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World Journal of Gastroenterology 2025年第1期31卷 152-156页

作者： Jing zhang Chun-Lin Ou Department of Immunology School of Basic MedicineCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Pathology Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational *** are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell *** dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases *** development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ***,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote *** show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.

关键词： Transfer RNA derived small RNAs Acute pancreatitis Liquid biopsy Biomarker Cell pyroptosis Ferroptosis

Effects of continuous cooling rate on morphology of granular bainite in pipeline steels

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Journal of Iron and Steel Research International 2020年第6期27卷 681-690页

作者： shu-jun Jia Ba Li Qing-you Liu yi Ren shuai zhang Hong Gao Department of Structural Steels Central Iron and Steel Research InstituteBeijing 100081China State Key Laboratory of Metal Material for Marine Equipment and Application of Iron and Steel Research Institutes of Ansteel Group Corporation Anshan 114009LiaoningChina

The morphology and characteristics of granular bainite (GB) in pipeline steels at different continuous cooling rates were investigated by scanning electron microscopy, transmission electron microscopy and electron back-scattered diffraction (EBSD). The results show that the morphology of ferrite matrix in GB turned from the lath sheaf structure into the nearly equiaxed large grain with the cooling rate decreasing from high (60℃/s) to low (5-10℃/s). At the medium cooling rate (20-40℃/s), GB consisted of the irregular ferrite matrix, the granular martensite/austenite (M/A) constituents and abundant substructures inside. The formation of the irregular ferrite and substructure was attributed to the high-temperature recovery which occurred at relatively high-temperature stage before phase transformation. The granular morphology of M/A constitu-ents was formed from the carbon-rich triple junctions which were produced by the multidirectional substructure interfaces converged with each other. Particularly, some martensite in M/A constituents was misoriented from the adjacent ferrite by very small misorientation angle, which could be characterized by the mean band contrast function of EBSD qualitatively or semiquantitatively.

关键词： Granular bainite Continuous cooling M/A constituent Cooling rate Irregular substructure

Study of enzyme biosensor based on carbon nanotubes modified electrode for detection of pesticides residue

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Chinese Chemical Letters 2008年第5期19卷 592-594页

作者： shu Ping zhang Lian Gang Shan Zhen Ran Tian yi Zheng Li yi Shi Deng Song zhang College of Science University of Shanghai for Science and Technology Shanghai 200093 China School of Material Science and Engineering Shanghai University Shanghai 200072 China Jiangsu Food Science College Jiangsu 223003 China Nano-science Technology Center Shanghai University Shanghai 200444 China

The paper describes a controllable layer-by-layer （LBL） self-assembly modification technique of multi-walled carbon nanotubes （MWNTs） and poly（diallyldimethylammonium chloride）（PDDA） towards glassy carbon electrode （GCE）, Acetylcholinesterase （ACHE） was immobilized directly to the modified GCE by LBL self-assembly method, the activity value of AChE was detected by using i-t technique based on the modified Ellman method. Then the composition of carbaryl were detected by the enzyme electrode with 0.01U activity value and the detection limit of carbaryl is 10^- 12 g L ^-1 so the enzyme biosensor showed good properties for pesticides residue detection.

关键词： Acetylcholinesterase Carbon nanotubes modified electrode Layer-by-layer self-assembly Immobilization

LANTHANIDE ION DOPANT EFFECT ON THE PHASE TRANSFORMATION IN ULTRASONIC ASSISTANT SOL-GEL DERIVED TITANIA NANOSTRUCTURES

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LANTHANIDE ION DOPANT EFFECT ON THE PHASE TRANSFORMATION IN ...

Simulation of fixed-bed adsorption process considering particle size distribution

2010全国压电和声波理论及器件技术研讨会

作者： Cheng HU~1,Yue-tao YANG~2,Hao YANG~2,Xiao-jun LIU~2,shu-yi zhang~2 1 Liaoning Academy of Environmental Science,Liaoning Province Key Laboratory of Basin Pollution Control 88 Taishang Road,Shenyang,Liaoning 110031,China 2 Key Laboratory of Modern Acoustics,Ministry of Education,Institute of Acoustics,Nanjing University, 22 Hankou Road,Nanjing,Jiangsu 210093,China

In this work,TiO nanoparticles doped with holmium（Ⅲ） ion have been prepared by an ultrasonic assistant sol-gel *** present the results of the investigation of holmium（Ⅲ） ion doping on the structural properties of TiO and its effect on the anatase to rutile phase *** is found that the transformation temperature,measured from the XRD experiments,is found to increase with *** anatase lattice is shown to deform predominantly along the c-axis to accommodate substitutionally-incorporated holmium（Ⅲ） *** order to understand the location of the dopant in TiO lattice, photoacoustic（PA） absorptions of f-f transitions of the samples are *** results show that the holmium（Ⅲ） ions incorporate interstitially as well as *** retards the anatase-to-rutile transformation temperature.

关键词： Ultrasound irradiation nanomaterials titanium dioxide

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Chinese Journal of Chemical Engineering 2024年第10期74卷 175-189页

作者： Zhaoyuan zhang yidan shu School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province Guangzhou 510275China

The distribution of adsorbent particle sizes typically has a significant impact on adsorption *** fixed-bed adsorption studies adopt the assumption of average particle size to simplify the adsorption model,but this does not eliminate the deviation between experiments and simulations caused by particle size distribution in *** this study,the population balance equation(PBE)and fixed-bed adsorption kinetics model were combined to simulate the adsorption process in a fixed-bed reactor,modeling the distribution of adsorbate uptake over time on adsorbent particles of different *** integrated and optimized the PBE and fixed-bed mass transfer model in the algorithm,and the resulting combined model adopts a variable time step size,which can achieve a balance between computational efficiency and error while ensuring computational *** slicing the model in the spatial dimension,multiple sets of PBE can be calculated in parallel,improving computational *** adsorption process of single-component and multi-component CO_(2)/CH_(4)/N_(2)on 4A zeolite without binder was simulated,and the influence of adsorbent particle size distribution was *** results show that the assumption of average adsorbent particle size,which was commonly made in published work,will underestimate the time required for adsorbates to break through the fixed bed compared with the assumption of uniform adsorbent particle *** model helps to consider the impact of adsorbent particle size distribution on the adsorption process,thereby improving the prediction accuracy of adsorbent performance.

关键词： Population balance equation Particle size distribution Fixed-bed adsorption

Reduction and melting behavior of carbon composite lateritic bauxite pellets

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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 381-388页

作者： ying-yi zhang Jie Zhao Yuan-hong Qi Xiang-li Cheng Zong-shu Zou State Key Laboratory of Advance Steel Processes and Products Central Iron and Steel Research Institute School of Material and Metallurgy Northeast University

Direct reduction of low-grade lateritic bauxite was studied at high temperature to recover Fe and beneficiate AlzO3 slag. The re- sults show that a metallization rate of 97.9% and a nugget recovery rate of 85.1% can be achieved when the reducing and melting tempera- tures are 1350 and 1480℃, respectively. Moreover, a higher-grade calcium aluminate slag （A1203 = 50.52wt%） can also be obtained, which is mainly composed of ct-A1203, hercynite （FeAI：O4）, and gehlenite （Ca2A12SiO7）. In addition, high-quality iron nuggets have been produced from low-grade lateritic bauxite. The nugget is mainly composed of iron （93.82wt%） and carbon （3.86wt%）, with almost no gangue （slag）.

关键词： bauxite ore pellets direct reduction process melting behavior metallization

Clinical considerations of anticoagulation therapy for patients with atrial fibrillation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 609-615页

作者： shu zhang Arrhythmias Center and Clinical EP Lab. Cardiovascular Institute and Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

Atrial fibrillation (AF) increases the risk of stroke. New anticoagulation agents have recently provided alternative and promising approaches. This paper reviews the current state of anticoagulation therapy in AF patients, focusing on various clinical scenarios and on comparisons, where possible, between western and eastern populations.

关键词： Anticoagulation therapy Atrial fibrillation,Warfarin Dabigatran Riveroxaban Apixaban

Facet Engineering in Constructing Lewis Acid-Base Pairs for CO_(2) Cycloaddition to High Value-Added Carbonates

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Research 2023年第1期2022卷 331-339页

作者： shu Shang Wei Shao Xiao Luo Ming Zuo Hui Wang Xiaodong zhang yi Xie Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Institute of Energy Hefei Comprehensive National Science CenterHefei 230031China

Cycloaddition of epoxides with CO_(2) to synthesis cyclic carbonates is an atom-economic pathway for CO_(2) utilization with promising industry application value,while its efficiency was greatly inhibited for the lack of highly active catalytic ***,by taking BiOx(X=Cl,Br)with layered structure for example,we proposed a facet engineering strategy to construct Lewis acid-base pairs for CO_(2) cycloaddition,where the typical BiOBr with(O10)facets expose surface Lewis acid Bi sites and Lewis base Br sites *** the combination of in-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and theoretical calculations,the oxygen atom of the epoxide is interacted with the Lewis acid Bi site to activate the ternary ring,then facilitates the attack of the carbon atom by the Lewis base Br site for the ring-opening of the epoxide,which is the rate-determining step in the cycloaddition *** a result,the BiOBr-(010)with rich surface Lewis acid-base pairs showed a high conversion of 85%with 100% atomic economy in the synthesis of cyclic-carbonates without any *** study provides a model structure for CO,cycloaddition to high value-added long chain chemicals.

关键词： reaction base synthesis

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棉铃虫敏感品系对两种药剂的毒力比较

天津农业科学 2003年第2期9卷 31-33页

作者：胡学雄谷希树白义川张惟天津市植物保护研究所天津300112

通过生物测定方法比较了棉铃虫敏感品系对4.5%高效氯氰菊酯乳油和40%甲·甲·氯乳油两种药剂的毒力反应,结果表明,两者的LC50分别为18.5643mg·kg-1,11.6494mg·kg-1,LC50比值达到1.594,即40%甲·甲·氯乳油对棉铃虫敏感品系的毒力要高... 详细信息

通过生物测定方法比较了棉铃虫敏感品系对4.5%高效氯氰菊酯乳油和40%甲·甲·氯乳油两种药剂的毒力反应,结果表明,两者的LC50分别为18.5643mg·kg-1,11.6494mg·kg-1,LC50比值达到1.594,即40%甲·甲·氯乳油对棉铃虫敏感品系的毒力要高于4.5%高效氯氰菊酯乳油,存在显著性差异。

关键词：棉铃虫敏感品系氯氰菊酯乳油甲·甲·氯乳油毒力反应生物测定法棉花害虫

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang zhang Xia Sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor