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Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong gao shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua gao Yunfeng Zhang Menglei Wang Ruoxuan Yang shuai Feng Xuan Cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Redox reactions

An Unprecedented Efficiency with Approaching 21%Enabled by Additive‑Assisted Layer‑by‑Layer Processing in Organic Solar Cells

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Nano-Micro Letters 2025年第2期17卷 372-375页

作者： shuai Xu Youdi Zhang Yanna Sun Pei Cheng Zhaoyang Yao Ning Li Long Ye Lijian Zuo Ke gao Key Laboratory of Advanced Green Functional Materials College of ChemistryChangchun Normal UniversityChangchun 130032People’s Republic of China Shandong Provincial Key Laboratory for Science of Material Creation and Energy Conversion School of Chemistry and Chemical EngineeringShandong UniversityQingdao 266237People’s Republic of China College of Polymer Science and Engineering Sichuan UniversityChengdu 610065People’s Republic of China State Key Laboratory and Institute of Elemento‑Organic Chemistry Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai UniversityTianjin 300071People’s Republic of China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640People’s Republic of China Tianjin Key Laboratory of Molecular Optoelectronic Sciences School of Materials Science and EngineeringTianjin UniversityTianjin 300350People’s Republic of China State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China

Recently published in Joule,Feng Liu and colleagues from Shanghai Jiaotong University reported a record-breaking 20.8%power conversion efficiency in organic solar cells(OSCs)with an interpenetrating fibril network active layer morphology,featuring a bulk p-in structure and proper vertical segregation achieved through additive-assisted layer-by-layer *** optimized hierarchical gradient fibrillar morphology and optical management synergistically facilitates exciton diffusion,reduces recombination losses,and enhances light capture *** approach not only offers a solution to achieving high-efficiency devices but also demonstrates the potential for commercial applications of OSCs.

关键词： Organic solar cells Additive-assisted layer-by-layer processing Three-dimensional fibril morphology Bulk p-i-n structure Optical management

A systematic survey of PRMT interactomes reveals the key roles of arginine methylation in the global control of RNA splicing and translation

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Science Bulletin 2021年第13期66卷 1342-1357,M0004页

作者： Huan-Huan Wei Xiao-Juan Fan Yue Hu Xiao-Xu Tian Meng Guo Miao-Wei Mao Zhao-Yuan Fang Ping Wu shuai-xin gao Chao Peng Yun Yang Zefeng Wang CAS Key Laboratory of Computational Biology Bio-Med Big Data CenterShanghai Institute of Nutrition and HealthCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China National Facility for Protein Science in Shanghai Zhang-Jiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Xijing Hospital of Digestive Diseases Fourth Military Medical UniversityXi’an 710000China

Thousands of proteins undergo arginine methylation,a widespread post-translational modification catalyzed by several protein arginine methyltransferases(PRMTs).However,global understanding of their biological functions is limited due to the lack of a complete picture of the catalytic network for each ***,we systematically identified interacting proteins for all human PRMTs and demonstrated their functional importance in mRNA splicing and *** demonstrated significant overlapping of interactomes of human PRMTs with the known methylarginine-containing *** PRMTs are functionally redundant with a high degree of overlap in their substrates and high similarities between their putative methylation ***,RNA-binding proteins involved in regulating RNA splicing and translation contain highly enriched arginine methylation ***,inhibition of PRMTs globally alternates alternative splicing(AS)and suppresses *** particular,ribosomal proteins are extensively modified with methylarginine,and mutations in their methylation sites suppress ribosome assembly,translation,and eventually cell ***,our study provides a global view of different PRMT networks and uncovers critical functions of arginine methylation in regulating mRNA splicing and translation.

关键词： Post-translational modification Protein arginine methyltransferase RNA-binding protein Ribosomal proteins Alternative splicing mRNA translation

Nitrogen-doped Zn–Ni oxide for electrochemical reduction of carbon dioxide in sea water

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Rare Metals 2021年第11期40卷 3117-3124页

作者： shuai Zhang xin-Tong gao Peng-Fei Hou Tie-Rui Zhang Peng Kang Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Chemistry Beijing University of Chemical TechnologyBeijing 100029China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China

Nitrogen-doped Zn-Ni oxide nanoparticles prepared by ammonia treatment are efficient electrocatalysts for CO_(2) reduction to *** single-phase nanostructures of N-Zn-Ni oxide nanoparticles exhibited high electrocatalytic CO_(2) reduction activity with CO Faradaic efficiency of 91.5% and partial current density of 3.2 mA·cm^(-2) at-0.95 V(*** hydrogen electrode’RHE) in NaCl aqueous ***’ N-Zn-Ni oxides catalyst achieved CO Faradaic efficiency over 89%at—0.8 V(***) in natural seawater’ much better than the CO_(2) reduction activity of benchmark Ag/C catalysts in seawater’ and demonstrated strong tolerance to several metal ion impurities with retained CO *** notable reactivity toward CO_(2) reduction and contamination-tolerance is attributed to peculiar synergistic effect from binary Zn-Ni oxide and nitrogen doping.

关键词： Electrochemical CO_(2)reduction Nitrogendoped Zn–Ni oxide Seawater Heavy metal ions-tolerance electrocatalyst CO production

Microstructure and microhardness of aluminium alloy with underwater and in-air wire-feed laser deposition

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International Journal of Minerals,Metallurgy and Materials 2023年第4期30卷 670-677页

作者： Ning Guo Qi Cheng Yunlong Fu Yang gao Hao Chen shuai Zhang xin Zhang Jinlong He State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology at WeihaiWeihai 264209China Shandong Institute of Shipbuilding Technology Weihai 264209China School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China China Oil&Gas Pipeline Network Corporation Beijing 100101China

This study carried out the underwater and in-air wire-feed laser deposition of an aluminium alloy with a thin-walled tubular structure. For both the underwater and in-air deposition layers, both were well-formed and incomplete fusion, cracks, or other defects did not *** with the single-track deposition layer in air, the oxidation degree of the underwater single-track deposition layer was slightly *** both the underwater and in-air deposition layers, columnar dendrites nucleated close to the fusion line and grew along the direction of the maximum cooling rate in the fusion region(FR), while equiaxed grains formed in the deposited region(DR). As the environment changed from air to water, the width of DR and height of FR decreased, but the deposition angle and height of DR increased. The grain size and ratio of the high-angle boundaries also decreased due to the large cooling rate and low peak temperature in the water ***, the existence of a water environment benefitted the reduction of magnesium element burning loss in the DR. The microhardness values of the underwater deposition layer were much larger than those of the in-air layer, owing to the fine grains and high magnesium content.

关键词： wire-feed laser deposition microstructure magnesium element burn loss microhardness

Colonic tubular duplication combined with congenital megacolon:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12768-12774页

作者： Zhe-Ming Zhang shuai Kong xin-xin gao Xiang-Hao Jia Chun-Ning Zheng School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Gastrointestinal Surgery Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Colonic duplication refers to a spherical or tubular cavity which shows similar properties with the native colon and is attached to the mesenteric side of the alimentary *** is the rarest in alimentary tract *** upon anatomic feature,colonic duplications can be classified as spherical(cystic)or tubular,with the latter being less common(approximately 20%).Symptoms of colonic duplication are dependent on the duplication site and extent,and patient age,***,patients with colonic duplication manifest typical intestinal obstruction,potentially accompanied by recurrent dark or bright red bloody stool,varying degrees of anemia-related symptoms,and body *** SUMMARY A young male patient was admitted to our hospital due to recurrent abdominal *** definite diagnosis was achieved by computed tomography(CT)or electronic colonoscopy,and the bowel preparation efficacy was *** disease was suspected,and thus laparoscopic exploration was *** approximately 60-cm-long inverted duplicated colon with severe edema and dilation was *** originated from the mesenteric side of the transverse colon and ended in the terminal part of the descending colon with a blind *** parallel native colon had a thickened colonic wall,became stiff,and was poor in *** patient then underwent subtotal colectomy and was discharged 7 d after the *** 3 mo post-surgery to date,the patient had regular bowel movement once daily and a steady increase in body *** Tubular colonic duplication is a rare type of alimentary tract duplication that can be detected by ultrasonography,CT,or magnetic resonance imaging based on the actual clinical *** resection of aberrant colon(including the duplicated colonic segment and other potentially involved colonic segments)is the only approach to cure this medical condition.

关键词： Colonic duplication Chronic constipation Subtotal colectomy Congenital megacolon Case report

The insensitive mechanism of poultry to zearalenone:A review

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Animal Nutrition 2021年第3期7卷 587-594页

作者： Kuntan Wu Chenxi Ren Yangfan Gong xin gao Shahid Ali Rajput Desheng Qi shuai Wang Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan430070China Cargill Animal Nutrition Technology Application Center Bazhou065000China

Zearalenone(ZEN)is one of the most common contaminating mycotoxins and is mainly produced by Fusarium *** and its metabolites can interfere with estrogen function and affect animals'reproductive *** are most susceptible to ZEN,and ZEN is less harmful to poultry than to *** exact mechanism for the difference in susceptibility remains *** this review,we summarized some possible reasons for the relative insensitivity of poultry to ZEN,such as the lower total amount ofα-zearalenol(α-ZOL)and theα-ZOL-to-β-ZOL ratio which reduce the toxicity of ZEN to *** faster hepatic and enteric circulation,and excretion capacity in poultry can excrete more ZEN and its *** are other possible factors such as the transformation of intestinal microorganisms,differ-ences in hydroxysteroid dehydrogenases'activity,high estrogen levels,and low estrogen receptors affinity which can also cause poultry to be relatively insensitive to *** this review,we summarized the hazards,pollution status,metabolic pathways,and some measures to mitigate ZEN's ***,we discussed the possible mechanisms of low reproductive toxicity by ZEN in poultry.

关键词： Zearalenone Poultry Low sensitivity Metabolism Detoxification

Simultaneously enhanced moisture tolerance and defect passivation of perovskite solar cells with cross-linked grain encapsulation

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Journal of Energy Chemistry 2021年第5期30卷 455-462页

作者： Ke Xiao Qiaolei Han Yuan gao shuai Gu xin Luo Renxing Lin Jia Zhu Jun Xu Hairen Tan National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093JiangsuChina School of Electronics Science and Engineering Nanjing UniversityNanjing 210093JiangsuChina

The grain surfaces(film surface and grain boundary)of polycrystalline perovskite films are vulnerable sites in solar cells since they pose a high defect density and initiate the degradation of perovskite *** simultaneously defect passivation and grain protection from moisture is crucial for the viability of perovskite solar ***,an in situ cross-linked grain encapsulation(CLGE)strategy that improves both device stability and defect passivation is ***-linkable semiconducting small molecules are mixed into the antisolvent to uniformly form a compact and conducting cross-linked layer over the grain *** cross-linked coating layer not only passivates trap states and facilitates hole extraction,but also enhances the device stability by preventing moisture *** the CLGE strategy,a high power conversion efficiency(PCE)of 22.7%is obtained in 1.55-eV bandgap planar perovskite solar *** unencapsulated devices with CLGE exhibit significantly enhanced device stability again moisture and maintain>90%of their initial PCE after shelf storage under ambient condition for over10,000 h.

关键词： Perovskite solar cell Cross-link Defect passivation Stability Moisture tolerance