检索结果-南通市图书馆

Ocular surface in patients with different degrees of myopia

International Journal of Ophthalmology(English edition) 2024年第7期17卷 1313-1321页

作者： Yan-Yun Lyu shuang Wang Xiao-Niao Chen Zhen-Yu Wang Shan-Shan Huang Yan Yuan Hong-shuang lu Wen-Li Yang Li-Ya Qiao Lei Tian Ying Jie Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University and Beijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Department of Ophthalmology the Third Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100039China Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan

AIM:To investigate the clinical features of the ocular surface in patients with different degrees of myopia.METHODS:A cross-sectional study was conducted involving 122 participants with myopia in Beijing Tongren Hospital from February to June,2023.After completing the Ocular Surface Disease Index(OSDI)score scale,measurements were taken for refraction,biometric parameters and ocular surface parameters.The prevalence,severity and related parameters of the dry eye among different groups based on axial length(AL)were compared.Correlation analysis was performed between ocular surface parameters and refraction/biometric measurement parameters.RESULTS:Statistically significant differences were observed in refractive error,corneal thickness,anterior chamber depth,and subfoveal choroidal thickness among the groups(all Pluorescein staining(CFS)points increased significantly(PluSION:AL elongation is a risk factor for dry eye onset in myopic participants.The longer the AL,the more severe the dry eye is,with the increased CFS spots and tear film instability.Additionally,SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.

关键词： myopia axial length ocular surface dry eye

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon honeycomb structure with high axial thermal transport and strong robustness

引用

稀有金属:英文版 2023年第8期42卷 2679-2687页

作者： Wei-Jun Ren shuang lu Cui-Qian Yu Jia He Jie Chen China-EU Joint Lab for Nanophononics MOE Key Laboratory of Advanced Micro-Structured MaterialsCenter for Phononics and Thermal Energy ScienceSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China

Thermal transport properties of low-dimensional nanomaterials are highly anisotropic and sensitive to the structural disorder,which can greatly limit their applications in heat dissipation.In this work,we unveil that the carbon honeycomb structures which have high in-plane thermal conductivity simultaneously possess high axial thermal conductivity.Based on non-equilibrium molecular dynamics simulations,we find that the intrinsic axial thermal conductivity of carbon honeycomb structure reaches 746 W·m^(-1)·K^(-1)at room temperature,comparable to that of good heat dissipation materials such as hexagonal boron nitride.By comparing the phonon transmission spectrum between carbon honeycombs and few layer graphene,the physical mechanism responsible for the high axial thermal conductivity of carbon honeycombs is discussed.More importantly,our simulation results further demonstrate that the high axial thermal conductivity of carbon honeycomb structure is robust to the structural disorder,which is a common issue during the mass production of the carbon honeycomb structure.Our study suggests that the carbon honeycomb structure has unique advantages to serve as the thermal management material for practical applications.

关键词： Carbon honeycomb Thermal conductivity Molecular dynamics simulation Phonon transmission Structural disorder

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

引用

Neural Regeneration Research 2022年第8期17卷 1761-1768页

作者： Wei-Tao Yan Yan-Di Yang Xi-Min Hu Wen-Ya Ning Lyu-shuang Liao shuang lu Wen-Juan Zhao Qi Zhang Kun Xiong Department of Neurobiology and Human Anatomy School of Basic Medical ScienceCentral South UniversityChangshaHunan ProvinceChina Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Human Resources Third Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Hunan Key Laboratory of Ophthalmology ChangshaHunan ProvinceChina

Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis,apoptosis and necroptosis act in consort in a multimeric protein complex,PANoptosome.This allows all the components of PANoptosis to be regulated simultaneously.PANoptosis provides a new way to study the regulation of cell death,in that different types of cell death may be regulated at the same time.To test whether PANoptosis exists in diseases other than infectious diseases,we chose cerebral ischemia/reperfusion injury as the research model,collected articles researching cerebral ischemia/reperfusion from three major databases,obtained the original research data from these articles by bibliometrics,data mining and other methods,then integrated and analyzed these data.We selected papers that investigated at least two of the components of PANoptosis to check its occurrence in ischemia/reperfusion.In the cell model simulating ischemic brain injury,pyroptosis,apoptosis and necroptosis occur together and this phenomenon exists widely in different passage cell lines or primary neurons.Pyroptosis,apoptosis and necroptosis also occurred in rat and mouse models of ischemia/reperfusion injury.This confirms that PANoptosis is observed in ischemic brain injury and indicates that PANoptosis can be a target in the regulation of various central nervous system diseases.

关键词： apoptosis brain central nervous system ischemia/reperfusion middle cerebral artery occlusion necroptosis oxygen and glucose deprivation PANoptosis pyroptosis regulated cell death

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The occurrence characteristics of oil in shales matrix from organic geochemical screening data and pore structure properties:An experimental study Author links open overlay panel

引用

Petroleum Science 2024年第1期21卷 1-13页

作者： Zi-Zhi Lin Jun-Qian Li shuang-Fang lu Qin-Hong Hu Peng-Fei Zhang Jun-Jie Wang Qi Zhi Hong-Sheng Huang Na Yin Yue Wang Tian-Chen Ge National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Sanya Offshore Oil&Gas Research Institute Northeast Petroleum UniversitySanya 572025HainanChina College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590ShandongChina

The occurrence characteristics of shale oil are of great significance to the movability of shale oil.In this study,the occurrence characteristics of oil in the shale matrix at Funing Formation shale in Subei Basin were quantitatively evaluated by organic geochemistry and microscopic pore structure characterization experiments.The Multiple Isothermal Stages Pyrolysis(MIS)experiment results show that the content of total oil,adsorbed oil,and free oil in the shales are 3.15-11.25 mg/g,1.41-4.95 mg/g,and 1.74-6.51 mg/g,respectively.among which the silicon-rich shale has the best oil-bearing.The relative content of free oil shows an increasing trend in pores with pore diameters greater than 3 nm.When the relative content of free oil reaches 100%,the pore size of silicon-rich shale is about 200 nm,while that of calcium-rich shale,clay-rich shale,and siliceous mixed shale is about 10 nm.The occurrence law of adsorbed oil is opposite to that of free oil,which indicates that shale oil will occur in the pores and fractures in a free state in a more extensive pore size range(>200 nm).This study also enables us to further understand the occurrence characteristics of shale oil under the interaction of occurrence state and occurrence space.

关键词： Shale oil Occurrence characteristics Sequential solvent extraction Low-temperature nitrogen adsorption Funing Formation Dongtai Depression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Rare primary colonic T cell lymphoma with curative resection by endoscopic submucosal dissection:A case report

引用

World Journal of Clinical Cases 2024年第22期12卷 5229-5235页

作者： Yu-Hui Sun shuang-shuang lu Ying Fang Zhe Xiong Qiu-Yue Sun Jin Huang Nanjing Medical University The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Gastroenterology Center The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Dalian Medical University The Affiliated Changzhou Second People's Hospital of Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND The gastrointestinal tract is a well-known extranodal site of lymphoma.B-cell lymph-oma is the most common type,while T-cell lymphoma is uncommon.Primary gastrointestinal lymphoma mainly occurs in the stomach and small intestine,and the colon is less frequently involved,especially in females.CASE SUMMARY A 45-year-old woman was admitted to our hospital for physical examination.Gastroenteroscopy revealed a visible pedunculated polyp in the transverse colon,for which endoscopic submucosal dissection(ESD)was performed.Pathology suggested highly active proliferation of T lymphocytes with atypical hyperplasia.CONCluSION A middle-aged female patient was found to have colonic T-cell lymphoma by endoscopy.The lesion was successfully removed by ESD,and the surgical margin was negative.It is essential to raise awareness of colonic T-cell lymphoma and choose the appropriate treatment.

关键词： Primary colorectal lymphoma T-cell lymphoma Endoscopic submucosal dissection Pedunculated polyp Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integration of Theory and Practice in Medical Morphology Curriculum in Postgraduate Training:A Flipped Classroom and Case-based Learning Exercise

引用

当代医学科学(英文) 2023年第4期43卷 741-748页

作者： Xi-min HU Zhi-xin LI Jing DENG Yang HAN shuang lu Qi ZHANG Zi-qiang luO Kun XIONG Department of Anatomy and Neurobiology School of Basic Medical ScienceCentral South UniversityChangsha 410000China Clinical Medicine Eight-year Program 02 Class18 GradeXiangya School of MedicineCentral South UniversityChangsha 410000China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410000China Department of Physiology School of Basic Medical ScienceCentral South UniversityChangsha 410008China Hunan Key Laboratory of Ophthalmology Changsha 410000China Key Laboratory of Emergency and Trauma Ministry of EducationCollege of Emergency and TraumaHainan Medical UniversityHaikou 016000China

Objective:The integration of training in theory and practice across the medical education spectrum is being encouraged to increase student understanding and skills in the sciences.This study aimed to determine the deciding factors that drive students'perceived advantages in class to improve precision education and the teaching model.Methods:A mixed strategy of an existing flipped classroom(FC)and a case-based learning(CBL)model was conducted in a medical morphology curriculum for 575 postgraduate students.The subjective learning evaluation of the individuals(learning time,engagement,study interest and concentration,and professional integration)was collected and analyzed after FC-CBL model learning.Results:The results from the general evaluation showed promising results of the medical morphology in the FC-CBL model.Students felt more engaged by instructors in person and benefited in terms of time-saving,flexible arrangements,and professional improvement.Our study contributed to the FC-CBL model in Research Design in postgraduate training in 4 categories:1)advancing a guideline of precision teaching according to individual characteristics;2)revealing whether a learning background is needed for a Research Design course to guide setting up a preliminary course;3)understanding the perceived advantages and their interfaces;and 4)barriers and/or improvement to implement the FC-CBL model in the Research Design class,such as a richer description of e-learning and hands-on practice.Conclusion:Undertaking a FC-CBL combined model could be a useful addition to pedagogy for medical morphology learning in postgraduate training.

关键词： flipped classroom case-based learning medical morphology curriculum research design postgraduate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein-based nanocarriers for efficient Etoposide delivery and cancer therapy

引用

Nano Research 2023年第8期16卷 11216-11220页

作者： Bo Wang Xiaoxiong Xu Bo Li Zheng Wei shuang lu Jingjing Li Kai Liu Hongjie Zhang Fan Wang Yang Yang Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200433China Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education)Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China School of Materials Science and Engineering Tongji UniversityShanghai 201804China

Etoposide,a DNA damage-inducing agent,is widely used for malignant tumors.However,insufficient solubility,poor bioavailability and adverse events limited the treatment outcomes and prognosis.To address this,we here developed a novel biosynthetic and unfolded protein nanocarrier to load and deliver Etoposide.Compared with the pristine agent,the loading efficiency of the nanoformulated drug increased four times and the half-life time increased to 17.6 h with controlled release of the Etoposide for 6 days.The half-maximal inhibitory concentration at 48 h was lower than that at 24 h,suggesting a long-acting anti-tumor property.Moreover,the anti-tumor performance in rat models was significantly enhanced by improving solubility and cellular internalization.Additionally,immunogenicity and adverse toxicologic effects such as kidney and liver toxicity were significantly weakened.Therefore,the assembly strategy enables etoposide with higher efficacy,bioavailability,and safety,and has great potential in the comprehensive treatment of malignant tumors.

关键词： Etoposide nanocarrier solubility cellular internalization malignant tumors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulatory perspectives of combination products

引用

Bioactive Materials 2022年第4期7卷 492-503页

作者： Jiaxin Tian Xu Song Yongqing Wang Maobo Cheng shuang lu Wei Xu Guobiao Gao Lei Sun Zhonglan Tang Minghui Wang Xingdong Zhang Center for Medical Device Evaluation National Medical Products AdministrationBeijingChina NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial&Institute of Regulatory Science for Medical Devices&NMPA Research Base of Regulatory Science for Medical Devices Sichuan UniversityChengduChina National Engineering Research Center for Biomaterials&College of Biomedical Engineering Sichuan UniversityChengduChina Center for Drug Evaluation National Medical Products AdministrationBeijingChina

Combination products with a wide range of clinical applications represent a unique class of medical products that are composed of more than a singular medical device or drug/biological product.The product research and development,clinical translation as well as regulatory evaluation of combination products are complex and challenging.This review firstly introduced the origin,definition and designation of combination products.Key areas of systematic regulatory review on the safety and efficacy of device-led/supervised combination products were then presented.Preclinical and clinical evaluation of combination products was discussed.Lastly,the research prospect of regulatory science for combination products was described.New tools of computational modeling and simulation,novel technologies such as artificial intelligence,needs of developing new standards,evidence-based research methods,new approaches including the designation of innovative or breakthrough medical products have been developed and could be used to assess the safety,efficacy,quality and performance of combination products.Taken together,the fast development of combination products with great potentials in healthcare provides new opportunities for the advancement of regulatory review as well as regulatory science.

关键词： Combination products Definition Designation Safety and efficacy Regulatory science

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collective cell behaviors manipulated by synthetic DNA nanostructures

引用

Fundamental Research 2023年第5期3卷 809-812页

作者： Xiaochen Wang Xiwen Xing shuang lu Guangle Du Yi Zhang Yubin RenYulong Sun Jing Sun Qihui Fan Kai Liu Fan Wang Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China Department of Biotechnology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Organic Chemistry I University of UlmAlbert-Einstein-Allee 1189081 UlmGermany Songshan Lake Materials Laboratory Dongguan 523808China

Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound healing.The development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical applications.Here a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were investigated.We found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape factor.These DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape factor.Our results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic intervention.This may provide a new chemical strategy for tissue engineering and tumor therapy.

关键词： DNA materials Nanomaterial Cell monolayer Collective motion Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus

引用

Zoological Research 2021年第1期42卷 28-42页

作者： Chuan-Ling Zhang Yi-Jia Li shuang lu Ting Zhang Rui Xiao Huai-Rong luo State Key Laboratory of Phytochemistry and Plant Resources in West China Yunnan Key Laboratory of Natural Medical ChemistryKunming Institute of Botanythe Chinese Academy of SciencesKunmingYunnan 650201China School of Pharmacy Inner Mongolia Medical UniversityHuhhotInner Mongolia 010110China University of the Chinese Academy of Sciences Beijing 100049China Key Laboratory of Molecular Pathology Inner Mongolia Medical UniversityHuhhotInner Mongolia 010059China Key Laboratory for Aging and Regenerative Medicine Department of PharmacologySchool of PharmacySouthwestern Medical UniversityLuzhouSichuan 646000China

Depression is a prevalent mental disorder that is associated with aging and contributes to increased mortality and morbidity.The overall prevalence of geriatric depression with clinically significant symptoms is currently on the rise.Recent studies have demonstrated that altered expressions of long non-coding RNAs(lncRNAs)in the brain affect neurodevelopment and manifest modulating functions during the depression.However,most lncRNAs have not yet been studied.Herein,we analyzed the transcriptome of dysregulated lncRNAs to reveal their expressions in a mouse model exhibiting depressive-like behaviors,as well as their corresponding response following antidepressant fluoxetine treatment.A chronic unpredictable mild stress(CUMS)mouse model was applied.A sixweek fluoxetine intervention in CUMS-induced mice attenuated depressive-like behaviors.In addition,differential expression analysis of lncRNAs was performed following RNA-sequencing.A total of 282 lncRNAs(134 up-regulated and 148 down-regulated)were differentially expressed in CUMS-induced mice relative to non-stressed counterparts(Pluoxetine intervention.Gene Ontology(GO)analyses showed an association between significantly dysregulated lncRNAs and protein binding,oxygen binding,and transport activity,while the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis indicated that these dysregulated lncRNAs might be involved in inflammatory response pathways.Fluoxetine effectively ameliorated the symptoms of depression in CUMS-induced mice by regulating the expression of lncRNAs in the hippocampus.The findings herein provide valuable insights into the potential mechanism underlying depression in elderly people.

关键词： Depression Elderly Fluoxetine LncRNA Chronic unpredictable mild stress

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：