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不通气的沸腾汽-液-固三相搅拌槽中的汽液分散和固体悬浮

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高校化学工程学报 2007年第5期21卷 753-759页

作者：白丁包雨云高正明北京化工大学化学工程学院北京100029

在直径为0.476m的椭圆底搅拌槽中,采用直径为0.238m的单层六叶深凹叶盘式涡轮桨(HEDT),在液位为0.5m的全挡板条件下研究了沸腾状态下,蒸汽、去离子水和玻璃珠组成的汽-液-固体系中搅拌功率、气含率及固体颗粒完全离底悬浮特性,并与常温... 详细信息

在直径为0.476m的椭圆底搅拌槽中,采用直径为0.238m的单层六叶深凹叶盘式涡轮桨(HEDT),在液位为0.5m的全挡板条件下研究了沸腾状态下,蒸汽、去离子水和玻璃珠组成的汽-液-固体系中搅拌功率、气含率及固体颗粒完全离底悬浮特性,并与常温通空气三相体系进行对比。研究结果表明,沸腾条件下的流体动力学性能与常温通气体系相比存在较大差异。在沸腾条件下,搅拌功率消耗随着搅拌转速的增加有所下降,但HEDT桨具有较高的载气能力,即使在高叶端线速度下,相对功率消耗(RPD)仍能保持在较高的水平;沸腾体系的气含率随单位质量流体输入功率的增加表现出先增后减的规律,即存在气含率的极大值,蒸汽成核位置和固体颗粒悬浮特性随搅拌功率增加而改变是造成上述行为的主要原因;沸腾体系中的气含率远远低于常温通空气体系。临界悬浮搅拌转速(NJSG)随固相体积分率的增加略有增加;沸腾体系中蒸汽量的变化对NJSG影响远小于常温通气体系。研究结果对于工业沸腾态三相搅拌反应器的设计和操作具有一定的参考价值。

关键词：沸腾态搅拌槽汽-液-固三相体系气含率临界悬浮相对功率消耗

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面向大规模定制的产品模块化设计

成组技术与生产现代化 2006年第2期23卷 56-58页

作者：高长银付书明李明郑州航空工业管理学院机电工程系郑州450015 机械工业第六设计研究院郑州450007

介绍了面向大规模定制的产品模块化设计的基本思想及模块创建过程和模块配置过程的研究现状,在此基础上进一步指出了面向MC的模块化设计面临的新课题.

关键词：大规模定制模块化设计模块创建模块配置

Anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab for first-line treatment in advanced natural killer T cell lymphoma

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1665-1674页

作者： Jie Xiong shu Cheng Xiao gao Shan-He Yu Yu-Ting Dai Xin-Yun Huang Hui-Juan Zhong Chao-Fu Wang Hong-Mei Yi Hao Zhang Wei-Guo Cao Rong Li Wei Tang Yan Zhao Peng-Peng Xu Li Wang Wei-Li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Nuclear Medicine Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Pathology Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Otolaryngology Shanghai Rujin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Radiation Shanghai Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Hematology Navy Medical Center of PLAShanghaiChina Pole de Recherches Sino-Francais en Science du Vivant et Genomique Laboratory of Molecular PathologyShanghaiChina

Natural killer T cell lymphoma(NKTCL)is highly aggressive,with advanced stage patients poorly responding to intensive *** explore effective and safe treatment for newly diagnosed advanced stage NKTCL,we conducted a phase ll study of anti-metabolic agent pegaspargase plus PD-1 antibody sintilimab(NCT04096690).Twenty-two patients with a median age of 51 years(range,24-74)were enrolled and treated with induction treatment of pegaspargase 2500 IU/m2 intramuscularly on day 1 and sintilimab 200 mg intravenously on day 2 for 6 cycles of 21 days,followed by maintenance treatment of sintilimab 200 mg for 28 cycles of 21 *** complete response and overall response rate after induction treatment were 59%(95%Cl,43-79%)and 68%(95%Cl,47-84%),*** a median follow-up of 30 months,the 2 year progression-free and overall survival rates were 68%(95%Cl,45-83%)and 86%(95%Cl,63-95%),*** most frequently grade 3/4 adverse events were neutropenia(32%,n=7)and hypofibrinogenemia(18%,n=4),which were manageable and led to no discontinuation of *** proportion score of PD-L1,peripheral blood high-density lipoprotein cholesterol,and apolipoprotein A-l correlated with good response,while PD-1 on tumor infiltrating lymphocytes and peripheral Treg cells with poor response to pegaspargase plus sintilimab *** conclusion,the chemo-free regimen pegaspargase plus sintilimab was effective and safe in newly diagnosed,advanced stage *** lipid profle and immunosuppressive signature contributed to treatment resistance,providing an alternative therapeutic approach dual targeting fatty acid metabolism and CTLA-4 in NKTCL.

关键词： killer metabolism lymphoma

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参数概率灵敏度分析的神经网络方法及其应用

计算力学学报 2011年第B04期28卷 29-32页

作者：何琴淑杨玉明肖世富中国工程物理研究院总体工程研究所绵阳621900

参数概率灵敏度分析是可靠性设计中非常重要的一项工作,它可以提供基本变量分布参数的变化引起可靠性的变化信息,为判断系统参数的重要性提供依据。本文将商用有限元计算-神经网络方法-Monte Carlo法相结合,基于这种快速响应模型的复杂... 详细信息

参数概率灵敏度分析是可靠性设计中非常重要的一项工作,它可以提供基本变量分布参数的变化引起可靠性的变化信息,为判断系统参数的重要性提供依据。本文将商用有限元计算-神经网络方法-Monte Carlo法相结合,基于这种快速响应模型的复杂结构可靠性分析方法,针对结构随机参数的概率灵敏度分析,提出一个考虑随机变量全局分散性的新的度量参数,作为一种工程实用的快速近似方法,相对于传统的确定性及局部灵敏度具有更清晰的意义和指导作用,通过一个算例实现了该法在工程上的应用,并利用ANSYS的概率分析模块验证了该法的有效性。

关键词：神经网络 Monte Carlo 快速响应模型概率灵敏度

The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 684-695,I0002-I0007页

作者： Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang shuaixi Yang Mengsu Zeng Guangyu Ding shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang gao Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Radiology Zhongshan HospitalFudan UniversityShanghaiChina Department of Biostatistics Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghaiChina

Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis *** aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC ***:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were *** diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively *** difference was compared between patients receiving PET/CT or not after propensity score ***:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was *** 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,Pming PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score ***:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accura

关键词： Intrahepatic cholangiocarcinoma(ICC) staging positron emission tomography/computed tomography(PET/CT) clinical management

黄土高原沟壑区小流域土壤有机碳与环境因素的关系

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环境科学 2008年第10期29卷 2879-2884页

作者：魏孝荣邵明安高建伦西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室陕西省黄龙县气象局黄龙715700

研究不同环境要素共同作用下的土壤有机碳分布特征及其与环境因素的关系对于全面准确评估黄土高原地区土壤有机碳状况和土壤碳循环具有重要意义.结合野外调查和室内分析,研究了黄土高原沟壑区典型小流域土壤不同组分有机碳分布特征及其... 详细信息

研究不同环境要素共同作用下的土壤有机碳分布特征及其与环境因素的关系对于全面准确评估黄土高原地区土壤有机碳状况和土壤碳循环具有重要意义.结合野外调查和室内分析,研究了黄土高原沟壑区典型小流域土壤不同组分有机碳分布特征及其与地形条件、土地利用方式和土壤类型之间的关系.结果表明,黄土沟壑区小流域土壤总有机碳变异较小(变异系数为34%),高活性有机碳变异较大(变异系数为43%),有机碳的变异性随其活性的增强而增大.各组分有机碳之间极显著正相关,而且在不同环境条件下的含量顺序一致.各组分有机碳在不同地形条件下以塬面土壤最高,沟道土壤最低;在不同土地利用方式下以林地和农田土壤较高,草地土壤较低;在不同土壤类型中则以黑垆土最高,红土最低.不同环境条件下各组分有机碳之间的关系分析表明,环境条件不但直接影响有机碳的分布,还通过影响有机碳不同组分之间的关系来改变其分布特征.研究区总有机碳与活性有机碳之间的关系受环境条件影响最大,中活性与高活性有机碳之间的关系受环境条件影响最小.

关键词：黄土沟壑区有机碳土地利用地形条件土壤类型

The 96-week clinical outcomes after cessation of nucleos(t)ide analog treatment in chronic hepatitis B patients

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Gastroenterology Report 2021年第4期9卷 313-322,I0002页

作者： Wen-Xiong Xu Yang-Mei Li Jian-Guo Li Yong-Yu Mei You-ming Chen Xue-Jun Li Chao-shuang Lin Hong Deng Zhi-Xin Zhao Dong-Ying Xie Zhi-Liang gao Liang Peng Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Prevention and Health Care The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Chronic hepatitis B(CHB)patients have a high virological relapse rate after cessation of nucleos(t)ide analog(NA)treatment,but the clinical outcome remains *** study aimed to investigate the 96-week clinical outcomes and the risk factors for relapse in CHB after cessation of ***:This study was a prospective trial;74 eligible patients were *** patients underwent NA cessation and follow-up according to the 2012 Asian Pacific Association for the Study of the Liver ***,biochemical(aspartate aminotransferase[AST],alanine aminotransferase[ALT],total bilirubin,urea nitrogen,creatinine),virological data(hepatitis B surface antigen[HBsAg],hepatitis B e antigen[HBeAg],hepatitis B e antibody[HBeAb],hepatitis B virus[HBV]DNA levels),and color Doppler ultrasound examination results were recorded and ***:After NA cessation,19 cases were HBsAg-negative without relapse during the 96-week *** the 55 cases of HBsAg-positive after cessation,four types of clinical outcomes were *** patients had no relapse during the 96-week follow-up(type A,21.8%),7 patients underwent virological relapses but spontaneously had a non-virological relapse(type B,12.7%),10 patients maintained virological relapse(type C,18.2%),and 26 patients turned to clinical relapse,received NA retreatment,and achieved ALT normalization and negative conversion of HBV DNA within 12 months(type D,47.3%).The 2-year overall cumulative rates of virological and clinical relapses were 58.1%and 24.3%,*** factors associated with virological relapse were duration of negative HBV DNA,EOT(end of treatment)HBsAg,and original status of *** EOT HBsAg was also an independent factor for clinical ***:There are four types of clinical outcomes in patients with CHB after cessation of NA *** research is needed to explore the mechanism of different clinical *** EOT HBsAg level is an independent

关键词： chronic hepatitis B nucleos(t)ide analogs cessation relapse hepatitis B virus

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间隙高度对涡轮叶顶间隙流动的影响

工程热物理学报 2008年第6期29卷 935-939页

作者：牛茂升臧述升黄名海上海交通大学机械与动力工程学院叶轮机械研究所上海200240

叶顶间隙流动是导致涡轮动叶中产生流动损失的主要原因之一。对某动力涡轮第一级内三维流动的数值计算结果表明,流体在经过动叶叶顶间隙以后在约25%叶顶轴向弦长处(τ=3 mm)在叶顶与吸力边夹角处卷起形成间隙涡,造成流动阻塞,同时在间... 详细信息

叶顶间隙流动是导致涡轮动叶中产生流动损失的主要原因之一。对某动力涡轮第一级内三维流动的数值计算结果表明,流体在经过动叶叶顶间隙以后在约25%叶顶轴向弦长处(τ=3 mm)在叶顶与吸力边夹角处卷起形成间隙涡,造成流动阻塞,同时在间隙内叶片顶部10%叶顶轴向弦长处(τ=3 mm)开始在压力边出现叶顶分离涡,使得间隙流动损失增加。随着间隙高度增大,通过间隙的流量增加,间隙涡形成位置后移,间隙涡、叶顶分离涡尺寸变大,在流道内影响范围增大,导致流动损失变大。

关键词：涡轮动叶叶顶间隙流动间隙涡叶顶分离涡

Classification of Motor Imagery EEG Using Wavelet Envelope Analysis and LSTM Networks

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Classification of Motor Imagery EEG Using Wavelet Envelope A...