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gNAS mutations suppress cell invasion by activating MEg3 in growth hormone–secreting pituitary adenoma

Oncology Research 2024年第6期32卷 1079-1091页

作者： CHAO TANg CHUNYU ZHONg JUNHAO ZHU FENg YUAN JIN YANg YONg XU CHIYUAN ma Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(gHPAs)harbor somatic activating mutations in gNAS(αsubunit of stimulatory g protein).Mutations in gNAS are associated with clinical features of smaller and less invasive ***,the role of gNAS mutations in the invasiveness of gHPAs is *** mutations were detected in gHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEg3)was evaluated with ***3 was manipulated in gH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEg3 on tumor growth and *** invasiveness of gHPAs was significantly decreased in mice with mutated gNAS compared with that in mice with wild-type ***,the invasiveness of mutant gNASexpressing gH3 cells ***3 is uniquely expressed at high levels in gHPAs harboring mutated ***,MEg3 upregulation inhibited tumor cell invasion,and conversely,MEg3 downregulation increased tumor cell ***,gNAS mutations inhibit EMT in ***3 in mutated gNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that gNAS mutations may suppress cell invasion in gHPAs by regulating EMT through the activation of the MEg3/Wnt/β-catenin signaling pathway.

关键词： gHPAs gNAS mutation MEg3 β-catenin EMT

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geochemical characteristics and exploration significance of ultra-deep Sinian oil and gas from Well Tashen 5,Tarim Basin,NW China

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Energy geoscience 2024年第1期5卷 24-36页

作者： Zicheng Cao Anlai ma Qinqi Xu Quanyong Pan Kai Shang Fan Feng Yongli Liu Northwest Petroleum Oilfield Company SINOPECUrumqi830011China Petroleum Exploration and Production Research Institute SINOPEC102260BeijingChina

The Well Tashen 5(TS5),drilled and completed at a vertical depth of 9017 m in the Tabei Uplift of the Tarim Basin,NW China,is the deepest well in *** has been producing both oil and gas from the Sinian at a depth of 8780e8840 m,also the deepest in Asia in terms of oil *** this paper,the geochemical characteristics of Sinian oil and gas from the well were investigated and compared with those of Cambrian oil and gas discovered in the same *** oil samples,with Pr/Ph ratio of 0.78 and a whole oil carbon isotopic value of31.6‰,have geochemical characteristics similar to those of Ordovician oils from the No.1 fault in the North Shuntuoguole area(also named Shunbei area)and the Middle Cambrian oil from wells Zhongshen 1(ZS1)and Zhongshen 5(ZS5)of Tazhong *** maturity of light hydrocarbons,diamondoids and aromatic fractions all suggest an approximate maturity of 1.5%e1.7%Ro for the ***(4-+3-)methyldiamantane concentration of the samples is 113.5 mg/g,indicating intense cracking with a cracking degree of about 80%,which is consistent with the high bottom hole temperature(179℃).The Sinian gas samples are dry with a dryness coefficient of *** gas is a mixture of kerogen-cracking gas and oil-cracking gas and has Ro values ranging between 1.5%and 1.7%,and methane carbon isotopic values of41.6‰.Based on the equivalent vitrinite reflectance(R_(eqv)=1.51%e1.61%)and the thermal evolution of source rocks from the Cambrian Yu'ertusi Formation of the same well,it is proposed that the Sinian oil and gas be mainly sourced from the Cambrian Yu'ertusi Formation during the Himalayan period but probably also be joined by hydrocarbon of higher maturity that migrated from other source rocks in deeper *** discovery of Sinian oil and gas from Well TS5 suggests that the ancient ultra-deep strata in the northern Tarim Basin have the potential for finding volatile oil or condensate reservoirs.

关键词： Ultra-deep Sinian oil and gas Oil-cracking Well Tashen 5 Tarim Basin

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In Vitro Propagation and Artificial Seed Production of Fritillaria cirrhosa D. Don, an Endangered Medicinal Plant

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Phyton-International Journal of Experimental Botany 2024年第6期93卷 1297-1310页

作者： Qian Tao guiqi Han Bujin ma Hongmei Jia Can Zhao Wenshang Li Zhuyun Yan Chengdu University of Traditional Chinese Medicine State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest ChinaChengdu610000China

Fritillaria cirrhosa ***(Liliaceae)is an endangered perennial bulbous plant and its dry bulb is a valuable med-icinal material with antitussive and expectorant ***,lack of resources and expensive prices make it difﬁcult to meet clinical *** study presents a regeneration system aimed at overcoming the challenge of inadequate supply in ***,focusing on:(1)callus induction,(2)bulblets and adventitious bud induction,and(3)artiﬁcial seed *** development was achieved in 84.93%on Murashige and Skoog(MS)medium fortiﬁed with 1.0 mg·L^(-1) *** optimal medium for callus differentiation into regenerated bulb-lets was MS medium supplemented with 1.0 mg·L^(-1)6-benzyladenine(6-BA)and 0.2 mg·L^(-1)α-naphthaleneacetic acid(NAA).Subsequently,bulblets and adventitious buds were induced from regenerated bulblet sections cul-tured on MS medium fortiﬁed with 0.3 mg·L^(-1)6-BA+1.0 mg·L^(-1)2,4-dichlorophenoxyacetic acid(2,4-D),2.0 mg·L^(-1)6-BA+0.5 mg·L^(-1),and the induction rates were 88.17%and 84.24%,*** regenerated bulblets were transplanted into a substrate of humus soil,river sand,and pearlite(1:1:1)after low-temperature *** germination rate was 42.80%after culture for 30 *** bulblets were used for encap-sulations in liquid MS medium containing 3%sucrose(w/v)+0.5 mg·L^(-1) NAA+2.0 mg·L^(-1)6-BA+3%sodium alginate(w/v)with a 10 min exposure to 2%CaCl_(2).Under non-aseptic conditions,the germination rate reached 81.67%,while the rooting rate was 20.56%after 45 *** capsule added 1.0 g·L^(-1) carbendazim and 1.0 g·L^(-1) activated carbon was the best component of artiﬁcial *** study successfully established an efﬁcient regen-eration system for the rapid propagation of ***,involving in vitro bulblet regeneration and artiﬁcial seed *** method introduces a novel approach for efﬁcient breeding and germplasm preservation,making it suitable for large-scale industrial resou

关键词： Artiﬁcial seed callus induction Fritillaria cirrhosa organogenesis plant propagation

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Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients

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World Journal of gastrointestinal Oncology 2024年第2期16卷 364-371页

作者： Ji-Chun Tang Jia-Wei ma Jin-Jin Jian Jie Shen Liang-Liang Cao Department of Anesthesiology The Affiliated Hospital of Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Anesthesiology People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture 843599Xinjiang Uygur Autonomous RegionChina Department of Critical Care Medicine Jiangnan University Medical CenterWuxi 214122Jiangsu ProvinceChina Department of Critical Care Medicine People's Hospital of Aheqi CountyKizilsu Kirgiz Autonomous Prefecture843599Xinjiang Uygur Autonomous RegionChina

BACKgROUND According to clinical data,a significant percentage of patients experience pain after surgery,highlighting the importance of alleviating postoperative *** current approach involves intravenous self-control analgesia,often utilizing opioid analgesics such as morphine,sufentanil,and *** for colo-rectal cancer typically involves general ***,optimizing anes-thetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative *** study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients'postoperative *** To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal *** Following the inclusion criteria and exclusion criteria,a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included,of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group,and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research *** data collection,the effects of postoperative analgesia,sedation,and recovery were *** Compared to the control group,the research group had shorter recovery times for orientation,extubation,eye-opening,and spontaneous respiration(Pgroup also showed lower Visual analog scale scores at 24 h and 48 h,higher Ramany scores at 6 h and 12 h,and improved cognitive function at 24 h,48 h,and 72 h(Pgnificantly reduced at various time points in the research group compared to the control group(Pgroup at multiple time points(Pg

关键词： Multimodal analgesia Anesthesia Colorectal cancer Postoperative pain

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An efficient recycling strategy to eliminate the residual“impurities”while heal the damaged structure of spent graphite anodes

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green Energy & Environment 2024年第6期9卷 1027-1034页

作者： Dan Yang Ying Yang Haoran Du Yongsheng Ji Mingyuan ma Yujun Pan Xiaoqun Qi Quan Sun Kaiyuan Shi Long Qie Institute of New Energy for Vehicles School of Materials Science and EngineeringTongji UniversityShanghai201804China State Key Laboratory of material Processing and Die&Mold Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China shuangdeng group Co. Ltd.Taizhou225500China School of materials Science and Engineering Sun Yat-Sen UniversityGuangzhou510275China

The recycling of graphite from spent lithium-ion batteries(LIBs)is overlooked due to its relatively low added value and the lack of efficient recovering *** reuse the spent graphite anodes,we need to eliminate their useless components(mainly the degraded solid electrolyte interphase,SEI)and reconstruct their damaged ***,a facile and efficient strategy is proposed to recycle the spent graphite on the basis of the careful investigation of the composition of the cycled graphite anodes and the rational design of the regeneration *** regenerated graphite,which is revitalized by calcination treatment and acid leaching,delivers superb rate performance and a high specific capacity of 370 mah g^(-1)(~99% of its theoretical capacity)after 100 cycles at 0.1 C,superior to the commercial graphite *** improved electrochemical performance could be attributed to unchoked Li^(+) transport channels and enhanced charge transfer reaction due to the effective destruction of the degraded SEI and the full recovery of the damaged structure of the spent *** work clarifies that the electrochemical performance of the regenerated graphite could be deteriorated by even a trace amount of the residual“impurity”and provides a facile method for the efficient regeneration of graphite anodes.

关键词： graphite Anode Regeneration Solid electrolyte interphase Spent lithium-ion battery

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A Meeting of Mood Swings——Recapping the annual group of Seven Summit in Italy

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Beijing Review 2024年第43期67卷 30-31页

作者： ma Miaomiao 不详

In Borgo Egnazia,a luxury resort near the town of Fasano in south Italy's Apulia Region,the group of Seven(g7)Summit concluded on June 16,with members each having their own strategic considerations and the next steps remaining *** summit brought together the leaders of its seven member countries-Canada,France,germany,Italy,Japan,the United Kingdom and the United States,as well as representatives of the European Union,i.e.,European Council President Charles Michel and European Commission President Ursula von der Leyen.

关键词： Italy resort Canada

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VSe_(2)/V_(2)C heterocatalyst with built-in electric field for efficient lithium-sulfur batteries:Remedies polysulfide shuttle and conversion kinetics

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Journal of Energy Chemistry 2024年第2期89卷 397-409,I0010页

作者： Yanwei Lv Lina Bai Qi Jin Siyu Deng Xinzhi ma Fengfeng Han Juan Wang Lirong Zhang Lili Wu Xitian Zhang Key Laboratory for Photonic and Electronic Bandgap materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina

Lithium sulfur(Li-S)battery is a kind of burgeoning energy storage system with high energy ***,the electrolyte-soluble intermediate lithium polysulfides(Li PSs)undergo notorious shuttle effect,which seriously hinders the commercialization of Li-S ***,a unique VSe_(2)/V_(2)C heterostructure with local built-in electric field was rationally engineered from V_(2)C parent via a facile thermal selenization *** exquisitely synergizes the strong affinity of V_(2)C with the effective electrocatalytic activity of VSe_(2).More importantly,the local built-in electric field at the heterointerface can sufficiently promote the electron/ion transport ability and eventually boost the conversion kinetics of sulfur *** Li-S battery equipped with VSe_(2)/V_(2)C-CNTs-PP separator achieved an outstanding initial specific capacity of 1439.1 m A h g^(-1)with a high capacity retention of 73%after 100 cycles at0.1 *** impressively,a wonderful capacity of 571.6 ma h g^(-1)was effectively maintained after 600cycles at 2 C with a capacity decay rate of 0.07%.Even under a sulfur loading of 4.8 mg cm^(-2),areal capacity still can be up to 5.6 m A h cm^(-2).In-situ Raman tests explicitly illustrate the effectiveness of VSe_(2)/V_(2)C-CNTs modifier in restricting Li PSs *** with density functional theory calculations,the underlying mechanism of VSe_(2)/V_(2)C heterostructure for remedying Li PSs shuttling and conversion kinetics was *** strategy of constructing VSe_(2)/V_(2)C heterocatalyst in this work proposes a universal protocol to design metal selenide-based separator modifier for Li-S ***,it opens an efficient avenue for the separator engineering of Li-S batteries.

关键词： Li-S battery Shuttle effect Separator modifier VSe_(2)/V_(2)C heterostructure Built-in electric field

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Double-confined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C toward ultra-stable Li-/Na-ion batteries

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Rare Metals 2024年第5期43卷 2067-2079页

作者： Dan Wang Qun ma Huan He Zhi-Yuan Wang Run-guo Zheng Hong-Yu Sun Yan-guo Liu Chun-Li Liu School of materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and Electrolyte Functional material Hebei Province Qinhuangdao 066004China Department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin 17035Korea

Antimony-based materials with high capacities and moderate potentials are promising anodes for lithium-/-sodium-ion ***,their tremendous volume expansion and inferior conductivity lead to poor structural stability and sluggish reaction ***,a doubleconfined nanoheterostructure Sb/Sb_(2)S_(3)@Ti_(3)C_(2)T_(x)@C has been fabricated through a solvothermal method followed by low-temperature heat *** dual protection of“MXene”and“carbon”can better accommodate the volume expansion of Sb/Sb_(2)S_(3).The strong covalent bond(Ti-S,Ti-O-Sb,C-O-Sb)can firmly integrate Sb-based material with Ti_(3)C_(2)T_(x)and carbon,which significantly improves the structure *** addition,the carbon layer can restrain the oxidation of MXenes,and the nano-Sb/Sb_(2)S_(3)can facilitate electron/ion transport and suppress the restacking of *** heterogeneous interface between Sb and Sb_(2)S_(3)can further promote interfacial charge *** MXene-Sb/Sb_(2)S_(3)@C-1 with the optimal Sb content shows high specific capacities,comparable rate properties and ultra-stable cycling performances(250 m Ah·g^(-1)after 2500 cycles at 1 A·g^(-1)for sodium-ion batteries).Ex situ X-ray diffractometer(XRD)test reveals the storage mechanism including the conversion and alloying process of MXene-Sb/Sb_(2)S_(3)@*** voltammetry(CV)test results demonstrate that the pseudocapacitance behavior is dominant in MXene-Sb/Sb_(2)S_(3)@C-1,especially at large *** design paves the way for exploring high-performance alloy-based/conversion-type anode for energy storage devices.

关键词： Sb/Sb_(2)S_(3) MXene Carbon Anode Lithium-ion batteries Sodium-ion batteries

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Fluoro-functionalized plant biomass adsorbent:Preparation and application in extraction of trace perfluorinated compounds from environmental water samples

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Journal of Environmental Sciences 2024年第3期137卷 703-715页

作者： Xi Tan Yan Shi Chun-Feng ma Quan Chi Yu-Hang Yang Wen-Xiang Zhang Hua-Ming Xiao Xian Wang Key Laboratory of Analytical Chemistry of the State Ethnic Affairs Commission School of Chemistry and Materials ScienceSouth-Central Minzu UniversityWuhan 430074China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Key Laboratory of Oilseeds Processing of Ministry of Agriculture Hubei Key Laboratory of Lipid Chemistry and NutritionOil Crops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Perfuorinated compounds(PFCs)are toxic and widely present in the environment,and therefore effective adsorbents are required to remove PFCs from environmental *** the present study,a new type of fuorinated biomass materials was synthesized via an ingenious fuorosilanization *** adsorbents were applied for the adsorption of 13typical PFCs,including perfuorocarboxylic acids(PFCAs)and perfuorosulfonic acids(PFSAs).By comparing their adsorption performance,Fluorinated cedar slag(FCS)was discovered to have the best absorption efficiency and enabled highly efficient enrichment of *** adsorption recovery of FCS with the investigated PFCs is greater than 90%under the optimal adsorption *** to the high affinity of F-F sorbent-sorbate interaction,FCS had good adsorption capacities of PFCs from aqueous solution,with the maximum adsorption capacity of 15.80 mg/g for PFOS and 10.71 mg/g for PFOA,***,the adsorption time could be achieved in a short time(8 min).Using the FCS absorbent,an innovative FCS-solid phase extraction assisted with high performance liquid chromatography-electrospray-tandem mass spectrometry(FCS-SPE-HPLC-ESI-MS/MS)method was first developed to sensitively detect PFCs in the environmental water *** intra-day and inter-day recovery rates of the 13 compounds ranged from 90.7%-104.3%,with the RSD of 2.1%-4.7%(intra-day)and 2.5%-8.5%(inter-day),*** research demonstrates the potential of the newly fuoro-functionalized plant biomass to adsorb PFCs from environmental water,with the advantages of high adsorption efficiencies,high antiinterference,easy operation and low economic cost.

关键词： Fluoro-functionalized biomass Perfuorinated compounds(PFCs) Adsorption efficiency mass spectrometry(MS) Fluorinated cedar slag(FCS)

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Atmospheric VOCs in an industrial coking facility and the surrounding area:Characteristics,spatial distribution and source apportionment

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Journal of Environmental Sciences 2024年第4期138卷 660-670页

作者： Meicheng Wen Weiqiang Deng Jin Huang Shu Zhang Qinhao Lin ChaoWang Shengtao ma Wanjun Wang Xin Zhang guiying Li Taicheng An guangdong-Hong Kong-macao Joint Laboratory for Contaminants Exposure and Health Guangdong Key Laboratory of Environmental Catalysis and Health Risk ControlInstitute of Environmental Health and Pollution controlGuangdong University of TechnologyGuangzhou 510006China guangdong Engineering Technology Research Center for Photocatalytic Technology Integration and Equipment Guangzhou Key Laboratory of Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China Institute of Environmental Science Shanxi UniversityTaiyuan 030006China

Industrial coking facilities are an important emission source for volatile organic compounds(VOCs).This study analyzed the atmospheric VOC characteristics within an industrial coking facility and its surrounding *** concentrations of total VOCs(TVOCs)in the surrounding residential activity areas(R1 and R2),the coking facility(CF)and the control area(CA)were determined to be 138.5,47.8,550.0,and 15.0μg/m^(3),*** cold drum process and coking and quenching areas within the coking facility were identified as the main polluting *** spatial variation in VOCs composition was analyzed,showing that VOCs in the coking facility and surrounding areas were mainly dominated by aromatic compounds such as BTX(benzene,toluene,and xylenes)and naphthalene,with concentrations being negatively correlated with the distance from the coking facility(pg area were analyzed,finding that coking emissions accounted for 73.5%,33.3% and 27.7% of TVOCs in CF,R1 and R2,*** results demonstrated that coking emissions had a significant impact on VOC concentrations in the areas surrounding coking *** study evaluates the spatial variation in exposure to VOCs,providing important information for the influence of VOCs concentration posed by coking facility to surrounding residents and the development of strategies for VOC abatement.

关键词： Coking facility Volatile organic compounds Emission inventory Spatial distribution Source apportionment

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