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用于高度可拉伸生物器件的可打印金属——聚合物导体

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科学新闻 2019年第2期 153-153页

作者： Lixue Tang Shiyu Cheng Luyao Zhang Hanbing Mi Lei Mou shuaijian yang Zhiwei Huang Xinghua Shi 蒋兴宇国家纳米科学中心

文章简介液态金属如镓的合金在常温下不仅自身具有流动性,电流也能在其中流动,因而成为可拉伸器件和电路的理想材料。但是液态金属具有巨大的表面能(难以铺展),且其表面会自发形成绝缘氧化膜,这就使得液态金属在各种基底上的印刷成为一... 详细信息

文章简介液态金属如镓的合金在常温下不仅自身具有流动性,电流也能在其中流动,因而成为可拉伸器件和电路的理想材料。但是液态金属具有巨大的表面能(难以铺展),且其表面会自发形成绝缘氧化膜,这就使得液态金属在各种基底上的印刷成为一个难题。

关键词：可拉伸液态金属聚合物

Capturing the hierarchically assorted modules of protein–protein interactions in the organized nucleome

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Molecular Plant 2023年第5期16卷 930-961页

作者： shuaijian Dai Shichang Liu Chen Zhou Fengchao Yu Guang Zhu Wenhao Zhang Haiteng Deng Al Burlingame Weichuan Yu Tingliang Wang Ning Li Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina Tsinghua-Peking Joint Centre for Life Sciences Centre for Structural BiologySchoolof Life Sciences and Schoolof MedicineTsinghua UniversityBejing 100084China The Hk.UST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhenGuangdong 518057China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong SARChina Department of Pharmaceutical Chemistry University of CaliforniaSan FranciscoSan FranciscoCAUSA

Nuclear proteins are major constituents and key regulators of nucleome topological organization and manipulators of nuclear *** decipher the global connectivity of nuclear proteins and the hierarchically organized modules of their interactions,we conducted two rounds of cross-linking mass spectrometry(XL-MS)analysis,one of which followed a quantitative double chemical cross-linking mass spectrometry(in vivo qXL-MS)workflow,and identified 24,140 unique crosslinks in total from the nuclei of soybean *** in vivo quantitative interactomics enabled the identification of 5340 crosslinks that can be converted into 1297 nuclear protein–protein interactions(PPIs),1220(94%)of which were non-confirmative(or novel)nuclear PPIs compared with those in *** were 250 and 26 novel interactors of histones and the nucleolar box C/D small nucleolar ribonucleoprotein complex,*** analysis of orthologous Arabidopsis PPIs produced 27 and 24 master nuclear PPI modules(NPIMs)that contain the condensate-forming protein(s)and the intrinsically disordered region–containing proteins,*** NPIMs successfully captured previously reported nuclear protein complexes and nuclear bodies in the ***,these NPIMs were hierarchically assorted into four higher-order communities in a nucleomic graph,including genome and nucleolus *** combinatorial pipeline of 4C quantitative interactomics and PPI network modularization revealed 17 ethylene-specific module variants that participate in a broad range of nuclear *** pipeline was able to capture both nuclear protein complexes and nuclear bodies,construct the topological architectures of PPI modules and module variants in the nucleome,and probably map the protein compositions of biomolecular condensates.

关键词： nucleome 4C interactomics in vivo qXL-MS biomolecular modulomics CHAMPION 4D biomolecular modulomes

Drug discovery of sclerostin inhibitors

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2150-2170页

作者： Sifan Yu Dijie Li Ning Zhang shuaijian Ni Meiheng Sun Luyao Wang Huan Xiao Dingdong Liu Jin Liu Yuanyuan Yu Zongkang Zhang Samuel Tin Yui Yeung Shu Zhang Aiping Lu Zhenlin Zhang Baoting Zhang Ge Zhang Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Integrated Bioinfomedicine and Translational Science School of Chinese MedicineHong Kong Baptist UniversityKowloon TsaiHong Kong 999077China Institute of Precision Medicine and Innovative Drug Discovery HKBU Institute for Research and Continuing EducationShenzhen 518000China School of Chinese Medicine Faculty of Medicinethe Chinese University of Hong KongHong Kong 999077China The Key Laboratory of Aerospace Medicine Ministry of EducationAir Force Medical UniversityXi’an 710000China Shanghai Clinical Research Center of Bone Disease Department of Osteoporosis and Bone DiseasesShanghai Jiao Tong University Afﬁliated Sixth People’s HospitalShanghai 200000China

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-related diseases, making it a promising therapeutic target for the treatment of WNT-related bone diseases. Additionally, emerging evidence indicates that sclerostin contributes to the development of cancers, obesity, and diabetes, suggesting that it may be a promising therapeutic target for these diseases. Notably, cardiovascular diseases are related to the protective role of sclerostin. In this review, we summarize three distinct types of inhibitors targeting sclerostin, monoclonal antibodies, aptamers, and small-molecule inhibitors, from which monoclonal antibodies have been developed. As the first-in-class sclerostin inhibitor approved by the U.S. FDA,the monoclonal antibody romosozumab has demonstrated excellent effectiveness in the treatment of postmenopausal osteoporosis;however, it conferred high cardiovascular risk in clinical trials. Furthermore,romosozumab could only be administered by injection, which may cause compliance issues for patients who prefer oral therapy. Considering these above safety and compliance concerns, we therefore present relevant discussion and offer perspectives on the development of next-generation sclerostin inhibitors by following several ways, such as concomitant medication, artificial intelligence-based strategy, druggable modification, and bispecific inhibitors strategy.

关键词： Sclerostin WNT signalling pathway Sclerostin inhibitors Antibody Bone diseases Aptamer Small molecule inhibitors Artificial intelligence

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甘肃小三峡集控计算机监控系统的设计与实现

智能电网 2015年第10期3卷 934-936页

作者：汤帅健王晓国网电力科学研究院/南京南瑞集团公司江苏省南京市210003 国投甘肃小三峡发电有限公司甘肃省白银市730900

随着许多流域内水电站日益增多,对于电站的成本、安全、经济以及运行人员劳动强度等方面的要求也越来越高。为了能有效降低投资成本、保证人员现场安全,并且对整个梯级电站进行经济调度,提高梯级水电站群的综合管理水平,必须对流域内水... 详细信息

随着许多流域内水电站日益增多,对于电站的成本、安全、经济以及运行人员劳动强度等方面的要求也越来越高。为了能有效降低投资成本、保证人员现场安全,并且对整个梯级电站进行经济调度,提高梯级水电站群的综合管理水平,必须对流域内水电站群进行集中调度和控制。基于NC2.0监控系统平台的甘肃小三峡集控中心计算机监控系统实现了大峡、小峡、乌金峡三个梯级电站的远程集控。介绍了该系统的设计原则、系统结构与特点、控制调节与方式,并简要介绍了数据分区与安全防护。

关键词：梯级水电站集控计算机监控系统

Design and Synthesis of the Novel Long-acting GLP-1 Derivatives

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Design and Synthesis of the Novel Long-acting GLP-1 Derivati...

基于3S技术的应急物流配送车辆导航定位系统研究

2011年全国药物化学学术会议——药物的源头创新

作者： Xiaoyun Zhu,shuaijian Ni,Hai Qian~*,Wenlong Huang~* Centre of Drug Discovery,State Key Laboratory of Natural Medicines,China Pharmaceutical University,24 Tongjiaxiang,Nanjing,Jiangsu 210009,China

＜正＞The current belief is that the GLP-1 compound class may be able to control the progression of the type 2 diabetes disease not only by controlling blood glucose but also via several other effects, such as stimula...

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交通与计算机 2008年第5期26卷 119-122页

作者：朱帅剑毛海军东南大学南京210096

近年来,随着应急物流需求的日益增强,其时效性、安全性的要求也不断提高。基于此,提出了基于3S技术的应急物流配送车辆导航定位系统,将RS技术集成到传统的导航定位系统中。探讨3S集成技术在应急物流配送中的应用,介绍系统的工作流程及原... 详细信息

近年来,随着应急物流需求的日益增强,其时效性、安全性的要求也不断提高。基于此,提出了基于3S技术的应急物流配送车辆导航定位系统,将RS技术集成到传统的导航定位系统中。探讨3S集成技术在应急物流配送中的应用,介绍系统的工作流程及原理,并分析了系统的5个主要功能模块。

关键词：应急物流车辆导航定位系统 RS GIS GPS

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提升汽车零部件电泳线符合性探讨

涂层与防护 2021年第6期42卷 25-28页

作者：黄祉伟梁锦华郑诚汤帅健广汽丰田汽车有限公司广州511455

通过汽车零部件电泳线实际规划者和实际使用者的陈述,探讨如何提高技术要求与工艺的符合性,达到降低改造成本、不符合返修成本、追加项目成本和安全问题整改成本等目的。

关键词：汽车零部件电泳线技术要求工艺管理符合性提升安全提升