie Lu Weidong Tian Jian-Xiang Liu State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Department of Biostatistics and Computational Biology School of Life Sciences Fudan University

Soil salinity is a widespread abiotic stress constraint threatening agricultural production, as it severely inhibits growth and development of crops. Several salt stress signaling pathways have been discovered in the model plant Arabidopsis thaliana, which include components for sensing the stress, transmitting the signal and regulating the downstream genes （Deinlein et al. 2o14; Julkowska and Testerink 2015）. In nature, plant roots directly encounter heterogeneous soils and therefore their responses to saline environments require dynamic changes in growth, a process in which plant cell walls play important roles （Tenhaken 2o15）. However, the molecular mechanisms underlying cell wall remodeling under stress conditions are still unclear.

关键词： Figure CSI

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Propofol protects against blood-spinal cord barrier disruption induced by ischemia/reperfusion injury

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Neural Regeneration Research 2017年第1期12卷 125-132页

作者： Li-jie Xie Jin-xiu Huang Jian Yang Fen Yuan shuang-shuang zhang Qi-jing Yu Ji Hu Department of Anesthesiology Liyuan Hospital of Tongji Medical CollegeHuazhong University of Science & Technology Department of Anesthesiology Renmin Hospital of Wuhan University

Propofol has been shown to exert neuroprotective effects on the injured spinal ***,the effect of propofol on the blood-spinal cord barrier（BSCB） after ischemia/reperfusion injury（IRI） is poorly ***,we investigated whether propofol could maintain the integrity of the *** cord IRI（SCIRI） was induced in rabbits by infrarenal aortic occlusion for 30 ***,30 mg/kg,was intravenously infused 10 minutes before aortic clamping as well as at the onset of ***,48 hours later,we performed histological and m RNA/protein analyses of the spinal *** decreased histological damage to the spinal cord,attenuated the reduction in BSCB permeability,downregulated the m RNA and protein expression levels of matrix metalloprotease-9（MMP-9） and nuclear factor-κB（NF-κB）,and upregulated the protein expression levels of occludin and *** findings suggest that propofol helps maintain BSCB integrity after SCIRI by reducing MMP-9 expression,by inhibiting the NF-κB signaling pathway,and by maintaining expression of tight junction proteins.

关键词： nerve regeneration spinal cord ischemia reperfusion injury blood–spinal cord barrier propofol matrix metalloprotease-9 nuclear factor-κB tight junction proteins neural regeneration

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Cytotoxicity of six copper-bearing intrauterine devices on Chinese hamster ovary cells: the influence of frame, shape and copper surface area

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Journal of Reproduction and Contraception 2015年第3期26卷 160-172页

作者： Tong CHEN Ying LI Wen-li zhang Wei-sai ZHOU shuang-shuang zhang Jian-ping LIU Pharmaceutic Institute of China Pharmaceutical University Institute of Planned Parenthood Research of Jiangsu Province

Objective To evaluate the cytotoxicity of six commonly used copper-bearing intrauterine devices （Cu-IUDs） on Chinese hamster ovary （CHO-K1） cells and to investigate the influence of frame, shape and copper surface area of Cu-IUDs on cell toxicity.Methods Cu-IUDs were incubated in 10% FBS-DMEM/F12 culture medium at 37 ℃ for 24 h. The extracts were analyzed by flame atomic absorption spectrometer and were then diluted into different concentrations with culture medium. Finally, cytotoxicity of these original and diluted extracts on CHO-K1 cells was detected by cell counting kit-8 （CCK-8） assay.Results The viabilities of cells treated with the original extracts of six Cu-IUDs （TCu220C bulb, TCu220C, GCu220, GCu300, Yuangong Cu270 and Yuangong Ⅱ- 300） were all below 10% and the cupric ion concentrations in these extracts were 28.22 mg/L, 31.80 mg/L, 92.80 mg/L, 99.74 mg/L, 114.90 mg/L and 119.20 mg/L, respectively. After these original extracts were diluted, significant differences in cytotoxicity were exhibited. IUDs with larger copper surface areas （GCu300 and Yuangong Ⅱ-300） showed more cytotoxicity than those with smaller areas （GCu220 and Yuangong Cu270） respectively; When different shapes of Cu-IUDs were compared, TCu220C bulb showed lower cytotoxicity than TCu220C, and GCu300 exhibited higher toxicity than Yuangong Ⅱ-300; TCu220C displayed significantly lower cytotoxicity than GCu220 due to their differences in *** We presented evidence on the cytotoxic effects of copper ions released from Cu-IUDs on CHO-K1 cells and found that shape, frame together with copper surface area of Cu-IUDs had obvious influence on the cytotoxicity.

关键词： copper-bearing intrauterine device (Cu-IUD) Chinese hamster ovary (CHO-K1) cell counting kit-8 (CCK-8) cytotoxicity extract concentration influential factor

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Quantum gate-assisted teleportation in noisy environments:robustness and fidelity improvement

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Communications in Theoretical Physics 2024年第1期76卷 36-48页

作者： Sajede Harraz Jiaoyang zhang shuang Cong Department of Automation University of Science and Technology of ChinaHefei 230027China

Quantum teleportation as the key strategy for quantum communication requires pure maximally shared entangled states among quantum *** practice,quantum decoherence drastically degrades the shared entanglement during entanglement distribution,which is a serious challenge for the development of quantum ***,most of the decoherence control strategies proposed thus far are either resource-intensive or *** overcome this obstacle,we enable noise-resistant teleportation through a noisy channel with a limited number of qubits and without applying time-consuming weak *** apply a quantum gate control unit consisting of a controlled NOT gate and a rotation gate after the original teleportation protocol is ***,we demonstrate that a teleportation fidelity of unity is attainable when environment-assisted measurement is added to the proposed teleportation protocol via quantum ***,we present an entanglement distribution process by employing the designed quantum gate control unit followed by the deterministic standard teleportation protocol to improve teleportation fidelity by establishing improved shared *** performance analysis indicates that the proposed teleportation schemes offer a competitive fidelity and success probability compared with the conventional schemes and a recent weak measurement-based teleportation protocol.

关键词： quantum communication quantum teleportation decoherence control quantum gate environment-assisted measurement

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An effective strategy of constructing multi-metallic oxides of ZnO/ CoNiO_(2)/CoO/C microflowers for improved supercapacitive performance

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Chinese Journal of Chemical Engineering 2024年第3期67卷 1-8页

作者： Wei Guo Yan zhang Xiaxin Lei shuang Wang College of Physics Taiyuan University of TechnologyJinzhong 030600China College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

In this work,a new ZnO/CoNiO_(2)/CoO/C metal oxides composite is prepared by cost-effective hydrothermal method coupled with annealing process under N_(2) ***,the oxidation-defect annealing environment is conducive to both morphology and component of the composite,which flower-like ZnO/CoNiO_(2)/CoO/C is *** from good chemical stability of ZnO,high energy capacity of CoNiO_(2) and CoO and good conductivity of C,the as-prepared sample shows promising electrochemical behavior,including the specific capacity of 1435 C·g^(-1) at 1 A·g^(-1),capacity retention of 87.3%at 20 A·g^(-1),and cycling stability of 90.5%for 3000 cycles at 5 A·g^(-1),***,the prepared ZnO/CoNiO_(2)/CoO/C/NF//AC aqueous hybrid supercapacitors device delivers the best specific energy of 55.9 W·h·kg^(-1) at 850 W·kg^(-1).The results reflect that the as-prepared ZnO/CoNiO_(2)/CoO/C microflowers are considered as high performance electrode materials for supercapacitor,and the strategy mentioned in this paper is benefit to prepare mixed metal oxides composite for energy conversion and storage.

关键词： Composites Electrochemistry Hydrothermal Transition metal oxides Structural control Supercapacitors

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Dynamic Modeling and Experimental Verification of an RPR Type Compliant Paralle Mechanism with Low Orders

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 83-94页

作者： shuang zhang Jingfang Liu Huafeng Ding Yanbin zhang School of Mechatronics Engineering Henan University of Science and TechnologyLuoyangHenanChina Faculty of Materials and Manufacturing College of Mechanical Engineering and Applied Electronics TechnologyBeijing University of TechnologyBeijingChina Key laboratory of advanced manufacturing technology Beijing University of TechnologyBeijingChina School of Mechanical Engineering and Electronic Information China University of Geosciences(Wuhan)WuhanChina Center of Machinery Equipment Advanced Manufacturing of Henan Province LuoyangChina

Efficiency of calculating a dynamic response is an important point of the compliant mechanism for posture *** modeling with low orders of a 2R1T compliant parallel mechanism is studied in the *** mechanism with two out-of-plane rotational and one lifting degrees of freedom(DoFs)plays an important role in posture *** on elastic beam theory,the stiffness matrix and mass matrix of the beam element are established where the moment of inertia is *** improve solving efficiency,a dynamic model with low orders of the mechanism is established based on a modified modal synthesis ***,each branch of the RPR type mechanism is divided into a ***,a set of hypothetical modes of each substructure is obtained based on the C-B ***,dynamic equation of the whole mechanism is established by the substructure assembly.A dynamic experiment is conducted to verify the dynamic characteristics of the compliant mechanism.

关键词： Compliant parallel mechanism Dynamic model Modal synthesis method Dynamic experiment

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Anti-saturation fault-tolerant adaptive torsional vibration control with fixed-time prescribed performance for rolling mill main drive system

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Journal of Iron and Steel Research International 2024年第3期31卷 660-669页

作者： shuang Liu Chen Du Cong zhang Zhen-hua Bai Key Lab of Industrial Computer Control Engineering of Hebei Province Yanshan UniversityQinhuangdao 066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004HebeiChina

An anti-saturation fault-tolerant adaptive torsional vibration control method with fixed-time prescribed performance for the rolling mill main drive system(RMMDS)was investigated,which is affected by control input saturation,actuator faults,sensor measurement errors,and parameter ***,we gave a continuously differentiable saturation function to approximate the control input saturation characteristic of the RMMDS,translating the saturation characteristic into the matched uncertainty and unknown time-varying gain in the ***,an RMMDS mathematical model with unmatched uncertainty and unknown time-varying gain was developed,taking into account the presence of control input saturation,actuator faults,sensor measurement errors,and parameter *** on the established mathematical model,an error transformation model of the roll speed tracking was constructed by the equivalent error transformation *** to the error transformation model,a barrier Lyapunov function and a novel adaptive controller were studied to ensure that the roll speed tracking error always evolves inside a fixed-time asymmetric ***,numerical simulations were performed in Matlab/Simulink to verify the effectiveness and superiority of the proposed control method in suppressing the RMMDS torsional vibration.

关键词： Fixed-time prescribed performance Control input saturation Actuator fault Unknown time-varying gain Adaptive control Asymmetric constraint

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Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells

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World Journal of Gastroenterology 2021年第36期27卷 6079-6092页

作者： Hai-Yan Cui Jian-Sheng Rong Ju Chen Jie Guo Jia-Qin Zhu Mei Ruan Rong-Rong Zuo shuang-shuang zhang Jun-Mei Qi Bao-Hua zhang Department of Pathology The Fourth People’s Hospital of Zibo CityZibo 255000Shandong ProvinceChina Department of Pathology Zibo Central HospitalZibo 255036Shandong ProvinceChina Department of Ultrasound Medicine Zibo Central HospitalZibo 255036Shandong ProvinceChina Department of Health The Fourth People’s Hospital of Zibo CityZibo 255000Shandong ProvinceChina Department of Gastroenterology The Fourth People’s Hospital of Zibo CityZibo 255000Shandong ProvinceChina Department of Oncology The Fourth People’s Hospital of Zibo CityZibo 255000Shandong ProvinceChina

BACKGROUND Gastric cancer is a prevalent malignant cancer with a high incidence and significantly affects the health of modern people ***(DDP)is one of the most common and effective chemotherapies for patients with gastric cancer,but DDP resistance remains a severe clinical *** To explore the function of M2 polarized macrophages-derived exosomal microRNA(miR)-588 in the modulation of DDP resistance of gastric cancer *** M2 polarized macrophages were isolated and identified by specific markers using flow cytometry *** exosomes from M2 macrophages were identified by transmission electron microscopy and related *** uptake of the PKH67-labelled M2 macrophages-derived exosomes was detected in SGC7901 *** function and mechanism of exosomal miR-588 from M2 macrophages in the modulation of DDP resistance of gastric cancer cells was analyzed by CCK-8 assay,apoptosis analysis,colony formation assay,Western blot analysis,qPCR analysis,and luciferase reporter assay in SGC7901 and SGC7901/DDP cells,and by tumorigenicity analysis in nude *** M2 polarized macrophages were isolated from mouse bone marrow stimulated with interleukin(IL)-13 and ***-cultivation of gastric cancer cells with M2 polarized macrophages promoted DDP resistance.M2 polarized macrophagesderived exosomes could transfer in gastric cancer cells to enhance DDP *** miR-588 from M2 macrophages contributed to DDP resistance of gastric cancer ***-588 promoted DDP-resistant gastric cancer cell growth in ***-588 was able to target cylindromatosis(CYLD)in gastric cancer *** depletion of CYLD reversed miR-588 inhibition-regulated cell proliferation and apoptosis of gastric cancer cells exposed to *** In conclusion,we uncovered that exosomal miR-588 from M2 macrophages contributes to DDP resistance of gastric cancer cells by partly targeting ***-588 may be applied as a potential therapeutic target for the

关键词： Gastric cancer Cisplatin resistance M2 polarized macrophages Exosome miR-588 Cylindromatosis

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