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Amino Acids Functionalized Graphene Oxide for Enhanced Hydrophilicity and Antifouling Property of Poly(vinylidene fluoride) Membranes

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Chinese Journal of Polymer Science 2016年第7期34卷 805-819页

作者：李建华 shuang-shuang wang de-bin zhang xing-xing ni 张其清 Institute of Biomedical and Pharmaeeutical Teehnology Fuzhou University Fuzhou 350001 China

Herein, functionalized graphene oxide（GO） was prepared by the covalent functionalization with amino acids（lysine, glycine, glutamic acid and tyrosine） in this study. Zeta potential results demonstrated that covalent functionalization of GO with amino acids was favourable for their homogeneous dispersion in water and organic solvents. Based on the higher absolute value of zeta potential and the better dipersion stability of GO-lysine, the PVDF/GO-lysine hybrid membranes were then prepared via the phase inversion induced by immersion precipitation technique. SEM images showed a better pore diameter and porosity distribution on the PVDF/GO-lysine membrane surface. The zeta potential absolute value of the PVDF/GO-lysine membrane surface was higher than that of the virgin PVDF membrane. Furthermore, the PVDF/GO-lysine membranes surface exhibited good hydrophilicity. The water flux of PVDF/GO-lysine membranes can reach two times of that of the virgin PVDF membrane. And the BSA adsorbed amount on PVDF/GO-lysine surface was decreased to 0.82 mg/cm^2 for PVDF/GO-lysine-8% membrane. Filtration experiment results indicated that the fouling resistance was significantly improved for the PVDF/GO-lysine membranes. As a result, lysine functionalized GO will provide a promising method to fabricate graphene oxide based hybrid membranes with effective antifouling property and hydrophilicity.

关键词： PVDF membrane Graphene oxide Amino acids Hydrophilicity Antifouling property

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Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome

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World Journal of Gastroenterology 2018年第8期24卷 894-904页

作者： Lei-Min Yu Ke-Jia Zhao shuang-shuang wang Xi wang Bin Lu Department of Gastroenterology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou 310053Zhejiang ProvinceChina Key Laboratory of Digestive Pathophysiology of Zhejiang Province First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

AIM To study the role of microbial metabolites in the modulation of biochemical and physiological processes in irritable bowel syndrome(IBS).METHODS In the current study, using a metabolomic approach, we analyzed the key metabolites differentially excreted in the feces of control mice and mice with IBS, with or without Clostridium butyricum(C. butyricum) treatment. C57 BL/6 mice were divided into control, IBS, and IBS + C. butyricum groups. In the IBS and IBS + C. butyricum groups, the mice were subjected to water avoidance stress(WAS) for 1 h/d for ten days. Gas chromatography/mass spectrometry(GC-MS) together with multivariate analysis was employed to compare the fecal samples between groups. RESULTS WAS exposure established an appropriate model of IBS in mice, with symptoms of visceral hyperalgesia and diarrhea. The differences in the metabolite profiles between the control group and IBS group significantly changed with the progression of IBS(days 0, 5, 10, and 17). A total of 14 differentially excreted metabolites were identified between the control and IBS groups, and phenylethylamine was a major metabolite induced by stress. In addition, phenylalanine metabolism was found to be the most relevant metabolic pathway. Between the IBS group and IBS + C. butyricum group, 10 differentially excreted metabolites were identified. Among these, pantothenate and coenzyme A(Co A) biosynthesis metabolites, as well as steroid hormone biosynthesis metabolites were identified as significantly relevant metabolic *** The metabolic profile of IBS mice is significantly altered compared to control mice. Supplementation with C. butyricum to IBS mice may provide a considerable benefit by modulating host metabolism.

关键词： Irritable bowel syndrome Metabolite Gas chromatography/mass spectrometry Clostridium butyricum

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

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World Journal of Hepatology 2015年第9期7卷 1209-1232页

作者： Bing Hu shuang-shuang wang Qin Du Department of Oncology and Institute of Traditional Chinese Medicine in Oncology Longhua Hospital Shanghai University of Traditional Chinese Medicine

Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.

关键词： Hepatocarcinoma Traditional Chinesemedicine Prevention Treatment Traditional Chinesemedicine syndrome (Zheng) Therapeutic principle Chinese herbal formula Chinese herb

Highly Thermally Conductive Polydimethylsiloxane Composites with Controllable 3D GO@f-CNTs Networks via Self-sacrificing Template Method

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Chinese Journal of Polymer Science 2024年第7期42卷 897-906,I0005页

作者： shuang-shuang wang Dian-Ying Feng Zhi-Ming Zhang Xia Liu Kun-Peng Ruan Yong-Qiang Guo Jun-Wei Gu Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an710072China Shandong Institute of Nonmetallic Materials Jinan250031China Queen Mary University of London Engineering School Northwestern Polytechnical UniversityXi’an710072China

Constructing controllable thermal conduction networks is the key to efficiently improve thermal conductivities of polymer *** this work,graphite oxide(GO)and functionalized carbon nanotubes(f-CNTs)are combined to prepare“Line-Plane”-like hetero-structured thermally conductive GO@f-CNTs fillers,which are then performed to construct controllable 3D GO@f-CNTs thermal conduction networks via selfsacrificing template method based on oxalic ***,thermally conductive GO@f-CNTs/polydimethylsiloxane(PDMS)composites are fabricated via casting *** the size of oxalic acid is 0.24 mm and the volume fraction of GO@f-CNTs is 60 vol%,GO@f-CNTs/PDMS composites present the optimal thermal conductivity coefficient(λ,4.00 W·m^(-1)·K^(-1)),about 20 times that of theλof neat PDMS(0.20 W·m^(-1)·K^(-1)),also much higher than theλ(2.44 W·m^(-1)·K^(-1))of GO/f-CNTs/PDMS composites with the same amount of randomly dispersed ***,the obtained GO@f-CNTs/PDMS composites have excellent thermal stability,whoseλdeviation is only about 3%after 500 thermal cycles(20-200℃).

关键词： Polydimethylsiloxane Hetero-structured thermally conductive fillers Self-sacrificing template Thermal conduction networks

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Mycobacterium abscessus infection after facial injection of argireline:A case report

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World Journal of Clinical Cases 2021年第8期9卷 1996-2000页

作者： Chao-Feng Chen Jie Liu shuang-shuang wang Yu-Fang Yao Bo Yu Xiao-Ping Hu Department of Dermatology&Venereology Peking University Shenzhen HospitalShenzhen 518036Guangdong ProvinceChina

BACKGROUND The incidence of infection with Mycobacterium abscessus(***)has increased in recent *** increase is partly associated with invasive cosmetic *** SUMMARY The purpose of this case summary is to increase clinicians'awareness of *** infection and reduce mycobacterial infection caused by cosmetic *** report the case of a 45-year-old woman who received acetyl hexapeptide-8(argireline)injections in the forehead and temples,and erythema,nodules,and abscesses appeared at the injection sites after one *** pus specimens were examined by microbiological culture and confirmed to be positive for *** 500 mg twice daily and moxifloxacin 400 mg once daily were administered for 5 mo and the lesions gradually *** We report here for the first time a case of infection with *** after argireline *** condition is easily misdiagnosed as a common bacterial *** examinations are helpful for diagnosis and standardized cosmetic procedures can prevent infection with ***.

关键词： Argireline Mycobacterium abscessus Nontuberculous Mycobacterium Infection Injection Antibiotic therapy Case report

Clinically significant endoscopic findings in patients of dyspepsia with no warning symptoms:A cross-sectional study

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World Journal of Clinical Cases 2021年第15期9卷 3597-3606页

作者： Li-Qi Mao shuang-shuang wang Yan-Lin Zhou Lin Chen Lei-Min Yu Meng Li Bin Lv Department of Gastroenterology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina Department of Gastroenterology Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical UniversityTaizhou 317000Zhejiang ProvinceChina Department of Gastroenterology Guangxing Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007Zhejiang ProvinceChina

BACKGROUND Dyspepsia is one of the commonest clinical ***,controversy remains over the role of endoscopy in patients with *** studies have evaluated the diagnostic value of endoscopy in patients with no warning symptoms according to the Rome IV *** To study the diagnostic value of endoscopy in dyspeptic patients with no warning *** This cross-sectional study included dyspeptic patients with no warning symptoms who met the inclusion and exclusion criteria at The First Affiliated Hospital,Zhejiang Chinese Medical University from April 2018 to February *** clinical data were collected using questionnaires,including dyspeptic information,warning symptoms,other diseases,family history and basic demographic *** on dyspeptic symptoms,patients can be divided into epigastric pain syndrome,postprandial distress syndrome or overlapping *** A total of 1016 cases were enrolled,304(29.9%)had clinically significant findings that were detectable by *** endoscopy findings included esophageal lesions in 180(17.7%)cases,peptic ulcers in 115(11.3%)cases and malignancy in 9(0.89%)*** logistic regression analysis showed that males[odds ratio(OR)=1.758,P25(OR=1.660;P=0.005),epigastric pain(OR=1.423;P=0.019)and Helicobacter pylori infection(OR=1.949;P25,epigastric pain or Helicobacter pylori infection.

关键词： Rome IV Dyspepsia Questionnaire Endoscopy Warning symptoms Diagnosis

Herbal Medicine Teng-Long-Bu-Zhong-Tang Inhibits the Growth of Human RKO Colorectal Cancer by Regulating Apoptosis, Senescence, and Angiogenesis

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 110-114页

作者： Meng-Meng Wei shuang-shuang wang Jia-Lu Zheng Lei Chen Xiao Peng Jin-Fang Chen Hong-Mei An Bing Hu Institute of Traditional Chinese Medicine in Oncology Longhua HospitalShanghai University of Traditional Chinese Medicine Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai Out-patient Department Pingdu Hospital of Traditional Chinese MedicineShandong Student Affairs Department Shanghai University of Traditional Chinese Medicine Department of Science and Technology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiChina

Background: Teng-Long-Bu-Zhong-Tang(TLBZT) is a traditional Chinese herbal medicine used to treat colorectal cancer(CRC). In the present study, we observed the anti-cancer effects of TLBZT on human RKO CRC. Materials and Methods: Mice were subcutaneously transplanted with RKO cells, divided into control, 5-Fu-administered, TLBZT-administered, and TLBZT and 5-Fu combination-administered groups, and treated with 5-Fluorouracil(5-Fu) and/or TLBZT. Apoptosis was detected by Td T-mediated d UTP nick-end labeling assay. The activity of caspase-3,-8, and-9 was detected using specific commercial kits. Cell senescence was assessed using senescence β-galactosidase staining. Protein expression was evaluated by immunohistochemistry. Results: TLBZT inhibited RKO CRC tumor growth, enhanced the anti-cancer effects of 5-Fu, induced apoptosis, and activated caspase-3,-8, and-9. TLBZT induced cell senescence accompanied by the downregulation of cyclin E1 and cyclin-dependent kinase 2 expressions. TLBZT also inhibited angiogenesis and the expression of hypoxia-inducible factor 1 subunit alpha and vascular endothelial growth factor-A. Conclusions: TLBZT inhibited RKO CRC tumor growth and enhanced the anti-cancer effects of 5-Fu, and it could be associated with apoptosis and cell senescence induction, and angiogenesis inhibition.

关键词： Angiogenesis apoptosis cell senescence Chinese herbal medicine colorectal cancer

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Engineering atomic Rb-N configurations to tune radical pathways for highly selective photocatalytic H2O2 synthesis coupled with biomass valorization

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Journal of Energy Chemistry 2025年第1期100卷 215-225页

作者： Jiaye Li shuang Pan Yihuang Chen Qiong Liu College of Chemistry and Materials Engineering Wenzhou University Guangdong Provincial Key Laboratory of Chemical Measurement and Emergency Test Technology (China) Institute of Analysis Guangdong Academy of Sciences (China National Analytical CenterGuangzhou)

Photocatalytic oxygen reduction for hydrogen peroxide （H2O2） synthesis presents a green and costeffective production ***,achieving highly selective H2O2synthesis remains challenging,necessitating precise control over free radical reaction pathways and minimizing undesirable oxidative ***,we report for the visible light-driven simultaneous co-photocatalytic reduction of O2to H2O2and oxidation of biomass using the atomic rubidium-nitride modified carbon nitride（CNRb）.The optimized CNRb catalyst demonstrates a record photoreduction rate of 8.01 mM h-1for H2O2generation and photooxidation rate of 3.75 mM h-1for furfuryl alcohol to furoic acid,achieving a remarkable solar-to-chemical conversion （SCC） efficiency of up to 2.27%.Experimental characterizations and DFT calculation disclosed that the introducing atomic Rb–N configurations allows for the high-selective generation of superoxide radicals while suppressing hydroxyl free radical *** is because the Rb–N serves as the new alternative site to perceive a stronger connection position for O2adsorption and reinforce the capability to extract protons,thereby triggering a high selective redox product *** study holds great potential in precisely regulating reactive radical processes at the atomic level,thereby paving the way for efficient synthesis of H2O2coupled with biomass valorization.

关键词： Atomic economy Radical pathway regulation Rubidium atom coordination Biomass valorization

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen shuang wang Deli wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction