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N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-κB pathway in rats

International Journal of Ophthalmology(English edition) 2024年第2期17卷 228-238页

作者： yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-Lun Xiao Meng Gao Lu-Ming Zhang shuan-Hu Zhou shu-na yu Xiao-Li Wang Yan-Song Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina School of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments of Orthopedic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To observe the effects of N-acetylserotonin(naS)administration on retinal ischemia-reperfusion(RIR)injury in rats and explore the underlying mechanisms involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-kappa B(NF-κB)signaling ***:A rat model of RIR was developed by increasing the pressure of the anterior chamber of the *** male Sprague Dawley were randomly divided into five groups:sham group(n=8),RIR group(n=28),RIR+naS group(n=28),RIR+FPS-ZM1 group(n=8)and RIR+naS+FPS-ZM1 group(n=8).The therapeutic effects of naS were examined by hematoxylin-eosin(H&E)staining,and retinal ganglion cells(RGCs)*** expression of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins and the phosphorylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohistochemistry staining and Western blot *** expression of HMGB1 protein was also detected by enzyme-linked immunosorbent assay(ELISA).RESULTS:H&E staining results showed that naS significantly reduced retinal edema and increased the number of RGCs in RIR *** naS therapy,the HMGB1 and RAGE expression decreased significantly,and the activation of the NF-κB/NLRP3 pathway was antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,naS exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPS-ZM1 led to a significant decrease of p-NF-κB and NLRP3 expression,so as to the IL-1βexpression and retinal edema,accompanied by an increase of RGCs in RIR ***:naS may exhibit a neuroprotective effect against RIR via the HMGB1/RAGE/NF-κB signaling pathway,which may be a useful therapeutic target for retinal disease.

关键词： retinal diseases retinal ischemia—reperfusion injury N-acetylserotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

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Partial Linear Model Averaging Prediction for Longitudinal Data

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Journal of Systems Science & Complexity 2024年第2期37卷 863-885页

作者： LI na FEI yu ZHANG Xinyu Faculty of Science Kunming University of Science and TechnologyKunming 650500China School of Statistics and Mathematics Yunnan University of Finance and EconomicsKunming 650221China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

Prediction plays an important role in data *** averaging method generally provides better prediction than using any of its *** though model averaging has been extensively investigated under independent errors,few authors have considered model averaging for semiparametric models with correlated *** this paper,the authors offer an optimal model averaging method to improve the prediction in partially linear model for longitudinal *** model averaging weights are obtained by minimizing criterion,which is an unbiased estimator of the expected in-sample squared error loss plus a *** properties,including asymptotic optimality and consistency of averaging weights,are established under two scenarios:(i)All candidate models are misspecified;(ii)Correct models are available in the candidate *** studies and an empirical example show that the promise of the proposed procedure over other competitive methods.

关键词： Asymptotic optimality longitudinal data model averaging estimator partially linear model prediction

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Land use change and its driving factors in the ecological function area:A case study in the Hedong Region of the Gansu Province,China

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Journal of Arid Land 2024年第1期16卷 71-90页

作者： WEI Zhudeng DU na yu Wenzheng School of Geographical Science Nanjing University of Information Science&TechnologyNanjing 210044China

Land use and cover change(LUCC)is important for the provision of ecosystem *** increasing number of recent studies link LUCC processes to ecosystem services and human well-being at different scales ***,the dynamic of land use and its drivers receive insufficient attention within ecological function areas,particularly in quantifying the dynamic roles of climate change and human activities on land use based on a long time *** study utilizes geospatial analysis and geographical detectors to examine the temporal dynamics of land use patterns and their underlying drivers in the Hedong Region of the Gansu Province from 1990 to *** indicated that grassland,cropland,and forestland collectively accounted for approximately 99% of the total land *** initially increased and then decreased after 2000,while grassland decreased with *** contrast,forestland and construction land were continuously expanded,with net growth areas of 6235.2 and 455.9 km^(2),*** 1990 to 2020,cropland was converted to grassland,and both of them were converted to forestland as a *** expansion of construction land primarily originated from *** 2000 to 2005,land use experienced intensified temporal dynamics and a shift of relatively active zones from the central to the southeastern *** yield,economic factors,and precipitation were the major factors accounting for most land use *** impacts on land use changes were stronger before 1995,succeeded by the impact of animal husbandry during 1995-2000,followed by the impacts of grain production and gross domestic product(GDP)after ***,agricultural and pastoral activities,coupled with climate change,exhibited stronger enhancement effects after 2000 through their interaction with population and economic *** patterns closely correlated with ecological restoration projects in China since *** study implies the importance of synergy be

关键词： land use land type geographic detector driving mechanism Hedong Region

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Comparative analysis of the microbiome of sympatric wintering Bean Geese,Domestic Ducks,humans,and soil at Shengjin Lake of China reveals potential public risk to human health

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Avian Research 2024年第2期15卷 279-286页

作者： Gang Liu na Xu Chongyang yu College of Life Sciences Anhui Medical UniversityHefei 230032China

The gut microbiota of migratory waterbirds is affected by various complex factors,including cross-species transmission,which increases the risk of pathogen spreading among sympatric animals and poses a potential public health risk to *** this study,we investigated the microbial communities of wintering Bean Geese(Anser fabalis),Domestic Ducks(*** domesticus),humans,and soil using high-throughput sequencing of the 16S rRna gene region in Shengjin Lake,*** total,6,046,677 clean reads were obtained,representing 41,119 operational taxonomic units(OTUs)across the four *** dominant microbial phyla were the Proteobacteria,Firmicutes,Bacteroidota,and *** Sorensen similarity index and alpha and beta diversity results showed that the gut microbial communities of Bean Geese and Domestic Ducks were more similar to those of the other *** analysis revealed that Faecalibacterium prausnitzii,Pseudomonas fragi,and Bradyrhizobium elkanii were hubs of the three major *** common microbiomes were iden-tified in Bean Geese,Domestic Ducks,humans,and soil in Shengjin Lake.A total of 96 potential pathogens were identified among the four groups,with 20 specific potentially pathogenic microbiomes found in the gut of Bean *** of these pathogens are responsible for significant financial losses in the poultry industry and pose risks to human *** pneumoniae,Morganella morganii,Escherichia coli,and Ralstonia insidiosa are potential core pathogens found in the four groups at Shengjin Lake that can cause diseases in humans and an-imals and facilitate cross-species transmission through various ***,humans are at risk of con-tracting these pathogens from migratory birds because of their frequent contact with domestic ***,further studies are required to explore the potential pathogenic species and transmission pathways among sympatric wintering Bean Geese,Domestic Ducks,humans,and soil.

关键词： Microbiome Migratory waterbird Pathogens Poultry Sympatric species

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Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： yu-Fa Luo shu-Qiang Li School of Life and Environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using Dna data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to East Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and East/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an East-West direction from the middle Eocene.

关键词： Geological event Climate change Ballooning organism Faunal exchange Species distribution

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Low-Brightness Object Recognition Based on Deep Learning

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Computers, Materials & Continua 2024年第5期79卷 1757-1773页

作者： shu-Yin Chiang Ting-yu Lin Department of Information and Telecommunications Engineering Ming Chuan UniversityTaoyuan City333Taiwan

This research focuses on addressing the challenges associated with image detection in low-light environments,particularly by applying artificial intelligence techniques to machine vision and object recognition *** primary goal is to tackle issues related to recognizing objects with low brightness *** this study,the Intel RealSense Lidar Camera L515 is used to simultaneously capture color information and 16-bit depth information *** detection scenarios are categorized into normal brightness and low brightness *** the system determines a normal brightness environment,normal brightness images are recognized using deep learning *** low-brightness situations,three methods are proposed for *** first method is the SegmentationwithDepth image(SD)methodwhich involves segmenting the depth image,creating amask from the segmented depth image,mapping the obtained mask onto the true color(RGB)image to obtain a backgroundreduced RGB image,and recognizing the segmented *** second method is theHDVmethod(hue,depth,value)which combines RGB images converted to HSV images(hue,saturation,value)with depth images D to form HDV images for *** third method is the HSD(hue,saturation,depth)method which similarly combines RGB images converted to HSV images with depth images D to form HSD images for *** experimental results,in normal brightness environments,the average recognition rate obtained using image recognition methods is 91%.For low-brightness environments,using the SD method with original images for training and segmented images for recognition achieves an average recognition rate of over 82%.TheHDVmethod achieves an average recognition rate of over 70%,while the HSD method achieves an average recognition rate of over 84%.The HSD method allows for a quick and convenient low-light object recognition *** research outcome can be applied to nighttime surveillance systems or nighttime road safety systems

关键词： Low-brightness depth image image segmentation image recognition HDV HSD

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Cu-substituted nickel hexacyanoferrate with tunable reaction potentials for superior ammonium ion storage

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Journal of Materials Science & Technology 2024年第2期169卷 19-27页

作者： Leiyu Fan Guangchang shu Yiwen Liu Haoxiang yu Lei Yan Liyuan Zhang Jie shu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China

In this work,a variety of Cu_(x)Ni_(2-x)Fe(CN)_(6)(x=0,0.4,0.8,1.2,1.6,2)cathodes for ammonium ion batteries are prepared and their electrochemical performances are *** the introduction of copper in nickel hexacyanoferrate,the electrochemical performance varies without changing the structure of nickel *** increase of Cu content in nickel hexacyanoferrate leads to the enhancement of reaction potential and *** results suggest that the substitution of Cu for Ni has a positive effect on improving the cycling stability and rate capacity of nickel hexacyanoferrate when x in Cu_(x)Ni_(2-x)Fe(CN)_(6)is less than ***,Cu_(0.4)Ni_(1.6)Fe(CN)_(6)exhibits the best cycling per-formance(capacity retention of 97.54%at 0.3 C)and the highest rate capacity(41.4 mAh g^(-1)at 10 C)in Cu_(x)Ni_(2-x)Fe(CN)_(6).Additionally,the X-ray diffraction(XRD)and X-ray photoelectron spectroscopy(XPS)tests also reveal that the structural evolution of Cu_(0.4)Ni_(1.6)Fe(CN)_(6)is highly reversible upon NH_(4)^(+)***,this work proposes a candidate material for ammoniumion batteries and offers a novel avenue for adjusting the operating potential of the material.

关键词： Nickel hexacyanoferrate Copper hexacyanoferrate NH_(4)^(+)storage Ammonium ion batteries Aqueous batteries

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Pd-catalyzed intermolecular Si–O formation via Si–C activation

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Science China Chemistry 2024年第8期67卷 2661-2669页

作者： shuang Liu yu-shu Chen Yichen Wu Peng Wang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesShanghai 200032China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistryand Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China

The development of efficient Si–O bond formation reaction with 100% atom-economy, excellent functional group tolerance, and broad scope under mild conditions is highly desired due to the prevalence of silanol, silyl ether, and their derivatives in synthetic chemistry and materials science. Here, we have realized the Pd-catalyzed Si–O formation reaction via a Si–C activation approach with 100% atom-economy by employing silacyclobutanes(SCBs) and various hydroxy-containing substrates, including water,alcohols, phenols, and silanols. This protocol features a broad substrate scope, remarkable functional compatibility and mild conditions, providing a series of silanols, silyl ethers in high efficiency. Notably, this protocol could also be used for selective protection of hydroxy functionalities, and for the access of a class of novel polymers containing Si–O main chain. Preliminary mechanistic studies unveiled that this reaction underwent a Pd-catalyzed concerted ring-opening mechanism.

关键词： Si–O formation Si–C activation palladium silacyclobutane silanol silyl ether

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Progress in preparation of AlN-reinforced magnesium matrix composites:A review

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China Foundry 2024年第1期21卷 1-10页

作者： Lu Chen shu-lin Lü Di-jia Zhao Wei Guo Jian-yu Li shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material,AlN has very good thermophysical and mechanical *** addition,AlN is an effective refining agent for Mg alloys because it has a lattice constant similar to that of ***,AlN is an ideal reinforcement for magnesium matrix composites(MMCs),and is attracting increasing *** review addresses the development of preparation technologies for AlN-reinforced Mg matrix *** mainstream preparation techniques include stir casting,melt infiltration,powder metallurgy,and in-situ *** addition,the advantages and disadvantages of these techniques are analyzed in depth,and it is pointed out that the next direction for the preparation of high-performance AlN-reinforced MMCs is less aluminization and multiple technologies integration.

关键词： AlN MMCs preparation thermophysical property mechanical property

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Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-yu Sun shu-Wen Tang yu-Hong yu Xin-Tong Du Xiao-Bao Wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

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