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Cellular rejuvenation:molecular mechanisms and potential therapeutic interventions for diseases

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1571-1609页

作者： shuaifei ji Mingchen Xiong Huating Chen Yiqiong Liu Laixian Zhou Yiyue Hong Mengyang Wang Chunming Wang Xiaobing Fu Xiaoyan Sun Research Center for Tissue Repair and Regeneration Affiliated to Medical Innovation Research Department and 4th Medical Center PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048P.R.China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipa999078 Macao SARChina

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,with more predisposition to deteriorated *** refers to giving aged cells or organisms more youthful characteristics through various techniques,such as cellular reprogramming and epigenetic *** great leaps in cellular rejuvenation prove that ageing is not a one-way street,and many rejuvenative interventions have emerged to delay and even reverse the ageing *** the mechanism by which roadblocks and signaling inputs influence complex ageing programs is essential for understanding and developing rejuvenative ***,we discuss the intrinsic and extrinsic factors that counteract cell rejuvenation,and the targeted cells and core mechanisms involved in this ***,we critically summarize the latest advances in state-of-art strategies of cellular *** rejuvenation methods also provide insights for treating specific ageing-related diseases,including cellular reprogramming,the removal of senescence cells(SCs)and suppression of senescence-associated secretory phenotype(SASP),metabolic manipulation,stem cells-associated therapy,dietary restriction,immune rejuvenation and heterochronic transplantation,*** potential applications of rejuvenation therapy also extend to cancer ***,we analyze in detail the therapeutic opportunities and challenges of rejuvenation *** rejuvenation interventions will provide further insights into anti-ageing and ageing-related disease treatment in clinical settings.

关键词： therapeutic mechanisms potential

Postoperative UFT-/Tegafur-based Chemotherapy Versus Postoperative Radiotherapy for Early-stage Non-small Cell Lung Cancer:A Systematic Review and Network Meta-analysis

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Journal of Oncology Research 2019年第2期1卷 11-18页

作者： Lixin Yu Mi Song shuaifei ji School of basic medicine Air Force Medical UniversityXi’anChina Graduate school general hospital of PLABeijingChina

Background:Both of UFT-/Tegafur-based postoperative chemotherapy and postoperative radiotherapy have made large progress in treatment of early-stage non-small cell lung *** it is unclear that,whether UFT-/Tegafur-based postoperative chemotherapy is superior to postoperative radiotherapy for early-stage non-small cell lung cancer with no direct ***:Electronic databases(Pubmed,embase,cochrane library and ***)were searched to obtain relevant *** systematic review and meta-analysis is reported in accordance with the Preferred Items for Systematic Reviews and Meta-analysis(PRISMA)Statement and was registered at International Prospective Register of Systematic Reviews(number CRD42018095979).Sensitive analysis was conducted by excluding overweight *** plot and egger’s test were performed to conduct publication ***:Twenty-one randomized control trials were *** results suggested UFT-/Tegafur-based postoperative chemotherapy could improve overall survival over postoperative radiotherapy[HR=0.69(0.59-0.80),p=0.000].But subgroup analysis about stage showed there was no significant difference between them,no matter of stage I,II and *** to chemotherapy regime,both UFT-/Tegafur+platinum+vinca alkaloid[HR=0.68(0.56-0.82),p=0.000]and UFT-/Tegafur only[HR=0.66(0.54-0.79),p=0.000]were superior to *** analysis about radiotherapy delivery method and dose showed,significant improvement of chemotherapy over radiotherapy for Cobalt-60 only[HR=0.54(0.39-0.75),p=0.000],Cobalt-60 and linac[HR=0.69(0.59-0.81),p=0.000]and≥45 Gy[HR=0.64(0.54-0.75),p=0.000],but not for linac only[HR=0.78(0.60-1.03),p=0.081]and≥45 Gy[HR=0.86(0.67-1.11),p=0.241].Conclusion:UFT-/Tegafur-based postoperative chemotherapy was superior to postoperative radiotherapy for improving overall survival of early-stage non-small cell lung cancer,but it is not always so under certain circumstance,such as RT delivery method and radiati

关键词： Chemotherapy Radiotherapy Postoperative Early-stage non-small cell lung cancer Meta-analysis

Sebaceous gland reprogramming with a single gene, PPARG, and small molecules

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3913-3916页

作者： Yiqiong Liu shuaifei ji Huanhuan Gao Huating Chen jiangbing Xiang Shaoyuan Cui Christos CZouboulis Aizhen Cai Xiaobing Fu Xiaoyan Sun Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center PLA General Hospital and PLA Medical CollegePLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin InjuryRepairand RegenerationResearch Unit of Trauma CareTissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051100048 BeijingP.R.China Department of Nephrology The First Medical CenterChinese PLA General HospitalState Key Laboratory of Kidney Diseases100048 BeijingChina Departments of Dermatology VenereologyAllergologyand ImmunologyStaedtisches Klinikum DessauBrandenburg Medical School Theodor Fontane and Faculty of Health Sciences BrandenburgDessauGermany Institute of General Surgery Department of General Surgerythe 1st Medical CenterPLA General Hospital28 Fu Xing Road100853 BeijingP.R.China

Dear Editor,Sebaceous glands(SG)contribute to 90%of the skin surface lipid production and play critical roles in regulating proper skin functions including epidermal barrier maintenance,dermal immune responses,and global body anti-microbial activities.1 Reduced sebaceous lipid has been implicated in diverse skin diseases,including scarring alopecia,inflammation,chronic itch,as well as premature aging of the skin.2 Especially,scar repair after deep burns or large-scale skin defect often leads to irreversible loss of *** to lacking SG,the regenerated tissues cannot fully recapitulate the structural and functional integrity of normal ***,generation of expandable SG cells with developmental and lipid-producing potentials represents a promising approach for treating diseased,damaged,or aged skin with better quality of ***,direct cellular reprogramming has been widely used for obtaining difficult-to-maintain human cells by cell type-specific transcription factors(TFs).

关键词： programming maintain irreversible

Clothing Image Detection and Recognition Based on Faster RCNN

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Clothing Image Detection and Recognition Based on Faster RCN...

Control System for Wheeled Humanoid Following Robot

作者： shuaifei ji Runping Han jianfeng Wei Rui Wang Chinese Fashion Science & Technology Research Institute Beijing Institute of Fashion Technology School of Information Engineering Beijing Institute of Fashion Technology

Clothing image detection and recognition algorithm is proposed in this paper,which involves the design of two neural network models based on improved Faster R-CNN [1].In our work,in order to train neural networks,ModaNet [2] dataset is selected and improvements on it are made,that is,the improper bounding boxes of footwear and boots in ModaNet dataset are modified based on their polygon ***,by making the following improvements on Faster R-CNN,our two neural network models are established,which use VGG16[3] and the first 40 layers of ResNet50 [4] as feature extration network,*** using ResNet50 for feature extraction,the last 10 layers of ResNet50 are selected as part of the final classification and regression *** addition,the softmax activation function in RPN is replaced with *** experimental comparison,it is found that both of these two models can well accomplish the task.

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Control System for Wheeled Humanoid Following Robot

Batik-DG:Improved DeblurGAN for Batik Crack Pattern Generation

作者： Baiyong Ding shuaifei ji Runping Han Lihong Chen Chinese Fashion Science & Technology Research Institute Beijing Institute of Fashion Technology Fashion Accessory Art and Engineering College Beijing Institute of Fashion Technology

Aiming at application and development prospects of following robot,a control system for humanoid 18-DOF robot supported by four wheels is *** system adopts the double-controller structure composed of master controller Raspberry Pi and slave controller STM32 for servo control of robot based on multi-sensor information *** this control system,USB camera and two-axis pan-tilt are used for capturing images with wide viewing ***-scale template matching and Median-Flow algorithm are used for target *** Filter is used to fuse acceleration and angular velocity given by attitude sensor to obtain the reliable upright *** algorithms are applied to the control system to realize robot’s upright angle control,speed control and turning angle ***’s action adjustment is achieved by controlling its joint steering *** experimental results show that this low-cost wheeled humanoid robot has good self-balancing stability,anti-interference and following stability.

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Batik-DG:Improved DeblurGAN for Batik Crack Pattern Generati...

作者： Yiyang Huang jianxia Su jianming Wang shuaifei ji School of Information Engineering Beijing Institution of Fashion Technology School of Materials Design and Engineering Beijing Institution of Fashion Technology Chinese Fashion Science & Technology Research Institute

As a traditional handcraft in China,batik is valuable for both decoration and fashion design due to its unique crack ***,previous researches on batik crack pattern generation remain space in promoting *** recent years,Generative Adversarial Networks（GAN） show great ability in realistic image generation,and DeblurGAN performs well in image deblurring task,showing good potentiality in image *** this paper,we improve DeblurGAN for batik crack pattern generation by several ***,transposed convolution is replaced with ***,Hybrid Dilated Convolution（HDC） is added to the ***,RaLSGAN is utilized instead of WGAN-GP,and several additional loss functions such as L1,L2 and so forth are tested *** network is trained on BIFT-Batik dataset and performs well to some degrees both in visual verisimilitude and IQA indexes including PSNR and *** name our network as Batik-DG（Batik-DeblurGAN）.

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年龄相关性黄斑变性患者人工晶状体的选择

山东大学耳鼻喉眼学报 2017年第4期31卷 36-39页

作者：冀帅飞张婕严宏第四军医大学唐都医院眼科陕西西安710038 重庆医科大学附属第一医院眼科/眼科学重庆市重点实验室/重庆市眼科研究所重庆400016

年龄相关性黄斑变性(AMD)是引起65岁以上人群视力严重损伤的重要原因。白内障和AMD两者常同时存在于老年人群,合并AMD的白内障患者人工晶状体的选择仍然存在争议。就近年来人工晶状体在AMD患者中的应用情况做一总结。

关键词：年龄相关性黄斑变性白内障人工晶状体

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老年人跌倒评估工具的研究

中国医药导报 2020年第34期17卷 60-63页

作者：宋咪皮红英徐月冀帅飞解放军医学院北京100853 中国人民解放军总医院护理部北京100853

跌倒是老年人伤害死亡的首要原因,严重地影响老年人的身心健康、生活质量及预期寿命,阻碍健康老龄化进程。作为跌倒预防的重要环节,风险评估有助于早期识别跌倒风险。针对危险因素进行相应的干预,能有效降低老年人跌倒发生率。本研究目... 详细信息

跌倒是老年人伤害死亡的首要原因,严重地影响老年人的身心健康、生活质量及预期寿命,阻碍健康老龄化进程。作为跌倒预防的重要环节,风险评估有助于早期识别跌倒风险。针对危险因素进行相应的干预,能有效降低老年人跌倒发生率。本研究目的是通过对跌倒评估工具进行综述,厘清老年人跌倒评估指征、内容,评估工具的适用范围及评估效果,为医护人员区分、选择适合的跌倒评估工具提供参考,为跌倒的规范化评估及评估流程的改进提供思路。

关键词：跌倒老年人评估工具综述

细胞治疗在创伤性脊髓损伤中的有效性和安全性研究进展

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西北国防医学杂志 2019年第5期40卷 314-322页

作者：范建平任帅帅张拔渤陈学敏冀帅飞王小成陆军军医大学士官学校解放军73141部队解放军总医院第五医学中心空军军医大学基础医学院空军军医大学航空航天卫生学教研室空军军医大学航空航天临床医学中心

脊髓损伤是平时和战时最危重的创伤之一,严重影响患者生理和心理健康并给社会带来极大经济负担。近年来,细胞移植治疗脊髓损伤备受关注,并且取得了极大进展。本研究就各种类型细胞移植治疗创伤性脊髓损伤的有效性和安全性研究情况做出总... 详细信息

脊髓损伤是平时和战时最危重的创伤之一,严重影响患者生理和心理健康并给社会带来极大经济负担。近年来,细胞移植治疗脊髓损伤备受关注,并且取得了极大进展。本研究就各种类型细胞移植治疗创伤性脊髓损伤的有效性和安全性研究情况做出总结,主要包括施万细胞、嗅鞘细胞、骨髓间充质干细胞、神经前体细胞、少突胶质前体细胞、脂肪干细胞、诱导多功能干细胞、牙髓干细胞和活化巨噬细胞,以期为未来的临床研究提供参考。

关键词：脊髓损伤细胞治疗有效性安全性