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Predictive factors for sustained response to interferon treatment in patients with chronic hepatitis C: a randomized, open, and multi-center controlled trial

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 213-219页

作者： Yao Xie DaoZhen Xu ZhiMeng Lu KangXian Luo JiDong Jia YuMing Wang GuiZhen Zhao shulin zhang DaZhi zhang Ninth Clinical Department Beijing Ditan Hospital Beijing 100011 China. xieyao@***

BACKGROUND:This study was undertaken to investigate the predictive factors of sustained viral response in roferon-A or pegasys treated chronic hepatitis C patients after logistic regression analysis of the factors that might be associated with the therapeutic effects of interferon (IFN).;METHODS:All patients enrolled into this randomized, open and multi-center controlled trial were divided into two groups randomly and treated with pegasys and roferon-A for 24 weeks, then followed up for another 24 weeks. Before treatment, hepatitis C virus (HCV) genotype was determined, and HCV-RNA in serum was detected before and at the end of treatment and follow-up. HCV-RNA turning negative was considered the major index for evaluating the therapeutic effect. The clinical characteristics including gender, age, infection route of HCV, treatment with IFN, platelet count, AST/ALT ratio and treatment drugs were analyzed by logistic regression.;RESULTS:Intention to treat (ITT) and per-protocol (PP) population groups have 208 and 197 patients respectively. In the PP group, after treatment for 24 weeks, the response rates of female patients aged less than 50 years, infected through non-transfusion, relapsed after IFN treatment, and presented with a AST/ALT ratio/=1, virus load equal or more than 8 x 10(5) IU/ml, and genotype 1 infection, and treated finally with roferon-A. But, at the end of follow-up, the patients with a AST/ALT ratio>/=1 and virus load more than 8 x 10(5) IU/ml had a higher rate of sustained response than did those with a AST/ALT ratio

关键词： hepatitis C virus chronic hepatitis C interferon peg-IFN genotype

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铁路起重机四轴转向架主要悬挂参数优化

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机械管理开发 2024年第2期39卷 155-157,160页

作者：谢义朋黄誉发凌斌邹峰李志鹏张书林中车株洲车辆有限公司技术开发部湖南株洲412003

通过对比国内现有铁路起重转向架的各项技术,介绍一种新型的焊接式铁路起重机转向架,描述了其基本结构及关键参数,同时利用SIMPACK多体动力学仿真分析软件,建立铁路起重机动力学计算模型,研究减振器阻尼系数、轴箱拉杆定位刚度对车辆动... 详细信息

通过对比国内现有铁路起重转向架的各项技术,介绍一种新型的焊接式铁路起重机转向架,描述了其基本结构及关键参数,同时利用SIMPACK多体动力学仿真分析软件,建立铁路起重机动力学计算模型,研究减振器阻尼系数、轴箱拉杆定位刚度对车辆动力学性能的影响,为转向架悬挂参数选取提供理论依据。

关键词：铁路起重机四轴转向架悬挂参数计算模型

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±800kV与500kV混压大跨越钢管混凝土塔等效风荷载分析

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电力勘测设计 2024年第6期 24-30页

作者：张树林孟宪乔郑治祥徐智东李正良汪之松中国能源建设集团安徽省电力设计院有限公司安徽合肥230601 重庆大学重庆400044

大跨越钢管混凝土塔相比于普通钢管塔存在质量、刚度突变的特点。为探究钢管混凝土塔和钢管塔在风荷载作用下的响应规律及设计风荷载的取值,该文以实际工程为例,通过有限元模拟分析了两种塔型的动力特性和风振响应,并将等效静力风荷载... 详细信息

大跨越钢管混凝土塔相比于普通钢管塔存在质量、刚度突变的特点。为探究钢管混凝土塔和钢管塔在风荷载作用下的响应规律及设计风荷载的取值,该文以实际工程为例,通过有限元模拟分析了两种塔型的动力特性和风振响应,并将等效静力风荷载与规范结果进行比较。结果表明:钢管混凝土塔的刚度明显高于钢管塔,且前几阶频率相对密集,振型间相互耦合明显;按规范等效风荷载的结构响应大于时程分析响应极值;按规范计算的钢管混凝土塔风振系数在灌入混凝土顶部附近存在突变;钢管混凝土塔顶部位移、加速度响应明显小于钢管塔,且钢管混凝土塔的脉动响应下降更为明显。

关键词：钢管混凝土塔钢管塔等效静力风荷载风振系数风振响应

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Rattling-like behavior and band convergence induced ultra-low lattice thermal conductivity in MgAl_(2)Te_(4) monolayer

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Journal of Materiomics 2024年第5期10卷 1004-1016页

作者： Da Wan shulin Bai Xiaodong Li Jingyi zhang Peng Ai Wanrong Guo Shuwei Tang College of Materials Science and Engineering Liaoning Technical UniversityFuxinLiaoning123000China Faculty of Chemistry Northeast Normal UniversityChangchunJilin130024China

Inspired by the excellent stability exhibited by experimentally synthesized two-dimensional(2D)MoSi_(2)N_(4) layered material,the thermal and electronic transport,and thermoelectric(TE)properties of MgAl2Te4 monolayer are systematically investigated using the First-principles calculations and Boltzmann transport *** mechanical stability,dynamic stability,and thermal stability(900 K)of the MgAl_(2)Te_(4) monolayer are demonstrated,*** MgAl_(2)Te_(4) monolayer exhibits a bandgap of 1.35 eV using the HSE06 functional in combination with spin-orbit coupling(SOC)*** convergence in the valence band is favorable to improve the thermoelectric *** rattling thermal damping effect caused by the weak bonding of Mgsingle bondTe bonds in MgAl2Te4 monolayer leads to ultra-low lattice thermal conductivity(0.95/0.38 W/(m·K)@300 K along the x-/y-direction),which is further demonstrated by the phonon group velocities,phonon relaxation time,Grüneisen parameters,and scattering *** optimal zT of 3.28 at 900 K is achieved for the p-type MgAl_(2)Te_(4) monolayer,showing the great promising prospect for the excellent p-type thermoelectric *** current work not only reveals the underlying mechanisms responsible for the excellent TE properties,but also elaborates on the promising thermoelectric application of MgAl_(2)Te_(4) monolayer material at high temperature.

关键词： Thermoelectric material Mg atomic rattling Band convergence Ultra-low lattice thermal conductivity

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Research into Application of Directed-Graph Storage Structure in Workflow Based on Object Petri Model-Defining

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通讯和计算机（中英文版） 2006年第3期3卷 25-30页

作者： Jian Yuan shulin Sui Wenxia zhang College of Automatization and Electronic Engineering Qingdao University of Science and Technology Qingdao 266042 China

Storage structure and algorithm of graph play an important role in Object Petri"s simulation and workflow analysis. Object Petri is a type of directed graph. Through studying the problem of graph storage, a directed graph data structure (carried out by trifurcate chain-table) is put forward, and its construction algorithm is given. It can enhance the speed and decrease the complexity of the algorithm. The trifurcate chain-table structure of Object Petri is emphasized in this paper and it is of benefit to expanding various analysis algorithms of Object Petri. So the model-definingof workflow is easily carried out.1

关键词： Object Petri Workflow-Modeling Trifurcate Storage Structure

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Hif-1α在斑马鱼吞噬细胞迁移及发育中的生物学功能

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武汉轻工大学学报 2024年第2期43卷 50-55页

作者：汪豪罗舸洋魏泽昊司马重圆晏博张舒林余晓丽武汉轻工大学生命科学与技术学院武汉430023 上海市公共卫生临床中心上海201508

探究斑马鱼低氧诱导因子-1α(Hif-1α)基因在中性粒细胞和巨噬细胞的发育和迁移中所起的作用。将斑马鱼分为野生对照组和Hif-1α基因突变组。使用CRISPR/Cas9技术对斑马鱼的Hif-1α基因进行突变。随后,通过苏丹黑B染色法观察了野生对照... 详细信息

探究斑马鱼低氧诱导因子-1α(Hif-1α)基因在中性粒细胞和巨噬细胞的发育和迁移中所起的作用。将斑马鱼分为野生对照组和Hif-1α基因突变组。使用CRISPR/Cas9技术对斑马鱼的Hif-1α基因进行突变。随后,通过苏丹黑B染色法观察了野生对照组和Hif-1α基因突变组中性粒细胞的染色情况,以及通过中性红染色法观察了巨噬细胞的染色情况并对结果进行了统计分析。结果显示成功构建缺失8个碱基的斑马鱼Hif-1α基因突变体,且Hif-1α基因突变的斑马鱼幼鱼发育3 d后,中性粒细胞迁移到急性损伤部位的数量显著减少,突变型斑马鱼后脑室中的小胶质巨噬细胞数量比野生型显著增多。综上,本研究成功构建了斑马鱼Hif-1α基因纯合突变体,同时表明Hif-1α基因具有抑制中性粒细胞向炎症区域迁移的作用,并促进脑室巨噬细胞的生长发育,为后续研究急性损伤模型提供基础。

关键词： Hif-1α基因纯合突变体斑马鱼幼鱼中性粒细胞迁移巨噬细胞发育

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Geodynamics on Formation and Evolution of Bohaiwan Basin,China

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Journal of Earth Science 1997年第1期16卷 53-55页

作者： zhang shulin Tian ShichengDepartment of Petroleum Geology, China University of Geosciences, Wuhan 430074

he Bohaiwan basin is a Cenozoic lacustrine fault basin, which was composed of many subbasins in Eogene. The subbasins can be classified into three types,such as extension subbasin,shove subbasin and transform subbasin, and five subtypes. In the light of the structural styles and distributions of the subbasins, regional dynamic setting and basalt data in the Bohaiwan basin, this paper proposes an inland transformextension model.

关键词： structural style transformextension model geodynamics of sedimentary basin Bohaiwan basin.

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Surface plasmon decorated InGaO deep-UV photodetector array for image sensing and water quality monitoring via highly effective hot electron excitation and interfacial injection

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Science China(Technological Sciences) 2024年第8期67卷 2449-2460页

作者： SHU LinCong SHA shulin XI ZhaoYing LI Lei YAO SuHao zhang JiaHan JI XueQiang zhang ShaoHui BIAN Ang JIANG MingMing GUO YuFeng TANG WeiHua LIU Zeng Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Information Engineering Inner Mongolia UniversityHohhot 010021China College of Science MIIT Key Laboratory of Aerospace Information Materials and PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China School of Science Jiangsu University of Science and TechnologyZhenjiang 212100China School of Integrated Circuits Beijing University of Posts and TelecommunicationsBeijing 100876China

In addition to the plasmon-mediated resonant coupling mechanism,the excitation of hot electron induced by plasmon presents a promising path for developing high-performance optoelectronic devices tailored for various *** study introduces a sophisticated design for a solar-blind ultraviolet(UV)detector array using linear In-doped Ga_(2)O_(3) (InGaO)modulated by platinum(Pt)nanoparticles(PtNPs).The construction of this array involves depositing a thin film of Ga_(2)O_(3) through the plasmonenhanced chemical vapor deposition(PECVD)***,PtNPs were synthesized via radio-frequency magnetron sputtering and annealing *** performance of these highly uniform arrays is significantly enhanced owing to the generation of high-energy hot *** process is facilitated by non-radiative decay processes induced by ***,the array achieves maximum responsivity(R)of 353 mA/W,external quantum efficiency(EQE)of 173%,detectivity(D*)of approximately 10~(13)Jones,and photoconductive gain of *** addition,the standard deviation for photocurrent stays below17%for more than 80%of the array units within the ***,the application of this array extends to photon detection in the deep-UV(DUV)*** includes critical areas such as imaging sensing and water quality *** leveraging surface plasmon coupling,the array achieves high-performance DUV photon *** approach enables a broad spectrum of practical applications,underscoring the significant potential of this technology for the advancement of DUV detectors.

关键词： InGaO PECVD surface plasmon solar-blind UV photodetector array optoelectronic applications

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AN^2 APPLICATION IN THE METRODS OF POPULATION GEOGRAPHY

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Journal of Geographical Sciences 1995年第1期5卷 87-90页

作者： zhang shulin(Dept. of Geography, Chongqing Teachers College, Chongqing 630047,People’s Republic of China)

This paper tries to present another theoretical view in the study of population geography by applying the principle of artificial neural *** is our view that the approach to population geography study is of two kinds ... 详细信息

关键词： Aritifical Neural Network (AN^2) connectionism population geography research approach analysis by synthesis

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用盈亏平衡点法建立单井采油极限含水率模型

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地质科技情报 2001年第1期20卷 49-51页

作者：黄耀琴张树林中国地质大学资源学院湖北武汉430074

经济极限含水率是油气田开发决策的一个重要参考依据。在总结国内外研究成果的基础上 ,根据油田的采油特点和我国的现行财税制度 ,并对照中国石油天然气集团公司的统一经济技术指标 ,用盈亏平衡点法建立单井采油极限含水率模型。根据采... 详细信息

经济极限含水率是油气田开发决策的一个重要参考依据。在总结国内外研究成果的基础上 ,根据油田的采油特点和我国的现行财税制度 ,并对照中国石油天然气集团公司的统一经济技术指标 ,用盈亏平衡点法建立单井采油极限含水率模型。根据采油成本中各项费用和产液量之间的关系 ,将采油成本划分为变动成本和固定成本 ,结合克拉玛依油田单井采油的资料 ,证实这套模型对于油田单井采油具有良好的实用性 ,同时。

关键词：油气开发单井采油极限含水率盈亏平衡点经济评价采油成本

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