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Ethambutol-induced optic neuropathy with rare bilateral asymmetry onset:A case report

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World Journal of Clinical Cases 2022年第2期10卷 663-670页

作者： Wen-Yan Sheng shuang-qing Wu Ling-Ya su Li-Wei Zhu Department of Ophthalmology Affiliated Hangzhou Chest HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Ethambutol-induced optic neuropathy(EON)most commonly manifests as bilateral symmetrical loss of vision and often cause serious and irreversible visual impairment because of the lack of early detection and effective *** followed a case of EON with rare binocular asymmetric clinical manifestations and observed the changes of visual function and retinal structure after drug withdrawal,so as to further understand the clinical characteristics of this *** suMMARY A 54-year-old man complained of gradual visual decline in the left *** patient presented with best-corrected visual acuity of 20/20 in the right eye and 20/50 in the left *** vision examination revealed difficulty in reading green color plates in the left *** visual field manifested as concentric contraction in the left *** nearly a month of drug withdrawal,the right eye had a similar decline in visual *** the last visit,19 mo after drug withdrawal,the visual function significantly recovered in both *** follow-up optical coherence tomography(OCT)examination,both eyes manifested the thickness of the retinal nerve fiber layer from mild thickening to thinning and finally temporal atrophy,and the ganglion cell-inner plexiform layer showed significant *** difference was that a reversible structural disorder in the outer retina of the nasal macula was detected in the left eye by macular high-definition *** Nephropathy and high blood pressure,which damage the retinal microcirculation,may cause damage to the outer layer of the *** may influence photoreceptor as well as retinal ganglion cells.

关键词： Ethambutol-induced optic neuropathy Retinal nerve fiber layer Ganglion cell-inner plexiform layer Optical coherence tomography Asymmetry Case report

Effects of MicroRNA-10b on lung cancer cell proliferation and invasive metastasis and the underlying mechanism

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Asian Pacific Journal of Tropical Medicine 2014年第5期7卷 364-367页

作者： Qiao-Li su shuang-qing Li Duo-Ning Wang Feng Liu Bo Yuan Department of Respiratory Medicine Huaxi HospitalSichuan University

Objective:To study the influence of MicroRNA-lOb on proliferation and invasion of human low metastatic lung cancer cell 95-C and its ***:Lipofectamine MicroRNA-lOb eukaryotic expression plasmid was transfected into *** experiment group was divided into blank control group,empty vector transfected group and MicroRNA-lOb transfected *** time quantitative RT-PCR was used to detect the expression of MicroRNA-lOb and KLF4mRNA *** of cells were detected by cell proliferation assay,invasion of the delected the cell Transwell experiments,the expression of KLF4 protein was detected in Western blotting ***:The proliferation rate of MicroRNA-lOb piasmid transfection group increased significantly after transfection,invasion and migration ability enhancement,by comparison,there are statistically significant differences in the blank control group and negative control group(P0.05).Conclusions:MicroRNA-l0b may promote proliferation and invasion of 95-C cells by down regulating the expression of KLF4 protein.

关键词： MicroRNA-10b Lung cancer 95-C Proliferation Invasion

Microstructure and mechanical properties of Ti44Al6Nb1Cr2V alloy after gaseous hydrogen charging at 1373-1693 K

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Rare Metals 2023年第2期42卷 664-671页

作者： Teng-Fei Ma Rui-Run Chen De-shuang Zheng Jing-Jie Guo Hong-Sheng Ding Yan-qing su Heng-Zhi Fu School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

The hydrogenation behavior of Ti44A16Nb1Cr2V(at%)alloy at temperature range of 1373-1693 K and its effect on microstructure and room-temperature mechanical properties were studied systematically in this *** results show that hydrogen content increases with the increase in temperature,and the maximum hydrogen content is 0.126 wt%at 1693 *** heat of solution of hydrogen is calculated as 82.9 kJ·mol^(-1)by curve fitting,indicating that hydrogen absorptionin TiAl alloys is *** promotes the lamellar colony size because hydrogen promotes the diffusion of *** stabilizes B2phase during hydrogenation resulting in more residual B2phase in the hydrogenated *** nanohardness and elastic modulus decrease after hydrogenation due to that hydrogen weakens the *** Ti44A16Nb1Cr2V alloy exhibits higher plasticity and lower flow stress hydrogenation with 0.039 wt%H,and the ultimate compressive strength decreases from 1220 to 1130 MPa,while the fracture strain is enhanced by 26%.

关键词： TiAl alloys Hydrogenation Hydrogen content Nanohardness Compressive property

Unconventionally anisotropic growth of PbSe nanorods:Controllable fabrication under solution-solid-solid regime over Ag2Se catalysis for broadband photodetection

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Nano Research 2021年第10期14卷 3386-3394页

作者： su You Li Zhang qing Yang Hefei National Laboratory of Physical Sciences at the Microscale(HFNL) Department of ChemistryLaboratory of Nanomaterials for Energy Conversion(LNEC)University of Science and Technology of ChinaHefei 230026China

Broadband optoelectronic devices intrigue enormous interests on account of their promising potential in optical communications,sensors and environmental *** nanocrystals are promising candidates for the construction of next-generation photodetectors due to their fascinating intrinsic properties and solution-processed compatibility with varied ***,we report the fabrication of a broadband photodetector on the basis of high-quality solution-processed PbSe nanorods in rock-salt phase grown along unconventionally anisotropic growth direction ofzone *** rock-salt PbSe nanorods are synthesized in solution phase over the catalysis of Ag2Se with relatively high-temperature body-centered cubic phase via a solution-solid-solid growth regime using oleylamine and oleic acid as solvents and stabilizer surfactants,from which the PbSe nanorods with the unconventionally anisotropic growth direction are controllably grown in size and shape in the synthetic procedure typically with about 17 nm in diameter and 58 nm in length on ***,the PbSe nanorods-based photodetector exhibits a broadband response from 405 to 1,064 nm with a high responsivity of 0.78 A·W^(-1)and a fast response time of 17.5μ*** response time is much faster in comparison with most of the PbSe-based photodetectors with response time in millisecond level.

关键词： PbSe nanorod solution-solid-solid(SSS)growth regime superionic conductor catalysis unconventionally anisotropic growth direction near-infrared photodetector broadband photodetection

Numerical Study of Propulsion Mechanism for Oscillating Rigid and Flexible Tuna-Tails

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Journal of Bionic Engineering 2011年第4期8卷 406-417页

作者： Liang Yang Yumin su qing xiao State Key Laboratory of Autonomous Underwater Vehicle Harbin Engineering University Harbin 150001 P. R. China Department of Naval Architecture and Marine Engineering University of Strathelyde Glasgow G40LZ United Kingdom

Numerical study on the unsteady hydrodynamic characteristics of oscillating rigid and flexible tuna-tails in viscous flow-field is performed. Investigations are conducted using Reynolds-Averaged Navier-Stokes （RANS） equations with a moving adaptive mesh. The effect of swimming speed, flapping amplitude, frequency and flexure amplitude on the propulsion performance of the rigid and flexible tuna-tails are investigated. Computational results reveal that a pair of leading edge vortices develop along the tail surface as it undergoes an oscillating motion. The propulsive efficiency has a strong correlation with various locomotive parameters. Peak propulsive efficiency can be obtained by adjusting these parameters. Particularly, when input power coeffcient is less than 2.8, the rigid tail generates larger thrust force and higher propulsive efficiency than flexible tail. However, when input power coefficient is larger than 2.8, flexible tail is superior to rigid tail.

关键词： tuna-tail RANS propulsion mechanism hydrodynamic characteristics viscous flow-fields

OPTIMAL ERROR ESTIMATES OF THE PARTITION OF UNITY METHOD WITH LOCAL POLYNOMIAL APPROXIMATION SPACES

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Journal of Computational Mathematics 2006年第3期24卷 365-372页

作者： Yun-qing Huang Wei Li Fang su Hunan Key Laboratory for Computation and Simulation in Science and Engineering Institute for Computational and Applied Mathematics Xiangtan University Xiangtan 4 11105 China Department of Computational Science Xiangtan University Xiangtan 4 11105 China

In this paper, we provide a theoretical method（PUFEM）, which belongs to the analysis of the partition of unity finite element family of meshfree methods. The usual error analysis only shows the order of error estimate to the same as the local approximations[12]. Using standard linear finite element base functions as partition of unity and polynomials as local approximation space, in l-d case, we derive optimal order error estimates for PUFEM interpolants. Our analysis show that the error estimate is of one order higher than the local approximations. The interpolation error estimates yield optimal error estimates for PUFEM solutions of elliptic boundary value problems.

关键词： Meshless methods Partition of unity finite element method(PUFEM) Error estimate.

Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

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World Journal of Gastroenterology 2024年第10期30卷 1346-1357页

作者： Jing-Feng Chen Zhuo-qing Wu Hao-shuang Liu su Yan You-Xiang Wang Miao Xing Xiao-Qin Song su-Ying Ding Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Institute of Systems Engineering Dalian University of TechnologyDalian 116024Liaoning ProvinceChina College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina

BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD *** A cohort of 3553 participants followed for four consecutive health examinations over 4 years was *** incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were *** proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset *** A total of 83.13%of participants with MAFLD had normal ALT *** incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT *** with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,*** Most participants with MAFLD had normal ALT ***-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Cumulative effect Cox proportional hazards regression Cohort study

Control of pore environment in nickel-based metal-organic frameworks for SF_(6)/N_(2) separation

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Chinese Journal of Structural Chemistry 2023年第2期42卷 43-48页

作者： Hao-Ran Liu Shao-Min Wang Yong-Li Dong su-Tao Zheng shuang Ni Jie Xu qing-Yuan Yang School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an710049China Shaanxi Coal and Chemical Technology Institute Co. LtdXi'an710100China

In the semiconductor industry,recovering and capturing SF_(6)gas from the SF_(6)/N_(2)gas mixture has significant environmental and economic *** this work,two Ni-based metal-organic frameworks(MOFs),Ni(i-na)(bdc)_(0.5)(ina=isonicotinic acid,bdc=terephthalic acid)and methyl-functionalized Ni(3-min)(bdc)_(0.5)(3-min=3-methylisonicotinic acid),are constructed for SF_(6)***(ina)(bdc)_(0.5)and Ni(3-min)(bdc)_(0.5)are both highly stable nine-connected porous *** pore sizes of these two materials are similar,but the pore environments are different,which has a bearing on the performance of SF_(6)/N_(2)***(3-min)(bdc)0.s exhibits higher SF_(6)adsorption capacity(50.5 cm^(3)g^(-1))and IAST(ideal adsorbed solution theory)SF_(6)/N_(2)selectivity(91)owing to its smaller window diameter and suitable pore *** calculations indicate that the SF_(6)and N_(2)molecules interact with the framework at different cages,which reduces their competition for adsorption *** remarkable separation performance of Ni(ina)(bdc)_(0.5)and Ni(3-min)(bdc)_(0.5)is further verified by dynamic breakthrough ***,these two adsorbents have the potential to be utilized in industrial applications due to their excellent structural stability and recyclability.

关键词： SF_(6)/N_(2)separation Greenhouse gas Metal-organic frameworks Adsorption

An Overview of Epigenetics in Chinese Medicine Researches

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Chinese Journal of Integrative Medicine 2017年第9期23卷 714-720页

作者： HU Xue-qing su Shi-bing Research Center for Traditional Chinese Medicine Complexity System Shanghai University of Traditional Chinese MedicineShanghai201203China

Chinese medicine（CM） has contributed to human health care for several thousand years and is still popular in Asian countries. But the mechanisms underlying CM remain obscure, and need to be clarified by modern biological subjects and methods. Recently, CM researches on epigenetics have gained obvious improvement following rapidly developed molecular technologies. In this review, we revealed mutual characteristics of epigenetics and CM, such as holism, yin-yang dynamic nature, reversibility and balance, and visceral manifestation. Moreover, epigenetic modifications, including DNA methylation, histone post-transcriptional modifications, micro RNA interference, etc. may help explore the molecular basis of CM syndrome classification, and mechanisms of Chinese herbal medicine（CHM）, CHM compounds and Chinese herbal formulae activities. Meanwhile, CM and epigenetics might promote each other and jointly develop following the continuous progress of epigenetics in CM researches.

关键词： Chinese medicine epigenetics methylation histone modification Chinese herbal medicine,Chinese herbal formula Chinese medicine syndrome