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Effects of Combined Exposure to Formaldehyde and PM2.5 on the Brain of Balb/c Mice Asthma Model

生态毒理学报 2018年第6期13卷 124-135页

作者： Andrea Stojkoska Song Jing Kang Jun Liu Xudong shuai menglei Li Yong Zhao Liang Yang Xu Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079China

Epidemiological studies have shown that there is a link between asthma and brain damage,but toxicological studies have not fully confirmed yet,especially the effects of asthma on the brain. In this study,at first,we explore the effects of asthma on the brain through the establishment of an allergic asthma model. Then PM_(2.5),a typical outdoor air pollutant and formaldehyde,a typical indoor air pollutant were selected to be closer to the true environment and find whether there is any synergism between them. In this study,an ovalbumin( OVA)-sensitized mice asthma model was established. 30 male Balb/c mice were randomly divided into 5 groups:( 1) saline control group,( 2) OVA-sensitized group,( 3) OVA-combined with formaldehyde exposure group,( 4) OVA-combined with PM_(2.5) exposure group,( 5) Combination of OVA,formaldehyde and PM_(2.5) exposure group. The mice were inhaled with formaldehyde or/and instilled with PM_(2.5) from day 1 to 18. The mice asthma model was developed by OVA sensitization and challenge. The mice were sensitized with OVA+Al( OH)3( 5 mg OVA and 175 mg Al( OH)3 in 30 m L saline each time) or saline( 30 m L saline each time) by intraperitoneal injection on day 1,7 and *** was then followed by an aerosol challenge in 1% OVA( 30 min·d^(-1)) from day 19 to 25( 7 times) using an ultrasonic nebulizer. On the 26 th day,the organ coefficient of mice brain was counted,then the contents of oxidative stress of mice brain were measured,including reactive oxygen species( ROS),glutathione( GSH) and malondialdehyde( MDA),and the concentrations of NF-κB and interleukin-1β( IL-1β) were detected by using ELISA *** of interleukin-6( IL-6) was made with immunohistochemical method. Histological assay for brain was also conducted. In our results,all the OVA treated groups showed a significant increase of ROS and a significant decrease of GSH contents when compared with the control group. Except OVA-sensitized group,other OVA treated groups also showed a

关键词： formaldehyde PM2.5 brain allergic asthma oxidative stress

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Gut microbiome,cognitive function and brain structure:a multi-omics integration analysis

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Translational Neurodegeneration 2022年第1期11卷 178-191页

作者： Xinxiu Liang Yuanqing Fu Wen-ting Cao Zhihong Wang Ke Zhang Zengliang Jiang Xiaofang Jia Chun-ying Liu Hong-rou Lin Haili Zhong Zelei Miao Wanglong Gou menglei shuai Yujing Huang Shengdi Chen Bing Zhang Yu-ming Chen Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China School of Life Sciences Westlake University18 Shilongshan RdCloud TownHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of Medical Statistics and EpidemiologySchool of Public HealthSun Yat-Sen UniversityGuangzhou 510080China Chinese Center for Disease Control and Prevention National Institute for Nutrition and HealthBeijing 100050China School of Public Health Hainan Medical UniversityHaikou 571199China Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Trace Element Nutrition National Health CommissionBeijing 100050China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China.

Background:Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes,but evidence from large human cohorts is *** study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent ***:We included 1430 participants from the Guangzhou Nutrition and Health Study(GNHS)with both gut microbiome and cognitive assessment data available as a discovery cohort,of whom 272 individuals provided fecal samples twice before cognitive *** selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up *** 16S rRNA and shotgun metagenomic sequencing,tar-geted serum metabolomics,and cytokine measurements were performed in the *** validation analyses were conducted in an Alzheimer’s disease case-control study(replication study 1,n=90)and another community-based cohort(replication study 2,n=1300)with cross-sectional ***:We found protective associations of specific gut microbial genera(Odoribacter,Butyricimonas,and Bac-teroides)with cognitive impairment in both the discovery cohort and the replication study *** of Bacteroides was further validated in the replication study *** was positively associated with hippocampal volume(β,0.16;95%CI 0.06-0.26,P=0.002),which might be mediated by acetic *** intra-individual alterations in gut microbial composition were found in participants with cognitive *** also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired ***:Our findings reveal that specific gut microbial features are closely associated with cognitive impair-ment and decreased hippocampal volume,which may play an important role in dementia development.

关键词： Gut microbiome Cognitive impairment Brain structure Metagenomics Microbiome-gut-brain axis Cohort

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang menglei Wang Ruoxuan Yang shuai Feng Xuan Cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

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Gut microbiota,inflammation,and molecular signatures of host response to infection

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Journal of Genetics and Genomics 2021年第9期48卷 792-802页

作者： Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai menglei shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of EpidemiologySchool of Public HealthSun Yat-sen UniversityGuangzhou 510275China Taizhou Hospital Wenzhou Medical UniversityLinhai 325035China CAS Key Laboratory for Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Gut microbial dysbiosis has been linked to many noncommunicable ***,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to ***,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the *** demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,*** further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 *** metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and ***,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy *** results may provide novel insights into the cross-talk between gut microbiota and host immune system.

关键词： Gut microbiota Proinflammatory cytokines Proteomic biomarkers COVID-19 Host infection response

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Hidden metal-insulator transition in manganites synthesized via a controllable oxidation

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Science China Materials 2019年第4期62卷 577-585页

作者： Chuangye Song Iftikhar Ahmed Malik menglei Li Qinghua Zhang Lichen Wang Jing Wang Rongyan Chen Renkui Zheng shuai Dong Lin Gu Wenhui Duan Ce-Wen Nan Jinxing Zhang Department of physics Beijing Normal University Department of Physics Capital Normal University Institute of physics Chinese Academy of Sciences School of Materials Science and Engineering Tsinghua University Center for Advanced Quantum Studies Beijing Normal University State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences School of Physics Southeast University Department of Physics and State Key Laboratory of Low-Dimensional Quantum Physics Tsinghua University

Oxygen usually plays crucial roles in tuning the phase structures and functionalities of complex oxides such as high temperature superconductivity, colossal magnetoresistance, catalysis, etc. Effective and considerable control of the oxygen content in those functional oxides could be highly desired. Here, using perovskite manganite(La0.5Sr0.5)MnO3 as a paradigm, we develop a new pathway to synthesize the epitaxial thin films assisted by an in-situ chemical process, where the oxygen content can be precisely controlled by varying oxidative activity tuned by the atmospheric temperature(Tatm)during the growth. A hidden metal-insulator transition(MIT)emerges due to the phase competition, which is never shown in the phase diagram of this classic manganite. The oxygenmediated interaction between Mn ions together with the change of carrier density might be responsible for this emerging phase, which is compatible with the results of firstprinciple calculations. This work demonstrates that, apart from traditional cation doping, a precise modulation of anion(O2-, S2-, etc.) may provide a new strategy to control phase structures and functionalities of epitaxial compound thin films.

关键词： oxidative-activity oxygen-content manganites hidden metal-insulator transition

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一种基于LiDAR点云的河道纵横断面获取方法

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北京测绘 2020年第8期34卷 1114-1118页

作者：杜艺葛帅单萌蕾山东省水利勘测设计院济南250013 济南市房产测绘研究院济南250001

本文基于LiDAR点云进行河道纵横断面的获取。包括数据采集、数据预处理、点云滤波、精编DEM等步骤;根据已有的河道中心线,按照特定距离,在精编的DEM上提取断面点;通过空三立体模型进行关键断面点位置的调整,得到断面点成果;给出与实测... 详细信息

本文基于LiDAR点云进行河道纵横断面的获取。包括数据采集、数据预处理、点云滤波、精编DEM等步骤;根据已有的河道中心线,按照特定距离,在精编的DEM上提取断面点;通过空三立体模型进行关键断面点位置的调整,得到断面点成果;给出与实测断面数据的精度对比。该方法节省了外业实测断面点所需的人力物力财力,提高了工作效率和质量。

关键词：航空摄影激光雷达数字高程模型

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一种C型臂X线卵圆孔成像方法的建立与临床验证

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中华神经外科杂志 2024年第1期40卷 67-72页

作者：刘展陶胜忠卢慧鹏王艮卫耿晓腾尹梦磊马帅睢豫擘郑州大学第二附属医院神经外科郑州450000 平顶山市第一人民医院神经外科平顶山467000

目的建立一种C型臂X线卵圆孔成像方法并进行临床验证。方法收集2020年6月至2022年12月于郑州大学第二附属医院神经外科就诊并接受头颅薄层CT扫描患者(虚拟成像组,90例)的影像学资料,基于头颅CT三维重建图像进行卵圆孔模拟成像。前瞻性纳... 详细信息

目的建立一种C型臂X线卵圆孔成像方法并进行临床验证。方法收集2020年6月至2022年12月于郑州大学第二附属医院神经外科就诊并接受头颅薄层CT扫描患者(虚拟成像组,90例)的影像学资料,基于头颅CT三维重建图像进行卵圆孔模拟成像。前瞻性纳入2022年1月至2023年6月于郑州大学第二附属医院神经外科接受经皮穿刺三叉神经半月节球囊压迫术治疗的原发性三叉神经痛患者(真实穿刺组,12例),术中进行C型臂X线卵圆孔成像;患者取平卧位,标记鼻小柱下缘点(A点)及两侧眶外侧缘与颧弓上缘延长线的交点(B、C点)。沿水平轴旋转C型臂,确定B、A、C三点共线后,再于X线下确定A点重合于双侧眶下缘最外端连线,沿滑轨向穿刺侧偏斜球管20~25°,获取卵圆孔投影。将卵圆孔成像效果分为Ⅰ(完整、清晰显像)、Ⅱ(部分显像)、Ⅲ(裂隙样显像)3类。比较虚拟成像组模拟X线透视下与CT图像上卵圆孔Ⅰ类成像的一致性。观察真实穿刺组患者术中卵圆孔的成像效果。结果90例虚拟成像组患者中,Ⅰ类成像75例,Ⅱ类成像8例,Ⅲ类成像7例。与CT三维重建图像比较,模拟X线透视卵圆孔Ⅰ类成像的灵敏度为97.4%,特异度为100%,一致性检验显示一致性好(Kappa=0.92,P<0.001)。在12例患者经皮卵圆孔穿刺过程中,卵圆孔全部完整显像,顺利完成卵圆孔穿刺。结论通过X线面部解剖标志的特定投影确定C型臂的倾斜角度,从而建立的C型臂X线卵圆孔成像方法使多数患者可获得良好的卵圆孔成像效果,在卵圆孔穿刺术中可辅助卵圆孔显像。

关键词：卵圆孔颅底成像,三维体层摄影术,X线计算机三叉神经痛

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三维精准手术计划对减少高Hunt-Hess分级动脉瘤夹闭术中并发症的意义

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实用医学杂志 2023年第14期39卷 1779-1785页

作者：刘展陶胜忠王艮卫王在斌耿晓腾马帅张栋韬尹梦磊郑州大学第二附属医院神经外科郑州450000

目的探讨术者在进行合并严重颅内血肿的前循环动脉瘤夹闭时,能否在三维个体化的精准手术计划指导下,减少术中并发症的发生。方法使用3D Slicer软件对23例高Hunt-Hess分级的前循环动脉瘤患者术前CT和CTA图像进行融合及三维体绘制重建,制... 详细信息

目的探讨术者在进行合并严重颅内血肿的前循环动脉瘤夹闭时,能否在三维个体化的精准手术计划指导下,减少术中并发症的发生。方法使用3D Slicer软件对23例高Hunt-Hess分级的前循环动脉瘤患者术前CT和CTA图像进行融合及三维体绘制重建,制定精确的个体化手术方案并指导动脉瘤夹闭术,并比较规划手术中与实际术中发现的一致性。结果按照精准手术方案进行头位摆放和开颅,能明显减少术中对患者头位的调整及因术野狭窄而二次磨除蝶骨嵴;规划术野中显示的瘤颈形态、瘤颈瘤体过渡区薄弱部位以及瘤颈旁细小动脉对实际术中发现判断的灵敏度分别为90%、50%和75%,特异度分别为100%、100%和93.3%,Kappa值分别为0.701、0.623和0.732;规划夹闭方式对实际夹闭方式判断的灵敏度为100%,特异度25%,Kappa系数0.355。结论三维个体化的精准手术计划,能有效帮助术者对合并大量颅内出血的前循环动脉瘤手术夹闭过程做出精确预判,有利于减少术中并发症。

关键词：脑动脉瘤动脉瘤夹闭术中并发症 Hunt-Hess分级三维重建

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基于“法时用药”精准治疗夏季放化疗后肿瘤相关带状疱疹

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天津中医药大学学报 2022年第5期41卷 594-597页

作者：苏景阳王梦蕾傅越严江陈帅林胜友浙江中医药大学附属杭州市中医院杭州310007

通过查阅文献、跟师临证学习,分析总结基于“法时用药”精准治疗夏季放化疗后肿瘤相关带状疱疹的病因病机、治则治法、用药特色等临证诊疗思路,并附典型病案为广大医师治疗肿瘤相关带状疱疹提供指导帮助。

关键词：肿瘤带状疱疹夏季法时用药

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3种磷代阻燃剂在室内外灰尘中的粒径分布规律及人体暴露评估

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环境科学学报 2017年第7期37卷 2759-2766页

作者：曹治国董星依石玉盟孙丽芳赵小曼杨帅王梦蕾赵磊成闫广轩张鑫沈墨海余刚河南师范大学环境学院黄淮水环境污染与防治教育部重点实验室河南省环境污染控制重点实验室新乡453007 清华大学环境学院新兴有机污染物控制北京市重点实验室北京100084

磷代阻燃剂(Phosphorus flame retardants,PFRs)是目前被广受关注的一类新型有机污染物.探究了北京市5类典型室内外灰尘中3种PFRs(三(2-丁氧乙基)磷酸酯(Tris(2-butoxyethyl)phosphate,TBOEP)、磷酸三(2-氯乙基)酯(Tris(chloroethyl)phosphate,TCEP)、磷酸三(2-氯异丙基)酯(Tris(2-chloroisopropyl)phosphate,TCIPP))的污染特征、粒径分布规律及人体暴露水平.结果显示,3种PFRs在宾馆灰尘中的污染水平均最高,在道路灰尘中最低.PFRs在不同类型灰尘中的粒径分布特征存在显著差异.宾馆员工和儿童对灰尘中PFRs的暴露水平较高,需引起重视.

关键词：室内灰尘磷代阻燃剂污染特征粒径分布暴露评估

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