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Paillier陷门函数的两个变体的比特安全性分析

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计算机学报 2010年第6期33卷 1050-1059页

作者：苏东王克吕克伟中国科学院研究生院信息安全国家重点实验室北京100049

文中对Paillier陷门函数两个变体——Rabin-Paillier和RSA-Paillier进行了比特安全分析.对于Rabin-Paillier陷门函数,文中证明了从密文计算其明文的3 2n/2+log2n个最高有效位与对这个函数求逆一样困难,其中n为RSA模数N的二进制长度.该... 详细信息

文中对Paillier陷门函数两个变体——Rabin-Paillier和RSA-Paillier进行了比特安全分析.对于Rabin-Paillier陷门函数,文中证明了从密文计算其明文的3 2n/2+log2n个最高有效位与对这个函数求逆一样困难,其中n为RSA模数N的二进制长度.该结论的证明基于Boneh等人提出的素数域上的隐藏数问题的一个变体.文中使用Malykhin在2007年得到的指数和的界把该变体扩展到了Paillier模数N2的情况.对于RSA-Paillier陷门函数,该文完善了Morillo等人对于该函数明文最低有效位的困难性证明.通过设计一个随机化的算法使得Morillo等人提出的明文恢复算法在使用不完美的LSB预言机的时候也能工作.

关键词：比特安全 Paillier Rabin-Paillier RSA-Paillier 指数和的界隐藏数问题

连续聚合法合成高固含低粘度聚合物多元醇的研究

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化学反应工程与工艺 2005年第6期21卷 532-536页

作者：吕世军郭睿威天津大学化工学院天津300072

采用间歇法和单釜连续法合成了高固含聚合物多元醇(POP),采用动态光散射和扫描电镜研究了不同工艺下POP分散相粒子的粒径分布。实验结果表明:采用单釜连续聚合工艺能使POP产品分散相粒子粒径分布比较宽,从而能有效降低高固含POP粘度。... 详细信息

采用间歇法和单釜连续法合成了高固含聚合物多元醇(POP),采用动态光散射和扫描电镜研究了不同工艺下POP分散相粒子的粒径分布。实验结果表明:采用单釜连续聚合工艺能使POP产品分散相粒子粒径分布比较宽,从而能有效降低高固含POP粘度。采用单釜连续聚合工艺合成出了固含量45％,粘度为 5 900 mPa·s(25℃)的POP。

关键词：单釜连续高固含低粘度聚合物多元醇

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MIMO多中继辅助通信中的优化调度

通信学报 2008年第3期29卷 40-46页

作者：俞菲杨绿溪东南大学信息科学与工程学院江苏南京210096

针对中继辅助通信系统,讨论了多中继并行传输下的优化设计问题,提出了一种简化的线性优化方案,并从多用户分集的角度,在等待服务用户中选择中继协作分集增益较大的用户对其进行服务。这种方案巧妙地减少了由于多中继并行传输所造成的用... 详细信息

针对中继辅助通信系统,讨论了多中继并行传输下的优化设计问题,提出了一种简化的线性优化方案,并从多用户分集的角度,在等待服务用户中选择中继协作分集增益较大的用户对其进行服务。这种方案巧妙地减少了由于多中继并行传输所造成的用户间干扰,保持了多中继并行传输引入的空间分集所带来的性能优势,达到了提高系统总吞吐量的目的。

关键词：多中继协作联合优化多用户调度空间分集

SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

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Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du Yuhua Yan Juehua Yu Tailin Zhu Chu-Chung Huang Lingli Zhang Xingyue Shan Ren Li Yuan Dai Hui lv Xiao-Yong Zhang Jianfeng Feng Wei-Guang Li Qiang Luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

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基于重点区域覆盖的海军护航位置选择研究

交通运输系统工程与信息 2016年第1期16卷 209-216页

作者：高天航吕靖大连海事大学交通运输管理学院辽宁大连116026

针对目前护航海军普遍使用的伴随护航策略存在的效率较低及时间难以协调等问题,采用区域护航的理念,建立了基于重点区域覆盖的海军护航位置选择模型,该模型分为海盗选择及劫持模型,商船求救及海军救援模型,海军护航位置选择模型等3个子... 详细信息

针对目前护航海军普遍使用的伴随护航策略存在的效率较低及时间难以协调等问题,采用区域护航的理念,建立了基于重点区域覆盖的海军护航位置选择模型,该模型分为海盗选择及劫持模型,商船求救及海军救援模型,海军护航位置选择模型等3个子模型,对模型得到的海盗劫持高危水域进行重点区域部署,提高护航海军的护航效率.为了快速有效地求解该模型,综合运用遗传算法和贪心算法,提出一种改进的求解算法,使得计算结果更加符合实际需求.案例计算结果表明,该模型和算法能够为海军选择合理的区域护航位置,使得海军护航工作更加高效稳定.

关键词：水路运输海军护航重点区域覆盖海盗遗传算法贪心算法

Effective sideband cooling in an ytterbium optical lattice clock

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Chinese Physics B 2022年第9期31卷 234-237页

作者： Jin-Qi Wang Ang Zhang Cong-Cong Tian Ni Yin Qiang Zhu Bing Wang Zhuan-Xian Xiong Ling-Xiang He Bao-Long lv State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China Key Laboratory of Atomic Frequency Standards Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

Sideband cooling is a key technique for improving the performance of optical atomic clocks by preparing cold atoms and single ions into the ground vibrational *** this work,we demonstrate detailed experimental research on pulsed Raman sideband cooling in a 171 Yb optical lattice clock.A sequence comprised of interleaved 578 nm cooling pulses resonant on the 1st-order red sideband and 1388 nm repumping pulses is carried out to transfer atoms into the motional ground *** successfully decrease the axial temperature of atoms in the lattice from 6.5μK to less than 0.8μK in the trap depth of 24μK,corresponding to an average axial motional quantum number<*** oscillation spectroscopy is measured to evaluate the effect of sideband cooling on inhomogeneous *** maximum excitation fraction is increased from 0.8 to 0.86,indicating an enhancement in the quantum coherence of the *** work will contribute to improving the instability and uncertainty of Yb lattice clocks.

关键词： sideband cooling yterbium optical atomic clock optical lattice

A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis

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Cellular & Molecular Immunology 2019年第6期16卷 568-579页

作者： Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu Department of Clinical Immunology Xi Jing HospitalXi’an ShaanXi 710032P.R.China Department of Cell Biology National Translational Science Center for Molecular MedicineThe Fourth Military Medical UniversityXi’an ShaanXi 710032P.R.China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101P.R.China National Center for Protein Science Shanghai Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 201203P.R.China

The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell ***,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA *** this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA *** anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained *** a structural–functional approach,we depicted the interface between 5A12 and *** allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by *** study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development.

关键词： CD4^(+)Memory T cell CD147 Monoclonal Antibody Rheumatoid arthritis Immunotherapy

Machine learning predicts portal vein thrombosis after splenectomy in patients with portal hypertension: Comparative analysis of three practical models

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World Journal of Gastroenterology 2022年第32期28卷 4680-4696页

作者： Jian Li Qi-Qi Wu Rong-Hua Zhu Xing lv Wen-Qiang Wang Jin-Lin Wang Bin-Yong Liang Zhi-Yong Huang Er-Lei Zhang Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND For patients with portal hypertension(PH),portal vein thrombosis(PVT)is a fatal complication after *** platelet elevation is considered the foremost reason for ***,the value of postoperative platelet elevation rate(PPER)in predicting PVT has never been *** To investigate the predictive value of PPER for PVT and establish PPER-based prediction models to early identify individuals at high risk of PVT after *** We retrospectively reviewed 483 patients with PH related to hepatitis B virus who underwent splenectomy between July 2011 and September 2018,and they were randomized into either a training(n=338)or a validation(n=145)*** generalized linear(GL)method,least absolute shrinkage and selection operator(LASSO),and random forest(RF)were used to construct *** receiver operating characteristic curves(ROC),calibration curve,decision curve analysis(DCA),and clinical impact curve(CIC)were used to evaluate the robustness and clinical practicability of the GL model(GLM),LASSO model(LSM),and RF model(RFM).RESULTS Multivariate analysis exhibited that the first and third days for PPER(PPER1,PPER3)were strongly associated with PVT[odds ratio(OR):1.78,95%confidence interval(CI):1.24-2.62,P=0.002;OR:1.43,95%CI:1.16-1.77,P<0.001,respectively].The areas under the ROC curves of the GLM,LSM,and RFM in the training cohort were 0.83(95%CI:0.79-0.88),0.84(95%CI:0.79-0.88),and 0.84(95%CI:0.79-0.88),respectively;and were 0.77(95%CI:0.69-0.85),0.83(95%CI:0.76-0.90),and 0.78(95%CI:0.70-0.85)in the validation cohort,*** calibration curves showed satisfactory agreement between prediction by models and actual *** and CIC indicated that all models conferred high clinical net *** PPER1 and PPER3 are effective indicators for postoperative prediction of *** have successfully developed PPER-based practical models to accurately predict PVT,which would conveniently help clinicians r

关键词： Portal hypertension Splenectomy Portal vein thrombosis Postoperative platelet elevation rate Practical model Machine learning

健全全面从严治党体系:价值意蕴、核心要义及实践路径

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毛泽东研究 2024年第1期 25-35页

作者：吕曼中国纪检监察学院党建教研部

党的十八大以来,全面从严治党不断实现理论创新、实践创新和制度创新,实施战略向纵深推进,展现形态向体系化拓展,体现了我们党对管党治党规律的认识和把握不断深入,解决大党独有难题的思路更加开阔、举措更加系统,以党的自我革命引领社... 详细信息

党的十八大以来,全面从严治党不断实现理论创新、实践创新和制度创新,实施战略向纵深推进,展现形态向体系化拓展,体现了我们党对管党治党规律的认识和把握不断深入,解决大党独有难题的思路更加开阔、举措更加系统,以党的自我革命引领社会革命的意志更加坚定、能力更加强大。健全全面从严治党体系的核心要义是“一个坚持”“三个更加突出”“四个全”。健全全面从严治党体系,需要以全面从严治党的领导体系、制度体系、运行体系和责任保障体系为主体框架,使其横向上涵盖党的建设总体布局、纵向上贯彻落实“六个从严”要求。

关键词：全面从严治党体系党的建设总体布局自我革命依规治党