检索结果-南通市图书馆

Colonic diverticulitis with comorbid diseases may require elective colectomy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第39期19卷 6613-6617页

作者： Kevin CW Hsiao Joseph G Wann Chien-Sheng Lin Chang-Chieh Wu shu-wen jao Ming-Hsin Yang Department of Surgery Tri-Service General HospitalNational Defense Medical Center Department of Physiology College of MedicineNational Taiwan University Department of Emergency and Critical Care Medicine Cheng Hsin Rehabilitation Medical Center Department of Emergency Tri-Service General HospitalNational Defense Medical Center

AIM:To investigate the comorbid disease could be the predictors for the elective colectomy in colonic ***:A retrospective chart review of 246 patients with colonic diverticulitis admitted between 2000and 2008 was conducted,and 19 patients received emergent operation were identified and *** were collected with regard to age,sex,albumin level on admission,left or right inflammation site,the history of recurrent diverticulitis,preoperative comorbidity,smoking habits,medication,treatment policy,morbidity,and *** comorbid diseases included cardiovascular disease,diabetes,pulmonary disease,peptic ulcer disease,gouty arthritis,and *** in use included non-steroidal anti-inflammatory drugs,acetylsalicylic acid(Aspirin),and *** and multivariate logistic regression analyses were performed to identify the relevant risk factors correlating to ***:The mean age of the 246 patients was 69.5years(range,24-94 years).Most diverticulitis could be managed with conservative treatment(n=227,92.3%),and urgent colectomy was performed in 19patients(7.7%).There were three deaths in the surgical group and four deaths in the nonsurgical *** overall mortality rate in the study was 1.7%among patients with conservative treatment and 15.7%among patients undergoing urgent *** logistic regression analysis indicated that comorbidities were risk factors for urgent colectomy for ***:To avoid high mortality and morbidity related to urgent colectomy,we suggest that patients with colonic diverticulitis and comorbid diseases may require elective colectomy.

关键词： Colonic diverticulitis Colectomy Comorbid disease

Isolated rectal diverticulum complicating with rectal prolapse and outlet obstruction: Case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第48期11卷 7697-7699页

作者： Chuang-Wei Chen, shu-wen jao, Huang-Jen Lai, Ying-Chun Chill, Jung-Cheng Kang, Division of Colon and Rectal Surgery, Department of Surgery Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan, China Division of Colon and Rectal Surgery Department of Surgery Tri-Service General Hospital No. 325 Cheng-Gong Road Section 2 Taipei Taiwan China.

The occurrence of rectal diverticula is very rare, with only sporadic reports in the literature since 1911. Symptomatic rectal diverticula are encountered even less *** of these complicated events range from conservative treatments to major surgical *** present a hitherto unreported occurrence of isolated rectal diverticulum complicated with rectal prolapse and outlet obstruction. Delorme's procedure resulted in subsidence of symptoms and resolution of the diverticulum. It provides a minimal invasive surgical technique to successfully address the reported malady.

关键词：直肠窒息直肠下垂手术治疗临床表现

PEX10基因缺失对兔须癣毛癣菌生长及致病性的抑制作用

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

农业生物技术学报 2024年第1期32卷 189-199页

作者：潘瑶肖琛闻刘燕张蓬军应淑敏黄叶娥季权安韦强王静王教瑜鲍国连中国计量大学生命科学学院浙江省农业科学院畜牧兽医研究所浙江省农业科学院植物保护与微生物研究所/农产品质量安全危害因子与风险防控国家重点实验室

须癣毛癣菌(Trichophyton mentagrophytes)又称石膏样毛癣菌，对家兔(Oryctolagus cuniculus)具有严重危害性。过氧化物酶体生物合成因子10(peroxisomal biogenesis factor 10, PEX10)与植物病原真菌的药物敏感性具有密切关系，但是其... 详细信息

须癣毛癣菌(Trichophyton mentagrophytes)又称石膏样毛癣菌，对家兔(Oryctolagus cuniculus)具有严重危害性。过氧化物酶体生物合成因子10(peroxisomal biogenesis factor 10, PEX10)与植物病原真菌的药物敏感性具有密切关系，但是其影响动物病原真菌如须癣毛癣菌生长及致病性的机制尚不明晰。本研究首先构建PEX10基因敲除载体，通过根癌农杆菌介导的遗传转化(Agrobacterium tumefaciens-mediated transformation, AtMT)和转化子筛选，获得须癣毛癣菌PEX10基因敲除株；生长特性等表型分析显示，PEX10基因敲除株的生长速率显著减慢(P<0.01)，对盐酸小檗碱的敏感性显著提高(P<0.001)，侵染兔皮肤组织的能力减弱，致病性降低。本研究结果为真菌PEX10基因功能的研究和兔须癣毛癣菌病的防治提供参考。

关键词：须癣毛癣菌过氧化物酶体生物合成因子10(PEX10) 过氧化物酶体耐药性

柠檬精油活性成分柠檬醛抑制头颈癌细胞增殖的机制研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国中药杂志 2024年第9期49卷 2364-2375页

作者：陈利张亚军秦洪文胡武静刘俨娇肖国生杜慧慧杨东林重庆三峡学院生物与食品工程学院重庆404120 重庆文理学院药学院(创新靶向药物国际研究院) 重庆402160

探索柠檬精油中发挥抗肿瘤作用的活性物质以及抑制头颈癌细胞SCC15和CAL33增殖的分子机制,该研究利用噻唑蓝[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,MTT]鉴定出抑制头颈癌细胞增殖的活性物质为柠檬醛,并... 详细信息

探索柠檬精油中发挥抗肿瘤作用的活性物质以及抑制头颈癌细胞SCC15和CAL33增殖的分子机制,该研究利用噻唑蓝[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay,MTT]鉴定出抑制头颈癌细胞增殖的活性物质为柠檬醛,并测定了柠檬醛抑制头颈癌细胞和正常细胞的IC50;同时,利用5-ethynyl-2′-deoxyuridine(EdU)实验检测柠檬醛对头颈癌细胞增殖率的影响,通过克隆形成实验检测柠檬醛对头颈癌细胞体外肿瘤球形成的影响。通过流式细胞术检测柠檬醛对头颈癌细胞周期阻滞和凋亡诱导情况;采用蛋白印迹检测柠檬醛对头颈癌细胞周期和凋亡相关蛋白表达水平的影响。结果表明柠檬醛可有效抑制头颈癌细胞的生长增殖,具有抗肿瘤活性,其抑制CAL33和SCC15的半数抑制浓度分别为54.78、25.23μg·mL^(-1)。进一步分析发现细胞周期相关蛋白S期激酶关联蛋白2(SKP2)、原癌基因(C-MYC)、细胞周期依赖性激酶1(CDK1)、周期蛋白B(cyclin B)均呈下调趋势,细胞周期阻滞于G2/M期。此外,柠檬醛能够促使细胞凋亡相关蛋白半胱天冬蛋白酶-3(caspase-3)、半胱天冬蛋白酶-9(caspase-9)和多聚腺苷二磷酸核糖聚合酶(PARP)剪切形式呈现上调趋势,而且使自噬相关蛋白微管相关蛋白1轻链3B(LC3B)、泛素结合蛋白(P62)、自噬效应蛋白Beclin1(Beclin1)和溶酶体相关膜蛋白1(LAMP1)表达呈上调趋势,暗示柠檬醛诱导头颈癌细胞发生凋亡和激活自噬。利用双标质粒系统mCherry-GFP-LC3分析发现柠檬醛阻碍自噬体和溶酶体融合,使自噬流进程受阻。因此,柠檬精油中发挥抗头颈癌细胞增殖的主要活性成分是柠檬醛,该成分对头颈癌细胞具有显著的抑制作用,其分子机制可能是柠檬醛通过阻滞细胞周期,诱导细胞发生凋亡和自噬,最终抑制肿瘤细胞增殖。

关键词：柠檬醛头颈癌抗肿瘤凋亡自噬

同方期刊数据库

Adsorption behavior of heavy metal ions by carbon nanotubes grown on microsized Al/_2O_3 particles

在线全文

学校读者我要写书评

暂无评论

Journal of University of Science and Technology Beijing 2007年第1期14卷 77-84页

作者： shu-Huei Hsieh jao-Jia Horng Department of Materials Science and Engineering Formosa University Department of Safety Health and Environmental Engineering Yunlin University of Science and Technology

Carbon nanotubes （CNTs） were grown on the surface of microsized Al2O3 particles in CH4 atmosphere at 700℃ under the catalysis of Fe-Ni nanoparticles. The CNTs on Al2O3 were used for adsorbing Pb^2＋, Cu^2＋, and Cd^2＋ from the solution and the results were compared with active carbon powders, commercial carbon nanotubes, and Al2O3 particles. The as-grown CNTs/Al2O3 have demonstrated extraordinary absorption capacity with further treatment or oxidation, as well as hydrophilic ability that other CNTs lacked. The adsorption capacity of CNTs on Al2O3 is superior to other adsorbents and the preference order of adsorption on composite Al2O3 is pb^2＋〉Cu^2＋〉Cd^2＋. It seemed that the adsorption of those Pb^2＋, Cu^2＋, and Cd^2＋ did not change the surface properties of composite particles. The adsorption behaviors of Pb^2＋, Cu^2＋, and Cd^2＋ by CNTs on Al2O3 match well with the Langmuir isothermal adsorption model and the second order kinetic model. The calculated saturation amount adsorbed by 1 g of CNTs on Al2O3 are 67.11, 26.59, and 8.89 mg/g for Pb^2＋, Cu^2＋, and Cd^2＋ in single adsorption test, respectively.

关键词： carbon nanotube heavy metal adsorption alumina

胶体金免疫层析法快速检测中药材中除草剂扑草净残留

在线全文

学校读者我要写书评

暂无评论

药物分析杂志 2024年第1期44卷 174-184页

作者：柯童炜骆骄阳秦家安王玉丹罗雅雯何春娇秦旭华杨美华成都中医药大学药学院成都611137 中国医学科学院北京协和医学院药用植物研究所中草药物质基础与资源利用教育部重点实验室北京100193

目的:基于自制的扑草净抗原和单克隆抗体,建立了一种适用于快速检测中药材、饮片中三嗪类除草剂扑草净残留的免疫层析方法。方法:确定了抗体偶联量为7μg,稀释液配制条件为含1%OVA,0.1%Tween-80的0.1 mol·L^(-1) PBS优化条件,并采用T... 详细信息

目的:基于自制的扑草净抗原和单克隆抗体,建立了一种适用于快速检测中药材、饮片中三嗪类除草剂扑草净残留的免疫层析方法。方法:确定了抗体偶联量为7μg,稀释液配制条件为含1%OVA,0.1%Tween-80的0.1 mol·L^(-1) PBS优化条件,并采用T线划线浓度为0.05 mg·mL^(-1),C线划线浓度为0.5 mg·mL^(-1)的湿法试纸条,提升胶体金免疫层析试纸条的灵敏度,降低不同用药部位中药的基质效应,并进行大批量中药材检测。结果:试纸条检测灵敏度可达到1 ng·mL^(-1),实际样品检出限可达到0.1 mg·kg^(-1),所建立的方法适用于陈皮、蒲公英、三七、金银花等中药材中40种不同部位扑草净残留检测。对10批西洋参、5批山药、12批三七、5批黄芪、3批沙参、4批牛膝、14批菊花、9批生姜、6批菟丝子进行了实际样品快速检测,均未检出扑草净残留。结论:本方法检测方法快速准确,前处理简便,操作简单,推广性强,可作为现场快速筛查扑草净残留的有效手段,以保证中药材的质量和安全性。同时,该研究为开发多种中药材的农残快速检测具有一定的参考意义。

关键词：扑草净胶体金试纸条中药材除草剂快速检测适用性基质效应

在线全文

学校读者我要写书评

暂无评论

认知负荷对驾驶员识别行人意图的影响

人类工效学 2024年第1期30卷 11-16,39页

作者：郭文姣胡寅凤郑维任茗钰周艳艳宁波大学心理学系暨研究所浙江宁波315211 宁波大学群体行为与社会心理服务中心浙江宁波315211

目的准确识别行人意图对人车安全非常重要,但驾驶员在操作车辆时往往会面临一定的认知负荷.本研究考察认知负荷对驾驶员识别行人意图的影响.方法通过听觉N-back任务操纵认知负荷,要求被试(N =90)在模拟驾驶场景中识别行人意图.结果在... 详细信息

目的准确识别行人意图对人车安全非常重要,但驾驶员在操作车辆时往往会面临一定的认知负荷.本研究考察认知负荷对驾驶员识别行人意图的影响.方法通过听觉N-back任务操纵认知负荷,要求被试(N =90)在模拟驾驶场景中识别行人意图.结果在2-back双任务的高负荷下,驾驶员识别行人意图的辨别力显著低于1-back双任务和单任务,且后两者没有差异.结论增加认知负荷会削弱驾驶员识别行人意图的辨别力,提示对行人意图的识别需要认知资源的参与.因此,驾驶员应保持较低水平的认知负荷驾驶以提高人车交互安全.

关键词：交通工程车辆驾驶安全认知负荷行人意图识别驾驶辨别力认知资源事故预防

广西甘蔗褐条病病原菌鉴定与杀菌剂敏感度测定

在线全文

学校读者我要写书评

暂无评论

西南农业学报 2024年第4期37卷 816-823页

作者：陈潇航张小秋黄海荣宋修鹏李文教梁永检雷敬超王泽平祝光湖刘期怀李翔颜梅新广西农业科学院甘蔗研究所/中国农业科学院甘蔗研究中心/农业农村部广西甘蔗生物技术与遗传改良重点实验室/广西甘蔗遗传改良重点实验室南宁530007 百色市农业科学研究所/广西农业科学院百色分院/国家糖料产业技术体系百色综合试验站广西百色533612 广西南亚热带农业科学研究所广西崇左532415 广西应用数学中心/桂林电子科技大学广西桂林541004

[目的]明确广西甘蔗褐条病的致病菌,为科学有效防控甘蔗褐条病提供参考依据。[方法]利用植物组织分离法从广西甘蔗褐条病发病植株中分离纯化菌株,通过致病性测定、形态学观测及rDNA-ITS、GAPDH、LSU和EF-1α多基因系统发育分析鉴定病原... 详细信息

[目的]明确广西甘蔗褐条病的致病菌,为科学有效防控甘蔗褐条病提供参考依据。[方法]利用植物组织分离法从广西甘蔗褐条病发病植株中分离纯化菌株,通过致病性测定、形态学观测及rDNA-ITS、GAPDH、LSU和EF-1α多基因系统发育分析鉴定病原菌,并在室内使用菌丝生长速率法测试该病原菌对9种杀菌剂的敏感度。[结果]从甘蔗褐条病病叶中分离出1株病原真菌,编号为GHT-01,其菌落呈棕色或黑色,有少量白色气生菌丝;孢子单生或丛生,直或略弯曲,孢子为3隔4细胞,第3个细胞相较其他细胞更大、颜色更深,分生孢子大小为12.3~24.1μm×5.2~12.8μm;多位点序列分析结果显示其与Curvularia lunata的模式菌株(CBS730.96,CBS157.34)聚为一支;科赫式法则(Koch’s rules)测定结果表明,病原菌接种健康新鲜甘蔗叶片后表现的症状及从接种发病的叶片上再分离获得的病原菌,其分生孢子形态特征均与最初分离到的病原菌菌株一致。因此,鉴定该病原菌为新月弯孢菌(***)。9种杀菌剂对该病原菌的室内敏感度测定结果表明,40%苯甲·吡唑醚乳油和45%咪鲜胺水乳剂对病原菌的抑菌效果较好,其抑制中浓度(EC_(50))分别为1.43和1.54μg/mL,60%唑醚·代森联水分散粒剂的抑菌效果较差,其EC_(50)达205.82μg/mL。[结论]在广西发生的甘蔗褐条病病原菌为新月弯孢菌,且为首次报道,筛选出对该病原菌抑菌效果较好的杀菌剂分别为40%苯甲·吡唑醚乳油和45%咪鲜胺水乳剂。

关键词：甘蔗褐条病分子检测药剂筛选

维普期刊数据库博看期刊

同方期刊数据库

Prevalence and risk factors for Candida esophagitis among human immunodeficiency virus-negative individuals

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第30期10卷 10896-10905页

作者： Yan-Hua Chen Tzu-Ming jao Yow-Ling Shiue I-Jung Feng Ping-I Hsu Department of Internal Medicine Kaohsiung Veterans General Hospital Pingtung BranchPingtung 91245Taiwan Institute of Biomedical Sciences National Sun Yat-sen UniversityKaohsiung 80424Taiwan Department of Nursing Meiho UniversityPingtung 91202Taiwan Department of Medical Education and Research Kaohsiung Veterans General HospitalKaohsiung 813414Taiwan Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of MedicineTaipei 10617Taiwan Institute for Precision Medicine National Sun Yat-sen UniversityKaohsiung 80424Taiwan Division of Gastroenterology Department of Internal MedicineAn Nan HospitalChina Medical UniversityTainan 709204Taiwan

BACKGROUND Candida esophagitis(CE) is among the commonest esophageal infections and is known as an opportunistic fungal infection mostly affecting people living with the human immunodeficiency virus(HIV).However,some medical conditions might predispose HIV-negative individuals to esophageal *** epidemiology and associated endoscopic findings of CE among people without HIV have rarely been *** To investigate the prevalence of CE among HIV-negative persons,and determine risk factors predicting *** Between January 2015 and December 2018,all consecutive outpatients who underwent routine esophagogastroduodenoscopy as part of health check-ups at their own expense at the Health Check-up Center of the Kaohsiung Veterans General Hospital,Taiwan,were recruited in this *** with positive HIV serology results were *** and clinical characteristics including age,gender,economic status,smoking history,alcohol consumption,tea and coffee consumption,underlying diseases,body fat percentage,body mass index,endoscopic findings,and Helicobacter pylori infection status were carefully *** was confirmed by endoscopic biopsy and pathological assessment with hematoxylin and eosin and periodic acidSchiff *** evaluate independent factors predicting the development of CE,we conducted a univariate analysis of clinical *** variables found to be significant via univariate analysis were subsequently included in a multivariable analysis of potential risk factors for CE *** A total of 11802 participants were included in this ***-seven(0.4%) were confirmed as having CE by pathological *** analysis identified older age,the presence of chronic kidney disease,alcohol consumption,and steroid use(P = 0.023,< 0.001,0.033,and 0.004,respectively) as significantly associated with *** analysis revealed older age [adjusted odds ratio(OR) = 1.027;95%CI:1.001-1.053;P = 0.

关键词： Candida esophagitis Prevalence Risk factors Human immunodeficiency virus