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Network Pharmacology and Experimental Validation to Explore Mechanism of Tetrahydropalmatine on Acute Myocardial Ischemia

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1087-1098页

作者： liN Po-li cao Jun-ling REN Ping CHEN Jia-li cao Bo-ya HE Ping ZHENG Chang-hui li Qi-wen wang wei ZHANG Jian School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing(100029)China Department of Pharmacy Dongfang HospitalBeijing University of Chinese MedicineBeijing(100078)China School of Chinese Medicine Beijing University of Chinese MedicineBeijing(100029)China School of life Sciences Beijing University of Chinese MedicineBeijing(100029)China School of Basic Medical Sciences Guangzhou University of Chinese MedicineGuangzhou(510006)China Beijing Key Laboratory of TCM Syndrome and Formula Beijing(100029)China Key Laboratory of Beijing University of Chinese Medicine Ministry of EducationBeijing(100029)China

Objective:To explore the potential molecular mechanism of tetrahydropalmatine(THP)on acute myocardial ischemia(AMI).Methods:First,the target genes of THP and AMI were collected from SymMap Database,Traditional Chinese Medicine Database and Analysis Platform,and Swiss Target Prediction,***,the overlapping target genes between THP and AMI were evaluated for Grene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and protein-protein interaction network *** binding affinity between the protein and THP was assessed by molecular ***,the protective effects of THP on AMI model and oxygen and glucose deprivation(OGD)model of H9C2 cardiomyocyte were explored and the expression levels of target genes were detected by RT-qP CR in vivo and in ***:MMP9,PPARG,PTGS2,SLC6A4,ESR1,JAK2,GSK3B,NOS2 and AR were recognized as hub *** KEGG enrichment analysis results revealed that the potential target genes of THP were involved in the regulation of PPAR and hormone *** improved the cardiac function,as well as alleviated myocardial cell ***,THP significantly decreased the RNA expression levels of MMP9,PTGS2,SLC6A4,GSK3B and ESR1(Plity(Plism and the regulation of hormones.

关键词： tetrahydropalmatine acute myocardial infarction inflammation energy metabolism hormone

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Construction of a chromosome-level genome assembly for genome-wide identification of growth-related quantitative trait loci in Sinocyclocheilus grahami(Cypriniformes,Cyprinidae)

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Zoological Research 2021年第3期42卷 262-266页

作者： Yan-hui Yin Xin-hui Zhang Xiao-Ai wang Rui-Han li Yuan-wei Zhang Xin-Xin shan Xin-Xin You Xin-Di Huang An-li Wu Mo wang Xiao-Fu Pan chao Bian Wan-Sheng Jiang Qiong shi Jun-Xing Yang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyInnovative Academy of Seed DesignChinese Academy of SciencesKunmingYunnan 650224China Yunnan Key Laboratory of Plateau Fish Breeding Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650224China Yunnan Engineering Research Center for Plateau-Lake Health and Restoration Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650224China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineBGIShenzhenGuangdong 518083China BGI Education Center University of Chinese Academy of SciencesShenzhenGuangdong 518083China Key Laboratory for Conserving Wildlife with Small Populations in Yunnan Faculty of Biodiversity ConservationSouthwest Forestry UniversityKunmingYunnan 650224China Hunan Engineering Laboratory for Chinese Giant Salamander’s Resource Protection and Comprehensive Utilization and Key Laboratory of Hunan Forest and Chemical Industry EngineeringJishou UniversityZhangjiajieHunan 427000China

The Dianchi golden-line barbel,Sinocyclocheilus grahami(Regan,1904),is one of the“Four Famous Fishes”of Yunnan Province,*** its economic value,this species has been artificially bred successfully since 2007,with a nationally selected breed(“***,Bayou No.1”)certified in *** the future utilization of this species,its growth rate,disease resistance,and wild adaptability need to be improved,which could be achieved with the help of molecular markerassisted selection(MAS).In the current study,we constructed the first chromosome-level genome of ***,assembled 48 pseudo-chromosomes,and obtained a genome size of 1.49 *** also performed QTL-seq analysis of *** using the highest and lowest bulks(i.e.,largest and smallest size)in both a sibling and random *** screened two quantitative trait loci(QTLs)(Chr3,14.9-39.1 Mb and Chr17,4.1-27.4 Mb)as major growth-related *** candidate genes(e.g.,map2k5,stat1,phf21a,sox6,and smad6)were also identified,with functions related to growth,such as cell differentiation,neuronal development,skeletal muscle development,chondrogenesis,and *** results built a solid foundation for in-depth MAS studies on the growth traits of ***.

关键词： smallest trait Sino

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益智清心方单次给药毒性试验研究

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世界中医药 2024年第16期19卷 2399-2403页

作者：谭丽博吴素素魏微曹宇马丽娜裴卉李浩北京中医药大学北京100029 中国中医科学院望京医院北京100102 中国中医科学院西苑医院北京100091

目的:观察24 h内益智清心方经口灌胃后的急性毒性反应和死亡情况,评价益智清心方的安全性,为进一步的重复给药毒性试验以及临床用药提供参考。方法:选取24~33 g ICR小鼠,雌雄各半,随机分为益智清心方组和空白对照组,采用最大给药量法,... 详细信息

目的:观察24 h内益智清心方经口灌胃后的急性毒性反应和死亡情况,评价益智清心方的安全性,为进一步的重复给药毒性试验以及临床用药提供参考。方法:选取24~33 g ICR小鼠,雌雄各半,随机分为益智清心方组和空白对照组,采用最大给药量法,以最大灌胃体积40 mL/kg计,分别给予等体积的益智清心方药液和纯水,2次/d,给药期间定期监测小鼠一般状况和体质量,14 d后,收集血、尿样本,并进行大体解剖,评价益智清心方对脏器系数、血常规、尿常规等安全性指标的影响。结果:ICR小鼠按40 mL/kg经口灌胃给予最大可配制浓度为0.36 g干浸膏/mL的益智清心方药液,当日2次,累积剂量为98.6 g生药/kg体质量,约相当于成人临床拟用剂量的298倍(按公斤体质量计算)和38倍(按体表面积计算)。各组小鼠均未发现毒性相关的症状和死亡,益智清心方组小鼠在体质量、脏器系数、血常规、尿常规指标方面与对照组小鼠比较差异均无统计学意义(均P>0.05)。结论:本试验条件下,益智清心方的单次给药毒性试验中未见明显的急性毒性反应及死亡,提示其最大耐受量(MTD)>98.6 g生药/kg体质量。

关键词：临床前研究单次给药毒性小鼠阿尔茨海默病益智清心方安全性体质量脏器系数

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金属镁电解槽槽型选择的探讨

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世界有色金属 2024年第15期 7-9页

作者：王永荣曹香蕾郑有为李璞李积山青海盐湖镁业有限公司青海汇信资产管理有限责任公司青海盐湖工业股份有限公司

镁由于其独特的金属性质，成为二十世纪最受欢迎的轻金属材料，围绕其延伸的镁合金材料在汽车领域、电子、军事领域等广泛应用，作为储氢材料也是备受现代前沿科技的青睐。同时，镁电解技术相对于皮江法炼镁更加环保、节能。随着镁电解... 详细信息

镁由于其独特的金属性质，成为二十世纪最受欢迎的轻金属材料，围绕其延伸的镁合金材料在汽车领域、电子、军事领域等广泛应用，作为储氢材料也是备受现代前沿科技的青睐。同时，镁电解技术相对于皮江法炼镁更加环保、节能。随着镁电解技术的发展，电解槽类型又有了不同类型的发展。某公司前期引进的是单极电解槽，但是在生产过程中，该电解槽生产不稳定，能耗及原料消耗较高，氯气浓度低、洁净度差和氯气处理成本高，对于企业的发展非常不利。经过多种类型电解槽的技术对比，拟计划采用无水氯化镁颗粒熔化净化-多极槽电解生产金属镁工艺技术。

关键词：镁电解氯化镁单极槽多极槽熔化净化

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Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population

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Biomedical and Environmental Sciences 2022年第1期35卷 4-12页

作者： wang Jia Lu cao Qiu Yu XIN Zhuo Jun liU shan shan XU Min wang Tian Ge LU Jie li CHEN Yu Hong wang shuang Yuan ZHAO Zhi Yun XU Yu NING Guang wang wei Qing BI Yu Fang li Mian Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less *** sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese *** From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at *** measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and *** During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident *** regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and *** to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal ***,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese ***,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger.

关键词： Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study

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Construction of an anchoring SSR marker genetic linkage map and detection of a sex-linked region in two dioecious populations of red bayberry

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Horticulture Research 2020年第1期7卷 2262-2270页

作者： Yan wang hui-Min Jia Yu-Tong Shen Hai-Bo Zhao Qin-Song Yang Chang-Qing Zhu De-li Sun Guo-Yun wang chao-chao Zhou Yun Jiao Chun-Yan Chai li-Ju Yan Xiong-wei li hui-Juan Jia Zhong-shan Gao Fruit Science Institute College of Agriculture and BiotechnologyZhejiang University310058 HangzhouChina shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences201602 ShanghaiChina Yuyao Forestry Technology Extension Center 315400 NingboChina Institute of Forestry Ningbo Academy of Agricultural ScienceNingboChina Cixi Forestry Technology Extension Center 315300 CixiChina linhai Forestry Technology Extension Center 317000 TaizhouChina Forest&Fruit Tree Institute Shanghai Academy of Agricultural Sciences201403 ShanghaiChina

Red bayberry(Morella rubra)is an evergreen fruit tree found in southern China whose whole-genome sequence has recently been *** updated the linkage map of the species by adding 118 SSR markers and the femalespecific marker MrFT2_*** integrated map included eight linkage groups and spanned 491 *** sexassociated markers were identified,six of which were located in linkage group 8,in agreement with the previously reported location of the sex-determining *** MrFT2_BD-SEX marker was genotyped in 203 cultivated *** the females of the accessions,we found two female-specific alleles,designated W-b(151 bp)and W-d(129 bp).We previously found that‘Dongkui’,a female cultivar,could produce viable pollen(we refer to such plants‘Dongkui-male’)and serve as the paternal parent in *** genotypes of the MrFT2_BD-SEX marker were W-b/Z in‘Biqi’and W-d/Z in‘Dongkui-male’.The progeny of a cross between these parents produced a 3:1 female(W-)to male(ZZ)ratio and the expected 1:1:1:1 ratio of W-b/W-d:W-b/Z:W-d/Z:Z/*** addition,the flowering and fruiting phenotypes of all the F1 progeny fit their *** results confirm the existence of ZW sex determination and show that the female phenotype is controlled by a single dominant locus(W)in a small genomic region(59 kb and less than 3.3 cM).Furthermore,we have produced a homozygous“super female”(WW)that should produce all-female offspring in the F2 generation,providing a foundation for commercial use and presenting great potential for use in modern breeding programs.

关键词： breeding cultivar linkage

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消糖丸对T2DM合并H型高血压痰瘀证患者中医证候积分改善及血糖水平的影响

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糖尿病新世界 2024年第7期27卷 1-3,7页

作者：王璐璐曹慧陈伟万红霞李意平新沂市中医医院内分泌科江苏徐州221400

目的探究消糖丸对2型糖尿病(Diabetes Mellitus Type 2,T2DM)合并H型高血压痰瘀证患者中医证候积分、血糖水平的影响。方法选取新沂市中医医院于2023年1—8月收治的86例T2DM+H型高血压痰瘀证患者作为研究对象,采用单双数法分为对照组(n=... 详细信息

目的探究消糖丸对2型糖尿病(Diabetes Mellitus Type 2,T2DM)合并H型高血压痰瘀证患者中医证候积分、血糖水平的影响。方法选取新沂市中医医院于2023年1—8月收治的86例T2DM+H型高血压痰瘀证患者作为研究对象,采用单双数法分为对照组(n=43)和研究组(n=43),对照组行常规西药治疗,研究组在对照组用药基础上使用消糖丸治疗。对比两组患者的治疗效果、中医证候评分和血糖水平。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05);与治疗前相比,治疗后两组各项中医证候评分、血糖水平均显著降低,且研究组低于对照组,差异有统计学意义(P均<0.05)。结论T2DM合并H型高血压痰瘀证患者治疗中,消糖丸可以改善患者机体血糖水平,对帮助患者实现疾病预后有积极价值。

关键词：消糖丸 2型糖尿病 H型高血压痰瘀证中医证候积分糖化血红蛋白

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胰十二指肠切除术手术部位感染危险因素及耐药性分析

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中国现代普通外科进展 2024年第8期27卷 652-655页

作者：孟葳王楠徐建威李伟苏欣单慧翠董艳艳山东大学齐鲁医院医院感染管理处山东济南250012 山东大学齐鲁医院普通外科山东济南250012 山东大学齐鲁医院检验科山东济南250012

探讨开腹胰十二指肠切除术(OPD)发生手术部位感染的危险因素及病原菌耐药情况,指导手术部位感染防控及抗菌药物合理应用。收集2019年1月至2022年12月675例在我院接受OPD患者的临床资料,采用病例对照分析方法,回顾性调查42例感染者和42... 详细信息

探讨开腹胰十二指肠切除术(OPD)发生手术部位感染的危险因素及病原菌耐药情况,指导手术部位感染防控及抗菌药物合理应用。收集2019年1月至2022年12月675例在我院接受OPD患者的临床资料,采用病例对照分析方法,回顾性调查42例感染者和42例未感染者,采用单因素和多因素的非条件Logistic回归进行危险因素分析。BMI≥24(OR=3.745,95%CI:1.164~12.045)、手术时长>75百分位数(335 min,OR=4.588,95%CI:1.109~18.988)两个因素是发生手术部位感染的独立危险因素(P75百分位数(335 min)等两个因素为OPD术后发生手术部位感染的独立危险因素,应据此制定有效预防控制措施;如发生感染,应根据病原特点及药敏试验结果针对性地使用抗菌药物。

关键词：胰十二指肠切除术手术部位感染危险因素药敏试验

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2019—2020年160例儿童肺炎链球菌脑膜炎临床流行病学多中心研究

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中国当代儿科杂志 2024年第2期26卷 131-138页

作者：王彩云许红梅刘钢刘静俞蕙陈必全郑帼舒敏杜丽君徐志伟黄丽素李海波汪东白松婷单庆文朱春晖田健美郝建华林爱伟林道炯吴谨准张新华曹清陶仲宾陈源朱国龙薛萍汤正珍苏学文曲政海赵仕勇庞琳邓慧玲舒赛男陈英虎浙江大学医学院附属儿童医院感染科浙江杭州310052 重庆医科大学附属儿童医院感染科重庆400014 首都医科大学附属北京儿童医院感染科北京100045 湖南省儿童医院感染科湖南长沙410007 复旦大学附属儿科医院感染科上海201102 安徽省儿童医院感染科安徽合肥230022 南京医科大学附属儿童医院神经科江苏南京210008 四川大学华西第二医院儿科四川成都610044 山西省儿童医院神经内科山西太原030006 温州医科大学附属第二医院/育英儿童医院普儿科浙江温州325027 上海交通大学医学院附属新华医院感染科上海200092 吉林大学第一医院儿科门诊吉林长春130061 西安交通大学附属儿童医院陕西西安710002 郑州大学第一附属医院儿科河南郑州450052 广西医科大学第一附属医院儿科广西南宁530021 江西省儿童医院感染科江西南昌330006 苏州大学附属儿童医院感染科江苏苏州215002 河南开封市儿童医院感染科河南开封475000 山东大学儿童院感染科山东济南250022 海南省妇幼保健院感染科海南海口571103 厦门大学附属妇女儿童医院儿科福建厦门361003 山西省儿童医院新生儿科山西太原030006 上海交通大学医学院附属上海儿童医学中心感染科上海200127 兰州大学第一医院儿科甘肃兰州730013 河北医科大学第二医院儿科河北石家庄050004 青海省妇女儿童医院感染消化科青海西宁810007 太原市妇幼保健院儿内科山西太原030012 遵义市第一人民医院儿科贵州遵义563099 内蒙古自治区人民医院儿科内蒙古呼和浩特750306 青岛大学附属医院儿科山东青岛266003 杭州市儿童医院感染科浙江杭州310005 首都医科大学附属北京地坛医院儿科北京100102 西安市中心医院儿科陕西西安710004 华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿... 详细信息

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果160例PM患儿中,男103例,女57例;年龄15 d至15岁,其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%),血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素;113例(70.6%)患儿有1个或多个颅外感染病灶;18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例,91.9%),其次是精神萎靡(98例,61.3%)、呕吐(61例,38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症,常见并发症为硬膜下积液和/或积脓(43例,26.9%)、脑积水(24例,15.0%)、脑脓肿(23例,14.4%)、脑出血(8例,5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿,分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感;对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高;对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低;对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论儿童PM多见于3月龄至<3岁婴幼儿,颅内并发症多发生在<1岁患儿,发热是PM患儿最常见的临床表现,硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。

关键词：肺炎链球菌脑膜炎流行病学多中心研究儿童

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Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

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Signal Transduction and Targeted Therapy 2022年第1期7卷 322-330页

作者： hui Zhao Tie-Cheng wang Xiao-Feng li Na-Na Zhang liang li chao Zhou Yong-Qiang Deng Tian-shu cao Guan Yang Rui-Ting li\Yi-Jiao Huang Yuan-Guo li Yi-Ming Zhang Fang-Xu li Yu-Ren Zhou Yu-Hang Jiang Xi-shan Lu shi-hui Sun Meng-li Cheng Kai-Ping Gu Mei Zhang Qing-Qing Ma Xiao Yang Bo Ying Yu-wei Gao Cheng-Feng Qin State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences100071 BeijingChina Key Laboratory of Jilin Province for Zoonosis Prevention and Control Changchun 130122China School of Medicine Tsinghua University100084 BeijingChina State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of Lifeomics102206 BeijingChina shandong Normal University Jinan 250014China Suzhou Abogen Biosciences Suzhou 215123China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical Sciences100071 BeijingChina

Messenger RNA(mRNA)vaccine technology has shown its power in preventing the ongoing COVID-19 *** mRNA vaccines targeting the full-length S protein of SARS-CoV-2 have been authorized for emergency ***,we have developed a lipid nanoparticle-encapsulated mRNA(mRNA-LNP)encoding the receptor-binding domain(RBD)of SARS-CoV-2(termed ARCoV),which confers complete protection in mouse ***,we further characterized the protection efficacy of ARCoV in nonhuman primates and the Iong-term stability under normal refrigerator *** immunization of two doses of ARCoV elicited robust neutralizing antibodies as well as cellular response against SARS-CoV-2 in cynomolgus *** importantly,ARCoV vaccination in macaques significantly protected animals from acute lung lesions caused by SARS-CoV-2,and viral replication in lungs and secretion in nasal swabs were completely cleared in all animals immunized with low or high doses of *** evidenee of antibody-dependent enhancement of infection was observed throughout the ***,extensive stability assays showed that ARCoV can be stored at 2-8℃ for at least 6 months without decrease of *** these promising results strongly support the ongoing clinical trial.

关键词： doses stability protected

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