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Suppression of miR-17 Alleviates Acute Respiratory Distress-associated Lung Fibrosis by Regulating Mfn2

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Current Medical Science 2024年第5期44卷 964-970页

作者： Mei-xia XU Tao XU ning AN Department of Critical Care Medicine Wuhan Fourth HospitalWuhan430033China Institute of Anesthesiology and Critical Care Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective Acute respiratory distress syndrome(ARDS)patients currently have relatively high mortality,which is associated with early lung *** study aimed to investigate whether miR-17 suppression could alleviate ARDS-associated lung fibrosis by regulating *** A mouse model of ARDS-related lung fibrosis was constructed via intratracheal instillation of *** expression level of miR-17 in lung tissues was detected via quantitative real time polymerase chain reaction(qRT-PCR).In the ARDS mouse model of lung fibrosis,the mitigating effects of miR-17 interference were evaluated via tail vein injection of the miR negative control or the miR-17 *** pathological changes in the lung tissue were examined via HE staining and Masson’s trichrome staining,and the underlying molecular mechanism was investigated via ELISA,qRT-PCR and Western *** Bleomycin-induced pulmonary fibrosis significantly increased collagen deposition and the levels of hydroxyproline(HYP)and *** with miR-17 significantly reduced the levels of HYP and miR-17 and upregulated the expression of *** intravenous injection of the miR-17 antagomir alleviated lung inflammation and reduced collagen *** addition,interference with miR-17 could upregulate LC3B expression,downregulate p62 expression,and improve mitochondrial *** Interfering with miR-17 can improve pulmonary fibrosis in mice by promoting mitochondrial autophagy via Mfn2.

关键词： miR-17 Mfn2 acute respiratory distress syndrome pulmonary fibrosis mitochondria

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Resveratrol combats chronic diseases through enhancing mitochondrial quality

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Food Science and Human Wellness 2024年第2期13卷 597-610页

作者： Weichu Tao Hu Zhang xia Jiang ning Chen Tianjiu Research and Development Center for Exercise Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Sports MedicineWuhan Sports UniversityWuhan 430079China The University Hospital of Wuhan Sports University Wuhan 430079China

Resveratrol(RSV),as a functional food component extracted from natural plants,has been widely studied and recognized in preventing and treating various diseases,with major mechanisms including executing anti-inflammation and anti-oxidation functions,and improving mitochondrial *** diseases as non-communicable diseases are mainly caused by multiple factors,such as physiological decline and dysfunction in the body,and have become a significant challenge on public health *** is worth noting that chronic diseases such as Alzheimer's disease(AD),Parkinson's disease(PD),muscle atrophy,cardiovascular disease,obesity,and cancer are accompanied by abnormal mitochondrial ***,targeted regulation of mitochondria may be a meaningful way to prevent and treat chronic *** evidence has confirmed that RSV is actively involved in regulating mitochondria,and it has become an essential consideration to prevent and treat chronic diseases through targeting mitochondria and improving corresponding *** this article,current studies on RSV to optimize mitochondrial quality for preventing and alleviating chronic disease are systematically summarized,which can provide a theoretical reference for the development of functional foods or drugs to combat chronic diseases.

关键词： Resveratrol Functional food Mitochondrial quality Chronic disease Anti-inflammation Anti-oxidation

Spin-Rotation Coupling in Gravitation with Torsion

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Communications in Theoretical Physics 2007年第3X期48卷 473-476页

作者： QIU shu-xia SHAO Cheng-Gang Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

Based on the theory of gravitation with torsion developed by Hammond [Rep. Prog. Phys. 65 （2002） 599], thc interaction between the intrinsic spin of a particle and the mass source is calculated. It is shown that spin can interact with the gravitimagnetic field created by a rotational mass, where the spin-rotation coupling is also discussed. According to the recent torsion pendulum experiment with polarized electrons by Heckel et al. [Phys. Rev. Left. 97 （2006） 021603], we set a new limit on the value of the torsion coupling constant K as K E [0.53, 0.95], which has improved many orders than the constraints from the early spln-spin experiment with K 〈 2 × 10^14.

关键词： torsion spin-rotation torsion coupling constant

Starlet:Network defense resource allocation with multi-armed bandits for cloud-edge crowd sensing in IoT

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Digital Communications and Networks 2024年第3期10卷 586-596页

作者： Hui xia ning Huang Xuecai Feng Rui Zhang Chao Liu College of Computer Science and Technology Ocean University of ChinaQingdao266100China

The cloud platform has limited defense resources to fully protect the edge servers used to process crowd sensing data in Internet of *** guarantee the network's overall security,we present a network defense resource allocation with multi-armed bandits to maximize the network's overall ***,we propose the method for dynamic setting of node defense resource thresholds to obtain the defender(attacker)benefit function of edge servers(nodes)and ***,we design a defense resource sharing mechanism for neighboring nodes to obtain the defense capability of ***,we use the decomposability and Lipschitz conti-nuity of the defender's total expected utility to reduce the difference between the utility's discrete and continuous arms and analyze the difference ***,experimental results show that the method maximizes the defender's total expected utility and reduces the difference between the discrete and continuous arms of the utility.

关键词： Internet of things Defense resource sharing Multi-armed bandits Defense resource allocation

Existence of Positive Solutions for a Singular p-Laplacian Differential Equation

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Acta Mathematica Sinica,English Series 2008年第8期24卷 1331-1344页

作者： xia LI Zheng An YAO Wen shu ZHOU Department of Mathematics Shenzhen University Shenzhen 518060 P. R. China Department of Mathematics Zhongshan University Guangzhou 510275 P. R. China Department of Mathematics Jilin University Changchun 130012 P. R. China

In this paper, we are concerned with the existence of positive solutions for a singular p-Laplacian differential equation（φp（u＇））＇＋β/r φp（u＇）-γ ｜u＇｜^p/u ＋ g（r）=0,0〈r〈1,subject to the Dirichlet boundary conditions： u（0） = u（1） =0, where φp（s） = ｜sl^P-2s,p 〉 2,β 〉0, γ〉（p-1）/p （β ＋ 1）, and g（r） ∈ C^1 [0, 1] with g（r）〉 0 for all τ ∈ [0, 1]. We use the method of elliptic regularization, by carrying out two limit processes, to get a positive solution.

关键词： p-Laplacian differential equation positive solution existence

Safety lifetime analysis method for multi-mode time-dependent structural system

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Chinese Journal of Aeronautics 2022年第11期35卷 294-308页

作者： Yingshi HU Zhenzhou LU ning WEI xia JIANG Changcong ZHOU School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China

It is important to determine the safety lifetime of Multi-mode Time-Dependent Structural System(MTDSS). However, there is still a lack of corresponding analysis ***, this paper establishes MTDSS safety lifetime model firstly, and then proposes a Kriging surrogate model based method to estimate safety lifetime. The first step of proposed method is to construct the Kriging model of MTDSS performance function by using extremum learning function. By identifying possible extremum mode of MTDSS, the performance function of MTDSS can be equivalently transformed into the one of Single-mode Time-Dependent Structure(STDS).The second step is to use the Advanced First Failure Instant Learning Function(AFFILF) to train the Kriging model constructed in the first step, so that the convergent Kriging model can identify the possible First Failure Instant(FFI) of STDS. Then safety lifetime can be searched quickly by dichotomy search. By using AFFILF, the minimum instant that the state is not accurately identified by the current Kriging model is selected as the training point, which avoids the unnecessary calculation which may be introduced into the existing First Failure Instant Learning Function(FFILF).In addition, the Candidate Sample Pool(CSP) reduction strategy is also adopted. By adaptively deleting the random candidate sample points whose FFI have been accurately identified by the current Kriging model, the training efficiency is further improved. Three cases show that the proposed method is accurate and efficient.

关键词： Kriging Learning function Lifetime System reliability Time-dependent reliability analysis

An overview of prostate diseases and their characteristics specific to Asian men

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Asian Journal of Andrology 2012年第3期14卷 458-464,I0008页

作者： shu-Jie xia Di Cui Qi Jiang Department of Urology The First People's Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200080China

In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia （BPH）, prostate cancer （PCa） and chronic prostatitis （CP） that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of these diseases, we find that Asians have a lower incidence of PCa than whites, but the incidences of BPH and CP are similar. Asian men with CP often suffer from fewer disease sites, but have a higher frequency of pain during urination rather than after sexual climax. Prostate-specific antigen （PSA） is a widely used marker for the diagnosis of PCa in both Asian and Western countries. Although the PSA level may be lower in Asians, the threshold used is based on whites. After reviewing the treatments available for these diseases, we did not find a fundamental difference between Asians and whites. Furthermore, the selection for the most appropriate treatment based on the individual needs of patients remains a challenge to urologists in Asia. After considering the traits of prostate diseases that are specific to Asian men, we hope to pave the way for the development of specific diagnostic and therapeutic strategies targeted specifically to Asian men.

关键词： Asians benign prostatic hyperplasia chronic prostatitis prostate cancer

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第01期 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

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