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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin ying-yi Chen Yuan-Ming tsai Ti-Hui Wu Hsu-Kai Huang tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Potential prognostic,diagnostic and therapeutic markers for human gastric cancer

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World Journal of Gastroenterology 2014年第38期20卷 13791-13803页

作者： Ming-Ming tsai Chia-Siu Wang Chung-ying tsai Hsiang-Cheng Chi yi-Hsin Tseng Kwang-Huei Lin Department of Nursing Chang-Gung University of Science and Technology Department of General Surgery Chang Gung Memorial Hospital at Chiayi Department of Biochemistry College of MedicineChang-Gung University

The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and diagnosis are critical for improving prognoses in patients with GC. Gastroscopy with biopsy is an appropriate method capable of aiding the diagnosis of specific early GC tumor types; however, the stress caused by this method together with it being excessively expensive makes it difficult to use it as a routine method for screening for GC on a population basis. The currently used tumor marker assays for detecting GC are simple and rapid, but their use is limited by their low sensitivity and specificity. In recent years, several markers have been identiﬁed and tested for their clinical relevance in the management of GC. Here, we review the serum-based tumor markers for GC and their clinical significance, focusing on discoveries from microarray/proteomics research. We also review tissue-based GC tumor markers and their clinical application, focusing on discoveries from immunohistochemical research. This review provides a brief description of various tumor markers for the purposes of diagnosis, prognosis and therapeutics, and we include markers already in clinical practice and various forthcoming biomarkers.

关键词： Tumor marker Prognosis Gastric cancer Serum-based Tissue-based

Bilateral cerebral infarction in diabetic ketoacidosis and bilateral internal carotid artery occlusion:A case report and review of literature

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World Journal of Clinical Cases 2021年第15期9卷 3787-3795页

作者： yi-Chung Chen Su-Ju tsai Department of Physical Medicine and Rehabilitation Chung Shan Medical University HospitalTaichung 40201Taiwan

BACKGROUND Diabetic ketoacidosis(DKA)is a serious complication of type 1 diabetes mellitus(T1DM).Very rarely does DKA lead to cerebral edema,and it is even rarer for it to result in cerebral *** internal carotid artery occlusion(BICAO)is also rare and can cause fatal ***,case reports about acute cerebral infarction throughout both internal carotid arteries with simultaneous BICAO are very *** this study,we present a patient with BICAO,T1DM,hypertension,and hyperlipidemia,who had a catastrophic bilateral cerebral infarction after a DKA *** briefly introduce BICAO and the mechanisms by which DKA results in cerebral *** SUMMARY A 41-year-old woman presented with ischemic stroke that took place 3 mo prior over the left corona radiata,bilateral frontal lobe,and parietal lobe with right hemiplegia and Broca’s *** had a history of hypertension for 5 years,hyperlipidemia for 4 years,hyperthyroidism for 3 years,and T1DM for 31 *** first brain magnetic resonance imaging not only revealed the aforementioned ischemic lesions but also bilateral internal carotid artery *** was admitted to our ward for rehabilitation due to prior stroke *** took place on hospital day *** hospital day 6,she had a new massive infarction over the bilateral anterior cerebral artery and middle cerebral artery *** weeks of aggressive treatment,she remained in a coma and on mechanical ventilation due to respiratory *** discussion with her family,compassionate extubation was performed on hospital day 29 and she *** DKA can lead to cerebral infarction due to several *** people with existing BICAO and several stroke risk factors such as hypertension, T1DM,hyperlipidemia, DKA has the potential to cause more serious ischemic strokes.

关键词： Type 1 diabetes mellitus Diabetic ketoacidosis Bilateral internal carotid artery occlusion Cerebral infarction Case report

Intrathoracic caudate lobe of the liver:A case report and literature review

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World Journal of Gastroenterology 2014年第17期20卷 5147-5152页

作者： ying-yi Chen tsai-Wang Huang Hung Chang Hsian-He Hsu Shih-Chun Lee Division of Thoracic Surgery Department of Surgery Department of Radiology Tri-Service General HospitalNational Defense Medical Center

Heterotopic supradiaphragmatic livers are rare. A total of 23 cases of primary supradiaphragmatic livers have been reported in the literature. The clinical presentations of heterotopic supradiaphragmatic liver are variable. The simultaneous detection of intrathoracic accessory liver and pulmonary sequestration is extremely rare, and only one case has previously been reported. It is difficult to make a correct diagnosis preoperatively. We presented a 53-year-old woman with complaints of an intermittent, productive cough and dyspnea for two months that was refractory to medical treatment. She had no previous history of trauma or surgery. A chest radiograph only showed a widening of the mediastinum. Contrast-enhanced computed tomography of the chest revealed a well-circumscribed homogenous soft-tissue mass, approximately 4.35 cm × 2.5 cm × 6.14 cm in size, protruding through the right diaphragmatic crura to the right pleural cavity, attached to the inferior vena cava, esophagus and liver. There was no conclusive diagnosis before surgery. After the operation, we discovered that this patient was the first case of a supradiaphragmatic heterotopic liver, which passed through the inferior vena cava foramen and was coincidentally combined with an intralobar pulmonary sequestration that was found intraoperatively. We discussed its successful management with surgical resection via a thoracic approach and reviewed the published literature.

关键词： Intrathoracic liver Pulmonary sequestration Supradiaphragmatic ectopic liver

Pairing symmetry in layered BiS2 compounds driven by electron-electron correlation

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Frontiers of physics 2014年第2期9卷 194-199页

作者： yi Liang Xianxin Wu Wei-Feng tsai Jiangping Hu Institute of Physics Chinese Academy of Sciences Beijing 100190 China Department of Physics Sun Yat-sen University Kaohsiung 804 Taiwan China Department of Physics Purdue University West Lafayette IN 47907 USA

We investigate the pairing symmetry of layered BiS2 compomlds by assuming that electron-electron correlation is still important so that the pairing is rather short range. We lind that the extended .s-wave pairing symmetry always wins over d-wave when the pairing is confined between two short range sites up to next nearest neighbors. The pairing strength is peaked around the doping level ：r = 0.5. which is consistent with experimental observation. The extended s-wave pairing symmetry is very robust against spin orbital coupling because it is mainly determined by the structure of Fermi surfaces, Moreover. the extended s-wave pafiring can be distinguished from conventional swave pairing by measuring and comparing superconducting gaps of different Fermi surfaces.

关键词： s BiS2-based superconductor pairing symmetry electron-electron correlation

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期 195-213页

作者： Zhi-Peng Zhu Dian Jia William yi Wang Jun-Lei yin Xing-Yu Gao shu-Feng Yang Hai-Feng Song Jin-shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

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Time course analysis of sensory axon regeneration in vivo by directly tracing regenerating axons

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Neural Regeneration Research 2020年第6期15卷 1160-1165页

作者： Yan Gao yi-Wen Hu Run-shan Duan shu-Guang Yang Feng-Quan Zhou Rui-ying Wang Guilin Medical University GuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedic Surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedics Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins,representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neurons in the spinal *** recently developed method of in vivo electroporation of plasmid DNA encoding for enhanced green fluorescent protein into adult sensory neurons in the dorsal root ganglia provides a way to directly and specifically measure regenerating sensory axon lengths in whole-mount nerves.A mouse model of sciatic nerve compression was established by squeezing the sciatic nerve with *** DNA carrying enhanced green fluorescent protein was transfected by ipsilateral dorsal root ganglion electroporation 2 or 3 days before *** distribution of dorsal root or sciatic nerve was observed by confocal *** 12 and 18 hours,and 1,2,3,4,5,and 6 days of injury,lengths of regenerated axons after sciatic nerve compression were measured using green fluorescence ***-related protein caspase-3 expression in dorsal root ganglia was determined by western blot *** found that in vivo electroporation did not affect caspase-3 expression in dorsal root *** root ganglia and sciatic nerves were successfully removed and subjected to a rapid tissue clearing *** soma in dorsal root ganglia expressing enhanced green fluorescent protein or fluorescent dye-labeled microRNAs were imaged after tissue *** results facilitate direct time course analysis of peripheral nerve axon *** study was approved by the Institutional Animal Care and Use Committee of Guilin Medical University,China(approval ***201503010)on March 7,2014.

关键词： axon regeneration cell apoptosis dorsal root ganglion in vivo electroporation micro RNAs peripheral nervous system sciatic nerve tissue clearing

Access Control Mechanism for Blog Posts with Fine- Grained Ability Using Simple Operations

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Journal of Electronic Science and Technology 2017年第2期15卷 194-198页

作者： yi-Hui Chen Chi-Shiang Chan Yuan-Yu tsai Department of M-Commerce and Multimedia Applications Asia University Taichung 41354

Access control enables the owners to assign different users different permissions to see different views. The current blog system does not support fine-grained authorization. That is, the bloggers disallow to just assign partial contents of the blog posts （i.e., a paragraph or several paragraphs） to readers. The management cost is no doubt to be significantly increased while handling the authorizations on the huge amount of blog articles. In this paper, we propose a scheme for supporting a fine-grained access control mechanism on blog articles. The advantage is that bloggers are able to authorize partial contents of blog posts to different users or groups of users.

关键词： Index Terms Authorization blog articles finegrained access control.

An Analytical Solution for Wave Transformation Over Axi-Symmetric Topography

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China Ocean Engineering 2019年第6期33卷 694-703页

作者： CUONG San Sieu CHANG Jen-yi tsai Chia-Cheng CHOU Wan-Rong aInstitute of Oceanography National Taiwan UniversityTaipei 10617China Tainan University of Technology Tainan 71002China Department of Marine Environmental Engineering National Kaohsiung University of Science and TechnologyKaohsiung 81164China Department of Marine Environment and Engineering National Sun Yat-Sen UniversityKaohsiung 80424China Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701China

The present study considers wave scattering phenomena around a cylindrical island mounted on a general axisymmetric topography or a general submerged truncated axi-symmetric shoal based on the mild-slope equation. The method of separation of variables and Taylor series expansion are invoked to find the approximate solution to the variable water depth region which varies proportionally to an arbitrary power of radial distance. Validations against the solutions for the combined wave refraction and diffraction around a cylindrical island mounted on a paraboloidal shoal of Liu et al. in 2004 and the scattering and trapping of wave energy by a submerged truncated paraboloidal shoal of Lin and Liu in 2007 show excellent agreements as the power of radial distance being equal to two. For the solutions of wave refraction and diffraction around a cylindrical island mounted on a shoal with depth proportionally to an arbitrary power of radial distance, good agreements with Zhai et al.’s(2013) solutions are demonstrated. Since the robustness of the assumption of a general axi-symmetric geometry based on an arbitrary power variability of the radial distance, the present solution can be very conveniently employed to investigate the effects of bottom topography on wave scattering and trapping patterns.

关键词： general axi-symmetric topography mild-slope equation submerged truncated shoal wave refraction wave diffraction