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Chinese Chemical Letters 2024年第3期35卷 443-448页

作者： Linhe Xu Xueshan Hu shuang zhou Ze Zhang Junxian Zhang Chao Li Daxian Zuo Hao Liu Gang Chen Jiayu Wan Jinsong Tao State Key Lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China

Accurate detection of uric acid(UA)is crucial for diagnosing gout,yet traditional sweat-based UA sensors continue to face challenges posed by complex and costly electrode fabrication methods,as well as weakly hydrophilic substrates.Here,we designed and developed simple,low-cost,and hydrophilic sweat UA detection sensors constructed by carbon electrodes and cellulose paper substrates.The carbon electrodes were made by carbonized polyimide films through a simple,one-step laser engraving method.Our electrodes are porous,possess a large specific surface area,and are flexible and conductive.The substrates were composed of highly hydrophilic cellulose paper that can effectively collect,store,and transport sweat.The constructed electrodes demonstrate high sensitivity of 0.4μA Lμmol^(-1)cm^(-2),wide linear range of 2–100μmol/L.In addition,our electrodes demonstrate high selectivity,excellent reproducibility,high flexibility,and outstanding stability against mechanical bending,temperature variations,and extended storage periods.Furthermore,our sensors have been proven to provide reliable results when detecting UA levels in real sweat and on real human skin.We envision that these sensors hold enormous potential for use in the prognosis,diagnosis,and treatment of gout.

关键词： Laser-engraved carbon Polyimide Cellulose paper Hydrophilicity Sweat uric acid

Charge regulation by ferromagnetic metal/LiF spin-polarized interface for high-performance Li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng shuang zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu Jian-Wen Li Yuan-Lang Wan Zhi-Jia Zhang Yong Jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the Li metal anode(LMA)play a crucial role in its overall performance.Despite various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be investigated.Herein,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/LiF heterogeneous films(T^(M)-LiF-CC)as the substrate for LMA,which exhibit superior electrochemical performance.Utilizing ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-LiF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/LiF heterostructure.Co and LiF play individual roles in redistributing electrons and Li^(+)to promote homogeneous Li deposition.Co nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while LiF,with low surface diffusion barriers,ensures fast transportation of Li^(+).The Co-LiF-CC@Li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： Lithium metal anode Interfacial charge Ferromagnetic metal Lithium fluoride Spin polarization

Insight into the dynamics of non-Newtonian Carreau fluid when viscous dissipation,entropy generation,convective heating and diffusion are significant

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 34-46页

作者： zhou shuang-shuang Muhammad Ijaz Khan Sami Ullah Khan Sumaira Qayyum School of Science Hunan City UniversityYiyang 413000China Department of Mechanical Engineering Prince Mohammad Bin Fahd UniversityP.O.Box1664Al-Khobar 31952Kingdom of Saudi Arabia Department of Mathematics Namal UniversityMianwali 42250Pakistan Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan

The investigation endorsed the convective flow of Carreau nanofluid over a stretched surface in presence of entropy generation optimization.The novel dynamic of viscous dissipation is utilized to analyze the thermal mechanism of magnetized flow.The convective boundary assumptions are directed in order to examine the heat and mass transportation of nanofluid.The thermal concept of thermophoresis and Brownian movements has been re-called with the help of Buongiorno model.The problem formulated in dimensionless form is solved by NDSolve MATHEMATICA.The graphical analysis for parameters governed by the problem is performed with physical applications.The affiliation of entropy generation and Bejan number for different parameters is inspected in detail.The numerical data for illustrating skin friction,heat and mass transfer rate is also reported.The motion of the fluid is highest for the viscosity ratio parameter.The temperature of the fluid rises via thermal Biot number.Entropy generation rises for greater Brinkman number and diffusion parameter.

关键词： heat generation surface reaction CNTs based nano uid stretching/shrinking sheet thermal radiation

Therapeutic strategies targeting the epidermal growth factor receptor signaling pathway in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2362-2379页

作者： Yi zhou shuang Wu Fan-Jie Qu Department of Oncology Affiliated Dalian Third People’s Hospital of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and deaths.Overall,colorectal ranks third in incidence,but second in mortality.More than half of the patients are in advanced stages at diagnosis.Treatment options are complex because of the heterogeneity of the patient population,including different molecular subtypes.Treatments have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,etc.In recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.

关键词： Metastatic colorectal cancer Epidermal growth factor receptor B-type RAF mutation Kirsten rat sarcoma viral oncogene wild type Kirsten rat sarcoma viral oncogene G12C mutation Human epidermal growth factor receptor 2 overexpression/amplification

Precision targeting in hepatocellular carcinoma:Exploring ligandreceptor mediated nanotherapy

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World Journal of Hepatology 2024年第2期16卷 164-176页

作者： Xia-Qing zhou Ya-Ping Li shuang-Suo Dang Department of Infectious Diseases Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

Hepatocellular carcinoma(HCC)is the most common primary liver cancer and poses a major challenge to global health due to its high morbidity and mortality.Conventional chemotherapy is usually targeted to patients with intermediate to advanced stages,but it is often ineffective and suffers from problems such as multidrug resistance,rapid drug clearance,nonspecific targeting,high side effects,and low drug accumulation in tumor cells.In response to these limitations,recent advances in nanoparticle-mediated targeted drug delivery technologies have emerged as breakthrough approaches for the treatment of HCC.This review focuses on recent advances in nanoparticle-based targeted drug delivery systems,with special attention to various receptors overexpressed on HCC cells.These receptors are key to enhancing the specificity and efficacy of nanoparticle delivery and represent a new paradigm for actively targeting and combating HCC.We comprehensively summarize the current understanding of these receptors,their role in nanoparticle targeting,and the impact of such targeted therapies on HCC.By gaining a deeper understanding of the receptor-mediated mechanisms of these innovative therapies,more effective and precise treatment of HCC can be achieved.

关键词： Targeting Hepatocellular carcinoma Receptor Nanomedicine Chemotherapy

Bunch-length measurement at a bunch-by-bunch rate based on time–frequency-domain joint analysis techniques and its application

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Nuclear Science and Techniques 2024年第4期35卷 165-175页

作者： Hong-shuang Wang Xing Yang Yong-Bin Leng Yi-Mei zhou Ji-Gang Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

This paper presents a new technique for measuring the bunch length of a high-energy electron beam at a bunch-by-bunch rate in storage rings.This technique uses the time–frequency-domain joint analysis of the bunch signal to obtain bunch-by-bunch and turn-by-turn longitudinal parameters,such as bunch length and synchronous phase.The bunch signal is obtained using a button electrode with a bandwidth of several gigahertz.The data acquisition device was a high-speed digital oscilloscope with a sampling rate of more than 10 GS/s,and the single-shot sampling data buffer covered thousands of turns.The bunch-length and synchronous phase information were extracted via offline calculations using Python scripts.The calibration coefficient of the system was determined using a commercial streak camera.Moreover,this technique was tested on two different storage rings and successfully captured various longitudinal transient processes during the harmonic cavity debugging process at the Shanghai Synchrotron Radiation Facility(SSRF),and longitudinal instabilities were observed during the single-bunch accumulation process at Hefei Light Source(HLS).For Gaussian-distribution bunches,the uncertainty of the bunch phase obtained using this technique was better than 0.2 ps,and the bunch-length uncertainty was better than 1 ps.The dynamic range exceeded 10 ms.This technology is a powerful and versatile beam diagnostic tool that can be conveniently deployed in high-energy electron storage rings.

关键词： Bunch-by-bunch diagnostic Bunch-length measurement Synchronous phase measurement Joint time–frequency-domain analysis Longitudinal instability

Identification and Expression Profile of a Neuropeptide LFRFamide-Like Gene During Different Stages of Gonadal Development in the Cephalopod Sepia pharaonis

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Journal of Ocean University of China 2024年第2期23卷 499-508页

作者： QIU Jiayin SUN Lianlian LI shuang zhou Xu CHI Changfeng ZHENG Libing National and Provincial Joint Engineering Research Center for Marine Germplasm Resources Exploration and Utilization School of Marine Science and TechnologyZhejiang Ocean UniversityZhoushan 316022China

Neuropeptides are widely distributed in vertebrates and invertebrates,regulating a variety of physiological activities in the organisms,such as metabolism,feeding and reproduction.In this study,to explore the function of neuropeptide LFRFamide in Sepia pharaonis,the full-length cDNA of LFRFamide-like gene(named SpLFRFL,MG869822.1)was identified with rapid amplification of cDNA ends(RACE)method.The sequence of SpLFRFL was 860 bp in length and encoded 188 amino acids containing 4 different mature peptides:1 copy of PHTPFRFamide,NSLFRFamide,TIFRFamide,and 3 copies of GNLFRFamide.Multiple alignment and phylogenetic analysis results showed that SpLFRFL shared high identity with LFRFamides of Sepia officinalis and Sepiella japonica and had the closest relationship with them.Through quantitative Real-time PCR(qRT-PCR),it was found that the SpLFRFL gene was highly expressed in the optic lobe and brain at three different stages during gonad development in both genders.Moreover,the four mature peptides at a concentration of 0.01μmol L^(−1) could inhibit the protein synthesis in the Chinese hamster ovary cell strain-K1(CHOK1)induced by SpGnRH.These data suggest that SpLFRFL might be involved in the development and reproduction of S.pharaonis.The results can contribute to future studies on neuropeptide evolution and function and benefit the cuttlefish farming.

关键词： neuropeptide LFRFamide-like cephalopod cuttlefish Sepia pharaonis development reproduction

Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis

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Chinese Journal of Integrative Medicine 2024年第5期30卷 449-457页

作者： XIE shuang-ran MA Liang XU Xin-yu zhou Shu XIE Hui-miao XIE Chang-sheng The First Clinical Medical College Zhejiang Chinese Medical UniversityHangzhou 310053China Department of Medical Oncology Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical UniversityHangzhou 310007China Department of Dermatology the Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Famous Chinese Medicine Clinic the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310005China Department of Medical Oncology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006China

Backgroup:Currently,aromatherapy is being increasingly utilized in clinical practice,particularly in managing the side effects associated with radiotherapy and chemoradiotherapy.However,it remains to be established whether aromatherapy can effectively alleviate these symptoms.Objective:To investigate the effects of aromatherapy on the physical and mental health of patients with cancer undergoing radiotherapy and chemotherapy.Methods:Seven databases were researched from inception until September 29,2023,including PubMed,Scopus,and Web of Science,Chinese National Knowledge Infrastructure,Wanfang database,China Biology Medicine disc and VIP Chinese Medical Journal Database.Review Manager version 5.3 was utilized for data analysis.The Cochrane Risk of Bias tool RoB2 was employed to evaluate the quality of the literature included in the study.Evidence quality rating was assessed using the Grading of Recommendations Assessment,Development,and Evaluation(GRADE) approach through the GRADEpro GDT online tool.Results:Nineteen studies involving 1,541 patients were included.Aromatherapy can alleviate nausea [relative risk(RR)=0.64,95% confidence interval(CI):0.53 to 0.78,P<0.05,I^(2)=46%;standardized mean difference(SMD)=-0.86,95% CI:-1.21 to-0.51,P<0.05,I^(2)=64%] and vomiting(RR=0.54,95% CI:0.42 to 0.69,P<0.05,I^(2)=35%;SMD=-1.28,95% CI:-1.52 to-1.03,P<0.05,I^(2)=92%),improve sleep disorders [mean difference(MD)=-3.39,95% CI:-3.95 to-2.84,P<0.05,I^(2)=0%],relieve pain(SMD=-1.58,95% CI:-1.96 to-1.21,P<0.05,I^(2)=0%),mitigate fatigue(SMD=-1.28,95% CI:-2.44 to-0.11,P<0.05,I^(2)=93%) and enhance quality of life(SMD=0.50,95% CI:0.22 to 0.79,P<0.05,I^(2)=0%) in cancer patients after radiotherapy and chemotherapy,but it may not have a significant effect on anxiety.The risk of bias was high in the included studies using the Cochrane Risk of Bias tool RoB2,and no studies were considered to be of high grade according to the GRADE system.Conclusions:Aromatherapy is an efficacious,safe and economic adjunctive therapy for cancer patien

关键词： aromatherapy cancer chemoradiotherapy physical psychological

Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases:Recent advancements and prospects

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World Journal of Stem Cells 2024年第2期16卷 70-88页

作者： Min Meng Wei-Wei Zhang shuang-Feng Chen Da-Rui Wang Chang-Hui zhou Department of Central Laboratory Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Clinical Laboratory Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide.For diverse disease con-ditions,the currently available approaches are focused on alleviating clinical symptoms and delaying disease progression but have not shown significant therapeutic effects in patients with lung diseases.Human umbilical cord-derived mesenchymal stem cells(UC-MSCs)isolated from the human UC have the capacity for self-renewal and multilineage differentiation.Moreover,in recent years,these cells have been demonstrated to have unique advantages in the treatment of lung diseases.We searched the Public Clinical Trial Database and found 55 clinical trials involving UC-MSC therapy for pulmonary diseases,including coronavirus disease 2019,acute respiratory distress syndrome,bron-chopulmonary dysplasia,chronic obstructive pulmonary disease,and pulmonary fibrosis.In this review,we summarize the characteristics of these registered clinical trials and relevant published results and explore in depth the challenges and opportunitiesfaced in clinical application.Moreover,the underlying mole-cular mechanisms involved in UC-MSC-based therapy for pulmonary diseases are also analyzed in depth.In brief,this comprehensive review and detailed analysis of these clinical trials can be expected to provide a scientific reference for future large-scale clinical application.

关键词： Pulmonary diseases Mesenchymal stem cells Human umbilical cord Cell therapy Clinical trials

Boson star superradiance

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Science China(Physics,Mechanics & Astronomy) 2024年第6期67卷 69-78页

作者： He-Yu Gao Paul M.Saffin Yi-Jie Wang Qi-Xin Xie shuang-Yong zhou School of Physical Sciences University of Science and Technology of ChinaHefei 230026China School of Physics and Astronomy University of NottinghamUniversity ParkNottingham NG72RDUK Interdisciplinary Center for Theoretical Study University of Science and Technology of ChinaHefei 230026China Peng Huanwu Center for Fundamental Theory Hefei 230026China

Recently,it has been realized that in some systems internal space rotation can induce energy amplification for scattered waves,similar to rotation in real space.In particularly,it has been shown that energy extraction is possible for a Q-ball,a stationary non-topological soliton that is coherently rotating in its field space.In this paper,we generalize the analysis to the case of boson stars,and show that the same energy extraction mechanism still works for boson stars.

关键词： superradiance boson star field space rotation