检索结果-南通市图书馆

Porous Ti_(3)C_(2)T_(x) MXene nanosheets sandwiched between polyimide fiber mats for electromagnetic interference shielding

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第3期17卷 2070-2078页

作者： Wenhao Liang Juntao Wu Shan Zhang Pei-yan Zhao yi Cong Yongqiang Guo Guang-Sheng Wang Key Laboratory of Bioinspired Smart Interfacial Science and Technology of Ministry of Education School of ChemistryBeihang UniversityBeijing 100191China

With the rapid development of wireless communication technology and electronic devices,the issue of electromagnetic interference(EMI)is becoming increasingly *** a new and flexible electromagnetic interference shielding material has become a challenging ***,a sandwich-structured EMI shielding composite film was prepared using electrospinning and vacuum filtration *** this process,a porous MXene was synthesized through a reaction with cobalt acetate and served as the intermediate layer in the composite film to shield electromagnetic *** electrospun polyimide(PI)fibers were used as the top and bottom layers of the composite film,which can protect the porous MXene from *** lightweight and flexible composite film integrates electromagnetic interference shielding and thermal insulation capabilities,showing excellent comprehensive *** composite film achieves an EMI shielding effectiveness of 48.8 dB in X-band(8.2–12.4 GHz),and absolute shielding effectiveness of the composite film reached a satisfying 4142.43(dB·cm^(2))/*** to the design of a multi-layer porous structure,the density of the composite film is 0.65 g/***,the thermal conductivity of the film is 0.042 W/(m·K)due to the clamping of electrospun PI fibers,showing excellent thermal insulation ***,the composite film exhibits excellent high and low-temperature *** summary,this work provides a feasible strategy for preparing a lightweight polymer-based EMI shielding film.

关键词： porous MXene polyimide electromagnetic interference shielding thermal insulation

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： yi-Nan Zhu Zuo-Kang Lin Hai-yan Yu Ye Dai Zhi-Min Dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

维普期刊数据库

ZYX promotes invasion and metastasis of gastric cancer cells via WNK1/SNAI1axis

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 564-567页

作者： yi Jiang Dongfang Xiang Xianmei Wen Mingmin He yan Qin Xiaoxue Yao Zexuan yan Xiuli Geng Yong Ren Xiongwei Cai Youhong Cui yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pathology General Hospital of Central Theater Command of PLAWuhanHubei 430070China Department of Obstetrics and Gynecology Southwest HospitalArmy Medical University (Third Military Medical University)Chongqing 400038China Department of Pharmacy The Hospital of 83rd Group of PLAXinxiangHenan 453000China Department of Gynecology Chongqing Health Center for Women and ChildrenWomen and Children's Hospital of Chongqing Medical UniversityChongqing 400013China

Gastric cancer(GC)is the third most common cause of cancer death globally and a large portion of patients are diagnosed at advanced stages with cancer invasion and metastasis1,***,the mechanisms underlying the invasion and metastasis of GC remain to be *** plays critical roles in cell mobility via cytoskeleton regulation in various cell types.3 In this study,we further reported that ZYX promoted migration,invasion,and metastasis of GC ***,ZYX promoted WNK1 activation and SNAl1 up-regulation,inducing epithelial-mesenchymal transition(EMT)to enhance the mobility of GC *** of WNK1 impaired the mobility of GC ***,ZYX/WNK1 could be potential therapeutic targets for GC treatment.

关键词： WNK1 invasion metastasis

Stable carbon isotope composition and intrinsic water use efficiency in plants along an altitudinal gradient on the eastern slope of Yulong Snow Mountain, China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2024年第2期13卷 218-230页

作者： Feng Jiang Tao Pu Zi-Jing Xue yan-Wei Ma Xiao-yi Shi Fu-Xi Shi College of Geography and Environmental Sciences Zhejiang Normal University Yulong Snow Mountain Glacier and Environment Observation and Research Station/State Key Laboratory of Cryospheric Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed College of Forestry Jiangxi Agricultural University

Background Stable carbon isotope composition(δ13Cp) can be used to estimate the changes in intrinsic water use efficiency（iWUE） in plants,which helps us to better understand plants' response strategies to climate *** study focused on the variations in δ13Cpand iWUE for the different life-form plants（i.e.,herbs,shrubs,and trees）along an altitudinal gradient（3300,3600,3900,4100,4300,and 4500 m） on the eastern slope of Yulong Snow Mountain,southeastern margin of the Qinghai-Tibet *** response mechanisms of δ13Cpand iWUE for different life-form plants to altitude were thoroughly analyzed in this mountain *** The δ13Cpvalues of plants on the eastern slopes of Yulong Snow Mountain ranged from-30.4‰to-26.55‰,with a mean of-28.02‰,indicating a dominance of *** δ13Cpand iWUE values varied among different life-form plants in the order of herbs> shrubs> trees,particularly in 3600,3900,and 4300 ***δ13Cpand iWUE values for herbs and shrubs increased with altitude and were mainly controlled by air *** two parameters for trees exhibited a trend of initial decrease followed by an increase with *** 3900 m,the δ13Cpand iWUE values decreased with altitude,influenced by soil ***,above 3900 m,the two parameters increased with altitude,mainly regulated by air *** addition,iWUE was positively correlated with leaf P content but negatively correlated with leaf N:P ratio,especially for herbs and trees,suggesting that P plays a key role in modulating iWUE in this *** The diffe rentiated responses of water availability for different life-form plants to a higher altitudinal gradient are regulated by air temperature,soil moisture,and leaf P content in the Yulong Snow *** results provide valuable insights into understanding the wate r-carbon relationships in high-altitude ecosystems.

关键词： Stable carbon isotope Water use efficiency Altitude Life form Yulong Snow Mountain

Identification and immune analysis of antimicrobial peptides from the cigarette beetle(Lasioderma serricorne)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Insect Science 2024年第4期31卷 1121-1134页

作者： Yue Zhang yi yan Guy Smagghe Hong yang Ren-huai Dai Wen-jia yang Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region Institute of EntomologyGuizhou UniversityGuiyangChina Guizhou Provincial Key Laboratory for Rare Animal and Economic Insect of the Mountainous Region College of Biology and Environmental EngineeringGuiyang UniversityGuiyangChina

Antimicrobial peptides(AMPs)in insects are endogenous peptides that are effector components of the innate defense system of the *** may serve as antimicrobial agents because of their small molecular weight and broad-spectrum antimicrobial *** this study,we performed transcriptome analysis of cigarette beetle(Lasioderma serricorne)larvae,parasitized by the ectoparasitic wasp,Anisopteromalus *** AMP genes were significantly upregulated following *** parasitism,postulating the hypothesis that the parasitization enhanced the host's resistance against pathogenic microorganisms through the regulation of host AMP ***,3 AMP genes(LsDef1,LsDef2,and LsCole)were significantly upregulated and we studied their immune function in *** challenge and functional analysis showed that LsCole was responsible for the immune response against Gram-negative and Gram-positive bacteria,while LsDef1 and LsDef2 were involved in insect defense against Gram-positive *** recombinant LsCole exhibited antimicrobial activities against the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus ***2 showed an antibacterial effect against *** and LsDef2 exhibited antibiofilm activity against *** 2 AMPs disrupted cell membranes and caused leakage of *** cell *** results indicated that the 3 AMPs in *** are involved in the innate immunity of this pest *** AMPs may have potential as antimicrobial agents for bacterial infection ***,data are discussed in relation to new control strategies with greater biosafety against pest insects with use of microbial biocontrol agents in combination with RNA interference against the insect's defensive AMP genes.

关键词： antimicrobial activity antimicrobial peptides innate immune response Lasioderma serricorne RNA interference

Silurian integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第4期67卷 1005-1035页

作者： Zhongyang CHEN Qing CHEN Guangxu WANG Xiang FANG Peng TANG Guanzhou yan Wenwei YUAN Bing HUANG Xiaole ZHANG Kui yan Yuandong ZHANG yi WANG State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China

The Silurian palaeontology and stratigraphy of the Qinghai-Tibetan Plateau have been studied for more than100 *** the launch of the Second Tibetan Plateau Scientific Expedition and Research,it is necessary to update the summaries of the Silurian stratigraphy and fossil assemblages of the Qinghai-Tibetan Plateau and their correlation with its surrounding *** this study,we have selected 33 sections from the Qinghai-Tibetan Plateau and its surroundings areas,summarised the available data in terms of stratigraphic regionalisation,lithostratigraphy,chronostratigraphy,and biostratigraphy,and divided the study area into four stratigraphic provinces:the Xizang-Western Yunnan-Western Sichuan Province,the KunlunQilian Province,the South China Province,and the Tarim *** general,the Silurian strata in the Qinghai-Tibetan Plateau is more complete than those in other areas of *** studies of the vertebrate faunas,sporomorph assemblages,and brachiopod faunas of the study area indicate a closer geographical relationship between the South China,Tarim,and Indochina palaeoplates,than previously *** with the surrounding areas where Silurian strata have been extensively studied,the study of Silurian strata in the main part of the Qinghai-Tibetan Plateau is still in the preliminary *** the future,it is necessary to conduct research on the age,distribution,and resource potential of basal Silurian black shales to provide new directions for shale gas exploration and development in *** shallow marine strata of the middle to upper Silurian require further *** that the Silurian System in the Qinghai-Tibetan Plateau is more complete,it has the potential to supplement and improve the study of the carbon isotope stratigraphy of the Silurian in China.

关键词： Qinghai-Tibetan Plateau Silurian Stratigraphic regionalisation Lithostratigraphy Biostratigraphy Palaeogeographical evolution

维普期刊数据库

ExosomalmicroRNA let-7c-5p enhances cell malignant characteristics by inhibiting TAGLN in oral cancer

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第10期32卷 1623-1635页

作者： yi LI TIANyi WANG HAORAN DING SHIYONG ZHUANG XIAOBO DAI BING yan State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Head and Neck Oncology Surgery West China Hospital of StomatologySichuan UniversityChengdu610041China Frontier Innovation Center for Dental Medicine Plus Chengdu610041China

Background:Oral cancer,a malignancy that is prevalent worldwide,is often diagnosed at an advanced ***(miRNAs)in circulating exosomes have emerged as promising cancer *** role of miRNA let-7c-5p in oral cancer remains underexplored,and its potential involvement in tumorigenesis warrants comprehensive ***:Serum samples from 30 patients with oral cancer and 20 healthy controls were used to isolate exosomes and quantify their RNA *** of the exosomes was confirmed through transmission electron *** PCR was used to assess the miRNA *** effects of let-7c-5p and TAGLN overexpression on oral cancer cell viability,migration,and invasion were analyzed via CCK-8 and Transwell ***,we conducted mRNA sequencing of exosomal RNA from exosomes overexpressing let-7c-5p to delineate the gene expression profile and identify potential let-7c-5p target ***:let-7c-5p was upregulated in serumderived exosomes of patients with oral *** of let-7c-5p in the TCA8113 and CAL-27 cell lines enhanced their proliferative,migratory,and invasive capacities,and overexpression of let-7c-5p cell-derived exosomes promoted oral cancer cell *** mRNA sequencing revealed 2,551 differentially expressed genes between control cell-derived exosomes and overexpressed let-7c-5p cell-derived *** further identified TAGLN as a direct target of let-7c-5p,which has been implicated in modulating the oncogenic potential of oral cancer *** of TAGLN reverses the promoting role of let-7c-5p on oral cancer ***:Our findings highlight the role of exosomal let-7c-5p in enhancing oral cancer cell aggressiveness by downregulating TAGLN expression,highlighting its potential as a diagnostic and therapeutic strategy.

关键词： Oral cancer Exosomal microRNA let-7c-5p Tumorigenesis biomarkers Gene expression profiling TAGLN

Study on the local time asymmetry of the Earth's ring currents based on multiple low-Earth-orbit satellite magnetic observations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Technological Sciences 2024年第11期67卷 3354-3364页

作者： OU JiaMing JIANG yi yan Qing State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Zhuhai MUST Science and Technology Research Institute Macau University of Science and Technology Macau Institute of Space Technology and Application

The azimuthal morphology of Earth's ring currents has consistently shown asymmetry during extreme space weather events at low latitudes, particularly during geomagnetic storms. A dawn-dusk pattern has been detected during the storm main phase through near-Earth and in-situ magnetic measurements. This asymmetry is believed to arise from asymmetric solar windmagnetosphere coupling and is linked to the closure of the ring current. Recent evidence has confirmed the existence of asymmetric ring currents during quiet times and the storm recovery phase. This phenomenon may be closely related to the evolution of ring currents, including plasma injection and decay processes. In this study, the local time asymmetry of the ring current is estimated using data from low-Earth-orbit Swarm and Macao Science Satellite-1(MSS-1) missions. Spherical harmonics models are developed to quantify the magnetic field of ring currents through external Gauss coefficients during both quiet periods and the storm recovery phase. Several features of dawn-dusk asymmetry are observed in various cases in different months.(1) The maximum difference in magnetic value across local time ranges from 3 to 10 nT, showing relative invariance compared with various Sym-H levels.(2) Stronger magnetic signals are detected at the premidnight sector during quiet times and at the afternoon sector during the storm recovery phase.(3) Magnetic perturbations remain at a lower level during the postmidnight and morning sectors. Although the pattern of local time asymmetry differs between quiet times and the recovery phase,dawn-dusk asymmetry remains the most pronounced feature, affecting the trapping and loss of charged particles in the inner magnetosphere. Combining Swarm and MSS-1 magnetic observations can enable convenient monitoring of the detailed azimuthal local time effects of the ring current at various disturbance levels in the future.

关键词： Earth’s ring currents local time asymmetry, SHA model Macao Science Satellite-1

同方期刊数据库

Gastric cancer secreted miR 214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第3期32卷 489-502页

作者： WEIXUE WANG TONGTONG WANG yan ZHANG TING DENG HAIyanG ZHANG yi BA Department of GI Medical Oncology Tanjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin's Clinical Research Center for CancerTianjin Key Iaboratory of Digestive CancerKey Laboratory of Cancer Prevention and TherapyTianjin300060China

Diferent from necrosis,apoptosis,autophagy and other forms of cell death,ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated ftty acids under the action of iron divalent or lipoxygenase,leading to cell *** is currently used in the third line standard treatment of advanced gastric cancer,targeting the anti-angiogenesis ***,Apatinib mediated ferroptosis in vascular endothelial cells has not been reported *** exosomes can be taken up into target cells to regulate tumor development,but the mechanism related to vascular endothelial cell ferroptosis has not yet been ***,we show that exosomes secreted by gastric cancer cells carry miR-214.3p into vascular endothelial cells and directdy target zinc finger protein A20 to negatively regulate ACSL4,a key enzyme of lipid peroxidation during frroptosis thereby inhibiting ferroptosis in vascular endothelial cells and reducing the eficiency of *** conclusion,inhibition of miR-214-3p can increase the sensitivity of vascular endothelial cells to Apatinib,thereby promoting the antiangiogenic efect of Apatinib,suggesting a potential combination therapy for advanced gastric cancer.

关键词： Cellular ferroptosis Exosome Tyrosine kinase inhibitor Gastrointestinal tumors miRNA