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Controversial protamine in dealing with acute cardiac tamponade during radiofrequency ablation

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Chinese Medical Journal 2021年第20期134卷 2503-2505页

作者： Dong-Dong Que Li-Yun Feng ya-shu yang Xu-Dong Song Ping-Zhen yang Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China Sino-Japanese Cooperation Platform for Translational Research in Heart Failure Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China Laboratory of Heart Center Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China Department of Cardiology Heart CenterZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

To the Editor:During radiofrequency catheter ablation(RFCA),acute cardiac tamponade is a common but life-threatening occurrence in which rapid blood accumulation in the pericardium cavity compresses the heart and causes the systemic circulation to *** percutaneous pericardiocentesis and immediate autologous blood transfusion are *** administration of protamine for incessant bleeding is controversial,for pericardial blood clots may form spontaneously despite the neutralizing effects of heparin and may even necessitate *** aim is to discuss the necessity and optimum time of protamine administration and to explore the means to prevent blood clot formation.

关键词： acute transfusion dealing

Combined therapy with methylprednisolone and ulinastatin in experimental autoimmune encephalomyelitis

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Chinese Medical Journal 2013年第18期126卷 3439-3445页

作者： shu ya-qing yang Yu WANG Yu-ge DAI Yong-qiang XIAO Li QIU Wei LU Zheng-qi WU Ai-ming RUAN Heng-fang HU Xue-qiang Multiple Sclerosis Center Department of Neurology the Third Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Our previous study had demonstrated that ulinastatin （UTI） had a neuroprotective effect in experimental autoimmune encephalomyelitis （EAE）. Methylprednisolone has been recommended to be a standard drug in multiple sclerosis （MS） therapies. The present study was to investigate the protective effects of UTI combined methylprednisolone in EAE. Methods Mice were divided into a UTI treatment group, a methylprednisolone treatment group, a combined treatment group with UTI and methylprednisolone, a normal saline treatment group, and a normal control group. EAE mice were induced in groups receiving different combined treatments, or respective monotherapies. Demyelination was evaluated by Solochrome cyanin staining. 2＇,3＇-cyclic nucleotide 3＇- phosphodiesterase （CNP）/myelin basic protein （MBP）/the precursor form of nerve growth factor （proNGF）/p75/inducible nitric oxide synthase （iNOS） proteins in cerebral cortex of EAE were detected by Western blotting. Results The combined treatment group had a lower clinical score （0.61±0.06） and demyelinating score （1.33±0.33） than the groups with normal saline （clinical score： 1.39±0.08, P 〈0.001; demyelinating score： 2.75±0.49, P 〈0.05） or monotheraphies. Compared with the saline treated EAE group, UTI combined methylprednisolone significantly increased expressions of CNP （1.14±0.06 vs. 0.65±0.04, P 〈0.001）, MBP （1.28±0.14 vs. 0.44±0.17, P 〈0.001）, and decreased expressions of proNGF （1.08±0.10 vs. 2.32±0.12, P 〈0.001）, p75 （1.13±0.13 vs. 2.33±0.17, P 〈0.001）, and iNOS （1.05±0.31 vs. 2.17±0.13, P 〈0.001） proteins in EAE. Furthermore, UTI combined methylprednisolone could significantly upregulate MBP （1.28±0.14 vs. 1.01±0.15, P 〈0.05） expression and downregulate iNOS （1.05±0.31 vs. 1.35±0.14, P 〈0.05） expression compared to methylprednisolone treatment EAE group. And proNGF expression was significantly lower in combined treatment （1.08±0.10） than that in UTI （1.51±0.24, P 〈0.05） or methylprednisolone （1.31±0.04, P 〈0.05） trea

关键词： ulinastatin methylprednisolone combined therapy experimental autoimmune encephalomyelitis neuroprotection

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四种蛋白类肿瘤标志物对结直肠癌筛查的价值

世界华人消化杂志 2017年第11期25卷 996-1001页

作者：王敏崔博豪孙舒雅杨舒张雷天津医科大学基础医学院天津市300070 天津医科大学附属肿瘤医院肺部肿瘤科天津市300060

结直肠癌(colorectal cancer,CRC)是常见的恶性肿瘤之一,占我国恶性肿瘤的第4位,且近年来发病率仍有不断上升的趋势.开展有效的结CRC筛查工作能改善预后,显著降低患者的死亡率,具有重大意义.在众多筛查方式中,粪便与血清中的肿瘤标志物... 详细信息

结直肠癌(colorectal cancer,CRC)是常见的恶性肿瘤之一,占我国恶性肿瘤的第4位,且近年来发病率仍有不断上升的趋势.开展有效的结CRC筛查工作能改善预后,显著降低患者的死亡率,具有重大意义.在众多筛查方式中,粪便与血清中的肿瘤标志物检测技术操作简单,患者痛苦小,费用低,成为研究关注的热点.鉴于肿瘤标志物检测对CRC癌筛查的重要意义,本文对四种主要蛋白质类肿瘤标志物在CRC筛查中的研究现状作一文献综述,以期为临床提供理论依据.

关键词：金属蛋白酶1组织抑制剂转铁蛋白 M2型丙酮酸激酶结直肠癌筛查

急性脑血管病并发急性肾功能衰竭原因分析及护理对策

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实用护理杂志 2002年第4期18卷 9-10页

作者：席淑华杨亚娟张群第二军医大学长征医院护理部上海200003

目的　分析急性脑血管病并发急性肾功能衰竭的原因。方法　对 2 0例急性脑血管病并发急性肾功能衰竭的原因进行了分析。结果　 2 0例急性脑血管病并发急性肾功能衰竭患者均无肾脏病史 ,其中脑梗死 6例 ,脑出血14例 ,发生急性肾功能衰竭... 详细信息

目的　分析急性脑血管病并发急性肾功能衰竭的原因。方法　对 2 0例急性脑血管病并发急性肾功能衰竭的原因进行了分析。结果　 2 0例急性脑血管病并发急性肾功能衰竭患者均无肾脏病史 ,其中脑梗死 6例 ,脑出血14例 ,发生急性肾功能衰竭时间 2～ 11d。结论　脑部病变严重程度、药物应用不当、老年人器质退行性改变是导致脑血管病并发急性肾功能衰竭的最常见的原因。根据易发原因提出相应的护理对策。危重患者重点监测生命体征及肾功能 ,正确应用脱水剂 ,加强老年人病情观察及护理是防止急性肾功能衰竭的重要措施。

关键词：急性脑血管病急性肾功能衰竭护理

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya Gao shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang Wen-Hui Wei shu-Hui Fan Li Chen Jie Wang Xiao-Qian yang Chun-Hao yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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构建开放式商务英语专业实践教学模式的探索和实践

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泰州职业技术学院学报 2009年第4期9卷 60-62,76页

作者：赵曙亚杨智江苏财经职业技术学院江苏淮安223001

高职高专商务英语的实践教学是提高学生专业技能和培养学生核心能力的重要环节,也是实现人才培养规格的有效途径。而目前商务英语专业在实施实践教学过程中尚存在一些问题,针对这些问题,文章阐述了构建开放式商务英语专业实践教学模式... 详细信息

高职高专商务英语的实践教学是提高学生专业技能和培养学生核心能力的重要环节,也是实现人才培养规格的有效途径。而目前商务英语专业在实施实践教学过程中尚存在一些问题,针对这些问题,文章阐述了构建开放式商务英语专业实践教学模式的基本原则和基本思路。

关键词：商务英语开放式实践教学模式

Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong Li Li Dan Jing Peng Qidong yang Fuqiang yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

High-temperature-tolerant flexible supercapacitors: Gel polymer electrolytes and electrode materials

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Journal of Energy Chemistry 2025年第1期100卷 426-457页

作者： Chong Peng Xinyi Huang Mingwei Zhao shuling Liao Quanhong yang Nianjun yang Siyu Yu School of Chemistry & Chemical Engineering Southwest University Nanoyang Group Tianjin Key Laboratory of Advanced Carbon and Electrochemical Energy Storage School of Chemical Engineering and Technology and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin University Department of Chemistry & IMO-IMOMEC Hasselt University

The development of flexible supercapacitors(FSCs) capable of operating at high temperatures is crucial for expanding the application areas and operating conditions of supercapacitors. Gel polymer electrolytes and electrode materials stand as two key components that significantly impact the efficacy of hightemperature-tolerant FSCs(HT-FSCs). They should not only exhibit high electrochemical performance and excellent flexibility, but also withstand intense thermal stress. Considerable efforts have been devoted to enhancing their thermal stability while maintaining high electrochemical and mechanical performance. In this review, the fundamentals of HT-FSCs are outlined. A comprehensive overview of state-of-the-art progress and achievements in HT-FSCs, with a focus on thermally stable gel polymer electrolytes and electrode materials is provided. Finally, challenges and future perspectives regarding HT-FSCs are discussed, alongside strategies for elevating operational temperatures and *** review offers both theoretical foundations and practical guidelines for designing and manufacturing HT-FSCs, further promoting their widespread adoption across diverse fields.

关键词： Flexible supercapacitors High-temperature tolerance Gel polymer electrolytes Electrode materials