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Effect of blockage of costimulatory signal on murine abortion-prone model

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Chinese Medical j.urnal 2007年第14期120卷 1247-1250页

作者： ZHAO Fu-xi ZHANG Yuan-yuan LIU Run-hua LI shuan-ming Laboratory of Pathogenic Organism and Immunology Medical College of Shanxi Datong University Datong 037008 China Laboratory of Surgery Medical College of Shanxi Datong University Datong 037008 China

Background Inhibition of the key costimulatory signals results in T cell anergy, indicating the alloantigen-specific immunologic unresponsiveness. In this study, the effect of blockage of costimulatory signal CD86 on murine abortion-prone model was studied. Methods Thirty CBA/j.female mice cohabitated with DBA/2 male or BALB/c male mice were investigated. CBNj.xDBN2 matings were used as the abortion-prone model, and CBA/j.× BALB/c matings were used as the normal pregnant model. The abortion-prone models were divided into experimental and control groups, and the normal pregnant models were set as a normal group （10 mice in each group）. The mice in the experimental group were treated with anti-mouse CD86 monoclonal antibody （mAb）（100 μg） on day 4.5 of gestation, while the controls received irrelevant-isotype matched rat IgG2b. As for the normal group, nothing was given to the mice. The mice were killed on day 13.5 of gestation, embryo resorption rate and the expression of transforming growth factor β1 （TGF-β1）, plasminogen activator inhibitor 1 （PAI-1）, and matrix metalloproteinase 9 （MMP-9） were detected. Then the data were analyzed by Chi-square test and Fisher＇s exact test. Results The embryo resorption rate in the experimental （8.2%） and normal groups （7.7%） was significantly lower than that of the control （23.5%, P〈0.05）. No significant difference was detected between the experimental and normal groups （P〉0.05）. The positive expression rates of TGF-β1 and PAl-1 proteins in the experimental and normal groups were significantly higher than those in the control group （P〈0.05）. The positive expression rate of MMP-9 protein in the experimental and normal groups was significantly lower than that in the control group （P〈0.05）. No significant difference in the positive expression rates of the three proteins was detected between the experimental and normal groups （P〉0.05）. Conclusions Blockage of costimulatory signal CD86 at early pregnancy can treat uncertain recu

关键词： abortion embryo immunity pregnancy

福建省2009—2023年登革热流行病学特征

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中国热带医学 2024年第8期24卷 942-947页

作者：谢忠杭吴生根祝寒松黄文龙林嘉威李玲芳欧剑鸣福建省疾病预防控制中心应急处置与疫情管理所福建省人兽共患病研究重点实验室福建福州350001

目的分析2009—2023年福建省登革热发病趋势和流行特征,探索高发人群和热点区域,为制定针对性防控措施提供科学依据。方法从中国疾病预防控制信息系统收集2009—2023年福建省登革热监测资料,采用描述性流行病学方法进行分析,并对各县(区... 详细信息

目的分析2009—2023年福建省登革热发病趋势和流行特征,探索高发人群和热点区域,为制定针对性防控措施提供科学依据。方法从中国疾病预防控制信息系统收集2009—2023年福建省登革热监测资料,采用描述性流行病学方法进行分析,并对各县(区)发病率进行空间自相关分析。结果2009—2023年福建省登革热共报告发病3586例,年均发病率为0.61/10万,疫情总体呈逐年上升趋势(Z=18.35,P<0.001)。其中本地病例2362例、输入病例1224例,本地/输入比为1.93∶1(2362∶1224)。本地病例主要分布在福州市、莆田市和南平市,合计占87.81%(2074/2362);输入病例主要分布在泉州市、福州市和厦门市,合计占72.55%(888/1224)。本地/输入比,福州市、南平市和莆田市分别为6.20∶1(1557∶251)、3.92∶1(145∶37)、3.32∶1(372∶112),均高于全省平均水平。本地疫情空间分布呈聚类模式,有12个发病热点区域,均为福州市所辖县区。发病具有明显季节性:境外输入以7—9月(占45.73%,519/1135)为主,省外输入以8—11月(占93.25%,83/89)为主,本地病例以8—10月(占97.50%,2303/2362)为主。本地病例男女性别比0.88∶1,输入病例3.04∶1;本地病例发病年龄M(P_(25),P_(75))为48(32,62)岁,输入病例发病年龄M(P_(25),P_(75))为35(28,44)岁。结论2009—2023年福建省登革热疫情呈持续上升态势,发病存在时空聚集性,应在高发季节针对重点地区和人群加强防控措施。

关键词：登革热流行特征热点分析福建省

Syntheses and Structures of Two Zn-Pyrazole/carboxyl Coordination Frameworks

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Chinese j.urnal of Structural Chemistry 2021年第10期40卷 1265-1270页

作者： ou YANG Chen-Hao WEI Zi-j.an HE Liang GUO Yu-j.n LUO Ming-Bu LIN Qi-Pu College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Two pyrazole-based zinc(Ⅱ) metal-organic frameworks,[Zn_(4)(PDC)_(2)(BDC)(H_(2)O)_(2)]_(n) (compound 1,PDC=1H-pyrazole-3,5-dicarboxylic acid,BDC=benzene-1,4,-dicarboxylic acid) and[Zn_(3)(PDC)_(2)(BPY)_(3)(H_(2)O)_(2)]_(n)(compound 2,BPY=4,4-bipyridine),were synthesized and characterized by X-ray diffraction,elemental analysis,thermogravimetric analysis,infrared and fluorescence *** 1 crystallizes in space group Pna2_(1) with a=14.325(3),b=10.004(2),c=16.454(3)Å,V=2357.8(8)Å^(3),Z=4,M_(r)=821.83,D_(c)=2.298 g·cm^(-3),F(000)=1608,GOOF=1.163,the final R=0.0218 and w R=0.0686 for 5150 observed reflections with I>2σ(I).Compound 2crystallizes in monoclinic space group C2/c with a=17.034(2),b=11.6313(9),c=11.7608(13)Å,V=2034.9(4)Å^(3),Z=2,Mr=1006.91,D_(c)=1.643 g·cm^(-3),F(000)=1020,GOOF=1.084,the final R=0.0320 and wR=0.0768 for 2435 observed reflections with I>2σ(I).

关键词： pyrazole-carboxyl X-ray crystallography metal-organic frameworks luminescence

RGF1-RGI1,a Peptide-Receptor Complex,Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade

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Molecular Plant 2020年第11期13卷 1594-1607页

作者： Xiaoting Lu Hongyong Shi Yang ou Yanwei Cui j.nke Chang Liang Peng Xiaoping Gou Kai He j.a Li Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China

Root growth is maintained by the continuous division of cells in the apical *** MERISTEM GROWTH FACTOR 1(RGF1)is a critical peptide hormone regulating root stem cell niche *** studies discovered that five closely related leucine-rich repeat receptor-like protein kinases(LRRRLKs),named RGF1 INSENSITIVES(RGIs)or RGF1 RECEPTORS(RGFRs),are able to perceive the RGF1 signal and redundantly control root stem cell niche ***1 regulates root meristem activity mainly via two downstream transcription factors,PLETHORA 1(PLT1)and *** proteins connecting cell surface RGF1-RGI1 and nuclear PLTs,however,were not ***,we report that the mitogen-activated protein(MAP)kinase kinase 4(MKK4)and MAP kinase 3(MPK3)were coimmunoprecipitated with RGI1-FLAG after Arabidopsis seedlings were treated with *** and biochemical assays confirmed that MKK4 and MKK5,and their downstream targets MPK3 and MPK6,are essential RG卜dependent regulators of root meristem *** addition,we found that the MKK4/MKK5-MPK3/MPK6 module functions downstream of YDA,a *** results demonstrate that RGF1-RGI1 regulate the expression of PLT1/PLT2 via a YDA-MKK4/MKK5-MPK3/MPK6 signaling cascade.

关键词： root meristem RGF1 RGI1 RLK MAPK

Non-Stokes drag coefficient in single-particle electrophoresis:New insights on a classical problem

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Chinese Physics B 2019年第8期28卷 201-211页

作者： Mai-j.a Liao Ming-Tzo Wei Shi-Xin Xu H Daniel ou-Yang Ping Sheng Department of Physics Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Department of Physics Lehigh UniversityBethlehemPAUSA Department of Bioengineering Lehigh UniversityBethlehemPAUSA Centre for Quantitative Analysis and Modelling (CQAM) The Fields InstituteTorontoOntario M5T 3J1Canada

We measured the intrinsic electrophoretic drag coefficient of a single charged particle by optically trapping the particle and applying an AC electric field,and found it to be markedly different from that of the Stokes *** drag coefficient,along with the measured electrical force,yield a mobility-zeta potential relation that agrees with the *** using the measured mobility as input,numerical calculations based on the Poisson-Nernst-Planck equations,coupled to the Navier-Stokes equation,reveal an intriguing microscopic electroosmotic flow near the particle surface,with a well-defined transition between an inner flow field and an outer flow field in the vicinity of electric double layer’s outer *** distinctive interface delineates the surface that gives the correct drag coefficient and the effective electric *** consistency between experiments and theoretical predictions provides new insights into the classic electrophoresis problem,and can shed light on new applications of electrophoresis to investigate biological nanoparticles.

关键词： electrophoresis drag coefficient vortices belt charged colloidal particle

Research Progress in the Structure and Functions of Prohibitin

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j.urnal of Reproduction and Contraception 2010年第2期21卷 117-124页

作者： j.a-xian ou Si-fei HUANG Hong CHEN Department of Anatomy & Histo-Embryology Shanghai Medical School Fudan University Shanghai 200032 China

Prohibitin is named due to the negative regulatory role of its gene products in cell proliferation. Prohibitin gene is located at q21 of chromosome 17 in human beings and the protein is found at mitochondria, nucleus and cytoplasm. Due to its size and ring-shaped structure, prohibitin protein defines functional subcompartments in mitochondria. Its subunits, PHB1 and PHB2, suppress cell proliferation as in the protein itself Nevertheless, recent investigation suggests that prohibitin protein enhances cell proliferation as well. It has also been found to suppress cell apoptosis by reducing cytochrome C release via the avoidance of mitochondrial crista remodeling which is facilitated through type 1 optic atrophy protein （OPAl）. Acting as a binding site for ubiquitin, prohibitin protein regulates protein degradation by proteasome. Examples are the degradations of sperm mitochondria in a fertilized ovum or those of an abnormal sperm.

关键词： prohibitin cell proliferation mitochondrial cristae type 1 optic atrophy protein(OPAl) cell apoptosis

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Bach1在氧化应激中的作用机制及其进展

中国皮肤性病学杂志 2024年第8期38卷 940-944页

作者：邹荟陈教全欧珊珊吴伟鸿林天一李华平朱慧兰广州医科大学广东广州510182 广州市皮肤病医院广东广州510095

转录因子BTB-CNC同源体1(Bach1)主要作为转录抑制因子在大多数哺乳动物组织中广泛表达,通过亮氨酸拉链与小Maf蛋白形成异质二聚体,再结合靶基因启动子中的Maf识别元件(Maf recognition elements,MAREs),从而抑制或激活基因转录。Bach1... 详细信息

转录因子BTB-CNC同源体1(Bach1)主要作为转录抑制因子在大多数哺乳动物组织中广泛表达,通过亮氨酸拉链与小Maf蛋白形成异质二聚体,再结合靶基因启动子中的Maf识别元件(Maf recognition elements,MAREs),从而抑制或激活基因转录。Bach1作为重要的调节因子,可参与调控氧化应激、血管生成、肿瘤转移及细胞周期等关键环节。近年来,关于Bach1在氧化应激中的作用机制的研究取得了新进展,本文拟综述Bach1的结构功能,以及Bach1通过各种调控因子和通路在氧化应激中的调控作用,为氧化应激损伤所引发日晒伤、免疫抑制、光老化、皮肤癌变等皮肤疾病治疗提供思路。

关键词： BTB-CNC同源体1 氧化应激核因子NF-E2相关因子血红素加氧酶1 醌氧化还原酶1 谷胱甘肽

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我国盐穴资源评价及调查技术研究

水文地质工程地质 2024年第4期51卷 53-65页

作者：林振洲刘东明张乐蒋正中荆磊智庆全张杰周岳军贾定宇杨毅梁明星李洋欧洋翟景红中国地质科学院地球物理地球化学勘查研究所河北廊坊065000 国家现代地质勘查工程技术研究中心河北廊坊065000 中盐勘察设计院有限公司湖南长沙410027

在“双碳”目标大背景下,盐穴是实现地质储能、碳封存的重要方式之一,但我国盐穴资源数量、质量不明,盐穴调查技术体系不完善,严重制约盐穴资源开发利用。通过分析我国主要盐矿区地质勘探报告、储量核实报告、企业年报及文献报道等,形... 详细信息

在“双碳”目标大背景下,盐穴是实现地质储能、碳封存的重要方式之一,但我国盐穴资源数量、质量不明,盐穴调查技术体系不完善,严重制约盐穴资源开发利用。通过分析我国主要盐矿区地质勘探报告、储量核实报告、企业年报及文献报道等,形成了我国盐穴资源数量、可利用性的科学认识和基本判断;在盐穴集中区开展综合探测技术试验并结合前人试验成果,初步构建了盐穴资源调查技术体系。结果表明:(1)我国盐穴资源丰富,储量大、分布广、埋深适宜、具备规模化开发利用条件,其中华东和华中地区已有盐穴资源最为丰富。(2)通过建立盐穴资源可利用性评价体系,将全国盐穴资源分为Ⅰ、Ⅱ、Ⅲ3级,Ⅰ级已有盐穴资源占比约29.4%,主要分布在华东、华中地区的江苏、湖北、河南等省份,是开发利用的优选区;Ⅱ级已有盐穴资源占比约65.4%,广泛分布于华中、西北和西南地区,可作为开发利用远景区;Ⅲ级已有盐穴资源占比约5.2%,整体地质条件不适宜开发利用。(3)地面物探可查明盐矿区区域地质、盐层地质、水文地质及盐腔分布情况,指导盐穴建库选址;井中物探精度高,可获取盐矿品味、腔体结构等信息,服务储库建设及运行监测。研究结果可为我国盐穴资源规划及开发提供基础数据和技术支撑。

关键词：岩盐矿盐穴可利用评价调查技术地球物理探测

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哈尔滨市区一次飑线天气过程特征分析

黑龙江气象 2024年第2期41卷 9-14页

作者：姜兵于凯旋高梦竹曹蕾欧娜音董学贤哈尔滨市气象局黑龙江哈尔滨150028 黑龙江省气象台黑龙江哈尔滨150030 鸡西市气象局黑龙江鸡西158100

利用地面、高空等常规观测资料,结合多普勒雷达、地面自动站等非常规观测资料,对2020年6月28日哈尔滨市主城区一次飑线造成的雷雨大风、超短时强降雨、局地小冰雹天气过程进行综合分析。结果表明:这次飑线过程发生在高空槽后与850-925 ... 详细信息

利用地面、高空等常规观测资料,结合多普勒雷达、地面自动站等非常规观测资料,对2020年6月28日哈尔滨市主城区一次飑线造成的雷雨大风、超短时强降雨、局地小冰雹天气过程进行综合分析。结果表明:这次飑线过程发生在高空槽后与850-925 hPa高度自西南向东北伸展的暖温度脊叠置的大环流背景下,由地面温度锋区和中尺度辐合线触发的动力强迫产生飑线、冰雹等强对流天气。强降雨主要集中发生在15~20 min内,分钟降雨量较大值一般持续10~20 min,哈尔滨市不同行政区域降雨大值间隔在10~15 min左右,同时表现出气压陡增、温度骤降、风速变大的天气实况特征。在雷达拼图上表现出明显的飑线弓形回波特征。通过对本次天气过程的成因、雷达回波演变进行分析,并探讨本次飑线过程的预警着眼点及其可预警性,可以提高专业气象服务的能力和水平。

关键词：飑线专业服务短时暴雨强对流