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Expression of NALP3 in the Spleen of Mice with Portal Hypertension

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第2期30卷 170-172页

作者：夏泽锋王国斌万赤丹刘涛王帅王博程锐 Department of General Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

This study examined the mRNA expression of NALP3 in the spleen of the mice with hypersplenism due to portal hypertension （PH）. The mouse hypersplenism models were established by oral administration of tetrachloromethane （2 mL/kg/week for 12 weeks by oral gavage）. All the mice were randomly divided into a control group and an experimental group. The blood routine test was conducted, spleen index was calculated and spleen was histologically examined. Portal vein sera were taken for detection of the level of uric acid. The mRNA expressions of NALP3 and IL-1β in the spleen were detected by reverse transcriptase-polymerase chain reaction （RT-PCR）. The results showed that the platelet count was significantly lower in the experimental group [（674±102）× 10^9/L] than in the control group [（1307±181） × 10^9/L] （P〈0.05）, while the spleen index was significantly higher [（9.83 ±1.36） μg/g] in the experimental group than in the control group [（4.11 ±0.47） μg/g] （P〈0.05）. The histopathological changes of spleen followed the pattern of congestive splenomegaly. No significant difference was found in the uric acid level in the portal vein between the control group and the experiment group. The mRNA expressions of NALP3 and IL-1β were up-regulated significantly in the spleen in the experimental group as compared with those in the control group （P〈0.05）. It was concluded that NALP3 and IL-1β may play important roles in the pathogenesis of hypersplenism.

关键词： NALP3 interleukin-1β hypersplenism hypertension, portal

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： shuai Zhang Pei-Zhi Liu Yan-bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan wang Tian-Yu Wei Jia-Wei Jiang Ye wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

关键词：

新型丙烯酸酯聚合物的合成及其在棉织物上的应用

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东华大学学报（自然科学版） 2013年第1期39卷 60-65,69页

作者：帅博旺黄焰根孟卫东东华大学生态纺织教育部重点实验室上海201620

从三氯氧磷和N-羟乙基哌嗪出发,经多步反应合成了一种含有磷酰胺基的丙烯酸酯单体,该单体与含氟丙烯酸酯及其他功能性单体经乳液聚合形成了含氟共聚物PA1和不含氟的聚合物PA2.将这两种聚合物应用于棉织物整理,并对整理后的棉织物性能进... 详细信息

从三氯氧磷和N-羟乙基哌嗪出发,经多步反应合成了一种含有磷酰胺基的丙烯酸酯单体,该单体与含氟丙烯酸酯及其他功能性单体经乳液聚合形成了含氟共聚物PA1和不含氟的聚合物PA2.将这两种聚合物应用于棉织物整理,并对整理后的棉织物性能进行了测试.聚合物PA1具有良好的拒水性能和一定的阻燃性能,经其处理后的棉织物表面对水接触角为140°,其极限氧指数(LOI)为23.4%;而经过PA2整理的棉织物具有相对较好的阻燃性能,其LOI值为26.3%.

关键词：丙烯酸酯乳液聚合阻燃拒水

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

Fabrication of interface heating composite evaporator for rapid sewage treatment and water purification

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Science China(Technological Sciences) 2021年第10期64卷 2292-2299页

作者： MIAO Xiao LIU shuai wang Min GE bo ZHU ChangQing Shandong Provincial Key Laboratory of Optical Communication Science and Technology School of Physics Science and Information TechnologyLiaocheng UniversityLiaocheng 252059China School of Materials Science and Engineering Liaocheng UniversityLiaocheng 252059China

It is an ideal way to produce clean water after sewage treatment,during which two problems need to be solved:(1)how to deal with water soluble pollutants and surface oil slick;(2)photothermal devices should float on *** paper presents a multifunctional water treatment device that can produce clean water vapor under light after sewage *** bismuth oxybromide catalyst degrades water-soluble pollutants under light ***(SH)melamine sponge has two functions:selectively adsorb surface oil slick and ensure that photothermal devices *** hydrophilic layer provides water for local heating of the photothermal layer to produce water *** SH sponge remains stable and is easy to operate during wastewater treatment,and the efficiency of water vapor production through the photothermal device is increased by 7.2 times compared with that of pure water.

关键词： degradation oil-water separation photothermal device

Hot ductility behavior of a Fe-0.3C-9Mn-2Al medium Mn steel

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International Journal of Minerals,Metallurgy and Materials 2021年第3期28卷 422-429页

作者： Yong-jin wang shuai Zhao Ren-bo Song Bin Hu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The hot ductility of a Fe-0.3C-9Mn-2Al medium Mn steel was investigated using a Gleeble3800 thermo-mechanical *** tensile tests were conducted at different temperatures(600-1300℃)under a constant strain rate of 4×10^(−3)s^(−1).The fracture behavior and mechanism of hot ductility evolution were *** showed that the hot ductility decreased as the temperature was decreased from 1000℃.The reduction of area(RA)decreased rapidly in the specimens tested below 700℃,whereas that in the specimen tested at 650℃was lower than 65%.Mixed brittle-ductile fracture feature is reflected by the coexistence of cleavage step,intergranular facet,and dimple at the *** fracture belonged to ductile failure in the specimens tested between 720-1000℃.Large and deep dimples could delay crack *** change in average width of the dimples was in positive proportion with the change in *** wide austenite-ferrite intercritical temperature range was crucial for the hot ductility of medium Mn *** formation of ferrite film on austenite grain boundaries led to strain *** point elongation occurred at the austenite-ferrite intercritical temperature range during the hot tensile test.

关键词： medium Mn steel hot ductility reduction of area fracture behavior microstructure characterization

Wireless Networked Cognitive Radar System:Overview and Design Guidelines

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China Communications 2024年第12期21卷 1-27页

作者： Wu Qinhao wang Hongqiang Zhang bo wang shuai Intelligent Gaming and Decision-Making Laboratory Beijing 100010China College of Electronic Science National University of Defense TechnologyChangsha 410073China School of Information Science and Electronics Beijing Institute of TechnologyBeijing 100081China

Cognitive radar is a concept proposed by Simon Haykin in 2006 as a new generation of radar system that imitates human cognitive *** from the adaptive signal processing at the receiver in adaptive radar,the cognitive radar realizes closedloop adaptive policy adjustment of both transmitter and receiver in the continuous interaction with the *** a networked radar may significantly enhance the flexibility and robustness than its monostatic counterpart,the wireless networked cognitive radar(WNCR)attracts increasing *** article firstly reviews the concept and development of cognitive radar,especially the related researches of networked cognitive ***,the co-design of cognitive radar and communication is *** the communication quality between radar sensing nodes is the premise of detection,tracking,imaging and anti-jamming performance of the WNCR,the latest researches seldom consider the communication architecture design for ***,this article mainly focuses on the proposal of WNCR concept based on the researches of cognitive radar and analyzes research challenges of WNCR system in practical application,and the corresponding guidelines are proposed to inspire future research.

关键词： electronic countermeasures networked cognitive radar OODA loop radar-communication co-design spectrum sensing

Cooperative interception with fast multiple model adaptive estimation

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Defence Technology（防务技术） 2021年第6期17卷 1905-1917页

作者： Shao-bo wang Yang Guo Shi-cheng wang Zhi-guo Liu shuai Zhang Xi’an Research Institution of Hi-Technology China Xi’an Research Institution of Hi-Technology Northwestern Polytechnical UniversityChina

For the case that two pursuers intercept an evasive target,the cooperative strategies and state estimation methods taken by pursuers can seriously affect the guidance accuracy for the target,which performs a bang For the case that two pursuers intercept an evasive target,the cooperative strategies and state estimation methods taken by pursuers can seriously affect the guidance accuracy for the target,which performs a bang-bang evasive maneuver with a random switching *** Fast multiple model adaptive estimation(Fast MMAE)algorithm,the cooperative guidance law takes detection configuration affecting the accuracy of interception into *** the detection error model related to the line-of-sight(LOS)separation angle of two interceptors,an optimal cooperative guidance law solving the optimization problem is designed to modulate the LOS separation angle to reduce the estimation error and improve the interception *** to the uncertainty of the target bang-bang maneuver switching time and the effective fitting of its multi-modal motion,Fast MMAE is introduced to identify its maneuver switching time and estimate the acceleration of the target to track and intercept the target *** designed cooperative optimal guidance law with Fast MMAE has better estimation ability and interception performance than the traditional guidance law and estimation method via Monte Carlo simulation.

关键词： Cooperative guidance Optimal control Fast multiple model adaptive estimation (fast MMAE) Bang-bang maneuver Switch time Detection configuration Estimation error

Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor

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Science China Chemistry 2022年第7期65卷 1383-1400页

作者： Gengjia Chen Yujun Cai bo Li Minzhao Lin Xiaobin wang Zhiyong wang Xintao shuai Key Laboratory for Polymeric Composite&Functional Materials of Ministry of Education School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Nanomedicine Research Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Minimally Invasive Interventional Radiology Laboratory of Interventional Radiologythe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510275China

The dense desmoplastic stroma and immunosuppressive microenvironment of pancreatic cancer hinder the penetration of drugs and induce a considerable resistance to conventional chemoradiotherapy. Although nanomedicine has recently shown attractive potential in cancer immunotherapy, it remains a great challenge to achieve efficient drug delivery and potent immune ***, a stimuli-responsive nanosystem, comprising superparamagnetic iron oxide nanocrystals and nitric oxide(NO) donors,was developed for in-situ triggered catalytic cascade reaction to produce abundant free radicals and remodel the anti-tumor immunity. The nanosystem was activated in the tumor microenvironment to produce NO which dilated the tumor vasculature for efficient drug delivery, and the iron oxide nanocrystals catalyzed the reaction of NO to generate reactive oxygen-nitrogen species(RONS) with high cytotoxicity. Moreover, owing to the catalytic cascade reactions mediated by the nanosystem, the tumor associated macrophages(TAMs) were converted to a proinflammatory M1 phenotype and tumor infiltration of effector T cells was promoted to result in potent anti-tumor immunotherapy which could be readily monitored with magnetic resonance imaging(MRI).

关键词： nanozyme catalytic cascade reactions macrophages tumor microenvironment nitric oxide

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