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Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China

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Chinese Journal of Cancer Research 2017年第6期29卷 496-509页

作者： Margaret Wang Shangying Hu shuang zha o Wenhua zhang Qinjing Pan Xun zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui zhao Department of Cancer Epidemiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Pritzker School of Medicine University of ChicagoChicagoIL 60637-5415USA UJMT Fogarty Consortium NIH Fogarty International CenterBethesdaMD 20892-2220USA Department of Gynecological oncology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Cytology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Wuxiang Maternal and Child Health Care and Family Planning Service Center Changzhi 046300China Xiangyuan Maternal and Child Health Care and Family Planning Service Center Changzhi 046200China Department of Epidemiology University of North CarolinaChapel HillNC 27599-7435USA Department of Education National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

objective： CareHPV is a human papillomavirus （HPV） DNA test for low-resource settings （LRS）. This study assesses optimum triage strategies for careHPV-positive women in LRS. Methods： A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid （VIA）, liquid-based cytology and HPV testing by physician- and self-collected careHPV, and physician-collected Hybrid Capture 2 （HC2）. Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary. HPV-positivity was defined as _〉1.0 relative light units/cutoff （RLU/Co） for both careHPV and HC2. Primary physician-HC2, physician-careHPV and self-careHPV and in sequential screening with cytology, VIA, or increased HPV test-positivity performance, stratified by age, were assessed for cervical intraepithelial neoplasia （CIN） grade 2/3 or worse （CIN2/3＋） detection. Results： The sensitivities and specificities of primary HPV testing for CIN2＋ were： 83.8%, 88.1% for physician- careHPV; 72. 1%, 88.2% for self-careHPV; and 97.1%, 86.0% for HC2. Physician-careHPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2＋ versus 80.9% with cytology triage. Self-careHPV test- positive women with VIA triage was 26.5% versus 66.2 % with cytology triage. The sensitivity of HC2 test-positive women with VIA triage was 38.2 % versus 92.6% with cytology triage. The sensitivity of physician-careHPV testing for CIN2＋ decreased from 83.8% at _〉1.0 RLU/Co to 72.1% at _〉10.00 RLU/Co, while the sensitivity of self- careHPV testing decreased from 72.1% at _〉1.0 RLU/Co to 32.4% at _〉10.00 RLU/Co; similar trends were seen with age-stratification. Conclusions： VIA and cytology triage improved specificity for CIN2/3 than no triage. Sensitivity with VIA triage was unsuitable for a mass-screening program. VIA provider training might improve this strategy. Cytology triage could be feasible where a high-quality cytology program exists. Triage of HPV t

关键词： Cervical cancer human papillomavirus careHPV testing screening triage

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青光眼小梁切除术中巩膜瓣下填置游离小梁瓣的临床观察

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中国实用医药 2016年第25期11卷 48-49页

作者：陈爽赵清来姜婷大连市第五人民医院眼科 116021

目的探讨青光眼小梁切除术中巩膜瓣下填置游离小梁瓣的手术效果。方法 42例(45眼)青光眼患者在实施小梁切除术的同时于巩膜瓣下填充固定游离小梁组织,观察疗效。结果视力与术前比较提高>2行17眼(37.8%),眼压完全控制37眼(82.2%)。结论... 详细信息

目的探讨青光眼小梁切除术中巩膜瓣下填置游离小梁瓣的手术效果。方法 42例(45眼)青光眼患者在实施小梁切除术的同时于巩膜瓣下填充固定游离小梁组织,观察疗效。结果视力与术前比较提高>2行17眼(37.8%),眼压完全控制37眼(82.2%)。结论青光眼小梁切除术中巩膜瓣下填置游离小梁瓣是保持滤过道通畅的有效方法。

关键词：青光眼小梁切除术巩膜瓣游离小梁瓣眼压滤过泡

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Improved Known-Key Distinguisher on Round-Reduced 3D Block Cipher

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Chinese Journal of Electronics 2015年第1期24卷 199-204页

作者： zha Daren WU shuang WANG Qiongxiao University of Chinese Academy of Sciences Data Assurance and Communication Security Research Center of Chinese Academy of Sciences

The 3D block cipher is a three-dimensional version of AES(Advanced encryption standard), which use a three-dimensional state and similar round functions. In this paper, we will use the known-key attack model proposed by Knudsen and Rijmen, and propose an improved distinguisher on 15 rounds of 3D, which has 22 rounds in total. The distinguisher is constructed using rebound techniques. In the previous distinguisher, only three inbound phases are merged. Here we propose a method to merge four inbound phases using gradual matching *** improved complexity of this distinguisher is 2128 computations and 264 memory. The computational complexity is significantly reduced from 2200 in the previous attack.

关键词： 3D block cipher Known-key distinguisher Rebound attack Gradual matching.

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Study on creep-fatigue damage evaluation for advanced 9%–12% chromium steels under stress controlled cycling

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Acta Metallurgica Sinica(English Letters) 2011年第2期24卷 148-154页

作者： Peng zha o Fuzhen XUAN Key Laboratory of Safety Science of Pressurized System Ministry of Education School of Mechanical andPower Engineering East China University of Science and Technology Shanghai 200237 China

Creep-fatigue interaction is one of the main damage mechanisms in high temperature plants and their components. Assessment of creep-fatigue properties is of practical importance for design and operation of high temperature components. However, the standard evaluation techniques, i.e. time fraction rule and ductility exhaustion one have limitations in accounting for the effects of control mode on the cyclic deformations. It was found that conventional linear cumulative damage rule failed in accurately evaluating the creep-fatigue life under stress controlled condition. The calculated creep damages by time fraction rule were excessively high, which led to overly conservative prediction of failure lives. In the present study, it was suggested that such over estimation of creep damage was mainly caused by anelastic strain upon stress loading. For precise assessment under conditions of stress control, a modified creep damage model accounting for the effect of anelastic creep was proposed. The assessments of creep fatigue data under stress controlled condition were performed with the new approach developed in this paper for a rotor material and a boiler material used in ultra supercritical power plants. It was shown that a more moderate amount of creep damage was obtained by the new model, which gave better predictions of failure life.

关键词： Creep-fatigue Creep damage 9%–12%Cr steels Stress control Time fraction rule

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Remarkable Thermal Contraction in Small Size Single-Walled Boron Nanotubes

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Communications in Computational Physics 2014年第6期16卷 201-212页

作者： Xianhu zha shuang Li Ruiqin zhang Zijing Lin Department of Physics&Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of ChinaHefei 230026China. Department of Physics and Materials Science City University of Hong KongKowloon TongHong Kong. USTC-CityU Joint Advanced Research Centre Suzhou 215123China. Nano Structured Materials Center Nanjing University of Science and TechnologyNanjing 210094China.

Density functional theory combined with the Gr¨uneisen approximation is used to calculate the thermal properties of single-walled boron nanotubes(BNTs).The specific heat and thermal expansion are *** thermal expansion coeffi-cient of the BNT is found to be significantly correlated with tube size and chirality.A remarkable thermal contraction is found at small tube *** results indicate that BNTs would have potential applications in sensors,actuators,and memory materials.

关键词： Density functional theory Gruneisen approximation single-walled boron nanotubes remarkable thermal contraction.

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Improved thermoelectric properties of zone-melted p-type bismuth-telluride-based alloys for power generation

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Rare Metals 2022年第5期41卷 1490-1495页

作者： Ren-shuang zhai Tie-Jun Zhu State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang University.Hangzhou 310027China Thermoelectricity Technology Center Hangzhou Dahe Thermo-Magnetics Co.LtdHangzhou 310053China

Zone-melted bismuth-telluride-based alloys(ZM-BT) are extensively applied to manufacture commercial thermoelectric power generators(TEG). optimizing the average figure of merit(zT) during 300–500 K of ZM-BT is favora... 详细信息

关键词： alloys bismuth power

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A bioinspired magnetic responsive cilia array surface for microspheres underwater directional transport

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Science China Chemistry 2020年第3期63卷 347-353页

作者： shuang Ben Jinjia Yao Yuzhen Ning Zhihong zhao Jinlong zha Dongliang Tian Kesong Liu Lei Jiang Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of Chemistry Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191China

Bio-inspired surfaces are usually designed by imitating the surface properties of a particular biological species,or combing with the surface characteristics of multiple biological species to construct a cross-species ***,inspired by the structure and rhythmic swing of human pulmonary cilia,and the directional migration of pigeons by geomagnetic field,an integrated system of biomimetic hydrophobic magnetic cilia array surface with reversible deformation properties and excellent magnetic response performance for solid microspheres underwater transport is designed and *** by an external magnetic field,the magnetic responsive cilia array surface can directionally and continuously transport microspheres underwater in periodic *** work will shed new light on the designing of micromanipulation systems for micro-objects transport,and promote the practical application of micro-operating systems in underwater transportation and drug delivery.

关键词： cilia-inspired surface underwater microspheres transport magnetic response micro-operating system

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晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38+47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院水利部水土保持监测中心

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究，探究植被恢复引起土壤养分变化规律及其作用机制，对认识植被恢复与土壤养分的关系，指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象，通过调查采样和室内分析，探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复，先锋阔叶林和针叶林阶段的SoC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展，土壤C∶P和N∶P显著增加，C∶N的变化无明显规律，在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0—40 cm土层的土壤N∶P较上一阶段增加40.2%,40—100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律，研究区土壤逐渐由C,N的限制转变为P的限制；(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关，与孔隙度呈显著正相关，土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加，改善土壤理化性质，在植被恢复过程应同时注重P元素的调控，以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

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