检索结果-南通市图书馆

Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitors selitrectinib and repotrectinib

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第2期14卷 517-532页

作者： shuang Xiang Xiaoyun Lu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education(MOE) Guangdong Provincial Key Laboratory of New Drug Design and EvaluationGuangzhou City Key Laboratory of Precision Chemical Drug DevelopmentSchool of PharmacyJinan UniversityGuangzhou 510632China

Neurotrophic receptor kinase(NTRK) fusions are actionable oncogenic drivers of multiple pediatric and adult solid tumors,and tropomyosin receptor kinase(TRK) has been considered as an attractive therapeutic target for "pan-cancer" harboring these fusions.Currently,two generations TRK inhibitors have been developed.The representative second-generation inhibitors selitrectinib and repotrectinib were designed to overcome clinic acquired resistance of the first-generation inhibitors larotrectinib or entrectinib resulted from solvent-front and gatekeeper on-target mutations.However,xDFG(TRKAG667C/A/S,homologous TRKCG696C/A/S) and some double mutations still confer resistance to selitrectinib and repotrectinib,and overcoming these resistances represents a major unmet clinical need.In this review,we summarize the acquired resistance mechanism of the first-and second-generation TRK inhibitors,and firstly put forward the emerging selective type Ⅱ TRK inhibitors to overcome xDFG mutations mediated resistance.Additionally,we concluded our perspectives on new challenges and future directions in this field.

关键词： NTRK fusions TRK kinase Clinical resistance xDFG mutations Selective type II inhibitors

Rational Solutions of First Order Algebraic Ordinary Differential Equations

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第2期37卷 567-580页

作者： FENG shuang SHEN Liyong School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Let f(t,y,y')=∑ _(i=0)^(n )a_(i)(t,y)y'^(i)=0 be an irreducible first order ordinary differential equation with polynomial coefficients.Eremenko in 1998 proved that there exists a constant C such that every rational solution of f(t,y,y')=0 is of degree not greater than C.Examples show that this degree bound C depends not only on the degrees of f in t,y,y' but also on the coefficients of f viewed as the polynomial in t,y,y'.In this paper,the authors show that if f satisfies deg(f,y)0,then the degree bound C only depends on the degrees of f in t,y,y',and furthermore we present an explicit expression for C in terms of the degrees of f in t,y,y'.

关键词： Degree bound first order AODE height rational solution

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： Yu-Hua Zhang Zhi-Hua Xu shuang-shuang Ni Hong-Xia Luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic procedures.Gastroscopy is the gold standard for the diagnosis of peptic ulcer,but it is an invasive procedure.Gastrointestinal contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and safe.AIM To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in children.METHODS We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June 2022.All children were examined by routine ultrasound,gastrointestinal CEUS,and gastroscopy.The pathological results of gastroscopy were taken as the gold standard.Routine ultrasonography was performed before gastrointestinal CEUS.Conventional ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal cavity.Gastrointestinal CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal cavity.The results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal CEUS.All children received informed consent from their guardians for CEUS.This study was reviewed and approved by the hospital medical ethics committee.RESULTS Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by gastroscopy.There were 26 children with nonpeptic ulcer.There were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional ultrasound.The diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanced ultrasound and gastroscope is low.Fifteen cas

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

Partially-Observed Maximum Principle for Backward Stochastic Differential Delay Equations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1524-1526页

作者： shuang Wu Department of Applied Mathematics China University of PetroleumQingdao 266580China

Dear Editor,This letter investigates a partially-observed optimal control problem for backward stochastic differential delay equations(BSDDEs).By utilizing Girsanov’s theory and convex variational method,we obtain a maximum principle on the assumption that the state equation contains time delay and the control domain is convex.The adjoint processes can be represented as the solutions of certain time-advanced stochastic differential equations in finite-dimensional spaces.Linear backward stochastic differential equation(BSDE)was first introduced by Bismut in[1],while general BSDE was given by Pardoux and Peng[2].Since then,the theory of BSDEs developed rapidly.The corresponding optimal control problems,whose states are driven by BSDEs,have also been widely studied by some authors,see[3]-[5].

关键词： stochastic backward convex

维普期刊数据库博看期刊

Creep damage evolution process of asphalt binder based on viscoelastic characteristics

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 497-506页

作者： Xiaofei Qi shuang Tian Liyan Shan shuang Liu Yajie Wang School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China College of Water Conservancy&Architectural Engineering Shihezi UniversityShihezi 832003China

The creep damage evolution of asphalt binder plays a significant role in investigating the formation mechanism of rutting.The rutting is the common distress at high temperatures for asphalt pavements.However,the reliability of existing creep damage parameters is under questioned,and these parameters cannot accurately illustrate the change of intrinsic microstructure for asphalt binder.In this paper,a new test protocol was given access to study the evolution of viscoelastic parameters during creep damage.It was completed by inserting the frequency sweep during creep test.The frequency sweep curve clusters were fitted by the generalized Kelvin-Voigt model for obtaining the change law of model parameters.Based on the change law and sensitivity analysis of model parameters,(E_(2)+E_(3))/2 was proposed as the creep damage variable.According to the curve of(E_(2)+E_(3))/2 versus loading time,two stages during the creep test could be identified:an approximate constant value in phase I and a linear decrease in phase II.Intrinsic differences about creep property of binders could be determined by this new proposed parameter.Above results not only ensure better understanding of the creep damage mechanism of binders,but also lay the theoretical foundation on predicting the anti-rutting performance of binders.

关键词： Asphalt binder Multi-stage creep test Damage variable Evolution law

Insight into the dynamics of non-Newtonian Carreau fluid when viscous dissipation,entropy generation,convective heating and diffusion are significant

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 34-46页

作者： ZHOU shuang-shuang Muhammad Ijaz Khan Sami Ullah Khan Sumaira Qayyum School of Science Hunan City UniversityYiyang 413000China Department of Mechanical Engineering Prince Mohammad Bin Fahd UniversityP.O.Box1664Al-Khobar 31952Kingdom of Saudi Arabia Department of Mathematics Namal UniversityMianwali 42250Pakistan Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan

The investigation endorsed the convective flow of Carreau nanofluid over a stretched surface in presence of entropy generation optimization.The novel dynamic of viscous dissipation is utilized to analyze the thermal mechanism of magnetized flow.The convective boundary assumptions are directed in order to examine the heat and mass transportation of nanofluid.The thermal concept of thermophoresis and Brownian movements has been re-called with the help of Buongiorno model.The problem formulated in dimensionless form is solved by NDSolve MATHEMATICA.The graphical analysis for parameters governed by the problem is performed with physical applications.The affiliation of entropy generation and Bejan number for different parameters is inspected in detail.The numerical data for illustrating skin friction,heat and mass transfer rate is also reported.The motion of the fluid is highest for the viscosity ratio parameter.The temperature of the fluid rises via thermal Biot number.Entropy generation rises for greater Brinkman number and diffusion parameter.

关键词： heat generation surface reaction CNTs based nano uid stretching/shrinking sheet thermal radiation

Exponential Time Differencing Method for a Reaction-Diffusion System with Free Boundary

在线全文

学校读者我要写书评

暂无评论

Communications on Applied Mathematics and Computation 2024年第1期6卷 354-371页

作者： shuang Liu Xinfeng Liu Department of Mathematics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCalifornia92093-0112USA Department of Mathematics University of South CarolinaColumbiaSouth Carolina29208USA

For reaction-diffusion equations in irregular domains with moving boundaries,the numerical stability constraints from the reaction and diffusion terms often require very restricted time step sizes,while complex geometries may lead to difficulties in the accuracy when discretizing the high-order derivatives on grid points near the boundary.It is very challenging to design numerical methods that can efficiently and accurately handle both difficulties.Applying an implicit scheme may be able to remove the stability constraints on the time step,however,it usually requires solving a large global system of nonlinear equations for each time step,and the computational cost could be significant.Integration factor(IF)or exponential time differencing(ETD)methods are one of the popular methods for temporal partial differential equations(PDEs)among many other methods.In our paper,we couple ETD methods with an embedded boundary method to solve a system of reaction-diffusion equations with complex geometries.In particular,we rewrite all ETD schemes into a linear combination of specificФ-functions and apply one state-of-the-art algorithm to compute the matrix-vector multiplications,which offers significant computational advantages with adaptive Krylov subspaces.In addition,we extend this method by incorporating the level set method to solve the free boundary problem.The accuracy,stability,and efficiency of the developed method are demonstrated by numerical examples.

关键词： Reaction diffusion equations Free boundary Integrating factor method Level set method

Research progress in spasmodic torticollis rehabilitation treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第7期12卷 1205-1214页

作者： shuang Zhang Ni Zeng shuang Wu Hui-Hui Wu Mo-Wei Kong Department of Rehabilitation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550018Guizhou ProvinceChina Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

Spasmodic torticollis(ST)is a focal dystonia that affects adults,causing limited muscle control and impacting daily activities and quality of life.The etiology and curative methods for ST remain unclear.Botulinum toxin is widely used as a firstline treatment,but long-term usage can result in reduced tolerance and adverse effects.Rehabilitation therapy,with its minimal side effects and low potential for harm,holds significant clinical value.This article explores the effectiveness of adjunctive therapies,including exercise therapy,transcranial magnetic stimulation,shockwave therapy,neuromuscular electrical stimulation,vibration therapy,electromyographic biofeedback,and acupuncture,in the treatment of ST.The aim is to provide clinicians with additional treatment options and to discuss the efficacy of rehabilitation therapy for ST.

关键词： Spasmodic torticollis Rehabilitation therapy Botulinum toxin Exercise therapy Adjunctive therapy Effectiveness

Magnetically controllable multimode interference in topological photonic crystals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第5期13卷 998-1005页

作者： Weiyuan Tang Mudi Wang Shaojie Ma Che Ting Chan shuang Zhang New Cornerstone Science Laboratory Department of PhysicsThe University of Hong KongHong KongChina. Department of Physics The Hong Kong University of Science and TechnologyHong KongChina. Department of Optical Science and Engineering Fudan UniversityShanghai 200433China

Topological photonic insulators show promise for applications in compact integrated photonic circuits due to their ability to transport light robustly through sharp bendings.The number of topological edge states relies on the difference between the bulk Chern numbers across the boundary,as dictated by the bulk edge correspondence.The interference among multiple topological edge modes in topological photonics systems may allow for controllable functionalities that are particularly desirable for constructing reconfigurable photonic devices.In this work,we demonstrate magnetically controllable multimode interference based on gyromagnetic topological photonic insulators that support two unidirectional edge modes with different dispersions.We successfully achieve controllable power splitting in experiments by engineering multimode interference with the magnetic field intensity or the frequency of wave.Our work demonstrates that manipulating the interference among multiple chiral edge modes can facilitate the advancement of highly efficient and adaptable microwave devices.

关键词： multimode controllable microwave