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Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant

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Chinese Medical Journal 2007年第16期120卷 1400-1403页

作者： zhang Qi CAI Chang-jie LU Ming-qiang LI Xi JIANG Nan JIANG Hua XU Chi LI Hua WANG Gen-shu yi shu-hong zhang Jian zhang Jun-feng yi Hui-min zhang ying-cai CHEN Gui-hua Liver Transplant Center Third Affiliated Hospital of Sun Yat-sen University Transplantation Research Institute of Sun Yat-sen University Guangzhou 510630 China

Background The most frequently used therapy for post-transplantation recurrence of hepatitis B virus （HBV） infection is lamivudine, but this drug is associated with a high resistance rate due to YMDD mutant. In preliminary reports, adefovir dipivoxil （ADV） has been shown to have activity against lamivudine-resistant strains of HBV. However, clinical experience in treatment of HBV infection after liver transplantation （LT） is still not entirely clear. This study was aimed to evaluate the prophylactic efficacy of ADV plus hepatitis B immunoglobulin （HBIG） in patients with YMDD mutant before LT. Methods From March 2004 to March 2006, 16 patients with chronic hepatitis B had lamivudine-resistant YMDD mutants detected prior to liver transplantation and received treatment with ADV plus additional intramuscular HBIG after LT as prophylaxis against graft reinfection. Tests for liver function, serum HBsAg, anti-HBs （HBIG）, HBeAg, anti-HBc, anti-HBe, HBV-DNA, and creatinine were assessed pre- or post-liver transplantation. Results The median follow-up of these patients post-liver transplantation was 19.4 months. Fifteen patients survived and one patient died of recurrence of hepatocellular carcinoma （HCC）. There was significant difference （10.98% vs. 2.26%, P〈0.05） in YMDD mutant rate between the patients with HBV-DNA over 106 copies/ml and those with HBV-DNA less than 106 copies/mi. Fifteen patients （93.8%） had undetectable HBV-DNA at 4 weeks and 1 （6.3%） at 6 months after LT. No hepatitis B recurrence was detected by persistent testing of HBsAg, HBeAg, and HBV-DNA and no increase of serum creatinine level associated with ADV was observed in any of the patients. Conclusion ADV combined with intramuscular HBIG can effectively prevent patients with pre-transplantation YMDD mutant from HBV recurrence after LT.

关键词： liver transplantation adefovir dipivoxil YMDD mutant HBV recurrence

Ocular development in children with unilateral congenital cataract and persistent fetal vasculature

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 426-431页

作者： shu-yi zhang Hui Chen Jing-Hui Wang Wan Chen Qi-Wei Wang Jing-Jing Chen Xiao-Shan Lin Zhuo-Ling Lin Duo-Ru Lin Hao-Tian Lin Wei-Rong Chen State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM: To investigate the ocular development of patients who had unilateral congenital cataract(CC) combined with persistent fetal vasculature(PFV).METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral *** length(AL), keratometry, anterior chamber depth(ACD), lens thickness, and vitreous length were *** ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated ***: A total of 110 patients were included and divided into 4 groups: group 1(18 patients with CC and PFV, 0.05).CONCLUSION: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24 mo and longer in those older than 24 mo;the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24 mo and similar with those younger than 24 *** findings provide further understanding of ocular development in patients with both CC and PFV.

关键词： ocular development congenital cataract persistent fetal vasculature axial length keratometry

A clarification of authorship in an old publication

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Zoological Research 2016年第6期37卷 366-366页

作者： shu-yi zhang College of Animal Science and Veterinary Medicine Shenyang Agricultural University

Recently, the editorial office of Zoological Research （ZR） received a statement from Prof. shu-yi zhang regarding his authorship of an old publication （Ma et al., 2003） in ZR （see below）. He requested to withdraw his authorship of this article. The editorial office took this statement seriously and the editor- in-chief and associate editors-in-chief had in-depth discussions on this issue. Despite the fact that ZR announces clearly that it copes with the authorship measurements of International Committee of Medical Journal Editors （ICMJE, 2013）, and gives guidance to authors regarding the proper authorship in the Instruction to Author, the actual practice still depends on the author himself or herself （Liu, 2016）. As a way to clarify the related concerns, ZR decided to publish the clarification provided by Prof. zhang and the corresponding replies from the other co-authors of this article.

关键词： zhang this ZR

NUMERICAL SIMULATIONS OF THE CAVITATION PROCESS IN A ROOM-TEMPERATURE IONIC LIQUID

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NUMERICAL SIMULATIONS OF THE CAVITATION PROCESS IN A ROOM-TE...

2013全国压电和声波理论及器件技术研讨会

作者： Hai-xiao zhang Bin GAO Yue-tao YANG shu-yi zhang Xiao-jun LIU Key Laboratory of Modern Acoustics Ministry of EducationInstitute of AcousticsNanjing University

In this work,Flynn’s formulation is adopted to analyze the dynamics,temperature and pressure of the cavitation bubble in the room-temperature liquids（RTIL）because of their unique physical *** effects of the ultrasonic intensity,frequency and the initial radius of the bubble on the cavitation process are studied,and the temperature and pressure in the collapsing bubbles are also *** is found that the intensity of cavitation increases remarkably with the increase of the bulk solution temperature.

关键词： Ultrasonics Cavitation Room-temperature ionic liquid

A NEW TYPE OF ULTRASONIC GAS FLOWMETER WITH MULTI-TRACKS

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A NEW TYPE OF ULTRASONIC GAS FLOWMETER WITH MULTI-TRACKS

第三届全国压电和声波理论及器件技术研讨会

作者： Yu BEN,Zhong-ning zhang,shu-yi zhang Lab of Modern Acoustics,Institute of Acoustics,Nanjing University,Nanjing,Jiangsu 210093,China

In general,two major factors effect on the measurement precision of ultrasonic transit-time gas flowmeter:the calculations of gas velocity distribution in the pipe and the measurements of the transit time of ultrasonic transmitting from one transducer to *** this paper,considering the affect factors,a new design of ultrasonic gas flow meter is proposed,which is operated by a master slave control based on a single board computer and a *** order to calculate the velocity distribution in the whole pipe,the multi-tracks(5 tracks) are used to measure the transit times of ultrasonic waves between each pair of the corresponding transducers located at five different profles of the pipe,by which the gas velocity near the pipe wall can be described more accurately,especially at a low gas ***,the ultrasonic beam deflection altered with the change of the gas velocity is modified by software in order to improve the accuracy of time *** addition,the peak value transmission circuit is employed to optimize the self-adaptive ability of the system,which can also raise the SNR and reduce the measurement error resulting from the ultrasonic beam *** last,this work proposed a new algorithm for flow calculation based on the improvements mentioned *** results show that the method has better accuracy,rangeability,stability and repeatability compared to traditional ones.

关键词： Ultrasonic gas flowmeter multi-tracks peak value transmission circuit

THEORETICAL STUDY ON THERMAL WAVE LAMINATED IMAGING IN SCANNING ELECTRON-ACOUSTIC MICROSCOPY

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THEORETICAL STUDY ON THERMAL WAVE LAMINATED IMAGING IN SCANN...

第三届全国压电和声波理论及器件技术研讨会

作者： Shou-Jing ZHU,shu-yi zhang Lab of Modern Acoustics,Institute of Acoustics,Nanjing University,Nanjing 210093,China

The theory of thermal wave laminated imaging in scanning electron-acoustic microscopy is ***-dimensional thermal conduction and thermoelastic models are introduced to obtain the temperature field and the acoustic field in *** the thermal sources at different depths produce the acoustic signals with different phases,the acoustic signals with different phases are contributed by the structures of different ***,the laminated imaging can be obtained by selecting the different phases of the signals,then the quantitative laminated imaging are analyzed reasonably and effectively.

关键词： Laminated imaging thermal wave detection scanning electron-acoustic microscopy

FINITE ELEMENT SIMULATION OF CONTACT-IMPACT DYNAMICS FOR HIGH-POWER ULTRASONIC PROCESSING SYSTEM

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FINITE ELEMENT SIMULATION OF CONTACT-IMPACT DYNAMICS FOR HIG...

第三届全国压电和声波理论及器件技术研讨会

作者： Zhao-jiang CHEN,shu-yi zhang Lab of Modern Acoustics,Institute of Acoustics,Nanjing University,Nanjing 210093,China

Nonlinear contact-impact dynamic behavior of high-power ultrasonic processing systems is studied in experiment and ***,nonlinear contact-impact vibrations in a high-power ultrasonic processing system are studied *** a finite element method is used to analyze the observed experimental phenomena,in which a 2D axisymmetric model is developed,and the nonlinear contact-impact dynamic behavior is *** finite element method simulation results of the contact-impact behavior between the transducer horn and the sample show that the contact force between the horn tip and the sample is very complicated and includes super- and sub-harmonic frequency components in addition to the ultrasonic excitation *** subharmonic vibrations in the samples are simulated in detail,and the results show that the subharmonic vibrations will always occur as observed in the experiments.

关键词： Ultrasonic processing system contact-impact dynamics finite element simulation

Linked PNPLA3 polymorphisms confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B

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World Journal of Gastroenterology 2015年第28期21卷 8605-8614页

作者： Qin Pan Rui-Nan zhang Yu-Qin Wang Rui-Dan Zheng Yu-Qiang Mi Wen-Bin Liu Feng Shen Guang-Yu Chen Jia-Fa Lu Chan-Yan Zhu shu-yi zhang yi-Ming Chen Wan-Lu Sun Jian-Gao Fan Department of Gastroenterology Xinhua Hospital Shanghai Jiaotong University School of Medicine Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhou Department of Infectious Diseases Tianjin Infectious Disease Hospital Wu-Jiao-Chang Community Health Center Clinical Epidemiology Center Shanghai Jiaotong University School of Medicine Shanghai Key Laboratory of Children’s Digestion and Nutrition

AIM:To investigate the association of PNPLA3 polymorphisms with concurrent chronic hepatitis B(CHB) and nonalcoholic fatty liver disease(NAFLD).METHODS:A cohort of Han patients with biopsyproven CHB,with or without NAFLD(CHB group,n = 51;CHB + NAFLD group,n = 57),and normal controls(normal group,n = 47) were recruited from Northern(Tianjin),Central(Shanghai),and Southern(zhangzhou) *** PNPLA3 polymorphisms were genotyped by gene *** association between PNPLA3 polymorphisms and susceptibility to NAFLD,and clinical characteristics of NAFLD were evaluated on the basis of physical indices,liver function tests,glycolipid metabolism,and histopathologic *** association of PNPLA3 polymorphisms and hepatitis B virus(HBV) load was determined by the serum level of HBV ***:After adjusting for age,sex,and body mass index,we found that four linked single nucleotide polymorphisms(SNPs) of PNPLA3,including the rs738409 G allele(CHB + NAFLD group vs CHB group:odds ratio[OR]= 2.77,95%confidence interval[CI]:1.18-6.54;P = 0.02),rs3747206 T allele(CHB+ NAFLD group vs CHB group:OR = 2.77,95%CI:1.18-6.54;P = 0.02),rs4823173 A allele(CHB +NAFLD group vs CHB group:OR = 2.73,95%CI:1.16-6.44;P= 0.02),and rs2072906 G allele(CHB+ NAFLD group vs CHB group:OR = 3.05,95%CI:1.28-7.26;P = 0.01),conferred high risk to NAFLD in CHB *** patients with both CHB and NAFLD,these genotypes of PNPLA3 polymorphisms were associated with increased susceptibility to nonalcoholic steatohepatitis(NASH)(NAFLD activity score ≥3;P =0.01-0.03) and liver fibrosis(>1 Metavir grading;P =0.01-0.04).As compared to those with C/C and C/G at rs738409,C/C and C/T at rs3747206,G/G and G/A at rs4823173,and A/A and A/G at rs2072906,patients in the CHB + NAFLD group with G/G at rs738409,T/T at rs3747206,A/A at rs4823173,and G/G at rs2072906 showed significantly lower serum levels of HBV DNA(P< 0.01-0.05).CONCLUSION:Four linked SNPs of PNPLA3(rs738409,rs3747206,rs4823173,and rs2072906) a

关键词： Chronic hepatitis B Hepatitis B virus Nonalcoholic fatty liver disease PNPLA3 Singlenucleotidepolymorphism

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： yi-Qing Shen Qiu-Wan Wei yi-Ren Tian Yun-Zhi Ling Min zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis