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Pharmacokinetics of Mequindox and Its Metabolites in Swine

Agricultural Sciences in China 2011年第12期10卷 1968-1976页

作者： LIU yi-ming LIU ying-chun DING Huan-zhong FANG Bing-hu YANG Fan shan Qi ZENGZhen-ling Laboratory of Veterinary Pharmacology College of Veterinary Medicine South China Agricultural University Guangzhou 510640 P.R.China shanghai Veterinary Research Institute Chinese Academy of Agricultural Sciences Shanghai 200232 P.R.China

The present study was carried out to investigate the pharmacokinetics of mequindox （MEQ）, a new synthetic quinoxaline 1,4-dioxide derivative and its two main metabolites M1 [2-isoethanol mequinoox], M2 [2-isoethanol 1-desoxymequindox] in healthy swine. MEQ （10 mg kg-1 body weight） was administered to nine healthy cross-bread swine via oral, intramuscular, and intravenous routes in a randomized 3x3 crossover design with a 1-wk washout period. A sensitive high-performance liquid chromatography （HPLC） method was used for the determination of plasma concentrations of MEQ and its metabolites M1 and M2. Plasma concentration versus time profiles of MEQ and its metabolites, M1 and M2, were analyzed by noncompartmental analysis using WinNonlin 5.2 software. The mean maximum concentrations （Cmax） of M1 and M2 after intravenous administration of MEQ were （5.27±1.59） lag mL-1 at 1.78 h and （1.01±0.29） μg mL-1 at 0.92 h, respectively. The mean maximum concentrations （Cmax） ofMEQ, M1, and M2 were found to be （6.96±3.23）, （6.61±1.56）, and （0.78 ±0.25） lag mL-1 respectively at 0.15, 1.61, and 1.30 h after intramuscular administration of MEQ, respectively and （0.75±0.45）, （6.90±1.52）, and （0.62±0.21） lag mL-1, respectively at 0.40, 1.57, and 2.00 h, respectively after oral administration of MEQ. The apparent elimination half-lives （b2） ofMEQ, M1, and M2 were （0.84±0.35）, （7.57±3.93）, and （9.56±6.00） h, respectively after intravenous administration of MEQ; （0.50±0.25）, （6.30±3.00）, and （5.94±2.54） h, respectively after intramuscular administration of MEQ; and （1.64± 1.17）, （5.59±1.93）, and （16.25±10.27） h, respectively after oral administration of MEQ. The mean areas under the plasma concentration-time curve （AUC0-∝） of MEQ, M1, and M2 were （4.88±1.54）, （36.93±17.50）, and （5.16±94） μg h mL-1, respectively after intravenous administration of MEQ; （4.18±0.76）, （48.25±20.82）, and （4.88±2.21） μg h mL-1 , respectively after intramuscular administration of MEQ; and （1.01±0.40）, （48.83±20.7

关键词： mequindox metabolites pharmacokinetics HPLC swine

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Wind-dispersed seeds blur phylogeographic breaks:The complex evolutionary history of Populus lasiocarpa around the Sichuan Basin

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Plant Diversity 2023年第2期45卷 156-168页

作者： Xue Li Markus Ruhsam yi Wang Hong-ying Zhang Xiao-Yan Fan Lei Zhang Jing Wang Kang-shan Mao Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610065SichuanPR China Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK

The strength of phylogeographic breaks can vary among species in the same area despite being subject to the same geological and climate history due to differences in biological *** important phylogeographic breaks exist around the Sichuan Basin in Southwest China but few studies have focused on wind-dispersed ***,we investigated the phylogeographic patterns and the evolutionary history of Populus lasiocarpa,a wind-pollinated and wind-dispersed tree species with a circum-Sichuan Basin distribution in southwest *** sequenced and analyzed three plastid DNA fragments(ptDNA) and eight nuclear microsatellites(nSSRs) of 265 individuals of *** from 21 populations spanning the entire distribution *** patterns based on nSSR data revealed that there are three genetic groups in *** is consistent with the three phylogeographic breaks(Sichuan Basin,the Kaiyong Line and the 105°E line),where the Sichuan basin acts as the main barrier to gene flow between western and eastern ***,the distribution pattern based on ptDNA haplotypes poorly matched the phylogeographic breaks,and wind-dispersed seeds may be one of the main contributing *** distribution modelling suggested a larger potential distribution in the last glacial maximum with a severe bottleneck during the last interglacial.A DIYABC model also suggested a population contraction and expansion for both western and eastern *** results indicate that biological traits are likely to affect the evolutionary history of plants,and that nuclear molecular markers,which experience higher levels of gene flow,might be better indicators of phylogeographic breaks.

关键词： Phylogeography Sichuan basin Populus lasiocarpa Kaiyong line Demographic history

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Voice Guidance System for Color Recognition Based on IoT

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Computer Systems Science & Engineering 2023年第4期45卷 839-855页

作者： Wen-tsai Sung Guan-Rong Chen Sung-Jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030TaiwanChina Department of Information Technology Takming University of Science and TechnologyTaipei City11451TaiwanChina

We often need to identify the colors of such objects as buildings,clothing,photos,and traffic signs in everyday *** people cannot distinguish among such *** study proposes a method to help people,including colorblind people,identify *** establish a platform for color identification that is connected by the Internet of Things(IoT).The Espressif Systems 32(ESP32)single chip is connected to a Wi-Fi communication network to transmit data to the color identification *** system interface is displayed in the form of color code and color name *** speech synthesis module Speech Synthesizer Node 6288(SYN6288)is used to broadcast color-related *** there are many color conversion technologies in modern times,or other color recognition methods are not applicable to the guide-blind ***,the authors use the method of reading out color-related information to directly enable colorblind people to conveniently identify the colors of *** experiments:the accuracy of various colors,the accuracy of environmental impact,the comparison of the original sensing experiment and the effect of adding interference light sources,the time required for color sensing to identify various colors,and the interference test results of any color light source,it is proved that the research mentioned in this *** proposed method can not only improve the rate of recognition of the system in different environments,but can also accurately identify a variety of *** platform is integrated with the IoT to allow users to quickly monitor the displayed data.

关键词： Internet of Things color recognition SYN6288 ESP32

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Image Recognition Based on Deep Learning with Thermal Camera Sensing

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Computer Systems Science & Engineering 2023年第7期46卷 505-520页

作者： Wen-tsai Sung Chin-Hsuan Lin Sung-Jung Hsiao Department of Electrical Engineering National Chin-Yi University of TechnologyTaichung411030Taiwan Department of Information Technology Takming University of Science and TechnologyTaipei11451Taiwan

As the COVID-19 epidemic spread across the globe,people around the world were advised or mandated to wear masks in public places to prevent its spreading *** some cases,not wearing a mask could result in a *** monitor mask wearing,and to prevent the spread of future epidemics,this study proposes an image recognition system consisting of a camera,an infrared thermal array sensor,and a convolutional neural network trained in mask *** infrared sensor monitors body temperature and displays the results in real-time on a liquid crystal display *** proposed system reduces the inefficiency of traditional object detection by providing training data according to the specific needs of the user and by applying You Only Look Once Version 4(YOLOv4)object detection technology,which experiments show has more efficient training parameters and a higher level of accuracy in object *** datasets are uploaded to the cloud for storage using Google Colaboratory,saving human resources and achieving a high level of efficiency at a low cost.

关键词： Image recognition convolutional neural network YOLOv4 thermal camera sensing

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Hemorrhagic blisters in fulminant Aeromonas hydrophila bacteremia: Case report and literature review

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Asian Pacific Journal of Tropical Medicine 2019年第2期12卷 91-94页

作者： Yao-Tien Chang Sung-Yuan Hu Che-An tsai Department of Emergency Medicine Taichung Veterans General Hospital Department of Nursing College of Health National Taichung University of Science and Technology School of Medicine Chung Shan Medical University Institute of Medicine Chung Shan Medical University Department of Nursing College of Nursing Central Taiwan University of Science and Technology Division of Infectious Disease Department of Internal Medicine Taichung Veterans General Hospital

The Aeromonas species, belonging to the family Aeromonadaceae, are opportunistic pathogens found in humans with an incidence rate of 76 cases per million inhabitants in Southern *** incidence of Aeromonas septicemia is relatively low, accounting for less than 15% of *** diagnosed with Aeromonas hydrophila bacteremia who were presented with skin blisters and septic shock have been reported to have a mortality rate of 100%.Aeromonas infection must be considered in the differential diagnosis of gangrene-like tissue damage or skin lesions in patients with end-stage renal disease, due to the potential sources of infections.A 49-year-old Taiwan Residents diabetic woman with end-stage renal disease had underwent regular *** was referred to our hospital due to a one-day course of fever, dyspnea, hypotension, and fulminant hemorrhagic blisters covering her whole body.A physical examination uncovered multiple hemorrhagic blisters, along with a ruptured blister over the lower left *** tests revealed an elevation of liver enzymes, impaired renal function, lactatemia, and high anion-gap metabolic *** of both blood and hemorrhagic blister fluid grew Aeromonas ***, she experienced persistent shock despite aggressive intravenous fluid, empiric antibiotics, and inotropic agents with norepinephrine and *** diagnosis and prompt management using intravenous fluids, antibiotics and surgical debridement is recommended in order to improve a patient's survival rate.

关键词： Aeromonas hydrophila Bacteremia End-stage renal disease Hemorrhagic blister

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Dynamic control of district heating networks with integrated emission modelling:A dynamic knowledge graph approach

Energy and AI

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Energy and AI 2024年第3期17卷 29-47页

作者： Markus Hofmeister Kok Foong Lee yi-Kai tsai Magnus Müller Karthik Nagarajan Sebastian Mosbach Jethro Akroyd Markus Kraft Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridgeCB30ASUnited Kingdom Cambridge Centre for Advanced Research and Education in Singapore CARES Ltd.1 Create WayCREATE Tower#05-05138602Singapore CMCL Innovations Sheraton HouseCambridgeCB30AXUnited Kingdom The Alan Turing Institute 96 Euston RoadLondonNW12DBUnited Kingdom

This paper presents a knowledge graph-based approach for the dynamic control of a district heating network with integrated emission dispersion modelling. We propose an interoperable and extensible implementation to forecast the anticipated heat demand of a municipal heating network, minimise associated total generation cost based on a previously devised methodology, and couple it with dispersion simulations for induced airborne pollutants to provide automatic insights into air quality implications of various heat sourcing strategies. We create cross-domain interoperability in the nexus of energy and air quality via newly developed ontologies and semantic software agents, which can be chained together via The World Avatar dynamic knowledge graph to resemble the behaviour of complex systems. Furthermore, we integrate the City Energy Analyst into this ecosystem to provide building-level insights into energy demand and renewable generation potential to foster strategic analyses and scenario planning. Underlying calculations use building and weather data from the knowledge graph in place of inherent assumptions in the official software release, facilitating a more data-driven approach. All use cases are implemented for a mid-size town in Germany as a proof-of-concept, and a unified visualisation interface is provided, allowing for the examination of 3D buildings alongside their corresponding energy demand and supply time series, as well as emission dispersion data. With this work, we outline the potential of Semantic Web technologies to connect digital twins for holistic energy modelling in smart cities, thereby addressing the increasing complexity of interconnected energy systems.

关键词： Knowledge graph Digital twin Inter operability Energy modelling Emi ssion dispersi on

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Expert Consensus on Nurses'Human Caring for COVID-19 Patients in Different Sites

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Current Medical Science 2020年第4期40卷 602-607页

作者： Feng-jian ZHANGI De-ying HU yi-lan LIU Hong LI Xiao ping ZHU Shao-shan PAN Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fiujian Provincial Hospital Fujian 350001China Zhongnan Hospital Wuhan UniversityWuhan 430071China General Hospital of Southern Theatre Command of China People's Liberation Army Guangzhou 510010China

Summary:This study aims to develop the expert consensus on nurse's human caring for Corona Virus Disease 2019(COVID-19)patients in different sites,and thus provide a guideline on providing whole process and systematic caring for COVID-19 *** on the frontline experiences of human caring for COVID-19 patients and the review of literature,the initial draft of consensus was made and finalized after online meeting and *** experts reached consensus on the following parts:terms and definitions,principles of human caring for COVID-19 patients,and human caring measures for COVID-19 patients in different *** expert consensus is practical,concise,and reasonable for guiding the nurses providing human caring for COVID-19 patients,as well as other similar infectious diseases.

关键词： human caring nursing expert consensus COVID-19

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Nested case-control study on risk factors for opportunistic infections in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2019年第18期25卷 2240-2250页

作者： shan-shan Gong yi-Hong Fan Qing-Qing Han Bin Lv yi Xu Department of Gastroenterology First Affiliated Hospital of Zhejiang Chinese Medical University

BACKGROUND When opportunistic infections occur, patients with inflammatory bowel disease(IBD) commonly display a significantly increased rate of morbidity and *** increasing use of immunosuppressive agents and biological agents,opportunistic infections are becoming a hot topic in the perspective of drug safety in IBD patients. Despite the well-established role of opportunistic infections in the prognosis of IBD patients, there are few epidemiological data investigating the incidence of opportunis-tic infections in IBD patients in China. Besides, the risk factors for opportunistic infection in Chinese IBD patients remain *** To predict the incidence of opportunistic infections related to IBD in China, and explore the risk factors for opportunistic *** A single-center, prospective study of IBD patients was conducted. The patients were followed for up to 12 mo to calculate the incidence of infections. For each infected IBD patient, two non-infected IBD patients were selected as controls. A conditional logistic regression analysis was used to assess associations between putative risk factors and opportunistic infections, which are represented as odds ratios(OR) and 95% confidence intervals(CIs).RESULTS Seventy(28.11%) out of 249 IBD patients developed opportunistic *** difficile infections and respiratory syncytial virus infections were found in 24 and 16 patients, respectively. In a univariate analysis, factors such as the severity of IBD, use of an immunosuppressant or immunosuppressants, high levels of fecal calprotectin, and C-reactive protein or erythrocyte sedimentation rate were individually related to a significantly increased risk of opportunistic infection. Multivariate analysis indicated that the use of any immunosuppressant yielded an OR of 3.247(95%CI: 1.128-9.341), whereas the use of any two immunosuppressants yielded an OR of 6.457(95%CI: 1.726-24.152) for opportunistic infection. Interestingly, when im

关键词： Nested case-control study Opportunistic infections Inflammatory bowel disease

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Tuberculosis-associated hemophagocytic lymphohistiocytosis misdiagnosed as systemic lupus erythematosus:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3178-3187页

作者： Wen-Ting Chen Zhi-Cheng Liu Meng-shan Li ying Zhou Shen-Ju Liang yi Yang Department of Rheumatology and Clinical Immunology Army Medical CenterArmy Medical UniversityChongqing 400000China Southwest Hospital Army Medical UniversityChongqing 400000China

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare disorder with rapid progression and high *** occurs mostly due to infection,malignant tumors,and immune *** infections that cause HLH,viral infections,especially Epstein-Barr virus infections,are common,whereas tuberculosis is ***-associated HLH has a wide range of serological and clinical manifestations that are similar to those of systemic lupus erythematosus(SLE).CASE SUMMARY This study describes a case of tuberculosis-associated HLH misdiagnosed as SLE because of antinuclear antibody(ANA),Smith(Sm)antibody and lupus anticoagulant positivity;leukopenia;thrombocytopenia;pleural effusion;decreased C3,quantitatively increased 24 h urinary protein and *** patient was initially treated with glucocorticoids,which resulted in peripheral blood cytopenia and symptom ***,caseating granulomas and hemophagocytosis were observed in her bone *** was successfully treated with conventional category 1 antituberculous *** addition,we reviewed the literature on tuberculosis-associated HLH documented in Pub Med,including all full-text articles published in English from December 2009 to December 2019,and summarized the key points,including the epidemiology,clinical manifestations,diagnosis,and treatment of tuberculosis-associated HLH and the differences of the present case from previous *** Tuberculosis should be considered in patients with fever or respiratory *** drugs are important for treating tuberculosisassociated HLH.

关键词： Hemophagocytic lymphohistiocytosis Tuberculosis Systemic lupus erythematosus Misdiagnosis Case report

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Radio frequency compatibility analysis for BDSBAS and GPS/WAAS

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Research in Astronomy and Astrophysics 2021年第8期21卷 235-244页

作者： Cheng Liu Wei-Guang Gao Jun Lu yi Zhou shan-shan Chen Beijing institute of Tracking and Telecommunication Technology Beijing 100094China BeiDou Application Research Academy of Norinco Group Beijing 100089China Space Star Technology Beijing 100094China

Radio frequency signal compatibility is the basis of interoperability of the Satellite eBased Augmentation System(SBAS).SBAS should abide by relative international radio regulations of International Telecommunication Union(ITU) and meet the compatibility requirements of radio frequency signal between the Global Navigation Satellite System(GNSS)/SBAS,in order to avoid negative mutual *** to ITU Proposal and related reference and assumptions,the paper made simulation of signal receiving maximum power in the Bei Dou Satellite-Based Augmentation System(BDSBAS)global signal *** then,interference of BDSBAS to Global Positioning System(GPS)/WAAS(Wide Area Augmentation System) on L1/L5 bands were calculated and analyzed,with equivalent carrierto-noise ratio as the evaluation *** result shows that the carrier-to-noise ratio decrease of GPS/WAAS caused by BDSBAS B1 C and B2 a signals are extremely lower than inter-system interference of GPS/WAAS,and thus can be ignored in practical ***,BDSBAS will not cause the service performance degradation of GPS and WAAS.

关键词： space vehicles methods:data analysis celestial mechanics

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