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Adjuvant treatment for triple-negative breast cancer: a retrospective study of immunotherapy with autologous cytokine-induced killer cells in 294 patients

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Cancer Biology & Medicine 2019年第2期16卷 350-360页

作者： Yuhan Zhang shuaibing wang Beibei Yang Su Lu Yiyi Du Hong Liu The Second Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital/ National Clinical Research Center for Cancer/ Key Laboratory of Cancer Prevention and Therapy Tianjin/ Tianjin's Clinical Research Center for Cancer/ Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical University Ministry of Education Tianjin 300060 China Oncology Department China National Petroleum Corporation Central Hospital Langfang 065000 China

Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) ***: A total of 294 post-surgery TNBC patients participated in the research from January 1, 2009 to January 1, 2015. After adjuvant chemotherapy, autologous CIK cells were introduced in 147 cases(CIK group), while adjuvant chemotherapy alone was used to treat the remaining 147 cases(control group). The major endpoints of the investigation were the disease-free survival(DFS) and overall survival(OS). Additionally, the side effects of the treatment were ***: In the CIK group, the DFS and OS intervals of the patients were significantly longer than those of the control group(DFS:P = 0.047;OS: P = 0.007). The multivariate analysis demonstrated that the TNM(tumor-node-metastasis) stage and adjuvant CIK treatment were independent prognostic factors for both DFS [hazard ratio(HR)= 0.520, 95% confidence interval(CI):0.271-0.998, P = 0.049;HR = 1.449, 95% CI:1.118-1.877, P = 0.005, respectively] and OS(HR=0.414, 95% CI:0.190-0.903, P = 0.027;HR= 1.581, 95% CI:1.204-2.077, P = 0.001, respectively) in patients with TNBC. Additionally, longer DFS and OS intervals were associated with increased number of CIK treatment cycles(DFS: P = 0.020;OS: P = 0.040). The majority of the patients who benefitted from CIK cell therapy were relatively early-stage TNBC ***: Chemotherapy in combination with adjuvant CIK could be used to lower the relapse and metastasis rate, thus effectively extending the survival time of TNBC patients, especially those at early stages.

关键词： Immunotherapy triple-negative breast cancer cytokine-induced killer cell prognosis disease-free survival overall survival

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From kesterite 2D nanosheets to wurtzite 1D nanorods:controllable synthesis of Cu-Zn-Sn-S and their application in electrocatalytic hydrogen evolution

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Journal of Semiconductors 2023年第12期44卷 104-110页

作者： Yu Li shuaibing wang Jie Chen Ouyang Lin Zhe Yin Chunhe Yang Aiwei Tang Key Laboratory of Luminescence and Optical Information Ministry of EducationSchool of Physical Science and EngineeringBeijing Jiaotong UniversityBeijing 100044China

As typical quarternary copper-based chalcogenides,Cu–Zn–Sn–S nanocrystals(CZTS NCs)have emerged as a newfashioned electrocatalyst in hydrogen evolution reactions(HERs).Oleylamine(OM),a reducing surfactant and solvent,plays a significant role in the assisting synthesis of CZTS NCs due to the ligand ***,we adopted a facile one-pot colloidal method for achieving the structure evolution of CZTS NCs from 2D nanosheets to 1D nanorods assisted through the continuous addition of *** the process,the mechanism of OM-induced morphology evolution was further *** merely adding pure 1-dodecanethiol(DDT)as the solvent,the CZTS nanosheets were *** OM was gradually added to the reaction,the CZTS NCs began to grow along the sides of the nanosheets and gradually shrink at the top,followed by the formation of stable *** acidic electrolytic conditions,the CZTS NCs with 1.0 OM addition display the optimal HER activity with a low overpotential of 561 m V at 10 m A/cm^(2) and a small Tafel slope of 157.6 m V/dec compared with other CZTS *** enhancement of HER activity could be attributed to the contribution of the synergistic effect of the diverse crystal facets to the reaction.

关键词： 2D nanosheets 1D nanorods structure evolution Cu-Zn-Sn-S electrocatalytic hydrogen evolution

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A case study of regional eco-hydrological characteristics in the Tao River Basin, northwestern China, based on evapotranspiration estimated by a coupled Budyko Equation-crop coefficient approach

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Science China Earth Sciences 2015年第11期58卷 2103-2112页

作者： LI ChangBin ZHANG XueLei QI JiaGuo wang shuaibing YANG LinShan YANG WenJin ZHU GaoFeng HAO Qiang Key Laboratory of Western China’s Environmental Systems (Ministry of Education) Lanzhou University Center for Global Change and Earth Observations Michigan State University Ocean College Zhejiang University

In a case study in Tao River Basin, China, we derived a high spatial-resolution regional distribution of evapotranspiration(ET) using the single crop coefficient method and Budyko equation. We then further analyzed the spatio-temporal characteristics of this diverse eco-hydrological basin from 2001–2010. The results suggest that the single crop coefficient method based on leaf area index captures better spatial and temporal dynamics of the regional ET than did the Budyko Equation method. The rising temperature was the main reason for the increasing ET in the Tao River Basin during 2001–2010. Areas with high ET efficiency were distributed mainly in the areas where the vegetation coverage was high, and a lower runoff coefficient responded. The estimated spatial patterns of ET allowed an improved understanding of the eco-hydrological processes within the Tao River Basin and the method used might be generalized as a reference for future regional-scale eco-hydrological research.

关键词： evapotranspiration Budyko Equation single crop coefficient eco-hydrology Tao River Basin

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Structural characterization of char during co-gasification from torrefied sludge and Yangchangwan bituminous coal

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International Journal of Coal Science & Technology 2023年第5期10卷 12-20页

作者： Xinsha Zhang Yonghui Bai Jie Qin Shengli Shi Jiazhong Liu shuaibing wang Minhui Zhao Guiming Shi Changbing Ye Guangsuo Yu Yuxi Normal University YuxiYunnan653100China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan750021China Institute of Clean Coal Technology East China University of Science and TechnologyShanghai200237China

The present study aims to investigate the physico-chemical structural evolution characteristics of char structure of CO_(2) atmosphere torrefaction pretreated sludge with Yangchangwan bituminous coal(YC)during *** co-gasification reactivity of torrefied sludge and YC was measured using a thermogravimetric *** co-gasification reactivity of torrefied sludge with YC was thoroughly explored in depth by in situ heating stage microscope coupled with traditional characterization means of char sample(Scanning electron microscope,nitrogen adsorption analyzer,laser Raman spectroscopy).The results show that the gasification reaction rate of sludge treated under CO_(2) atmosphere and coal blended char was better than other char samples at 1100–1200℃.The torrefied sludge under CO_(2) atmosphere promoted its thermal decomposition to the maximum extent,so that it eventually was transformed into a large number of small broken *** specific surface area and ID1/IG ratio of blended char of torrefied sludge under CO_(2) atmosphere and YC were 1.70 and 1.07 times higher than that of YC,*** in situ technique revealed that YC char with the addition of torrefied sludge undergo gasification by shrinking core modes and the presence of obvious ash melting flow *** was more obvious than that of YC.

关键词： Characteristic-Char structure Torrefaction Co-gasification

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Design of High-Power Dual-Redundancy Electro-Mechanical Actuator for Scout and Strike UAV

Design of High-Power Dual-Redundancy Electro-Mechanical Actu...

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作者： Tao Yang shuaibing wang Jinpeng Yang China Academy of Aerospace Aerodynamics

As the technology advance of UAV（Unmanned Aerial Vehicle）,the large UAV is a prevalent trend,which is widely used for scout and strike in modern military *** flight safety is rather important because of the cost increase of UAV with various airborne devices ***（Electromechanical Actuator） is one of the key components in UAV *** its performance is reliable or not determines the flight *** this paper,in order to design high-power EMA for scout and strike UAV with fast response and high stability to ensure UAV safety,dual-redundancy technology is *** are two communication interfaces between the actuator and the flight mission *** control circuit and the drive circuit are in the form of dual redundancy,while there are two sets of windings in the *** controller and actuator design are introduced in details one by ***,the paper presents the dual-redundancy design *** ground tests simulating the real flight conditions are conducted,proving that the EMA design is feasible and its performance is *** UAV flight tests are needed later in the future to verify EMA performance in practice.

关键词： UAV dual-redundancy EMA

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连续顺序电阻点焊分流率的反向传播神经网络预测

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机械工程学报 2011年第22期47卷 87-92页

作者：张勇汪帅兵谢红霞马铁军西北工业大学陕西省摩擦焊接重点实验室西安710072

建立以材料电阻率、板厚、焊点间距为输入空间,分流率为输出空间的连续顺序电阻点焊分流率的3层误差反向传播(Back propagation,BP)神经网络预测模型。依据电阻点焊恒流控制的特点和点焊过程的电阻变化规律建立分流率的理论计算模型,由... 详细信息

建立以材料电阻率、板厚、焊点间距为输入空间,分流率为输出空间的连续顺序电阻点焊分流率的3层误差反向传播(Back propagation,BP)神经网络预测模型。依据电阻点焊恒流控制的特点和点焊过程的电阻变化规律建立分流率的理论计算模型,由该模型所得数据作为样本对网络进行训练和检验。对2.0 mm厚度的20钢及1.5 mm、1.0 mm厚度的10钢等厚度点焊的分流进行预测,预测相对误差最大值分别为2.83%、1.77%和3.67%。验证试验结果表明,应用建立的神经网络的预测结果进行分流补偿后,在焊点间距为30 mm和50 mm时,第2～5焊点熔核直径相对第1点的平均误差,1.0 mm厚度的10钢分别约为2.86%和3.99%,2.0 mm厚度的20钢分别约为2.46%和3.58%。证明采用建立的BP神经网络分流预测模型,对10钢和20钢恒流控制连续顺序点焊时的分流进行预测是可行的。

关键词：电阻点焊恒流控制分流神经网络预测模型

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油浸式电力变压器绕组温升的多物理场耦合计算方法

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中国电机工程学报 2016年第21期36卷 5957-5965,6040页

作者：谢裕清李琳宋雅吾王帅兵新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206

为了研究油浸式电力变压器运行过程中绕组温度的分布特性,该文提出了一种计算绕组温升的多物理场耦合有限元计算方法。应用最小二乘有限元法求解油流的流场控制方程,获得速度分布。建立油流与绕组耦合传热问题的统一温度场控制方程,应... 详细信息

为了研究油浸式电力变压器运行过程中绕组温度的分布特性,该文提出了一种计算绕组温升的多物理场耦合有限元计算方法。应用最小二乘有限元法求解油流的流场控制方程,获得速度分布。建立油流与绕组耦合传热问题的统一温度场控制方程,应用迎风有限元法对场域的温度分布进行求解,其中流体及固体间的传热分界面条件能够自动满足。考虑温度对于场域媒质物性参数以及绕组焦耳损耗的影响,将流场与温度场方程通过顺序迭代求解,获得整体场域的最终温度分布。运用该多物理场耦合有限元计算方法对一个油浸式变压器绕组模型进行了分析,并与Fluent软件的计算结果进行了对比。计算结果表明:该文提出的多物理场耦合有限元计算方法与Fluent软件计算的流场分布基本一致,绕组温度分布与Fluent软件的计算结果相比误差小于1K,验证了计算方法的有效性。同时,与经典伽辽金有限元法计算场域温度分布相比,迎风有限元法能够有效地抑制解的非物理振荡,提高了计算方法的稳定性。

关键词：油浸式电力变压器流场绕组温升多物理场耦合最小二乘有限元法迎风有限元法

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统一潮流控制器中串联耦合变压器特性及仿真模型研究

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电网技术 2017年第2期41卷 551-557页

作者：王帅兵李琳谢裕清赵国亮新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206 全球能源互联网研究院北京市昌平区102209

根据UPFC系统中串联耦合变压器的功能,分析了其特殊的工作方式和特点,并给出了220 k V输电线路中串联耦合变压器的一种壳式结构方案。根据串联耦合变压器铁芯和绕组的空间几何结构,采用电路与磁路的对偶原理,将磁路模型转化为电路模型... 详细信息

根据UPFC系统中串联耦合变压器的功能,分析了其特殊的工作方式和特点,并给出了220 k V输电线路中串联耦合变压器的一种壳式结构方案。根据串联耦合变压器铁芯和绕组的空间几何结构,采用电路与磁路的对偶原理,将磁路模型转化为电路模型。考虑到硅钢片的非线性饱和特性,采用复数磁导率计及涡流效应,以非线性电感和电阻来等效硅钢片,分析了频率和磁导率对硅钢片等效参数的影响。基于磁路法提取漏感参数,建立了串联耦合变压器的仿真电路模型。在低压物理样机上进行空载合闸和三相不对称直流偏磁的试验与仿真计算,测量结果与计算结果基本吻合,表明了所建模型适用于串联耦合变压器暂态模拟与不对称直流偏磁特性的分析。

关键词： UPFC 串联耦合变压器对偶原理涡流效应不对称直流偏磁

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我国水产生物技术的研究进展

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生物技术通报 2010年第8期26卷 89-92,97页

作者：熊良伟王帅兵王权江苏畜牧兽医职业技术学院泰州225300

水产生物技术是生物技术的重要组成部分,应用于水产养殖的各个学科中。从水产动物功能基因的筛选与克隆、分子标记的筛选与应用、基因工程和细胞工程育种、性别决定机制和性别控制研究、鱼类低温生物工程研究等五个方面阐述我国水产生... 详细信息

水产生物技术是生物技术的重要组成部分,应用于水产养殖的各个学科中。从水产动物功能基因的筛选与克隆、分子标记的筛选与应用、基因工程和细胞工程育种、性别决定机制和性别控制研究、鱼类低温生物工程研究等五个方面阐述我国水产生物技术的研究进展。

关键词：水产生物技术水产养殖育种

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T型三电平逆变器非对称矢量脉冲宽度调制相电流重构策略

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太阳能学报 2024年第4期45卷 450-459页

作者：申永鹏刘洋王帅兵齐文雷王延峰郑州轻工业大学电气信息工程学院郑州450002 国网伊犁伊河供电有限责任公司伊宁835000

针对T型三电平逆变器中点电流单传感器传统相电流重构方法存在不可观测区的问题,分析中点电流采样过程中不可观测区的存在机理,提出非对称矢量脉冲宽度调制相电流重构策略。通过移位PWM波延长基本电压矢量的作用时间,消除不可观测区,实... 详细信息

针对T型三电平逆变器中点电流单传感器传统相电流重构方法存在不可观测区的问题,分析中点电流采样过程中不可观测区的存在机理,提出非对称矢量脉冲宽度调制相电流重构策略。通过移位PWM波延长基本电压矢量的作用时间,消除不可观测区,实现相电流重构。实验结果表明,所提方法的电流重构误差低于2.2%,输出相电流畸变率低于3.48%。

关键词：脉冲调制相移信号采样相电流重构中点电流不可观测区

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