检索结果-南通市图书馆

Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE shuang-yi GAO Jian LI Yong-ran JIANG Shu-xin ZHANG Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2024年第2期17卷 297-303页

作者： De-shuang Li Hong-Xia Liao Jing-lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after ***:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,*** DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study *** aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined ***:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly *** and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high *** combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema ***,the long-term eff

关键词： diabetic macular edema aqueous humor cytokines aflibercept triamcinolone acetonide

Retroperitoneal leiomyoma located in the broad ligament: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第32期10卷 12022-12027页

作者： Xue-Song Zhang shuang-Zhu lin Yu-Jiao Liu Lei Zhou Qian-Dui Chen Wan-Qi Wang Jia-Yi Li Department of Gynecology First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Diagnosis and Treatment Center for Children First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Respiratory Medicine First Affiliated Hospital of Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Pathology First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina Department of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

BACKGROUND Retroperitoneal leiomyoma is a rare benign *** leiomyomas located in the latissimus uterine ligament are even *** leiomyomas have similar characteristics to uterine leiomyomas in terms of tissue,which results in confusion during *** SUMMARY A 47-year-old female with 3 years of pain in the right lower quadrant and discovery of a pelvic mass 13 d ago underwent open abdominal *** the right broad ligament,a solid mass with well circumscribed boundaries,approximately 15 cm×10 cm×10 cm in size was bluntly peeled *** pathological result was a spindle cell tumor,morphologically considered to originate from smooth *** results supported a deep soft tissue *** Retroperitoneal leiomyoma is a rare benign tumor,and surgical treatment can have a good therapeutic effect.

关键词： Leiomyoma Broad ligament Spindle cell tumor Surgery Case report

Clinical manifestations and gene analysis of Hutchinson-Gilford progeria syndrome:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第15期10卷 5018-5024页

作者： Su-Li Zhang shuang-Zhu lin Yan-Qiu Zhou Wan-Qi Wang Jia-Yi Li Cui Wang Qi-Ming Pang Department of Neuroscience Hainan Women and Children's Medical CenterHaikou 570100Hainan ProvinceChina Diagnosis and Treatment Center for Children First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND This case report describes a child with Hutchinson-Gilford progeria syndrome(HGPS,OMIM:176670)caused by LMNA(OMIM:150330)gene mutation,and we have previously analyzed the clinical manifestations and imaging characteristics of this *** 1-year treatment and follow-up,we focus on analyzing the changes in the clinical manifestations and genetic diagnosis of the *** SUMMARY In April 2020,a 2-year-old boy with HGPS was found to have an abnormal appearance,and growth and development lagged behind those of children of the same *** child’s weight did not increase normally,the veins of the head were clearly visible,and he had shallow skin color and sparse yellow *** blood DNA samples obtained from the patient and his parents were sequenced using high-throughput whole-exosome sequencing,which was verified by Sanger *** results showed that there was a synonymous heterozygous mutation of C.1824 C>T(P.G608G)in the LMNA *** Mutation of the LMNA gene provides a molecular basis for diagnosis of HGPS and genetic counseling of the family.

关键词： Hutchinson-Gilford progeria syndrome LMNA Children Physiological function Organ aging Case report

Two novel mutations in the VPS33B gene in a Chinese patient with arthrogryposis,renal dysfunction and cholestasis syndrome 1:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第30期10卷 11016-11022页

作者： Hui Yang shuang-Zhu lin Shi-Hui Guan Wan-Qi Wang Jia-Yi Li Gui-Dan Yang Su-Li Zhang Department of Neonatology Hainan Women and Children's Medical CenterHaikou 570100Hainan ProvinceChina Diagnosis and Treatment Center for Children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND The VPS33B(OMIM:608552)gene is located on chromosome *** found a female infant with autosomal recessive arthrogryposis,renal dysfunction and cholestasis syndrome 1(ARCS1)caused by mutation in *** child was diagnosed with ARCS1(OMIM:208085)after the whole exome sequencing revealed two heterozygous mutations(c.96+1G>C,c.242delT)in the VPS33B *** SUMMARY We report a Chinese female infant with neonatal cholestasis disorder,who was eventually diagnosed with ARCS1 by genetic *** testing revealed two new mutations(c.96+1G>C and c.242delT)in VPS33B,which is the causal *** patient was compound heterozygous,and her parents were both *** This study extends the mutational spectrum of the VPS33B gene to provide a molecular basis for the etiological diagnosis of ARCS1 and for genetic counseling of the family.

关键词： Arthrogryposis,renal dysfunction and cholestasis syndrome 1 VPS33B gene Children Heterozygous mutation Case report

Dynamic simulation and optimal control strategy for a parallel hybrid hydraulic excavator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第5期9卷 624-632页

作者： Xiao lin shuang-xia PAN Dong-yun WAN State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

The primary focus of this study is to investigate the control strategies of a hybrid system used in hydraulic excavators. First, the structure and evaluation target of hybrid hydraulic excavators are analyzed. Then the dynamic system model including batteries, motor and engine is built as the simulation environment to obtain control results. A so-called multi-work-point dynamic control strategy, which has both closed-loop speed PI (proportion integral) control and direct torque control, is proposed and studied in the simulation model. Simulation results indicate that the hybrid system with this strategy can meet the power demand and achieve better system stability and higher fuel efficiency.

关键词：杂合系统液压传动水力挖掘机动力学控制

Effect of low dose laser cycloplasty on deepening anterior chamber in chronic angle-closure glaucoma

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第12期16卷 2011-2017页

作者： Xuan-Li Zheng Hai-shuang lin Xiao-Jie Wang Jia-Qian Li Yan-Qian Xie Shao-Dan Zhang Yuan-Bo Liang Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research Institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To describe the outcome of using low-dose laser cycloplasty(LCP)in chronic angle-closure glaucoma(CACG).METHODS:A retrospective case *** charts of CACG patients who underwent LCP in the Eye Hospital of Wenzhou Medical University were *** main outcomes included intraocular pressure(IOP),the number of glaucoma medication,anterior segment parameters and surgery-related ***:A total of 7 eyes of 7 CACG patients(age 38.9±11.0y)underwent LCP with a mean follow-up of 27.1±13.7mo(range 16-48mo).Following LCP,mean IOP and glaucoma medications decreased from 26.1±6.1 mm Hg with 3.1±1.1 glaucoma medications pre-treatment to 14.9±3.1 mm Hg(P=0.027)with 0.4±1.1 glaucoma medications(P=0.001)at final *** anterior chamber depth(ACD),angle opening distance500 and trabecular-iris angle increased from 1.65±0.33 mm,0.05 mm(range 0-0.30 mm)and 5.1°(range,0-31.97°)at baseline to 1.98±0.43 mm(P=0.073),0.53 mm(range 0.42-0.91 mm,P=0.015),45.9°(range,40.2°-59.4°),(P=0.015)in the long-term follow-up,*** deepening of ACD and reopening of anterior chamber angle(ACA)was observed in 6 eyes(85.7%).CONCLUSION:LCP is a promising treatment option for patients with CACG via reducing IOP and glaucoma medication without serious *** addition,LCP can bring a significant deepening in ACD and reopening of ACA.

关键词： chronic angle-closure glaucoma low dose laser cycloplasty anterior chamber depth intraocular pressure

Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第31期10卷 11486-11492页

作者： shuang-Zhu lin Qi-Ji Ma Qi-Ming Pang Qian-Dui Chen Wan-Qi Wang Jia-Yi Li Su-Li Zhang Diagnosis and Treatment Center for Children The First Affiliated Hospital to Changchun University of Chinese MedicineChangchun 130021Jilin ProvinceChina The First Affiliated Hospital to Changchun University of Chinese Medicine Changchun 130021Jilin ProvinceChina Department of Neonatology Hainan Women and Children's Medical CenterHaikou 570100Hainan ProvinceChina Changchun University of Chinese Medicine Changchun 130000Jilin ProvinceChina

BACKGROUND Combined pituitary hormone deficiency 3(CPHD3;OMIM:221750)is caused by mutations within the LHX3 gene(OMIM:600577),which located on the subtelomeric region of chromosome 9 at band 9q34.3,has seven coding exons and six *** homeobox(LHX)3 protein is the key regulator of pituitary development in fetal *** SUMMARY We have diagnosed and treate an 11-year-old boy with combined pituitary hormone deficiency(CPHD).The main clinical manifestations were pituitary hormone deficiency,hydrocele of the tunica vaginalis,pituitary dwarfism,gonadal dysplasia,micropenis,clonic convulsion,and mild facial dysmorphic *** collected peripheral blood from the patient,the patient's older brother,as well as their parents,and sequenced them by using high-throughput whole-exosome sequencing,which was verified by Sanger *** results showed that there were two compound heterozygous variants of c.613G>C(p.V205L)and c.220T>C(p.C74R)in the LHX3 gene.c.613G>C(p.V205L)was inherited from his mother and c.220T>C(p.C74R)from his *** brother also has both variants and *** This study reported ununreported genetic mutations of LHX3,and recorded the treatment process of the patients,providing data for the diagnosis and treatment of CPHD.

关键词： Combined pituitary hormone deficiency LHX3 Children Gonadal dysplasia Case report

Regiocontrolled Rh(Ⅲ)-catalyzed C-C coupling/C-N cyclization mediated by distinctive 1,2-migratory insertion of gem-difluoromethylene allenes:Reaction development and mechanistic insight

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第5期34卷 250-255页

作者： Zhi Zhou Kaifeng Chen Yi Wang Xiuhua Zhong shuang lin Hui Gao Wei Yi Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology NMPA and State Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China

By developing gem-difluoromethylene allenes as viable partners,regiocontrolled Rh(Ⅲ)-catalyzed redoxneutral C-C coupling/C-N cyclization has been realized to build the pyridin-2(1H)-one motifs with the embedment of a Z-configured monofluoroalkene functionality,in which either(hetero)aromatic or vinylic amides were found to be *** experimental and computational mechanistic studies revealed that a tandem regioselective allene 1,2-insertion/β-H elimination/hydrogen transfer/oxidative addition/cyclization/cis-β-F elimination involving an unconventional Rh(Ⅲ)-Rh(I)-Rh(Ⅲ)catalytic cycle accounts for the established *** further FMO analysis and IGMH maps,a non-covalent weak interaction network between the gem-difluoromethylene part and the OPiv moiety was rationally defined for the unconventional and specific regioselectivity control.

关键词： Gem-difluoromethylene allenes C-H functionalization Regiocontrol Rhodium(Ⅲ)catalysis DFT calculations