检索结果-南通市图书馆

Monte Carlo Simulation on Layered Polymeric Films

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2014年第5期32卷 595-602页

作者： Ru Xia Xiang-song Wu 陈鹏 Jia-sheng Qian xiao-shuang Feng Anhui Province Key Laboratory of Environment-friendly Polymer Materials School of Chemistry and Chemical Engineering Anhui University Eco-Efficient Product & Process Laboratory (E2P2L) UMI 3464 Research & Innovation Center in Shanghai (RICS) Solvay(China) Co. Ltd.

Thin films of polymer blends composed of alternating copolymer, diblock copolymer and/or homopolymer are studied using Monte Carlo simulation. A multilayer morphology is observed in the film, that is, the blended polymers assemble into individual domains arranged from interior to the surfaces of the film. The coexisting components residing throughout the neighboring domains in the film make no distinguishable interface between any neighboring domains. By this means, it forms a vertical composition gradient in the polymeric film. Being different from layer-by-layer deposition of polyelectrolyte or hydrogen bonding approach etc., the layered structure in this study is formed by polymer blending in one step. Alternating copolymers are found to be essential components to form vertical composition gradient （layered structure） in thin films.

关键词： Monte Carlo simulation Polymer blends Alternating copolymer Layered structure.

Insight into the dynamics of non-Newtonian Carreau fluid when viscous dissipation,entropy generation,convective heating and diffusion are significant

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 34-46页

作者： ZHOU shuang-shuang Muhammad Ijaz Khan Sami Ullah Khan Sumaira Qayyum School of Science Hunan City UniversityYiyang 413000China Department of Mechanical Engineering Prince Mohammad Bin Fahd UniversityP.O.Box1664Al-Khobar 31952Kingdom of Saudi Arabia Department of Mathematics Namal UniversityMianwali 42250Pakistan Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan

The investigation endorsed the convective flow of Carreau nanofluid over a stretched surface in presence of entropy generation optimization.The novel dynamic of viscous dissipation is utilized to analyze the thermal mechanism of magnetized flow.The convective boundary assumptions are directed in order to examine the heat and mass transportation of nanofluid.The thermal concept of thermophoresis and Brownian movements has been re-called with the help of Buongiorno model.The problem formulated in dimensionless form is solved by NDSolve MATHEMATICA.The graphical analysis for parameters governed by the problem is performed with physical applications.The affiliation of entropy generation and Bejan number for different parameters is inspected in detail.The numerical data for illustrating skin friction,heat and mass transfer rate is also reported.The motion of the fluid is highest for the viscosity ratio parameter.The temperature of the fluid rises via thermal Biot number.Entropy generation rises for greater Brinkman number and diffusion parameter.

关键词： heat generation surface reaction CNTs based nano uid stretching/shrinking sheet thermal radiation

Exponential Time Differencing Method for a Reaction-Diffusion System with Free Boundary

在线全文

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 354-371页

作者： shuang Liu Xinfeng Liu Department of Mathematics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCalifornia92093-0112USA Department of Mathematics University of South CarolinaColumbiaSouth Carolina29208USA

For reaction-diffusion equations in irregular domains with moving boundaries,the numerical stability constraints from the reaction and diffusion terms often require very restricted time step sizes,while complex geometries may lead to difficulties in the accuracy when discretizing the high-order derivatives on grid points near the boundary.It is very challenging to design numerical methods that can efficiently and accurately handle both difficulties.Applying an implicit scheme may be able to remove the stability constraints on the time step,however,it usually requires solving a large global system of nonlinear equations for each time step,and the computational cost could be significant.Integration factor(IF)or exponential time differencing(ETD)methods are one of the popular methods for temporal partial differential equations(PDEs)among many other methods.In our paper,we couple ETD methods with an embedded boundary method to solve a system of reaction-diffusion equations with complex geometries.In particular,we rewrite all ETD schemes into a linear combination of specificФ-functions and apply one state-of-the-art algorithm to compute the matrix-vector multiplications,which offers significant computational advantages with adaptive Krylov subspaces.In addition,we extend this method by incorporating the level set method to solve the free boundary problem.The accuracy,stability,and efficiency of the developed method are demonstrated by numerical examples.

关键词： Reaction diffusion equations Free boundary Integrating factor method Level set method

The thiazoylmethoxy modification on pyrazole oximes: Synthesis and insecticidal biological evaluation beyond acaricidal activity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2014年第7期25卷 1014-1016页

作者： Hong Dai Yan-shuang xiao Zhong Li xiao-Yong Xu Xu-Hong Qian Shanghai Key Laboratory of Chemical Biology School of PharmacyEast China University of Science and Technology College of Chemistry and Chemical Engineering Nantong University

A series of new pyrazole oximes bearing substituted thiazole ring were designed and prepared. The structures of the title compounds were identified by spectral analyses, The results of primary bioassay indicated that some targeted compounds exhibited promising insecticidal activity besides acaricidal activity, particularly; compounds 8c and 8d were more potent against Tetranychus cinnabarinus and Plutella xylostella than other analogues.

关键词： Pyrazole oxime Substituted thiazole Acaricidal activity Insecticidal activity

Efficacy of Solitaire AB stent-release angioplasty in acute middle cerebral artery atherosclerosis obliterative cerebral infarction

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第19期9卷 5028-5036页

作者： Xi-Feng Wang Ming Wang Gang Li Xue-Yu Xu Wei Shen Jing Liu shuang-shuang xiao Jiang-Hong Zhou Department of Neurology Puai HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430033Hubei ProvinceChina

BACKGROUND In both national and international studies,the safety and effectiveness of treatment with the Solitaire stent in patients with ischemic stroke caused by acute large vessel occlusion were good,and the disability rate was significantly reduced.However,there are currently only a few reports on the differences in endovascular treatment for different etiological classifications,especially in the anterior cranial circulation,aorta atherosclerotic stenosis,and acute thrombosis.AIM To investigate the efficacy of Solitaire AB stent-release angioplasty in patients with acute middle cerebral artery atherosclerosis obliterative cerebral infarction.METHODS Twenty-five patients with acute middle cerebral atherosclerosis obliterative cerebral infarction were retrospectively enrolled in this study from January 2017 to December 2019.The Solitaire AB stent was used to improve anterior blood flow to maintain modified cerebral infarction thrombolysis[modified thrombolysis in cerebral infarction(mTICI)]at the 2b/3 level or above,the stent was then unfolded and released.RESULTS All 25 patients underwent successful surgery,with an average recanalization time of 23 min.One patient died of cerebral hemorrhage and cerebral herniation after the operation.The National Institutes of Health Stroke Scale(NIHSS)scores immediately after surgery(7.5±5.6),at 24 h(5.5±5.6)and at 1 wk(3.6±6.7)compared with the preoperative NIHSS score(15.9±4.4),were significantly different(P<0.01).One case of restenosis was observed 3 mo after surgery(the stenosis rate was 50%without clinical symptoms),the modified Rankin scale scores were 0 points in 14 cases(56%),1 point in 4 cases(16%),2 points in 2 cases(8%),3 points in 3 cases(12%),4 points in 1 case(4%),and 6 points in 1 case(4%).CONCLUSION In acute middle cerebral artery atherosclerosis obliterative cerebral infarction,when the Solitaire AB stent is unfolded and the forward blood flow is maintained at mTICI level 2b/3 or higher,stent release may be a safe and effective treatment method;however,long

关键词： Stent angioplasty Atherosclerosis obliterative Acute cerebral infarction

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang shuang-shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-Xiang Huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular membrane.However,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based therapies.We co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple myeloma.Here we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated cytotoxicity.Crystallographic analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in solution.BCMA-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived cells.Our results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

Cumulative effects of excess high-normal alanine aminotransferase levels in relation to new-onset metabolic dysfunction-associated fatty liver disease in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第10期30卷 1346-1357页

作者： Jing-Feng Chen Zhuo-Qing Wu Hao-shuang Liu Su Yan You-Xiang Wang Miao Xing xiao-Qin Song Su-Ying Ding Health Management Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Institute of Systems Engineering Dalian University of TechnologyDalian 116024Liaoning ProvinceChina College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyLuoyang 471003Henan ProvinceChina

BACKGROUND Within the normal range,elevated alanine aminotransferase(ALT)levels are associated with an increased risk of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the associations between repeated high-normal ALT measurements and the risk of new-onset MAFLD prospectively.METHODS A cohort of 3553 participants followed for four consecutive health examinations over 4 years was selected.The incidence rate,cumulative times,and equally and unequally weighted cumulative effects of excess high-normal ALT levels(ehALT)were measured.Cox proportional hazards regression was used to analyse the association between the cumulative effects of ehALT and the risk of new-onset MAFLD.RESULTS A total of 83.13%of participants with MAFLD had normal ALT levels.The incidence rate of MAFLD showed a linear increasing trend in the cumulative ehALT group.Compared with those in the low-normal ALT group,the multivariate adjusted hazard ratios of the equally and unequally weighted cumulative effects of ehALT were 1.651[95%confidence interval(CI):1.199-2.273]and 1.535(95%CI:1.119-2.106)in the third quartile and 1.616(95%CI:1.162-2.246)and 1.580(95%CI:1.155-2.162)in the fourth quartile,respectively.CONCLUSION Most participants with MAFLD had normal ALT levels.Long-term high-normal ALT levels were associated with a cumulative increased risk of new-onset MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Cumulative effect Cox proportional hazards regression Cohort study

Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第17期9卷 4230-4237页

作者： xiao-shuang Zhou Yuan-Yue Lu Yan-Fang Gao Wen Shao Jia Yao College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030012Shanxi ProvinceChina Department of Nephrology The Affiliated People's Hospital of Shanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina Department of Gastroenterology Shanxi Bethune HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Azathioprine(AZA)and its close analog 6-mercaptopurine are thiopurines widely used in the treatment of patients with cancer,organ transplantation,and autoimmune or inflammatory diseases,including systemic lupus erythematosus.Bone marrow inhibition is a common side effect of AZA,and severe bone marrow inhibition is related to decreased thiopurine S-methyltransferase(TPMT)activity.CASE SUMMARY We herein report a patient with proliferative lupus nephritis who was using AZA for maintenance therapy,had no common TPMT pathogenic site mutations,and exhibited severe bone marrow inhibition on the 15th day after oral administration.CONCLUSION This report alerts physicians to the fact that even though the TPMT gene has no common pathogenic site mutation,severe myelosuppression may also occur.

关键词： Azathioprine Thiopurine S-methyltransferase Bone marrow inhibition Lupus nephritis Case report

大学生手机成瘾倾向与其体育锻炼情况的相关性研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代预防医学 2022年第3期49卷 487-491页

作者：肖爽信阳师范学院体育学院

目的调查分析大学生手机成瘾倾向与其体育锻炼的相关性,为采用体育锻炼手段防治大学生手机成瘾提供依据。方法采用方便抽样法对河南省某高校3 122名大学生的体育锻炼情况和手机成瘾倾向进行调查分析。结果 (1)河南省某高校大学生的手机... 详细信息

目的调查分析大学生手机成瘾倾向与其体育锻炼的相关性,为采用体育锻炼手段防治大学生手机成瘾提供依据。方法采用方便抽样法对河南省某高校3 122名大学生的体育锻炼情况和手机成瘾倾向进行调查分析。结果 (1)河南省某高校大学生的手机成瘾倾向总分平均为39.94±9.90,手机成瘾检出率为17.8%;(2)"喜欢体育锻炼"组、"体育锻炼6次以上/w"组、"每次锻炼持续时间61 min以上"组、"体育锻炼得大汗淋漓"组和"已经有了自己喜欢的运动项目"的学生的手机成瘾倾向总分、各维度得分均最低,手机成瘾的检出率也最低;(3)大学生的体育锻炼频度、锻炼持续时间、体育锻炼强度以及对体育锻炼的喜欢程度、对"已经有了自己喜欢的运动项目"的认可度与手机成瘾倾向总分及其各维度得分均呈负相关。结论 (1)河南省某高校大学生手机成瘾倾向处于中等水平;(2)体育锻炼可以作为干预大学生手机成瘾的一个手段。

关键词：手机成瘾体育锻炼大学生