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Development and validation of a preoperative nomogram for predicting positive surgical margins after laparoscopic radical prostatectomy

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Chinese Medical Journal 2019年第8期132卷 928-934页

作者： Xiao-Jun Tian Zhao-Lun Wang Geng Li shuang-jie cao Hao-Ran Cui Zong-Han Li Zhuo Liu Bo-Lun Li Lu-Lin Ma Shen-Rong Zhuang Qi-Yan Xiao Department of Urology Peking University Third HospitalBeijing 100191China Peking University First Medical School Peking University First HospitalBeijing 100034China Peking University Second Medical School Peking University People's HospitalBeijing 100044China Institute of Biomedical English Peking University Health Science CenterBeijing 100191China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital and InstituteBeijing 100142China

Background:Positive surgical margins are independent risk factor for biochemical recurrence,local recurrence,and distant metastasis after radical ***,limited predictive tools are *** study aimed to develop and validate a preoperative nomogram for predicting positive surgical margins after laparoscopic radical prostatectomy(LRP).Methods:From January 2010 to March 2016,a total of 418 patients who underwent LRP without receiving neoadjuvant therapy at Peking University Third Hospital were retrospectively involved in this *** and pathological results of each patient were collected for further *** and multivariable logistic regression(backward stepwise method)were used for the nomogram *** concordance index(CI),calibration curve analysis and decision curve analysis were used to evaluate the performance of our ***:Of 418 patients involved in this study,142 patients(34.0%)had a positive surgical margin on final *** on the backward selection,four variables were included in the final multivariable regression model,including the percentage of positive cores in preoperative biopsy,clinical stage,free prostate specific antigen(fPSA)/total PSA(tPSA),and age.A nomogram was developed using these four *** concordance index(C-index)of the nomogram was 0.722 in the development cohort and 0.700 in the bootstrap *** bias-corrected calibration plot showed a limited departure from the ideal line with a mean absolute error of 2.0%.In decision curve analyses,the nomogram showed net benefits in the range from 0.2 to ***:A nomogram to predict positive surgical margins after LRP was developed and validated,which could help urologists plan surgical procedures.

关键词： Prostate cancer Positive surgical margins Laparoscopic radical prostatectomy Nomogram

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Solutions for the Prescribing Mean Curvature Equation

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Acta Mathematicae Applicatae Sinica 2008年第3期24卷 497-510页

作者： Dao-min cao shuang-jie Peng Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematics and Statistics Central China Normal University Wuhan 430079 China

By variational methods, for a kind of Yamabe problem whose scalar curvature vanishes in the unit ball BN and on the boundary S^N-1 the mean curvature is prescribed, we construct multi-peak solutions whose maxima are located on the boundary as the parameter tends to 0^＋ under certain assumptions. We also obtain the asymptotic behaviors of the solutions.

关键词： Mean curvature critical point concentrating solutions

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Viscosity and structure relationship with equimolar substitution of cao with MgO in the cao–MgO–Al_(2)O_(3)–SiO_(2)slag melts

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 70-79页

作者： Yong Hou Shuo Zhang jie Dang Jia Guo Hanghang Zhou Xuewei Lü College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Vanadium-Titanium Metallurgy and New Materials Chongqing UniversityChongqing 400044China

Currently,the Al_(2)O_(3)content in the high-alumina slag systems within blast furnaces is generally limited to 16wt%–18.5wt%,making it challenging to overcome this *** most studies that concentrated on managing the MgO/Al_(2)O_(3)ratio or basicity,this paper explored the effect of equimolar substitution of MgO for cao on the viscosity and structure of a high-alumina cao-MgO-Al_(2)O_(3)-SiO_(2)slag system,providing theoretical guidance and data to facilitate the application of high-alumina *** results revealed that the viscosity first decreased and then increased with higher MgO substitution,reaching a minimum at 15mol%MgO *** transform infrared spectroscopy(FTIR)results found that the depths of the troughs representing[SiO_(4)]tetrahedra,[AlO_(4)]tetrahedra,and Si-O-Al bending became progressively deeper with increased MgO *** of the Raman spectra showed that the average number of bridging oxygens per Si atom and the X_(Q^(3))/X_(Q^(2))(X_(Q^(i))is the molar fraction of Q^(i) unit,and i is the number of bridging oxygens in a[SiO_(4)]tetrahedral unit)ratio increased from 2.30 and 1.02 to 2.52 and 2.14,respectively,indicating a progressive polymerization of the silicate structure.X-ray photoelectron spectroscopy(XPS)results highlighted that non-bridging oxygen content decreased from 77.97mol% to 63.41mol% with increasing MgO concentration,whereas bridging oxygen and free oxygen contents *** analysis demonstrated a gradual increase in the polymerization degree of the tetrahedral structure with the increase in MgO ***,bond strength is another important factor affecting the slag *** occurrence of a viscosity minimum can be attributed to the complex evolution of bond strengths of non-bridging oxygens generated during depolymerization of the[SiO_(4)]and[AlO_(4)]tetrahedral structures by cao and MgO.

关键词： aluminosilicate viscosity structure spectroscopy

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Seg-CapNet:A Capsule-Based Neural Network for the Segmentation of Left Ventricle from Cardiac Magnetic Resonance Imaging

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Journal of Computer Science & Technology 2021年第2期36卷 323-333页

作者： Yang-jie cao shuang Wu Chang Liu Nan Lin Yuan Wang Cong Yang jie Li School of Software Zhengzhou UniversityZhengzhou 450000China Center of Modern Analysis and Gene Sequencing Zhengzhou UniversityZhengzhou 450000China Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200000China

Deep neural networks(DNNs)have been extensively studied in medical image ***,existing DNNs often need to train shape models for each object to be segmented,which may yield results that violate cardiac anatomical structure when segmenting cardiac magnetic resonance imaging(MRI).In this paper,we propose a capsulebased neural network,named Seg-CapNet,to model multiple regions simultaneously within a single training *** Seg-CapNet model consists of the encoder and the *** encoder transforms the input image into feature vectors that represent objects to be segmented by convolutional layers,capsule layers,and fully-connected *** the decoder transforms the feature vectors into segmentation masks by *** maps of each down-sampling layer in the encoder are connected to the corresponding up-sampling layers,which are conducive to the backpropagation of the *** output vectors of Seg-CapNet contain low-level image features such as grayscale and texture,as well as semantic features including the position and size of the objects,which is beneficial for improving the segmentation *** proposed model is validated on the open dataset of the Automated Cardiac Diagnosis Challenge 2017(ACDC 2017)and the Sunnybrook Cardiac Magnetic Resonance Imaging(MRI)segmentation *** results show that the mean Dice coefficient of Seg-CapNet is increased by 4.7%and the average Hausdorff distance is reduced by 22%.The proposed model also reduces the model parameters and improves the training speed while obtaining the accurate segmentation of multiple regions.

关键词： capsule neural network image segmentation left ventricle segmentation cardiac magnetic resonance imaging

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Process mineralogy characteristics of acid leaching residue produced in low-temperature roasting-acid leaching pretreatment process of refractory gold concentrates

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International Journal of Minerals,Metallurgy and Materials 2018年第10期25卷 1132-1139页

作者： shuang-hua Zhang Ya-jie Zheng Pan cao Chao-hui Li Shen-zhi Lai Xing-jun Wang School of Metallurgy and Environment Central South University Western Region Gold Yili Co. Ltd

To provide a theoretical basis for a suitable process to extract gold from refractory gold concentrates, process mineralogy on the acid leaching residue of gold calcine was studied by chemical composition, X-ray diffraction, scanning electron microscopy-energy spectrum, and mineral dissociation analysis. The results showed that the acid leaching residue contained Au 68.22 g/t, Ag 92.71 g/t, Fe 0.44%, As 0.10%, and S 0.55%. Gold and silver minerals existed as native gold, argentite, and proustite. Quartz, the main gangue mineral, accounted for 78.33 wt/%. The dissociation degree analysis showed that the proportions of monomer and exposed gold in acid leaching residue were 96.66 wt%. The cyanidation results showed that the cyanide gold leaching rate of acid leaching residues was close to 100 wt%. However, the maximum cyanide gold leaching rate of gold calcine was only 85.31 wt%. This suggests that acid leaching can increase the gold dissolution rate in the cyanide process.

关键词： acid leaching residue roasting process mineralogy precious metals occurrence states

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NONLINEAR LANGEVIN MODEL WITH PRODUCT STOCHASTICITY FOR BIOLOGICAL NETWORKS： THE CASE OF THE SCHNAKENBERG MODEL

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Journal of Systems Science & Complexity 2010年第5期23卷 896-905页

作者： Youfang cao jie LIANG Ministry of Education Key Laboratory of Systems Biomedicine Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China Department of Bioengineering University of Illinois at Chicago Chicago USA

Langevin equation is widely used to study the stochastic effects in molecular networks, as it often approximates well the underlying chemical master equation. However, frequently it is not clear when such an approximation is applicable and when it breaks down. This paper studies the simple Schnakenberg model consisting of three reversible reactions and two molecular species whose concentrations vary. To reduce the residual errors from the conventional formulation of the Langevin equation, the authors propose to explicitly model the effective coupling between macroscopic concentrations of different molecular species. The results show that this formulation is effective in correcting residual errors from the original uncoupled Langevin equation and can approximate the underlying chemical master equation very accurately.

关键词： Langevin equation master equation noise Schnakenberg model.

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Interdecadal Variations of the March Atmospheric Heat Source over the Southeast Asian Low-Latitude Highlands

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Advances in Atmospheric Sciences 2023年第9期40卷 1584-1596页

作者： Dayong WEN jie cao Yunnan Key Laboratory of Meteorological Disasters and Climate Resources in the Greater Mekong Subregion Yunnan UniversityKunming 650091China

Based on the fifth-generation reanalysis dataset from the European Centre for Medium-Range Weather Forecasts for 1979–2019,we investigated the effects of the circumglobal teleconnection(CGT)on the interdecadal variation of the March atmospheric heat source(AHS)over the Southeast Asian low-latitude highlands(SEALLH).The dominant mode of the March AHS over the SEALLH features a monopole structure with an 8–11-year *** variations in the AHS make an important contribution to the 11-year low-pass filtered component of the AHS index,whichexplains 54.3%of the total *** CGT shows a clear interdecadal variation,which explains 59.3%of the total *** March AHS over the SEALLH is significantly related to the CGT on interdecadal *** the CGT is optimally excited by a significant cyclonic vorticity source near northern Africa(i.e.,in its positive phase),the SEALLH is dominated by anomalous southerly winds and ascending motions on the east of the anomalous *** enhanced advection and upward transfer result in a high-enthalpy air mass that converges into and condenses over the SEALLH,leading to a largerthan-average March AHS over this *** key physical processes revealed by this diagnostic analysis are supported by numerical experiments.

关键词： interdecadal variation atmospheric heat source circumglobal teleconnection low-latitude highlands Rossby wave source

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Iterative Methods for Solving the Nonlinear Balance Equation with Optimal Truncation

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Advances in Atmospheric Sciences 2021年第5期38卷 755-770页

作者： Qin XU jie cao NOAA/National Severe Storms Laboratory NormanOklahoma 73069USA Cooperative Institute for Mesoscale Meteorological Studies University of OklahomaNormanOklahoma 73072USA Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China

Two types of existing iterative methods for solving the nonlinear balance equation(NBE)are *** the first type,the NBE is rearranged into a linearized equation for a presumably small correction to the initial guess or the subsequent updated *** the second type,the NBE is rearranged into a quadratic form of the absolute vorticity with the positive root of this quadratic form used in the form of a Poisson equation to solve NBE *** two methods are rederived by expanding the solution asymptotically upon a small Rossby number,and a criterion for optimally truncating the asymptotic expansion is proposed to obtain the super-asymptotic approximation of the *** each rederived method,two iterative procedures are designed using the integral-form Poisson solver versus the over-relaxation scheme to solve the boundary value problem in each *** testing with analytically formulated wavering jet flows on the synoptic,sub-synoptic and meso-αscales,the iterative procedure designed for the first method with the Poisson solver,named M1a,is found to be the most accurate and *** the synoptic wavering jet flow in which the NBE is entirely elliptic,M1a is extremely *** the sub-synoptic wavering jet flow in which the NBE is mostly elliptic,M1a is sufficiently *** the meso-αwavering jet flow in which the NBE is partially hyperbolic so its boundary value problem becomes seriously ill-posed,M1a can effectively reduce the solution error for the cyclonically curved part of the wavering jet flow,but not for the anti-cyclonically curved part.

关键词： nonlinear balance iterative method optimal truncation

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Numerical simulation of gas migration into mining-induced fracture network in the goaf

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International Journal of Mining Science and Technology 2017年第4期27卷 681-685页

作者： cao jie Li Wenpu State Key Laboratory of Gas Disaster Detection Prevention and Emergency Control. Chongqing 400037. China Chongqing Research Institute Co. Ltd. of China Coal Technology and Engineering Group Chongqing 400037 China State Key Laboratory of Coal Mine Disaster Dynamics and Control. Chongqing University. Chongqing 400044 China

Gas extraction practice has been proven for the clear majority of coal mines in China to be unfavorable using drill holes in the coal seam. Rather, mining-induced fractures in the goaf should be utilized for gas extraction. To study gas migration in mining-induced fractures, one mining face of 10 th Mine in Pingdingshan Coalmine Group in Henan, China, has been selected as the case study for this work. By establishing the mathematical model of gas migration under the influence of coal seam mining, discrete element software UDEC and Multiphysics software COMSOL are employed to model gas migration in mining-induced fractures above the goaf. The results show that as the working face advances, the goaf overburden gradually forms a mining-induced fracture network in the shape of a trapezoid, the size of which increases with the distance of coal face advance. Compared with gas migration in the overburden matrix, the gas flow in the fracture network due to mining is far greater. The largest mining-induced fracture is located at the upper end of the trapezoidal zone, which results in the largest gas flux in the network. When drilling for gas extraction in a mining-induced fracture field, the gas concentration is reduced in the whole region during the process of gas drainage, and the rate of gas concentration drops faster in the fractured zone. It is shown that with gas drainage, the gas flow velocity in the mininginduced fracture network is faster.

关键词： Gas migration Fractures Mining-induced Numerical simulation

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Preparation mechanism,physical characteristic and antitumor activity of nano-scheelite

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 468-474页

作者： Lin cao Fu-qiang Yang jie-xin cao School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Peking University Health Science Center Beijing 100083 China

After preparing the EU^3＋-doped scheelite nano-material by Pechini method with the nanoparticles of 30-50 nm in diameter, X-ray diffraction （XRD）, transmission electron microscopy （TEM） and high resolution transmission electron microscopy （HRTEM） were used to show a microcosmic description of the particle morphology and crystal structure. The spectrum signature of the nano-scheelite, which was taken by fluorescence spectrometer, was used to discuss the difference of luminescent performance between the nano-scheelite and bulk scheelite. The atomic site of the nano-scheelite was intuitively shown through HRTEM images and HRTEM simulated images from the relation between luminescent properties and crystal structure, which was analyzed by spectrum probe. The results of antitumor activity examined by the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） method show that the inhibition of human promyelocytic leukemia cell line （HL60） is enhanced immediately with increasing the concentration and presents a reliance on the quantity. The results of fluorescence spectra and structure show that the antitumor activity has something to do with micro-structure and surface charge.

关键词： scheelite fluorescence spectrum atomic site anti-tumor activity

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