检索结果-南通市图书馆

Dual-functional poly(2-methyl-2-oxazoline)/poly(2-(dimethylamine)ethyl methacrylate)mixed brushes with switchable protein adsorption and antibacterial properties

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of chemical engineering 2024年第2期66卷 19-30页

作者： Kang he Liangyu Zhu Yanmei Wang CAS Key Laboratory of Soft Matter chemistry Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefei 230026China

herein,binary mixed brushes consisting of poly(2-methyl-2-oxazoline)(PMOXA)and poly(2-(dimethylamine)ethyl methacrylate)(PDMAeMA)with different chain lengths were fabricated by successive grafting of NH_(2)-terminated PMOXA and SH-terminated PDMAeMA onto polydopamine-anchored *** mixed-brush coating was characterized by variable-angle spectroscopic ellipsometry,X-ray photoelectron spectroscopy,Fourier transform infrared spectroscopy,zeta potential measurements,water contact angle,and atomic force *** mixed brushes showed tunable surface charge,wettability,and surface roughness,depending on the degree of PDMAeMA swelling under varying pH and ionic strength(Ⅰ).Then the adsorption behaviors of pepsin,bovine serum albumin(BSA),γ-globulin,and lysozyme,four very different proteins with regard to isoelectric point,on the mixed brushes coating were studied by using fluorescence microscopy and surface plasmon *** the chain length of PDMAeMA was about twice as long as PMOXA,the mixed brushes not only had high adsorption capacity for pepsin,BSA,and y-globulin but also had a desorption efficiency of 86.9%,87.1%,and 93.5%,*** is explained that electrostatic attraction between the protonated PDMAeMA and positively charged acidic proteins(pepsin and BSA,whose isoelectric points were below the pK_(a) of PDMAeMA)would drive the intensive adsorption(at pH 3,I=10^(-3)mol·L^(-1)for pepsin,and pH 5,I=10^(-5)mol·L^(-1)for BSA),while desorption was dominated by the hydrophilic PMOXA when PDMAeMA was shrinking(at pH 7,I=10^(-1)mol·L^(-1)for pepsin,and pH 9,I=10^(-1)mol·L^(-1)for BSA).Furthermore,the isoelectric precipitation led to the adsorption of neutral protein(γ-globulin,whose isoelectric point was near the pK_a of PDMAeMA)at pH 7,I=10^(-5)mol·L^(-1),while electrostatic repulsion and antifouling PMOXA triggered the desorption of y-globulin at pH 3,I-10^(-1)mol·L^(-1).However,alkaline protein(lysozyme,whose isoelectric point was higher than

关键词： Switchable conformation transition Controllable protein adsorption Mixed brushes Isoelectric point Antibacterial surface

ZIF-90-loaded DNAzyme-responsive PROTAC for the self-powered degradation of NF-κB

在线全文

学校读者我要写书评

暂无评论

Science China chemistry 2024年

作者： Min Hou Liang Sun Tianyu Ren Mingda Li Chao Hu Rong Liu shuang Gu Mingyan Jiang Jianhui Jiang Jianjun he College of Physics and chemistry Hunan First Normal University hunan Provincial Key Laboratory of Animal Models and Molecular Medicine College of Biomedical Sciences College of Chemistry and Chemical Engineering Hunan University Xiangtan Central Hospital

Transcription factors(TFs) play vital roles in regulating gene expressions. Dysregulated or mutated TFs are implicated in a wide array of diseases, highlighting their potential as drug targets. However, TFs are considered undruggable by conventional inhibitor-based modalities. The recently emerged proteolysis targeting chimeras(PROTACs) have exhibited great potential in tackling TFs. In particular, DNA-ligand chimeras that arm e3 ligase-recruiting ligands to TF-binding double-strand DNA represent a promising strategy for the targeted proteolysis of TFs. here, we report a DNAzyme-inducible PROTAC(DzTAC)that selectively degrades NF-κB in a zinc ion-dependent manner. We further applied zinc-imidazolate metal–organic framework-90(ZIF-90) to encapsulate DzTAC(ZIF-90@DzTAC), facilitating its delivery into cancer cells while self-supplying Zn2+via adenosine triphosphate(ATP)-triggered ZIF-90 dissociation. Moreover, ZIF-90@DzTAC can enhance the treatment efficacy of doxorubicin-based chemotherapy in tumor-bearing mice. The developed DzTAC provides specific modulation over TF activity and opens an avenue for more functional nucleic acid-based control over targeted protein degradation.

关键词：

SYNTheSIS AND CHARACTeRIZATION OF A NOVeL BLUe LIGHT eMITTING ROD-COIL DIBLOCK OLIGOMeR

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2002年第5期20卷 401-407页

作者： Lifang Yang Haifeng he Hongqing Cao Xinhua Wan Qi-feng Zhou department of Polymer Science & engineering College of chemistry & Molecular engineering Peking university Beijing 100871, China department of Polymer Science & engineering College of Chemistry & Molecular Engineering Peking University 北京 100871 department of Polymer Science & engineering College of Chemistry & Molecular Engineering Peking University 北京 100871

Four new rod-coil diblock molecules, which had well-defined para-phenylene oligomers (PPP, from biphenyl to quinquephenyl) as rigid segments and poly(ethylene oxide) (PeO, M-w ca. 750) as flexible segments, were synthesized. The chemical structure and the number of repeating unit in PeO coil and PPP rod were characterized by H-1-NMR and MALDI-TOF mass spectrometry. The diblock oligomers showed good solubility in common organic solvents and aggregated in water as characterized by a blue shift in UV-vis absorption spectra, a red shift in emission spectra, quenching of the fluorescence and formation of the microfibrilla and fractal-like structures. The formation of different supramolecular structures meant that this effort might lead to commercial important highly organized functional materials.

关键词： rod-coil diblock oligomer MALDI-TOF mass spectrometry microfibrilla aggregate fractal-like pattern

exploring the Predominant Factors Influencing the Oxygen Reduction Performance of PtCo/C Catalysts

在线全文

学校读者我要写书评

暂无评论

chemical Research in Chinese Universities 2024年第4期40卷 753-760页

作者： LI Jinrong YU Xianghui SUN Qi PeNG Yong CAO shuang HOU Chun-Chao XU Qiang College of chemistry and chemical engineering Institute for Sustainable Energy and ResourcesQingdao UniversityQingdao266071P.R.China Leibniz Institute for Catalysis e.V. Albert-Einstein-Strasse 29aRostock18059Germany School of Materials Science and engineering Ocean University of ChinaQingdao266100P.R.China Shenzhen Key Laboratory of Micro/Nano-Porous Functional Materials(SKLPM) SUSTech-Kyoto University Advanced Energy Materials Joint Innovation Laboratory(SKAEM-JIL)Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of GuangdongDepartment of Chemistry and Department of Materials Science and EngineeringSouthern University of Science and Technology(SUSTech)Shenzhen518055P.R.China

PtCo nanoalloys(NAs)deposited on carbon black are emerging as robust electrocatalysts for addressing the sluggish kinetic issue of oxygen reduction reaction(ORR).However,developing a simple and low-cost method to synthesize PtCo/C with excellent performance is still a great *** this work,a one-pot method was used to successfully obtain the PtCo NAs on commercial carbon supports of acetylene black and Ketjenblack eCP600JD,*** with those grown on Ketjenblack eCP600JD,the PtCo NAs grown on acetylene black exhibited higher electrochemical surface area(eCSA)and mass activity(MA),which may be attributed to the different particle sizes of PtCo NAs,distinct hydrophilicity,electroconductivity and charge distribution between the carbon supports and PtCo *** study provides valuable insights into the optimal design of carbon-supported ORR electrocatalysts with exceptional activity and durability.

关键词： Oxygen reduction reaction PtCo nanoalloy Carbon-supported nanostructure Acetylene black

effect of Templates on the Structure and Stability of Ti-TMS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese chemical Letters 1999年第3期10卷 267-268页

作者： Qing DAI Nong Yue he Xing Li WANG Xun Wei SheN Yan GUO Chun Wei YUANI(National Laboratory of Molecular and Biomolecular electronics)(department of chemistry and chemical engineering, Southeast university, Naming 210096) Natl. Lab. Molec. Biomol. e. Southeast University Nanjing 210096 China Dept. of Chem. and Chem. engineering Southeast University Nanjing 210096 China

Pure Mesoporous TiO2 molecular sieves (Ti-TMS) were synthesized with different templates for the first time and the templates can be successfully removed by refluxing the samples in the etOH/H2O/KOH solution. The XRD pattern and TeM confirm that the uniformity and stability of Ti-TMS2 synthesized with dodecylamine as template is obviously inferior to that of Ti-TMS1 prepared with dodecylphosphate and hexadecylphosphate as templates. Furthermore, after the templates were removed, the mesostructure of Ti-TMS1 was preserved to a great degree than that of Ti-TMS2.

关键词： TiO2 mesoporous molecular sieves template

Oxidative Methylation of Toluene with Methane over Basic Zeolite Catalysts Promoted with Alkali Metal Bromides and Alkali Metal Oxides

在线全文

学校读者我要写书评

暂无评论

Chinese chemical Letters 2000年第9期11卷 827-830页

作者： Ling Ping ZHOU Wei LI Ke Yi TAO Xuan Wen LI he Xuan LI College of chemistry and Molecular engineering, Peking university, Beijing 100871 department of chemistry, Nankai university, Tianjin 300071 Coll. of Chem. and Molec. eng. Peking University Beijing 100871 China department of chemistry Nankai University Tianjin 300071 China

The catalytic effects for the oxidative methylation of toluene with methane over the basic zeolite catalysts prepared by promoting KY, KX, KM, KZSM-5 or KP with alkali-metal bromides and alkali-metal oxides have been investigated comparatively. The alkali-metal bromides promoted substrates are more effective than the alkali-metal oxides promoted systems. Moreover, the NaBr promoted systems are more active than KBr promoted systems. The most effective catalytic system (8wt%NaBr)/KZSM-5 gave a toluene conversion as high as 76.3% and a total C-8 selectivity of 76.4% (styrene/ethylbenzene=9.76) resulting in a total C-8 yield of 58.3%.

关键词： styrene methane oxidative methylation alkali-metal oxides alkali-metal bromides

长链烷基(2-羟乙基)二甲基氯化铵用作分析增敏试剂

在线全文

学校读者我要写书评

暂无评论

高等学校化学学报 1989年第4期10卷 364-368页

作者：谢晖俞汝勤湖南大学化学化工系

合成了3种含季氮原子及羟基的同系列分析增敏试剂十六烷基(2-羟乙基)二甲基氯化铵(heMAC)、十四烷基(2-羟乙基)二甲基氯化铵(TeMAC)和十二烷基(2-羟乙基)二甲基氯化铵(DeMAC),测试其基本物性,并用作测定微量钪、铁(Ⅲ)、锗的增敏试剂,... 详细信息

合成了3种含季氮原子及羟基的同系列分析增敏试剂十六烷基(2-羟乙基)二甲基氯化铵(heMAC)、十四烷基(2-羟乙基)二甲基氯化铵(TeMAC)和十二烷基(2-羟乙基)二甲基氯化铵(DeMAC),测试其基本物性,并用作测定微量钪、铁(Ⅲ)、锗的增敏试剂,获得了与阳离子表面活性剂及醇类有机溶剂联用时相仿的增敏效果。

关键词：胶束增敏剂 heMAC TeMAC DeMAC

STUDY ON The CATALYTIC ReACTION OF ACeTONe TO DIACeTONe ALCOHOL

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Catalysis 1996年第5期 121-126页

作者： Sun Hongwei, he Fei, Xu Genhui *, Ma Xinbin (department of chemical engineering, Tianjin university, Tianjin 300072)

ＳＴＵＤＹＯＮＴＨＥＣＡＴＡＬＹＴＩＣＲＥＡＣＴＩＯＮＯＦＡＣＥＴＯＮＥＴＯＤＩＡＣＥＴＯＮＥＡＬＣＯＨＯＬＳｕｎＨｏｎｇｗｅｉ，ＨｅＦｅｉ，ＸｕＧｅｎｈｕｉ＊，ＭａＸｉｎｂｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃ... 详细信息

ＳＴＵＤＹＯＮＴＨＥＣＡＴＡＬＹＴＩＣＲＥＡＣＴＩＯＮＯＦＡＣＥＴＯＮＥＴＯＤＩＡＣＥＴＯＮＥＡＬＣＯＨＯＬＳｕｎＨｏｎｇｗｅｉ，ＨｅＦｅｉ，ＸｕＧｅｎｈｕｉ＊，ＭａＸｉｎｂｉｎ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｃａｌＥｎｇｉｎｅｒｉｎｇ，Ｔｉａｎ...

关键词： Anion exchange resin Aldol condensation Acetone Diacetone alcohol

Nitric oxide assists nitrogen reduction reaction on 2D MBene: A theoretical study

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese chemical Letters 2024年第5期35卷 428-433页

作者： Chaozheng he Jia Wang Ling Fu Wei Wei henan engineering Center of New energy Battery Materials College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiu 476000China School of chemistry and chemical engineering Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage&Novel Cell TechnologyLiaocheng UniversityLiaocheng 252059China Institute of environment and energy Catalysis Shaanxi Key Laboratory of Optoelectronic Functional Materials and DevicesSchool of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’an 710021China College of Resources and environmental engineering Tianshui Normal UniversityTianshui 741001China

electrocatalytic synthesis of ammonia as an environment-friendly and sustainable development method has received widespread attention in recent ***-dimensional(2D)materials are a promising catalyst for ammonia synthesis due to their large surface *** this work,we have constructed a series of 2D metal borides(MBenes)with transition metal(TM)defects(TMd-MBenes)and comprehensively calculated the reactivity of electrocatalytic synthesis of ammonia-based on density functional *** results have demonstrated that the TMd-MBenes can effectively activate nitrogen oxide(NO)and nitrogen(N2)molecules *** interesting,the co-chemisorption of O atoms,dissociated from NO,can facilitate the spilled of the inert N2 molecules into single N atoms,which can further hydrogenate into ammonia easily with an ultralow limiting potential of 0.59 V on *** research has not only provided clues for catalyst design for experimental study but also paved the way for the industrial application of electrocatalytic ammonia synthesis.

关键词： 2D mbenes Nitrogen electro-reduction DFT N_(2)activation Ammonia synthesis