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Exosome-Transmitted miR-224-5p Promotes Colorectal Cancer Cell Proliferation via Targeting ULK2 in p53-Dependent Manner

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Biomedical and Environmental Sciences 2024年第1期37卷 71-84页

作者： yang Le Mei ZHENG Qi LIU Xiao Jia LI Xian Xian Veronica Lim CHEN Qi ZHAO Zhong Hua wang shu yang Department of Pathology School of Basic MedicineFudan UniversityShanghai 200032China Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand Department of Pathology Huashan HospitalFudan UniversityShanghai 200040China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Teladoc Health Inc Shanghai 200335China Shanghai Medical College Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Shanghai 200032China

Objective To investigate the role and molecular mechanism of exosomal miR-224-5p in colorectal cancer(CRC).Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR,***-luciferase reporter gene assay was used to determine the target gene of *** protein expressions of p53 and unc-51 like kinase 2(ULK2)in CRC cells were detected by western *** cytometry was used to detect cell cycle and *** proliferation was measured by CCK8 and EdU *** The miR-224-5p expression was upregulated in CRC tissues and increased progressively with the rise of CRC *** cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner,and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or ***,ULK2 was characterized as a direct target of miR-224-5p and was downregulated in CRC ***,ULK2 inhibited CRC cell proliferation in a p53-dependent ***,exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC *** Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC,which may offer promising targets for CRC prevention and therapy.

关键词： miR-224-5p Exosome ULK2 p53 Cell proliferation Colorectal cancer

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基于异构图神经网络的半监督网站主题分类

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计算机工程与科学 2024年第4期46卷 635-646页

作者：王谢中陈旭景永俊王叔洋北方民族大学计算机科学与工程学院宁夏银川750000 北方民族大学电气信息工程学院宁夏银川750000

互联网网站数量快速增长使现有方法难以准确分类特定网站主题,如基于URL的方法无法处理未反映在URL中的主题信息,基于网页内容的方法受到数据稀疏性和语义关系捕捉的限制。为此,提出一种基于异构图神经网络的半监督网站主题分类方法HGNN... 详细信息

互联网网站数量快速增长使现有方法难以准确分类特定网站主题,如基于URL的方法无法处理未反映在URL中的主题信息,基于网页内容的方法受到数据稀疏性和语义关系捕捉的限制。为此,提出一种基于异构图神经网络的半监督网站主题分类方法HGNN-SWT。该方法不仅利用网站文本特征来弥补仅使用URL特征的不足,还利用异构图对网站文本和词语的稀疏关系进行建模,通过处理图中的节点和边关系来提高分类性能。同时引入基于随机游走的邻居节点采样方法,考虑节点的局部特征和全局图结构,并提出特征融合策略,捕捉网站文本数据的上下文关系和特征交互。通过在自制的Chinaz Website数据集上的实验,证明了HGNN-SWT方法在网站主题分类任务中相较于现有方法具有更高的准确率。

关键词：网站主题异构图神经网络半监督特征融合

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Influence of the Coulomb exchange term on nuclear single-proton resonances

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Nuclear Science and Techniques 2016年第5期27卷 231-237页

作者： shu-yang wang Zhong-Lai Zhu Zhong-Ming Niu School of Physics and Materials Science Anhui University

Nuclear single-proton resonances are sensitive to the Coulomb field,while the exchange term of Coulomb field is usually neglected due to its *** combining the complex scaling method with the relativistic mean-field model,the influence of the Coulomb exchange term on the single-proton resonances is investigated by taking Sn isotopes and N=82 isotones as *** is found that the Coulomb exchange term reduces the singleproton resonance energy within the range of 0.4-0.6 MeV and leads to similar isotopic and isotonic trends of the resonance energy as those without the Coulomb exchange ***,the single-proton resonance width is also reduced by the Coulomb exchange term,whose influence generally decreases with the increasing neutron number and increases with the increasing proton ***,the influence of the Coulomb exchange term cannot change the trend of the resonance width with respect to the neutron number and proton ***,the influence of the Coulomb exchange term on the resonance width is investigated for the doubly magic nuclei ^(40)Ca,^(56,78)Ni,^(100,132)Sn,and ^(208)*** is found that the Coulomb exchange term reduces the proton resonance width within 0.2 MeV,whose magnitude depends on the specific nucleus and the quantum numbers of resonant states.

关键词：共振能量库仑场交换项质子数相对论平均场模型共振宽度中子数非定域性

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Studies on the esterifications of 9-(hydroxyimino)-4-methyl-8,9-dihydrofuro[2,3-h]chromen-2-one with acid chlorides under different conditions

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Chinese Chemical Letters 2008年第7期19卷 791-794页

作者： Ru shu Sun yang wang Peng Xia Department of Medicinal Chemistry School of Pharmacy Fudan University Shanghai 200032 China

The esterifications of 9-（hydroxyimino）-4-methyl-8,9-dihydrofuro[2,3-h]chromen-2-one （4） with acid chlorides afforded normal oxime-esters 3a-e in 35-78% yields in presence of excessive 4-dimethylaminopyridine as the acid scavenger, whereas the reactions gave unexpected 8-substituted products N-（8-chloro-4-methyl-2-oxo-2H-furo-[2,3-h]chromen-9-yl）amides （5a-c） and 4-methyl-2,9-dioxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-ylcarboxyloates （6d-e） by using excessive acid chlorides. The structures of 10 new compounds were determined by 1H NMR, 13C NMR, MS and HRMS, and the possible mechanism for the formation of unexpected products 5a--c and 6d-e was also proposed.

关键词： 9-(Hydroxyirnino)-4-methyl-8,9-dihydrofuro[2,3-h]chromen-2-one Oxime-ester N-(8-Chloro-4-methyl-2-oxo-2H-furo[2,3-h]chro-men-9-yl)amide 4-Methyl-2,9-dioxo-8,9-dihydro-2H-furo[2,3-h]chromen-8-ylcarboxyloate

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Simulation Technology of Environmental Impacts by Zero-energy Residential Buildings Based on Emergy Analysis Method

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Journal of Harbin Institute of Technology(New Series) 2014年第3期21卷 38-45页

作者： Hong Zhou Xiao-Long Xue wang-shu yang School of Architecture and Civil Engineering Xiamen University School of Management Harbin Institute of Technology

This paper presents a simulation technology of environmental impact for the building. By emergy analysis method,emergy costs of building( or construction engineering) can be calculated in the life cycle. It includes the engineering cost, environmental cost and social cost of building. Through integrating GIS technology with multi-agent technology,life cycle substance and energy metabolism of building( construction engineering) can be simulated and their environmental influence can be dynamically displayed. Based on the case study of entries works‘Sunny Inside'by Xiamen University in 2013 China International Solar Decathlon Competition,we discovered the changing pattern of surrounding environmental impact from waste streams of the zero-energy building and ordinary construction. The simulation results verified and showed the Odum principles of maximum power. This paper provides a new research perspective and integration approach for the environmental impact assessment in building and construction engineering. The result will help decision-making in design and construction engineering scheme.

关键词： emergy analysis method zero-energy building agent-based model dynamic simulation

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In Situ Synthesis of Heat Resistant Gradient Composite on Steel Surface

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Journal of Iron and Steel Research International 2009年第2期16卷 89-94页

作者： CUI Xiang-hong wang Feng wang shu-qi yang Zi-run GAO Ming-juan WEI Min-xian School of Materials Science and Engineering Jiangsu University Zhenjiang 212013 Jiangsu China

A heat resistant gradient composite was synthesized in situ on steel with the self-propagating high temperature synthesis （SHS） reaction of 3Ni-Al-Ti-C system during casting. The phases, microstructure, and composition of the composite were analyzed by using an X-ray diffractometer （XRD）, and a scanning electron microscope （SEM） coupled with an energy-dispersive X-ray spectroscope （EDS）. The formation mechanism of the composite is also discussed. TiC/Ni3 Al/steel gradient composite is achieved by forming the gradient distributions of Fe, Ni, and Al, accompanied with the gradient variation of the microstructure from TiC/Nia A1, to TiC/Ni3 Al/steel, and to steel. The composite is in situ synthesized through whole reaction of 3Ni-Al-Ti-C system in liquid steel and densification procedure, and the liquid steel infiltrates into pores in the SHS product and forces liquid Ni3Al to form self-compaction further.

关键词： steel heat resistant composite synthesis microstructure

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Fulde-Ferrell-Larkin-Ovchinnikov pairing states between s- and p-orbital fermions

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Frontiers of physics 2017年第5期12卷 27-33页

作者： shu-yang wang Jing-Wei Jiang Yue-Ran Shi Qiongyi He Qihuang Gong Wei Zhang State Key Laboratory of Mesoscopic Physics School of Physics Peking University Beijing 100871 China Department of Physics Renmin University of China Beifing 100872 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China Collaborative Innovation Center of Extreme Optics Shanxi University Taiyuan 030005 China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of China Beijing 100872 China

We study the pairing states in a largely imbalanced two-component Fermi gas loaded in an anisotropic two-dimensional optical lattice, where the spin-up and spin-down fermions are filled to the s- and px-orbital bands, respectively. We show that owing to the relative inversion of the band structures of the s and px orbitals, the system favors pairing between two fermions on the same side of the Brillouin zone, leading to a large stable regime for states with a finite center-of-mass momentum, i.e., the Fulde-Ferrell-Larkin-Ovchinnikov （FFLO） state. In particular, when two Fermi surfaces are close in momentum space, a nesting effect stabilizes a special type of π-FFLO phase with a spatial modulation of π along the easily tunneled x direction. We map out the zero-temperature phase diagrams within the mean-field approach for various aspect ratios within the two-dimensional plane and calculate the Berezinskii-Kosterlitz-Thouless （BKT） transition temperatures TBKT for different phases.

关键词： ultracold Fermi gas superfluid optical lattice

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甘蔗梢青贮及饲喂效果的研究进展

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饲料研究 2024年第2期47卷 172-176页

作者：郭芳珠王曙阳许富强孙夕思刘国琼应雄美王智能中国科学院近代物理研究所甘肃兰州730000 中国科学院大学生命科学学院北京101408 甘肃农业大学食品科学与工程学院甘肃兰州730070 云南省农业科学院甘蔗研究所云南红河661699

甘蔗梢是甘蔗的主要副产品之一,资源丰富且营养价值较为全面,是反刍动物粗饲料的来源之一。青贮是一种有效保存和开发甘蔗梢饲料的方法,但高含量的碳水化合物和酵母菌使甘蔗梢自然青贮容易腐败变质,而且高含量的纤维会影响动物的消化率... 详细信息

甘蔗梢是甘蔗的主要副产品之一,资源丰富且营养价值较为全面,是反刍动物粗饲料的来源之一。青贮是一种有效保存和开发甘蔗梢饲料的方法,但高含量的碳水化合物和酵母菌使甘蔗梢自然青贮容易腐败变质,而且高含量的纤维会影响动物的消化率和适口性。目前,对于甘蔗梢青贮的研究主要集中在各类添加剂的使用、混合青贮、甘蔗梢青贮饲喂反刍动物的效果以及甘蔗的收获期、品种、青贮时间等对甘蔗梢青贮产生的影响。文章综述了添加剂和混合青贮以及其他因素对甘蔗梢青贮品质、营养价值、有氧稳定性以及饲喂效果的影响,为推动甘蔗梢的利用和优质青贮饲料的调制提供参考。

关键词：甘蔗梢青贮添加剂混合青贮发酵品质营养成分饲喂效果

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Evolution of inclusions in vacuum induction melting of superalloys containing 70%return material

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Journal of Iron and Steel Research International 2024年第3期31卷 719-728页

作者： Jin-guo Gao shu-lei yang shu-feng yang Jing-she Li Wei Liu Meng-jing Zhao An-ren wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Metallurgical and Building Materials Business Department China International Engineering Consulting CorporationBeijing 100048China

The variation law of inclusions type and size in the vacuum induction melting process and ingot of Ni-based superalloy containing 70%return material was studied by industrial test sampling,and the mechanism of inclusions formation was analyzed with thermodynamic *** results show that there are mainly two types of composite inclusions in the vacuum induction melting of Ni-based superalloys,which are nitride-and oxide-based composite inclusions,like Al_(2)O_(3)-SiO_(2)-Cr_(2)O_(3),TiN-(Mo,Nb)C,*** type and proportion of inclusions from the center to the edge of the vacuum induction ingot did not change *** number density of inclusions from the center to the edge of the ingot varied less,and the size of inclusions became smaller from the center to the *** addition,thermodynamic calculations show that oxides(M_(2)O_(3))are present in the liquid phase and mainly contain Al,Ti,Cr,Fe and O *** nitride consists mainly of Ti and N and contains small amounts of Cr,C,Nb,and Mo *** is consistent with the results of industrial *** the temperature decreases,the precipitation phases such as M_(2)O_(3),MN,γ,MC,δ,γ'andμphases are gradually precipitated,where oxides and nitrides are present in the liquid *** contents of O and N elements are the main influencing factors for the inclusions content and precipitation temperature;when the nitrogen content is reduced to below 0.0015%,it can make MN precipitate below the liquid-phase line.

关键词： Ni-based superalloy Vacuum induction melting Return material Inclusion Thermodynamic

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Possible Tricritical Behavior and Anomalous Lattice Softening in van der Waals Itinerant Ferromagnet Fe3GeTe2 under High Pressure

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Chinese Physics Letters 2020年第7期37卷 61-64页

作者： Jie-Min Xu shu-yang wang Wen-Jun wang Yong-Hui Zhou Xu-Liang Chen Zhao-Rong yang Zhe Qu Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China

We present a high-pressure study of van der Waals ferromagnetic metal Fe3GeTe2 through electrical transport and Raman scattering measurements in diamond anvil cells at pressures up to 22.4 *** compression,the ferromagnetic transition temperature Pc manifested by a kink in resistance curve decreases monotonically and becomes undiscernable around Pc=10 GPa,indicative of suppression of the itinerant ***,by fitting the low temperature resistance to the Fermi liquid behavior of R=R0+AT2,we found that R0 shows a cusp-like anomaly and the coefficient A diverges around *** transport anomalies imply a tricritical point as commonly observed in itinerant ferromagnets under ***,the Raman-active E2g and A1g modes soften remarkably after an initial weak hardening and the peak widths of both modes broaden evidently on approaching Pc,followed by complete disappearance of both modes above this critical pressure.A possible underlying mechanism for such anomalous lattice softening near pc is discussed.

关键词： critical ferromagnetic approaching

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