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Insight-HXMT observations of the first binary neutron star merger GW170817

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Science China(Physics,Mechanics & Astronomy) 2018年第3期61卷 26-33页

作者： TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang jia Huo shumei jia LuHua jiang WeiChun jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li Zijian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang jianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan jiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao jianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Department of Physics Tsinghua University Beijing 100084 China University of Chinese Academy of Sciences Chinese Academy of Sciences Beijing 100049 China Department of Astronomy Beijing Normal University Beijing 100088 China Department of Engineering Physics Tsinghua University Beijing 100084 China

Finding the electromagnetic （EM） counterpart of binary compact star merger, especially the binary neutron star （BNS） merger, is critically important for gravitational wave （GW） astronomy, cosmology and fundamental physics. On Aug. 17, 2017, Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart, GRB 170817A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope （HE） onboard Insight-HXMT （Hard X-ray Modulation Telescope） is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart （SSS17a/AT2017gfo） with very large collection area （M000 cm2） and microsecond time resolution in 0.2-5 MeV. In addition, Insight-HXMT quickly implemented a Target of Opportunity （TOO） observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy （0.2-5 MeV） radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817A. Meanwhile, Insight-HXMT/HE provides one of the most stringent constraints （-10-7 to 104 erg/cm2/s） for both GRB170817A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event.

关键词： GW170817 BNS merger gravitational wave electromagnetic counterpart

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

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Science China(Physics,Mechanics & Astronomy) 2020年第4期63卷 2-19页

作者： Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang jia Huo shumei jia LuHua jiang WeiChun jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li Zijian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang jianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan jiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng jianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China

As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be *** we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

关键词： X-and γ-ray telescopes and instrumentation neutron stars black holes X-ray binaries γ-ray bursts

Synthesis, DNA-binding and photocleavage studies of ruthenium(Ⅱ) complexes [Ru(btz)_3]^(2+) and [Ru(btz)(dppz)_2]^(2+)

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Science China Chemistry 2009年第9期52卷 1504-1511页

作者： YU HuiJuan, HUANG shumei, KOU JunFeng, LI LvYing, jia HaiNa, CHAO Hui & JI LiangNian MOE Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China MOE Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou China

Two new ruthenium(Ⅱ) complexes, [Ru(btz)3](ClO4)2 (1) and [Ru(btz)(dppz)2](ClO4)2 (2) (btz = 4,4′-bithi-azole, dppz = dipyrido[3,2-a:2′,3′-c]phenazine), have been synthesized and characterized by elemental analysis, 1H NMR, ES-MS and X-ray crystallography. The DNA binding behaviors of two complexes have been studied by spectroscopic and viscosity measurements. The results suggest that complex 1 binds to CT-DNA via an electrostatic mode, while complex 2 via an intercalative mode. Under irradiation at 365 nm, both complexes were found to promote the cleavage of plasmid pBR 322 DNA from supercoiled form Ⅰ to nicked form Ⅱ. The mechanism studies reveal that singlet oxygen 1O2 and hydroxyl radical (OH-) play a significant role in the photocleavage process.

关键词： ruthenium(Ⅱ) complex DNA binding DNA photocleavage PDT

Surface hydrophobicity of gold nanoparticles modulated the maturation of mouse bone marrow-derived dendritic cells through heme oxygenase-1-mediated autophagy

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Surface hydrophobicity of gold nanoparticles modulated the m...

The enhanced X-ray Timing and Polarimetry mission—eXTP

全国环境纳米技术及生物效应学术研讨会

作者： shumei Zhai Yan Xin jianBo jia Bing Yan School of Chemistry and Chemical Engineering Shandong University

To reveal the correlation between the surface physicochemical properties of nanoparticles and their immunological effects on dendritic cells（DCs） systematically, we investigated the immunomodulation of mouse bone marrow-derived dendritic cells（BMDCs） by gold nanoparticles（AuNPs） with a gradient change in surface hydrophobicity with or without the stimulation of lipopolysaccharides（LPS） in vitro. The results showed that:（1） AuNPs induced the maturation of BMDCs under normal conditions, characterized by an increased surface expression of MHC class Ⅱ and CD86. When the logP reached 1.24, the AuNPs promoted the expression of MHCⅡ to the same level as that induced by LPS. The secretion of cytokines were mainly correlated with the surface hydrophobicity of AuNPs.（2） In contrast, the AuNPs with hydrophobic surface suppressed the activation of BMDCs induced by LPS. Treatment of BMDCs with AuNPs with logP of 0.37, 1.24 and 1.62 significantly suppressed the expression of MHCⅡ and CD86 in the presence of LPS. Consistently, the secretion of cytokines including TNF-α, IL-6 and IL-12 p70 decreased as the surface hydrophobicity of AuNPs increased;（3） Further investigation showed that the expression of heme oxygenase-1（HO-1） and p62 were differently regulated in BMDCs. Therefore, we suggested that HO-1 induced autophagy play a crucial role in the modulation of BMDCs maturation by AuNPs with certain surface hydrophobicity. These data provide a new strategy for the immunomodulation of DCs using nanotechnology.

关键词： gold nanoparticles surface hydrophobicity dendritic cells heme oxygenase-1 autophagy

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 3-27页

作者： ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji shumei jia WeiChun jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng jiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong jiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für Astronomie und Astrophysik Eberhard Karls Universität INAF-Istituto di Astrofisica e Planetologia Spaziali INFN-Roma Tor Vergata Via della Ricerca Scientifica 1 Department of Engineering Physics and Center for Astrophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Space Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espacials de Catalunya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Department of Astronomy University of Genevachemin d’Ecogia 16 Osservatorio di Astrofisica e Scienza Dello Spazio di Bologna Istituto Nazionale di Astofisica Astronomical Institute Czech Academy of Sciences Max Planck Institute for Extraterrestrial Physics Giessenbachstr.1 CEA Paris-Saclay/IRFU Beijing Institute of Spacecraft System Engineering CAST Osservatorio Astronomico di Brera Istituto Nazionale di Astofisica Space Research Center Polish Academy of Sciences Key Laboratory of Advanced Material Microstructure of Education Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Department of Physics and Center for Astrophysics Tsinghua University Universita’degli Studi di Udine Via delle Scienze 206 Mullard Space Science Laboratory University College London Department of Nuclear and Particle Physics University of Geneva SRON Netherlands Institute for Space Research Politecnico di Milano Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipartimento di Fisica e Chimica Fondazione Bruno Kessler Dr.Karl Remeis-Observatory and Erlangen Centre for Astroparticle Physics Universität Erlangen-Nürnberg University of Pavia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Department of Physics and Astronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave *** paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.

关键词： X-ray instrumentation X-ray polarimetry X-ray timing space mission:eXTP

More than a Few LAB Alleviate Common Allergies: Impact of Paraprobiotics in Comparison to Probiotical Live Cells

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Journal of Biosciences and Medicines 2014年第3期2卷 56-64页

作者： Nditange Shigwedha Lanwei Zhang Liubov Sichel Li jia Pimin Gong Wenli Liu shumei Wang Shuang Zhang Xue Han Wei Gao 1School of Food Science and Engineering Harbin Institute of Technology Harbin China 2Department of Food Science and Technology University of Namibia Windhoek Namibia 3Pure Research Products LLC Boulder USA Pure Research Products LLC Boulder USA School of Food Science and Engineering Harbin Institute of Technology Harbin China Wyeth Nutrition Suzhou China

The evidence in this paper indicates that the alarming increase of common allergies can be reduced by the intake of particular “probiotics” or “paraprobiotics” along with food. This appears to build a consensus in the pharmaceutical and food communities about the role of probiotics in the prevention and treatments of common allergies. Food allergy is one of the common allergies, defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Improving the digestion of foods and maintaining a healthy gastrointestinal (GI) tract is certainly critical to controlling food allergens. Therefore, the association between a leaky gut or an impaired intestinal permeability and food-allergenic reactions is explained. Gluten has been found to be somehow a justification for protein allergy, and should, therefore, be avoided by people with celiac disease. In several, in vitro models, surface layer (S- layer) proteins of selective paraprobiotics have shown potential in alleviating food allergies and intestinal disorders. Notably, lactobacilli paraprobiotics have proven to be the immediate immunomodulators against common allergies and other diseases, including viral (flu, hepatitis C), bacterial (bronchitis), asthma, chronic fatigue, fibromyalgia, gastrointestinal distress, and autism disorders in humans.

关键词： Paraprobiotics Food Allergy S-Layer Proteins Immunoglobulin E (IgE) Probiotical Cell Lysates Lactic Acid Bacteria (LAB)

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爱因斯坦探针：探索变幻多姿的X射线宇宙

中国科学：物理学、力学、天文学 2018年第3期48卷 2-21页

作者：袁为民张臣陈勇孙胜利张永合崔伟凌志兴黄茂海赵冬华王文昕裘予雷刘柱潘海武蔡洪波邓劲松贾振卿金驰川孙惠胡海波刘飞飞张墨宋黎明卢方军贾淑梅李承奎赵海升葛明玉张娟崔苇苇王于仨王娟孙小进金戈黎龙辉陈凡胜蔡志鸣郭彤刘国华刘华秋冯骅张双南张冰戴子高吴雪峰苟利军中国科学院国家天文台中国科学院空间天文与技术重点实验室北京100012 中国科学院大学天文与空间科学学院北京100049 中国科学院高能物理研究所北京100049 中国科学院上海技术物理研究所上海200083 中国科学院微小卫星创新研究院上海201203 清华大学天体物理中心北京100084 北方夜视技术股份有限公司南京211106 Department of Physics and Astronomy University of Nevada Las VegasNV 89154USA 北京大学科维理天文与天体物理研究所和天文系北京100871 南京大学天文与空间科学学院南京210093 中国科学院紫金山天文台南京210034

爱因斯坦探针(Einstein Probe,EP)是一颗面向时域天文学的、发现型的X射线天文探测卫星,是中国科学院空间科学战略性先导专项十三五规划的空间科学卫星系列任务之一.展望未来十年,时域天文学将进入一个前所未有的、多波段和多信使的大... 详细信息

爱因斯坦探针(Einstein Probe,EP)是一颗面向时域天文学的、发现型的X射线天文探测卫星,是中国科学院空间科学战略性先导专项十三五规划的空间科学卫星系列任务之一.展望未来十年,时域天文学将进入一个前所未有的、多波段和多信使的大视场监测的黄金时代.在软X射线窗口,灵敏且快速的全天监测为我们提供了一个难得的科学机遇.EP卫星将在这一能段窗口开展时域巡天监测,旨在发现和探索宇宙中的X射线暂现源和爆发天体,并发布预警以引导其他天文设备进行后随跟踪观测.EP的科学载荷包括一台宽视场软X射线监视器(3600平方度,0.5–4 keV)和一台后随观测X射线望远镜(0.3–8 keV).卫星具有快速机动反应能力以及暂现源警报的快速下传功能.由于采用了新颖的微孔龙虾眼X射线聚焦成像技术,其探测灵敏度和空间分辨率比目前在轨运行设备提高了1个数量级,将能监测更远、更大的宇宙空间范围.预期EP将在以下三方面做出贡献:高能暂现天体的系统性巡天监测,发现隐身的沉寂黑洞并测绘宇宙黑洞的分布、研究其形成演化和物质吸积过程,搜寻来自引力波事件的X射线信号并精确定位等.此外,EP的探测目标还将包括从中子星、白矮星、超新星、宇宙早期伽玛暴、X射线闪到恒星耀发等众多的天体和现象,涉及广泛的天体物理学分支.卫星计划于2022年底左右发射.运行寿命为3年,目标5年.

关键词： X射线:空间科学 X射线:时域天文学空间科学卫星:爱因斯坦探针

Comprehensive Prevention and Control Technology of Vegetable Diseases and Pests in Shandong Province

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Plant Diseases and Pests 2024年第1期15卷 26-27,32页

作者： Dongwen SUN Hui YU Yang QIN Yujie LIN Xiaomeng QI Yuxuan CHEN Yuxin HE Xinying YAN jia'er XU shumei GUO Shandong Agriculture and Engineering University Jinan 250100China

An in-depth research and practice has been conducted on vegetable diseases and pests in Shandong Province,and the principles of comprehensive and ecological control of diseases and pests are put forward,including agricultural control measures such as crop rotation,field cleaning,fertilizer and water management,physical control measures such as catching and killing,trapping,blocking,photoelectric energy treatment,biological control measures such as the use of natural enemies,pathogenic microorganisms,other beneficial organisms and metabolites,and scientific and rational chemical control *** prevention and control not only controls vegetable diseases and pests effectively,but also protects the ecological environment.

关键词： Vegetable Diseases and pests Comprehensive prevention and control

葛仙米藻胆蛋白和藻蓝蛋白对S180荷瘤小鼠肿瘤生长的影响及其作用机制

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食品工业科技 2022年第8期43卷 399-405页

作者：余佳陈颖马淑梅张瑞华王玉兰湖南炎帝生物工程有限公司湖南省微藻生物工程技术研究中心湖南株洲412007 湖南工业大学湖南株洲412007 中国医药工业研究总院上海200040 上海医药工业研究院创新药物与制药工艺国家重点实验室上海200437

目的:对人工养殖的葛仙米藻胆蛋白和藻蓝蛋白在S180荷瘤小鼠肿瘤生长的影响及作用机制研究。方法:通过考察S180荷瘤小鼠肿瘤体积、小鼠脏器指数和肿瘤组织切片观察,对葛仙米中藻胆蛋白、藻蓝蛋白的体内抗肿瘤活性进行评价,并初步研究了... 详细信息

目的:对人工养殖的葛仙米藻胆蛋白和藻蓝蛋白在S180荷瘤小鼠肿瘤生长的影响及作用机制研究。方法:通过考察S180荷瘤小鼠肿瘤体积、小鼠脏器指数和肿瘤组织切片观察,对葛仙米中藻胆蛋白、藻蓝蛋白的体内抗肿瘤活性进行评价,并初步研究了其作用机制。结果:体内抗肿瘤作用结果显示,葛仙米藻胆蛋白12.5、25、50 mg/kg剂量组对小鼠肉瘤S180的抑瘤率分别为11.19%、20.14%、37.65%。葛仙米藻蓝蛋白12.5、25、50 mg/kg剂量组对小鼠肉瘤S180的抑瘤率分别为19.74%、35.00%、52.06%。藻蓝蛋白能够明显促进抑癌蛋白P53和促凋亡蛋白Bax的表达,抑制凋亡抑制蛋白Bcl2的表达。结论:葛仙米藻蓝蛋白高剂量组可显著减少S180肉瘤细胞的增殖,葛仙米藻蓝蛋白低、中剂量和葛仙米藻胆蛋白高剂量也有一定的抑制作用,人工养殖的葛仙米中藻胆蛋白和藻蓝蛋白具有较好的体内抗肿瘤活性。

关键词：葛仙米藻胆蛋白藻蓝蛋白 S180荷瘤小鼠抗肿瘤