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Division and identification of vertical reservoir units in Archaeozoic metamorphic buried hill of Bozhong Sag,Bohai Bay Basin,East China

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Petroleum Exploration and Development 2022年第6期49卷 1282-1294页

作者： YI Jian LI Huiyong SHAN Xuanlong HAO Guoli YANG Haifeng WANG Qingbin XU Peng REN shuyue College of Earth Sciences Jilin UniversityChangchun 130061China Tianjin Branch of China National Offshore Oil Company Ltd. Tianjin 300452China

Based on the data associated with cores,sidewall cores,casting thin sections,reservoir physical properties,conventional logging and imaging logging,the classification schemes of vertical reservoir units are proposed for the two types of Archaeozoic buried hills(exposed and covered ones)in the Bozhong Sag,Bohai Bay *** geological characteristics and storage spaces of these reservoir units are described,and their identification markers in conventional and imaging log curves are *** Archaeozoic metamorphic buried hills can be vertically classified into two primary reservoir units:weathering crust and inner buried *** weathering crust contains four secondary units,i.e.,the clay zone,weathered glutenite zone,leached zone,disaggregation zone;and the interiors contain two secondary units,i.e.,interior fracture zone and tight *** particular,the inner fracture zone was further divided into cataclasite belts and dense-fracture *** is proposed that the favorable reservoirs of exposed Archaeozoic metamorphic buried hills are mainly developed in four parts including weathered glutenite zone,leached zone,disintegration zone superposed with the cataclasite belt and the cataclasite belt of inner fracture zone,and are controlled by both weathering and tectonic *** reservoirs in covered Archaeozoic metamorphic buried hills are mainly developed in the weathering crust superposed with the cataclasite belts and the cataclasite belts of inner fracture zone,and are mainly controlled by tectonic actions.

关键词： Bohai Bay Basin Bozhong Sag Archaeozoic metamorphic buried hills reservoir units logging identification

Prospect of immunotherapy alone in patients with advanced NSCLC with high btmb:a review and a meta-analysis

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Holistic Integrative Oncology 2023年第1期2卷 460-471页

作者： Feiyu Zhao Xiaochen Qiu Qinna Yang shuyue Gao Fan Yang Niansong Qian Departmentof Oncology Chinese PLA Medical SchoolBeijing 100853China Department of General Surgery The First Medical Center of ChinesePLA General HospitalBeijingChina Department of Oncology Department of Respiratory and Critical Care MedicineThe Eighth Medical Center of ChinesePLA General HospitalNo.17 A Heishanhu RoadHaidian DistrictBeijing 100853China

Lung cancer is the most prevalent cancer in the world,and the main treatment for advanced non-small cell lung cancer is immunotherapy combined with *** recent years,bTMB has received increasing attention as an emerging metric for monitoring the efficacy of tumour immunotherapy in terms of its operability,accessibility and real-time *** envisaged whether immunotherapy alone could be used to reduce the side effects of chemotherapy in patients with high bTMB lung *** thus did a meta-analysis in order to show that immunotherapy alone is feasible in patients with high bTMB *** This study aims to compare the efficacy of PD-1/PD-L1 inhibitors(namely,atezolizumab,pembrolizumab,nivolumab,or tislelizumab)versus chemotherapy in NSCLC *** search for relevant studies was conducted in three major databases(i.e.,PubMed,Embase,and Medline)up until January ***,we identified studies that reported risk ratios(HRs)for reporting progression-free survival(PFS)or overall survival(OS),or objective remission rates(ORs)for immunotherapy alone versus chemotherapy in high bTMB and low bTMB patient *** that NSCLC represents the predominant type of lung cancer,we exclusively focused on this *** analysis encompassed a meta-analysis of the identified literature,incorporating heterogeneity analysis and sensitivity *** quality of the evidence is evaluated using the Grading of Recommendations Assessment,Development and Evaluation(GRADE)approach to ascertain the reliability and robustness of the ***-We conducted a meta-analysis of seven randomised controlled trials including 4,755 patients with advanced non-small cell lung cancer(NSCLC)evaluated the efficacy of PD-1 or PD-L1 monotherapy compared to chemotherapy *** patients were randomized to receive either PD-1/PD-L1 treatment alone or chemotherapy alone as a *** the high bTMB patient group,PD-1/PD-L1 monotherapy resulted in significant improve

关键词： Blood tumor mutation burden NSCLC Immunotherapy alone Chemotherapy alone

“双碳”背景下可回收物回收模式现状调查及政策建议——以上海市黄浦区为例

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环境卫生工程 2023年第4期31卷 101-106页

作者：刘抒悦上海环境集团股份有限公司上海200336

“双碳”目标是我国构建人类命运共同体、实现可持续发展的重大战略决策,构建绿色低碳循环发展经济体系、加强再生资源回收利用是实现“双碳”目标的关键一环。通过采取3种研究方法 (实地走访、定性归纳、定量方法),对上海市黄浦区可回... 详细信息

“双碳”目标是我国构建人类命运共同体、实现可持续发展的重大战略决策,构建绿色低碳循环发展经济体系、加强再生资源回收利用是实现“双碳”目标的关键一环。通过采取3种研究方法 (实地走访、定性归纳、定量方法),对上海市黄浦区可回收物回收模式进行研究。结果显示:黄浦区已建立符合区域情况的“可回收物”体系,实现可回收物“点、站”基本覆盖,但也存在中心城区场地制约、邻避效应显著、居民分类意识不强、品类形态差异、回收企业积极性不足等一些问题,影响全程分类体系建设。基于黄浦区可回收物回收模式现状,系统性地提出加强居民精细分类宣传、合理规划设施建设、建立全程数字化监管体系、加强品类差异化补贴等建议。

关键词：上海市黄浦区可回收物回收模式

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MiR-181b-5p contributes to hepatic glycogen synthesis through EGR1/PTEN/AKT pathway

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MiR-181b-5p contributes to hepatic glycogen synthesis throug...

基于BP神经网络的连续状态并串联系统冗余度优化设计

中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议

作者： shuyue Wang Yulun Wu Meiting Yang Yuxin Li National Engineering Laboratory for Druggable Gene and Protein Screening School of Life SciencesNortheast Normal University Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education Northeast Normal University

MiR-181 family plays an important role in the regulation of various cellular ***,whether MiR-181 b-5 p mediates hepatic insulin resistance remains *** this study,we found that miR-181 b-5 p was significantly decreased in the liver of diabetic mice as well as in hepatocytes treated with high ***,inhibition of miR-181 b-5 p expression led to impairment of AKT/GSK pathway and reduced level of glycogenesis,whereas overexpression of miR-181 b-5 p resulted in activated AKT/GSK pathway and increased glycogen levels in *** Addition,up-regulation of miR-181 b-5 p reversed high glucose-induced suppression of glycogenesis in *** study revealed that EGR1 is a target of miR-181 b-5 p by luciferase reporter assay and western *** of EGR1 by transfecting with siRNA targeting EGR1 could significantly suppress the expression of PTEN and then increase glycogen ***1 knockdown reversed miR-181 b-5 p inhibition-induced reduced glycogenesis and activation of AKT/GSK *** conclusion,we found novel evidence suggesting that hepatic miR-181 b-5 p mediated glycogen synthesis through targeting EGR1 to regulate PTEN expression.

关键词： EGR1 hepatic glycogenesis high glucose miR-181b-5p PTEN

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机械强度 2007年第2期29卷 247-250页

作者：尹树悦陈东林空军工程大学工程学院西安710038

提出一种以费用为约束条件的连续状态并串联系统冗余度优化设计模型。用传统的优化算法很难求得该模型目标函数的显性表达式,文中提出用BP(back propagation)神经网络对目标函数进行逼近,得到的近似目标函数是标准sigmoid函数的线性组... 详细信息

提出一种以费用为约束条件的连续状态并串联系统冗余度优化设计模型。用传统的优化算法很难求得该模型目标函数的显性表达式,文中提出用BP(back propagation)神经网络对目标函数进行逼近,得到的近似目标函数是标准sigmoid函数的线性组合。仿真结果表明,该方法可以精确地求得系统的最优冗余度。

关键词：可靠性 BP神经网络连续状态冗余度优化设计 sigmold函数逼近

Effects of mixed-based biochar on water infiltration and evaporation in aeolian sand soil

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Journal of Arid Land 2022年第4期14卷 374-389页

作者： ZOU Yiping ZHANG shuyue SHI Ziyue ZHOU Huixin ZHENG Haowei HU Jiahui MEI Jing BAI Lu JIA Jianli School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China State Key Laboratory of Water Resource Protection and Utilization in Coal Mining Beijing 102211China National Institute of Clean-and-Low-Carbon Energy Beijing 102211China

Aeolian sandy soil in mining areas exhibits intense evaporation and poor water retention *** study was designed to find a suitable biochar application method to improve soil water infiltration and minimize soil water evaporation for aeolian sand *** the indoor soil column method,we studied the effects of three application patterns(A(0-20 cm was a mixed sample of mixed-based biochar and soil),B(0-10 cm was a mixed sample of mixed-based biochar and soil and 10-20 cm was soil),and C(0-10 cm was soil and 10-20 cm was a mixed sample of mixed-based biochar and soil)),four application amounts(0%(control,CK),1%,2%,and 4%of mixed-based biochar in dry soil),and two particle sizes(0.05-0.25 mm(S1)and0.980),but the R2 values of the Horton model exceeded 0.990 for all treatments(except for the treatment B2%(S2)).Compared with CK,all other treatments reduced cumulative soil

关键词： biochar water infiltration water evaporation aeolian sand soil mining areas

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患重大疾病未成年人监护问题的规范路径

学术研究 2024年第1期 70-78页

作者：雷小政闫姝月北京师范大学刑事法律科学研究院暨未成年人检察研究中心北京师范大学法学院北京100875

患重大疾病未成年人容易陷入生存、发展和安全困境,需要政府和社会予以关心帮助。这对患重大疾病未成年人的监护提出了特殊要求。在司法实践中,由于多方面因素影响,仍然存在着一些父母监护缺失、监护不当,委托照护“准入难”、督促监督... 详细信息

患重大疾病未成年人容易陷入生存、发展和安全困境,需要政府和社会予以关心帮助。这对患重大疾病未成年人的监护提出了特殊要求。在司法实践中,由于多方面因素影响,仍然存在着一些父母监护缺失、监护不当,委托照护“准入难”、督促监督与家庭教育指导“落地难”等问题。感染艾滋病病毒的未成年人在流行病学特征、抗病毒治疗、对抗外部歧视等方面具有特殊困境。完善其监护教育、监护保护可为患其他重大疾病未成年人的相关制度建设提供参照。针对患重大疾病未成年人,建议在家庭监护、社会监护、国家监护等各个层面全面贯彻实质监护理念,有针对性地修正、变更、撤销监护权的具体事由,建构专门化、系统化、差别化的档案制度和监护评估体系,立足社区治理补充监护教育、监护保护的短板,在立法上适当拓展委托照护人的范围。

关键词：重大疾病主体特性家庭监护社会监护国家监护

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我校物理学理科基地资料室建设的启示

高等理科教育 2001年第6期 30-32页

作者：宋姝玥华中师范大学物理系

本文通过对华中师范大学物理学理科基地资料室建设的指导思想及实践的介绍,阐述了基地资料室信息化环境建设中,在经费投入、文献信息资源建设、服务环境建设及人员素质提高等方面需要注意的问题.

关键词：物理学理科基地资料室建设师范大学

Association between atherogenic index of plasma and colorectal neoplasms in patients with hypertension

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Chinese Medical Journal 2023年第2期136卷 221-223页

作者： Muzhou Han Hao Wang Haiyun Shi Siying Zhu shuyue Yang Guiping Zhao Peng Li Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Clinical Epidemiology and Evidence-based Medicine Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China

To the Editor:Colorectal cancer(CRC)is the third most commonmalignancy and the second leading cause of cancer death worldwide.[1]Colorectal adenoma(CRA)is a precursor lesion of *** diagnosis and treatment ofCRAare important for preventing the occurrence ofCRC and improving *** the risks associated with invasive procedures and the high cost of colonoscopy,there is an urgent need to identify reliable non-invasive markers of colorectal neoplasms(CRNs).

关键词： neoplasms diagnosis death hypertension