检索结果-南通市图书馆

同方期刊数据库

Choice of operative method for pancreaticojejunostomy and a multivariable study of pancreatic leakage in pancreaticoduodenectomy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2021年第11期13卷 1405-1413页

作者： Hui Liang Jian-Guo Wu Fei wang bo-Xuan Chen Shi-Tian Zou Cong wang shuai-Wu Luo Department of Hepatobiliary and Pancreas The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND As one of the major abdominal operations,pancreaticoduodenectomy(PD)involves many *** operation is complex,and the scope of the operation is large,which can cause significant trauma in *** operation has a high rate of *** leakage is the main complication after *** pancreatic leakage occurs after PD,it can often lead to abdominal bleeding and infection,threatening the lives of *** study found that pancreatic leakage was affected by many factors including the choice of pancreaticojejunostomy method which can be well *** To investigate the choice of operative methods for pancreaticojejunostomy and to conduct a multivariate study of pancreatic leakage in *** A total of 420 patients undergoing PD in our hospital from January 2014 to March 2019 were enrolled and divided into group A(n=198)and group B(n=222)according to the pancreatointestinal anastomosis method adopted during the ***-to-mucosa pancreatojejunostomy was performed in group A and bundled pancreaticojejunostomy was performed in group *** operation time,intraoperative blood loss,and pancreatic leakage of the two groups were *** occurrence of pancreatic leakage after the operation in different patients was *** The differences in operative time and intraoperative bleeding between groups A and B were not significant(P>0.05).In group A,the time of pancreatojejunostomy was 26.03±4.40 min and pancreatic duct diameter was 3.90±1.10 *** measurements were significantly higher than those in group B(P0.05).The rates of pancreatic leakage in patients with preoperative albumin<30 g/L,preoperative jaundice time≥8 wk,and pancreatic duct diameter<3 mm,were 23.33%,33.96%,and 19.01%,*** were significantly higher than those

关键词： Pancreatoduodenectomy Pancreatojejunostomy Choice of operative methods Pancreatic leakage Multivariate analysis

Ultra-fast amorphization of crystalline alloys by ultrasonic vibrations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第11期142卷 76-88页

作者： Luyao Li Guo-Jian Lyu Hongzhen Li Caitao Fan Wenxin Wen Hongji Lin bo Huang Sajad Sohrabi shuai Ren Xiong Liang Yun-Jiang wang Jiang Ma Weihua wang Guangdong Key Laboratory of Electromagnetic Control and Intelligent Robots Shenzhen UniversityShenzhen 518060China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China National Engineering Research Center of Near-net-shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510640China Institute of Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200444China School of Engineering Science University of Chinese Academy of SciencesBeijing 101408China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The amorphization of alloys is of both broad scientific interests and engineering *** considered as an efficient strategy to regulate and even achieve record-breaking properties of metallic materials,a facile and rapid method to trigger solid-state amorphization is still being *** we report such a method to utilize ultrasonic vibration to trigger amorphization of intermetallic *** ultrasonic vibrations can cause tunable amorphization at room temperature and low stress(2 MPa)***,the ultrasonic-induced amorphization could be achieved in 60 s,which is 360 times faster than the ball milling(2.16×10^(4) s)with the similar proportion of *** elements redistribute uniformly and rapidly via the activated short-circuit *** experimental evidences and simulations show that the amorphous phase initiates and expands at nanograin boundaries,owing to the induction of lattice *** work provides a groundbreaking strategy for developing novel materials with tunable structures and properties.

关键词： Amorphization Ultrasonic vibration Lattice instability Elemental diffusion

Twins-like nanodrugs synchronously transport in blood and coalesce inside tumors for sensitive ultrasound imaging and triggerable penetrative drug delivery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aggregate

Aggregate 2024年第3期5卷 175-187页

作者： Yujun Cai Gengjia Chen Minzhao Lin bo Li Huihai Zhong Tan Li Zecong Xiao Yong wang Xintao shuai PCFM Lab of Ministry of Education School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhouChina Nanomedicine Research Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Radiology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina College of Chemistry and Materials Science Jinan UniversityGuangzhouChina

Nanodrugs capable of aggregating in the tumor microenvironment(TME)have demonstrated great efficiency in improving the therapeutic *** vari-ous approaches,the strategy utilizing electrostatic interaction as a driving force to achieve intratumor aggregation of nanodrugs has attracted great ***,the great difference between the two nanodrugs with varied physicochemical prop-erties makes their synchronous transport in blood circulation and equal-opportunity tumor uptake impossible,which significantly detracts from the beneficial effects of nanodrug aggregation inside *** herein propose a new strategy to construct a pair of extremely similar nanodrugs,referred to as“twins-like nanodrugs(TLNs)”,which have identical physicochemical properties including the same morphology,size,and electroneutrality to render them the same blood circulation time and tumor *** 1:1 mixture of TLNs(TLNs-Mix)intravenously injected into a mouse model efficiently accumulates in tumor sites and then transfers to oppositely charged nanodrugs for electrostatic interaction-driven coalescence via responding to matrix metalloproteinase-2(MMP-2)enriched in *** addition to enhanced tumor retention,the thus-formed micron-sized aggregates show high echo intensity essen-tial for ultrasound imaging as well as ultrasound-triggered penetrative drug *** to their distinctive features,the TLNs-Mix carrying sonosensitizer,immune adjuvant,and ultrasound contrast agent exert potent sonodynamic immunotherapy against hypovascular hepatoma,demonstrating their great potential in treating solid malignancies.

关键词： intratumor aggregation by coulombic interactions penetrative drug delivery sonodynamic immunother-apy twins-like nanodrugs ultrasound imaging

Screening compounds against HCV based on MAVS/IFN-β pathway in a replicon model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第44期16卷 5582-5587页

作者： Qiu-Xia Fu Li-Cui wang shuai-Zheng Jia bo Gao Yong Zhou Juan Du Ying-Li wang Xiao-Hui wang Jian-Chun Peng Lin-Sheng Zhan Laboratory of Blood-borne Virus Beijing Institute of Transfusion Medicine Beijing 100850 China

AIM:To develop a sensitive assay for screening compounds against hepatitis C virus (HCV).METHODS:The proteolytic cleavage of NS3/4A on enhanced yellow fluorescent protein (eYFP)-mitochondrial antiviral signaling protein (MAVS) was examined by reporter enzyme secreted placental alkaline phosphatase (SEAP),which enabled us to perform ongoing monitoring of anti-HCV drugs through repeated *** localization of eYFP-MAVS was assessed by fluorescence *** localization and protein levels were examined by Western ***:HCV NS3/4A protease cleaved eYFP-MAVSfrom mitochondria to block the activation of interferon (IFN)-β promoter,thus resulting in downregulation of SEAP *** decrease in SEAP activity was proportional to the dose of active NS3/4A *** this reporter assay was used to detect anti-HCV activity of IFN-α and cyclosporine ***:Our data show that this reporter system is a sensitive and quantitative reporter of anti-HCV *** system will constitute a new tool to allow the efficient screening of HCV inhibitors.

关键词： Mitochondrial antiviral signaling protein Hepatitis C virus Interferon-β Drug screening

CAS FGOALS-f3-L Model Datasets for CMIP6 DCPP Experiment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第10期40卷 1911-1922页

作者： shuai HU bo WU Yiming wang Tianjun ZHOU Yongqiang YU Bian HE Pengfei LIN Qing BAO Hailong LIU Kangjun CHEN Shuwen ZHAO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100864China

The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this *** FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled ***,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization *** hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,*** decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic *** preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean.

关键词： CMIP6 DCPP FGOALS-f3-L decadal prediction model initialization

Network pharmacology-based analysis of heat clearing and detoxifying drug JC724 on the treatment of colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2023年第1期15卷 90-101页

作者： Hua-Zhen Tang Zhen-Peng Yang shuai Lu Bing wang Yu-Ying wang Xi-bo Sun Jin-Xiu Qu Ben-Qiang Rao Department of Gastrointestinal Surgery Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastrointestinal Surgery Key Laboratory of Cancer FSMP for State Market RegulationBeijing 100038China Department of Breast Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTaian 271000Shandong ProvinceChina

BACKGROUND Heat-clearing and detoxifying drugs has protective effect on colorectal cancer(CRC).Given the complicated features of Traditional Chinese medicine formulas,network pharmacology is an effective approach for studying the multiple interactions between drugs and *** To systematically explore the anticancer mechanism of heat-clearing and detoxifying drug *** This study obtained the active compounds and their targets in JC724 from Traditional Chinese Medicine System Pharmacology *** addition,the CRC targets were obtained from Drugbank,TTD,DisGeNET and GeneCards *** performed transcriptome analysis of differentially expressed genes in CRC treated with *** diagram was used to screen the JC724-CRC intersection targets as candidate *** targets were selected by proteinprotein interaction network and herb ingredient-target-disease network *** functional and pathway of core targets were analysed by enrichment *** We found 174 active ingredients and 283 compound targets from JC724.940 CRC-related targets were reserved from the four databases and 304 CRC differentially expressed genes were obtained by transcriptome *** constructed the network and found that the five core ingredients were quercetin,βBeta sitosterol,wogonin,kaempferol and *** core JC724-CRC targets were CYP1A1,HMOX1,CXCL8,NQO1 and ***724 acts on multiple signaling pathways associated with CRC,including the Nrf2 signaling pathway,oxidative stress,and the IL-17 signaling *** In this study,we systematically analyzed the active ingredients,core targets and main mechanisms of JC724 in the treatment of *** study could bring a new perspective to the heat-clearing and detoxifying therapy of CRC.

关键词： Heat-clearing and detoxifying therapy Colorectal cancer Network pharmacology Transcriptomics

Chitin scaffold combined with autologous small nerve repairs sciatic nerve defects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第5期17卷 1106-1114页

作者： bo wang Chang-Feng Lu Zhong-Yang Liu shuai Han Pi Wei Dian-Ying Zhang Yu-Hui Kou Bao-Guo Jiang Department of Orthopedics and Trauma Key Laboratory of Trauma and Neural Regeneration(Ministry of Education/Peking University)Peking University People’s HospitalBeijingChina Department of Orthopedics Chinese PLA General HospitalBeijingChina National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijingChina

Although autologous nerve transplantation is the gold standard for treating peripheral nerve defects,it has many clinical *** an alternative,various tissue-engineered nerve grafts have been developed to substitute for autologous *** this study,a novel nerve graft composed of chitin scaffolds and a small autologous nerve was used to repair sciatic nerve defects in *** novel nerve graft greatly facilitated regeneration of the sciatic nerve and myelin sheath,reduced atrophy of the target muscle,and effectively restored neurological *** the epineurium of the small autogenous nerve was removed,the degree of nerve regeneration was similar to that which occurs after autogenous nerve *** findings suggest that our novel nerve graft might eventually be a new option for the construction of tissue-engineered nerve *** study was approved by the Research Ethics Committee of Peking University People's Hospital(approval No.2019 PHE27)on October 18,2019.

关键词： autologous small nerve chitin scaffold nerve defect nervous system peripheral nerve injury peripheral nerve regeneration sciatic nerve trauma

Anti-inflammatory iridoids from the stems of Cistanche deserticola cultured in Tarim Desert

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2016年第1期14卷 61-65页

作者： NAN Ze-Dong ZHAO Ming-bo Zeng Ke-Wu TIAN shuai-Hua wang Wei-Nan JIANG Yong TU Peng-Fei State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191China Leshan Vocational & Technical college Leshan 614000 China

In order to determine the chemical constituents of Cistanche deserticola cultured in Tarim desert,a systematically phytochemical investigation was carried *** constituents were isolated by silica gel,Sephadex LH-20,MCI gel,ODS column chromatography,and semi-preparative *** structures were determined on the basis of MS and NMR spectroscopic analyses,by chemical methods,and/or comparison with literature *** anti-inflammatory activities of the isolates were evaluated for their inhibitory effects on the lipopolysaccharide(LPS)-induced nitric oxide(NO)production in BV-2 mouse microglial *** iridoids were isolated and identified as cistadesertoside A(1),cistanin(2),cistachlorin(3),6-deoxycatalpol(4),gluroside(5),kankanoside A(6),ajugol(7),bartsioside(8),and 8-epi-loganic acid(9).Compound 9 exhibited potent inhibition on the NO production with an IC_(50) value being 5.2 μmol·L^(-1),comparable to the positive control quercetin(4.3 μmol·L^(-1)).Compound 1 was a new iridoid,and compounds 5,6,and 8 were isolated from this species for the first time.

关键词： Cistanche deserticola Iridoids Structure elucidation Anti—inflammatory activity

Zn release from fluid inclusions in a natural sphalerite

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2013年第5期20卷 420-426页

作者： Shu-ming Wen Jian Liu bo Li Run-sheng Han Yi Zhang Jiu-shuai Deng Faculty of Land Resource Engineering Kunming University of Science and Technology Southwest Institute of Geological Survey Center for Non-ferrous Mineral Resources Kunming University of Science and Technology

The type, size, and compositions of fluid inclusions in a natural sphalerite were investigated and the total concentration of Zn released from the fluid inclusions was measured. To compare the total concentration of Zn released from the fluid inclusions with that dissolved from the sphalerite itself, dissolution experiments and theoretical calculations for the dissolution equilibrium of the sphalerite were also performed. The results indicate that large numbers of fluid inclusions with various sizes exist in the sphalerite, which can be divided into four types, i.e., pure gaseous inclusions, pure liquid inclusions, gas-liquid inclusions, and gas-liquid inclusions containing solid minerals. These inclusions were broken open during the grinding process, and their compositions were released to the solution. The total concentration of Zn released from these inclusions reaches 18.35×10^-6 mol/L, which is much higher than that of Zn dissolved from the sphalerite itself （1.93×10^-6 mol/L） and the theoretical calculation value （2.73×10^-8 mol/L）.

关键词： zinc ore treatment sphalerite fluid inclusions flotation